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公开(公告)号：US20210355010A1
公开(公告)日：2021-11-18
申请号：US17043248
申请日：2019-03-28
Applicant: University of Manitoba
Inventor： Tanner R. Devlin , Jan A. Oleszkiewicz
Abstract: Aerobic granular sludge (AGS) is an energy efficient and compact biological wastewater treatment process. There is only one commercially available AGS technology which utilizes sequencing batch reactors (SBR). Many existing wastewater treatment facilities consist of long, continuous flow reactors that would not be readily suitable for retrofit to SBR. Therefore, a continuous flow process is preferred for municipalities that cannot economically invest in the only commercially available SBR technology (i.e., Nere-da®). Lab- and pilot-scale experimentation has demonstrated that stable granulation can be achieved in a continuous flow configuration GT suitable for retrofit into existing infrastructure. An anoxic/anaerobic/aerobic configuration can be designed and stably operated for conversion of flocculent biomass to AGS Preliminary pilot-scale results on primary effluent from a municipal wastewater treatment facility indicated that granules of 0.2-0.5 mm, SVI 70% can be formed within a month of steady operation.
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公开(公告)号：US20210181123A1
公开(公告)日：2021-06-17
申请号：US17117701
申请日：2020-12-10
Applicant: UNIVERSITY OF MANITOBA
Inventor： Can-Ming Hu , Yi-Pu Wang , Yongsheng Gui , Mun Kim
Abstract: A device for unidirectional propagation of microwaves comprises a resonant microwave structure arranged to transmit microwaves between two ports and a magnetic source arranged to provide a generally static magnetic field and to have a resonant frequency distinct from that of the microwave structure, which is disposed adjacent the microwave structure so as to be located in presence of electromagnetic fields emanating from the transmitted microwaves such that the magnetic field interacts with the electromagnetic fields of the microwaves so as to form a set of hybridized resonant frequencies at which zero intrinsic damping exists, one of the set of hybridized resonant frequencies being a real eigenvalue providing the unidirectional propagation from one of the first and second ports to the other. A related method comprises arranging the magnetic source at a prescribed position where the real eigenvalue matches the frequency of an input signal applied at a selected port.
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公开(公告)号：US20210069316A1
公开(公告)日：2021-03-11
申请号：US16772348
申请日：2018-12-11
Applicant: UNIVERSITY OF MANITOBA
Inventor： Xiaojian Yao , Zhujun Ao , Gary Kobinger
IPC: A61K39/12 , A61K39/385 , C12N15/62 , C07K14/005
Abstract: We have developed a series of Ebola vims envelope glycoprotein (EboGP)-based chimeric fusion proteins that are still able to maintain an efficient EboGP-mediated virus entry in various cell types including human antigen-presenting cells (APCs) while presenting large viral polypeptides, such as HIV Env v3-v5 domain (as large as 241 aa), at the apex and the sides of each EboGP monomer to elicit robust host immune responses. This invention demonstrates the feasibility of an EboGP-based chimeric fusion technology as a novel vaccine approach against different microbial pathogens, including that in human and animals, and against cancers.
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公开(公告)号：US10806746B2
公开(公告)日：2020-10-20
申请号：US15315163
申请日：2015-05-29
Applicant: The University of Manitoba
Inventor： Makanjuola Ogunsina , Pranati Samadder , Frank Schweizer , Gilbert Arthur , Temilolu Idowu
IPC: A61K31/7028 , A61K31/7032 , C07H15/04 , A61K31/7056 , A61K31/7034
Abstract: Glycosylated Antitumor Ether Lipids (GAELs) kill cancer cells by a nonapoptotic pathway which is an attractive strategy to avoid resistance. To further optimize the antitumor effect, we prepared various analogs of di-, and tri-cationic GAEL analogs differing in the nature of the sugar (D-glucose or L-glucose), the anomeric linkage as well as position of the glycerolipid moiety. The di- and tri-cationic GAELs were synthesized and their in vitro anticancer properties were evaluated against drug resistant and aggressively growing cancer cell lines derived from human breast, prostate, pancreatic and ovarian cancers. The most potent dicationic GAEL analogs were also studied against cancer stem cells obtained from breast BT 474, prostate DU145 and ovarian A2780cp cell lines. Our results indicate that the number of positive charges, the position of the amino substituents and the nature of the sugar have significant effects on the anticancer activities of these compounds. The most active analog kill 50% of the cells at concentration range of 0.5-5 μM and 90% of the cells at the concentration of 1-10 μM depending on type of cancer cells.
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公开(公告)号：US20200255879A1
公开(公告)日：2020-08-13
申请号：US16736654
申请日：2020-01-07
Applicant: The University of Manitoba
Inventor： Venkata Tayi , Michael Butler
Abstract: An enzymatic method is provided for restructuring an affinity ligand bound heterogenous glycoform antibody sample to a substantially homogenous single desired glycoform antibody sample for therapeutic uses and kits for performing the methods. A method for enzymatically altering the Fc region of an affinity ligand bound antibody from a heterogenous glycoform to a substantially homogenous single glycoform comprises: contacting the affinity ligand bound heterogeneous glycoform antibody with a reaction buffer designed for a particular glycoform modification for a time sufficient and under conditions to modify the glycoform of the Fc region to a substantially homogeneous single form; optionally adding one or more nucleotide sugars and/or cofactors; and releasing the substantially homogeneous single glycoform antibody sample from said affinity ligand. The invention also encompasses biopharmaceuticals comprising single glycoform mAbs and polyclonal sntibodies enzymatically produced for the treatment of cancers and immune disorders as well as compositions comprising the single glycoform antibodies as a biopharmaceutical.
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Patent Agency Ranking
16.发明授权公开(公告)号：US10728981B2
公开(公告)日：2020-07-28
申请号：US16185668
申请日：2018-11-09
Applicant: University of Manitoba
Inventor： Ngai Man Ho , Radwa Abdalaal , Henry Shu Hung Chung
Abstract: Low cost and low power LED lamps exhibit current harmonic contents due to their nonlinear characteristics. A large scale lighting network requires tens to hundreds LED lamp installations, the resultant harmonic currents pollute the grid seriously. Furthermore, light intensity fluctuations are becoming a concern nowadays to many users, as a safety and a health problems. This phenomenon is mainly caused by heavy loads as they lead to voltage fluctuations and deteriorating in PQ and hence visual flickering in LED lamps. A single phase transformer-less unified power quality conditioner (UPQC) topology is provided with its controls to mitigate all PQ problems in a network.
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公开(公告)号：US10463712B2
公开(公告)日：2019-11-05
申请号：US15569045
申请日：2016-04-25
Applicant: University of Manitoba
Inventor： Jean-Eric Ghia , Mohammed Fazle Alam Rabbi , Ehsan Khafipour , Peris Munyaka
Abstract: Treatment with catestatin changes the proportion of two major phyla Bacteroidetes and Firmicutes in the gut microbiota in an opposite manner observed in intestinal disorders like IBD, IBS or non-intestinal disorders like obesity. Specifically, administration of an effective amount of catestatin increased the relative percentage of Bacteroidetes and decreased the relative percentage of Firmicutes in the gut microbiota.
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公开(公告)号：US20190316986A1
公开(公告)日：2019-10-17
申请号：US16318547
申请日：2017-08-08
Applicant: University of Manitoba
Inventor： Nan Wu , Farjana Faisal , Samuel Osho
Abstract: A low cost and efficient damage detection method is developed by introducing a new piezoelectric composite coating combined with a self-powered wireless signal transmission module. The new piezoelectric composite coating composed with a piezoelectric layer, an electrical conductive layer and an insulator, is designed as the sensor and to be easily applied on rough surfaces of engineering structures, such as concrete and the welded joint area. An energy harvesting circuit and an automatic electronic switch controlled by the piezoelectric coating sensor are designed to power and control the wireless signal transmitter sending warning signals of the damage occurrence. Methodology is explained in detail, and successful detection of the occurrence of crack propagation on a beam structure has been realized through experimental testing.
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公开(公告)号：US20190046540A1
公开(公告)日：2019-02-14
申请号：US16160403
申请日：2018-10-15
Applicant: University of Manitoba , University Health Network , THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Paul Fernyhough , Nigel A. Calcutt , Lakshmi Kotra
IPC: A61K31/5513 , C07D417/12 , A61K31/46 , A61K31/496
Abstract: Treatments for therapy of a diabetic symmetrical polyneuropathy a subject in need thereof. The treatments includes administration of compositions comprising: an effective amount of a muscarinic acetylcholine receptor antagonist exemplified by pirenzepine, telenzepine, atropine, or derivatives thereof or salts thereof or analogs thereof or derivatives thereof, and a pharmacologically acceptable carrier. The composition may be injectable or alternatively, may be applied topically or alternatively, may be delivered orally. A suitable topical composition may comprise a lotion, a cream, a gel, or a viscous fluid. The muscarinic acetylcholine receptor antagonist may be a muscarinic acetylcholine receptor antagonist salt or a muscarinic acetylcholine receptor antagonist derivative or a muscarinic acetylcholine receptor antagonist analog.
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公开(公告)号：US20180263775A1
公开(公告)日：2018-09-20
申请号：US15760088
申请日：2016-09-16
Applicant: University of Manitoba
Inventor： Pallav SHAH
IPC: A61F2/24
CPC classification number: A61F2/2445 , A61F2/2409 , A61F2250/0004 , A61F2250/0018
Abstract: A two-part aortic annular support system for supporting an aortic annulus during aortic valve repair procedures for prevention of further annular dilation. The first part comprises a composite annular ring that is positionable from within an aortic valve into the left ventricular outflow tract at the level of annular plane. The composite ring comprises a semi-rigid section and a resiliently deformable section. The semi-rigid section is shorter in length than the deformable section. The deformable section is extendible into a commissure of the aortic valve. The second part is a resilient band that is positionable external to the aortic root. The resilient band is securable to the composite ring through the aortic annulus by suturing. The present disclosure also relates to a use of the aortic annular support system and a method of inserting and securing the aortic annular support system during a surgical intervention.
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