公开(公告)号：US20200289590A1

公开(公告)日：2020-09-17

申请号：US16790459

申请日：2020-02-13

Applicant: Virttu Biologics Limited ,  The University of Sheffield

Inventor： Joe Conner ,  Munitta Muthana ,  Claire Elizabeth Lewis

IPC: A61K35/763 ,  A61K41/00 ,  C12N5/0786 ,  A61K35/15 ,  A61K9/19 ,  A61M37/00 ,  A61K9/00 ,  A61K47/69 ,  A61K33/26 ,  A61K9/50 ,  C12N7/00

Abstract: A monocyte, monocyte derived cell or macrophage infected with an oncolytic herpes simplex virus is disclosed together with uses of such infected cells in the treatment of diseases such as cancer.

公开(公告)号：US20200268851A1

公开(公告)日：2020-08-27

申请号：US16650259

申请日：2018-10-24

Applicant: Sheffield Children's NHS Foundation Trust ,  University of Sheffield

Inventor： Neil Peter Wright ,  Charlotte Jane Elder

IPC: A61K38/22 ,  A61K47/36 ,  A61K9/00 ,  G01N33/50

Abstract: The disclosure relates to a composition comprising adrenocorticotropic hormone (ACTH) or a synthetic ACTH analogue for use in a diagnostic test for adrenal insufficiency. A method to conduct said diagnostic test; a combined diagnostic and method of treatment; and kits comprising the components for said test are also disclosed.

公开(公告)号：US20180372695A1

公开(公告)日：2018-12-27

申请号：US16064719

申请日：2016-12-21

Applicant: THE UNIVERSITY OF SHEFFIELD

Inventor： Robin MILLS ,  Robert S. DWYER-JOYCE ,  Matthew MARSHALL

IPC: G01N29/34 ,  G01B17/02 ,  G01N29/04 ,  G01N29/12 ,  G01N29/44

Abstract: A continuous wave ultrasound analysis device for analysing a surface of a component includes an input to receive ultrasound data relating to continuous wave, swept frequency ultrasound propagated through the component; a processing section to derive a standing wave amplitude spectrum from the received ultrasound data, and determine a property of an unconstrained layer on the surface based on the standing wave amplitude spectrum; and an output to output the determined property of the layer. A method of continuous wave ultrasound for analysing a surface is also provided.

公开(公告)号：US20180282169A1

公开(公告)日：2018-10-04

申请号：US15757182

申请日：2016-09-01

Applicant: UNIVERSITY OF SHEFFIELD

Inventor： JOSEPH RICHARD HENRY MANNING ,  SIDDHARTH VIJAY PATWARDHAN

IPC: C01B33/12 ,  B01J39/04 ,  B01J39/18 ,  C07C209/86

Abstract: A method for the production of a silica includes (1) reacting a silicic acid solution with an amine, to precipitate the silica from an aqueous solvent system. The method also includes removing at least a portion of the amine associated with the precipitated silica by treating the silica in an aqueous solvent system at a pH that is reduced from that of the reaction mixture (2). The reduction in pH may be by first reducing the pH of the aqueous solvent system, and then removing the silica from the aqueous solvent system. Alternatively the reduction in pH may be removing the silica from the aqueous solvent system first, before treating the silica with an aqueous solvent at a pH below that of the silica forming reaction. Subsequently the silica is removed from the solution (3).

公开(公告)号：US20180015089A1

公开(公告)日：2018-01-18

申请号：US15546626

申请日：2016-01-27

Applicant: STOREY ROBERT ,  ASTRAZENECA AB ,  THE UNIVERSITY OF SHEFFIELD ,  SHEFFIELD TEACHING HOSPITALS NHS FOUNDATION TRUST

Inventor： Lars Magnus ANDERSSON ,  Tomas Lars-Gunnar ANDERSSON ,  Olof Fredrik BENGTSSON ,  Hans Peter HELD ,  Garnet Edward HOWELLS ,  Eva Christina JENSEN ,  Robert STOREY

IPC: A61K31/519 ,  A61K31/616 ,  A61K9/20

CPC classification number: A61K31/519 ,  A61K9/20 ,  A61K31/60 ,  A61K31/609 ,  A61K31/616 ,  A61K2300/00

Abstract: The present disclosure relates to methods for reducing the rate of cardiovascular death, myocardial infarction, or stroke in a patient in recognized need thereof, comprising administering to the patient a pharmaceutical composition comprising 60 mg ticagrelor twice daily.

公开(公告)号：US09865771B2

公开(公告)日：2018-01-09

申请号：US15110991

申请日：2015-01-07

Applicant: QD LASER, INC. ,  UNIVERSITY OF SHEFFIELD

Inventor： Kenichi Nishi ,  Takeo Kageyama ,  Keizo Takemasa ,  Mitsuru Sugawara ,  Richard Hogg ,  Siming Chen

IPC: H01L33/06 ,  H01L33/08 ,  H01L33/24 ,  H01L33/32

CPC classification number: H01L33/06 ,  H01L33/08 ,  H01L33/24 ,  H01L33/30 ,  H01L33/32

Abstract: A semiconductor light-emitting element includes: a lower clad layer 12 that is provided on a substrate 10; an active layer 20 that is provided on the lower clad layer 12 and includes a quantum well layer 24 and a plurality of quantum dots 28 sandwiching a second barrier layer 22b together with the quantum well layer 24; and an upper clad layer 14 that is provided on the active layer 20, wherein a distance D between the quantum well layer 24 and the plurality of quantum dots 28 is smaller than an average of distances X between centers of the plurality of quantum dots 28.

公开(公告)号：US09707265B2

公开(公告)日：2017-07-18

申请号：US14414001

申请日：2013-07-12

Applicant: The University of Sheffield

Inventor： Steven J. Winder

IPC: A61K38/07 ,  A61K31/198 ,  A61K31/496 ,  A61K31/506 ,  A61K31/4155 ,  A61K31/517 ,  A61K31/69 ,  G01N33/50 ,  A61K38/17 ,  A01K67/027

CPC classification number: A61K38/07 ,  A01K67/0275 ,  A01K2217/052 ,  A01K2217/054 ,  A01K2217/15 ,  A01K2227/105 ,  A01K2267/0306 ,  A61K31/198 ,  A61K31/4155 ,  A61K31/496 ,  A61K31/506 ,  A61K31/517 ,  A61K31/69 ,  A61K38/1709 ,  G01N33/5041 ,  G01N2333/9015 ,  G01N2800/10 ,  A61K2300/00

Abstract: The invention provides a compound capable of inhibiting ubiquitination for use in treating a disorder or symptom associated with reduced dystroglycan function in a subject.

公开(公告)号：US20160336480A1

公开(公告)日：2016-11-17

申请号：US15110991

申请日：2015-01-07

Applicant: QD LASER, INC. ,  UNIVERSITY OF SHEFFIELD

Inventor： Kenichi NISHI ,  Takeo KAGEYAMA ,  Keizo TAKEMASA ,  Mitsuru SUGAWARA ,  Richard HOGG ,  Siming CHEN

IPC: H01L33/06 ,  H01L33/08 ,  H01L33/24 ,  H01L33/32

CPC classification number: H01L33/06 ,  H01L33/08 ,  H01L33/24 ,  H01L33/30 ,  H01L33/32

Abstract: A semiconductor light-emitting element includes: a lower clad layer 12 that is provided on a substrate 10; an active layer 20 that is provided on the lower clad layer 12 and includes a quantum well layer 24 and a plurality of quantum dots 28 sandwiching a second barrier layer 22b together with the quantum well layer 24; and an upper clad layer 14 that is provided on the active layer 20, wherein a distance D between the quantum well layer 24 and the plurality of quantum dots 28 is smaller than an average of distances X between centers of the plurality of quantum dots 28.

Abstract translation: 半导体发光元件包括：设置在基板10上的下包层12; 设置在下包层12上的有源层20，包括量子阱层24和与量子阱层24一起夹着第二阻挡层22b的多个量子点28; 以及设置在有源层20上的上覆盖层14，其中量子阱层24与多个量子点28之间的距离D小于多个量子点28的中心之间的距离X的平均值。

公开(公告)号：US20160207948A1

公开(公告)日：2016-07-21

申请号：US14914994

申请日：2014-09-02

Applicant: UNIVERSITY OF SHEFFIELD

Inventor： Richard Jackson ,  Richard Muimo ,  Matthew Lilley

IPC: C07F9/6503 ,  G01N33/53 ,  C07K16/44 ,  C07F9/6539 ,  C07K14/00

CPC classification number: C07F9/65031 ,  C07F9/58 ,  C07F9/6539 ,  C07F9/655345 ,  C07K14/001 ,  C07K16/44 ,  G01N33/5308 ,  G01N2440/14

Abstract: The invention relates to phosphohistidine analogues. The invention also relates to antibodies that specifically bind to the analogues and methods of generating said antibodies. In one embodiment of the invention there is provided a phosphohistidine analogue of Formula V: (V) wherein W is selected from H, CO2H or CONH2; and X is selected from CH or N.

Abstract translation: 本发明涉及磷酸组氨酸类似物。 本发明还涉及特异性结合产生所述抗体的类似物和方法的抗体。 在本发明的一个实施方案中，提供式V的磷酸组氨酸类似物：（V）其中W选自H，CO 2 H或CONH 2; 并且X选自CH或N.

公开(公告)号：US20160167352A1

公开(公告)日：2016-06-16

申请号：US14904368

申请日：2014-07-04

Applicant: The University of Sheffield

Inventor： Alma HODZIC ,  Patrick James SMITH

IPC: B32B37/00 ,  B32B27/36 ,  B32B7/12 ,  B29C37/00 ,  B32B37/12 ,  B32B27/28 ,  B29C70/88 ,  B29C70/30 ,  B32B27/38 ,  B32B5/00

CPC classification number: B32B37/0076 ,  B29C37/0025 ,  B29C70/30 ,  B29C70/42 ,  B29C70/88 ,  B29K2033/12 ,  B29K2063/00 ,  B29K2071/02 ,  B29K2105/0073 ,  B29K2105/12 ,  B29K2105/253 ,  B29K2307/04 ,  B29L2009/00 ,  B32B3/10 ,  B32B5/00 ,  B32B7/12 ,  B32B27/28 ,  B32B27/285 ,  B32B27/34 ,  B32B27/36 ,  B32B27/38 ,  B32B37/1292 ,  B32B2255/10 ,  B32B2255/26 ,  B32B2260/023 ,  B32B2260/046 ,  B32B2262/02 ,  B32B2262/0261 ,  B32B2262/065 ,  B32B2262/067 ,  B32B2262/10 ,  B32B2262/101 ,  B32B2262/106 ,  B32B2305/076 ,  B32B2307/50 ,  B32B2307/542 ,  B32B2307/546 ,  B32B2307/762 ,  B32B2605/18

Abstract: A method of fabricating a composite material, the method comprises the steps of a) providing a first layer of a fibre reinforced polymer, preferably a thermoset FRP, b) providing an array of thermoplastic islands across at least a proportion of a major surface of the first layer, c) providing a second layer of a fibre reinforced polymer, preferably a thermoset FRP, d) laying the second layer over at least some of the islands, and e) securing the first and second layers together. There is also disclosed a composite which comprises a first layer of a fibre reinforced polymer and a second layer of a fibre reinforced polymer, between which is an intervening layer comprising an array of thermoplastic islands.

Abstract translation: 一种制备复合材料的方法，所述方法包括以下步骤：a）提供第一层纤维增强聚合物，优选热固性FRP，b）提供横跨至少一部分主要表面的热塑性岛的阵列 第一层，c）提供第二层纤维增强聚合物，优选热固性FRP，d）将第二层铺设在至少一些岛上，以及e）将第一层和第二层固定在一起。 还公开了一种复合材料，其包括纤维增强聚合物的第一层和纤维增强聚合物的第二层，其间是包含热塑性岛的阵列的中间层。