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公开(公告)号：US12272468B2
公开(公告)日：2025-04-08
申请号：US18484587
申请日：2023-10-11
Applicant: University of Washington
Inventor： Daniel T. Chiu , Jiangbo Yu , Yu Rong , Changfeng Wu
Abstract: The present disclosure provides organic-inorganic hybrid polymer particles, which have desirable surface chemistry and optical properties that make them particularly suitable for biological and optical applications. The present disclosure also provides methods of making organic-inorganic hybrid polymer particles. The present disclosure also provides methods of using the organic-inorganic hybrid polymer particles for biological and optical applications.
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公开(公告)号：US12252737B2
公开(公告)日：2025-03-18
申请号：US18918205
申请日：2024-10-17
Applicant: University of Washington
Inventor： Georg Seelig , Richard Muscat , Alexander B. Rosenberg
IPC: C12Q1/6806 , C12N15/10 , C12Q1/6855
Abstract: Methods of uniquely labeling or barcoding molecules within a cell, a plurality of cells, and/or a tissue are provided. Kits for uniquely labeling or barcoding molecules within a cell, a plurality of cells, and/or a tissue are also provided. The molecules to be labeled may include, but are not limited to, RNAs, cDNAs, DNAs, proteins, peptides, and/or antigens.
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公开(公告)号：US12252736B2
公开(公告)日：2025-03-18
申请号：US18784019
申请日：2024-07-25
Applicant: University of Washington
Inventor： Georg Seelig , Richard Muscat , Alexander B. Rosenberg
IPC: C12Q1/6806 , C12N15/10 , C12Q1/6855
Abstract: Methods of uniquely labeling or barcoding molecules within a cell, a plurality of cells, and/or a tissue are provided. Kits for uniquely labeling or barcoding molecules within a cell, a plurality of cells, and/or a tissue are also provided. The molecules to be labeled may include, but are not limited to, RNAs, cDNAs, DNAs, proteins, peptides, and/or antigens.
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公开(公告)号：US12251086B2
公开(公告)日：2025-03-18
申请号：US17400983
申请日：2021-08-12
Applicant: University of Washington
Inventor： Eric J. Seibel , Saniel D. Lim , Mark E. Fauver
Abstract: A monitoring system includes a light source, a light detector, a processor, and a non-transitory computer readable medium storing instructions that, when executed by the processor, cause the monitoring system to perform functions. The functions include illuminating, via the light source, a biological sample that is within a container while a fixation process is performed on the biological sample. The functions also include determining, via the light detector, that an optical transmittance of the biological sample satisfies a condition. The functions also include ceasing the fixation process in response to determining that the optical transmittance of the biological sample satisfies the condition.
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公开(公告)号：US12234572B2
公开(公告)日：2025-02-25
申请号：US17294807
申请日：2019-11-19
Applicant: UNIVERSITY OF WASHINGTON
Inventor： Alfredo Quijano Rubio , Daniel Adriano Silva Manzano , David Baker , Umut Ulge , Marc Joseph Lajoie
Abstract: Conditionally active receptor agonists that, when activated, bind to IL-2 receptor βc heterodimer (IL-2Rβc), IL-4 receptor αc heterodimer (IL-4Rαc), or IL-13 receptor a subunit (IL˜13 Rα) are disclosed, as are components of the conditionally active receptor agonists and methods for using the conditionally active receptor agonists.
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Patent Agency Ranking
16.发明授权公开(公告)号：US12233117B2
公开(公告)日：2025-02-25
申请号：US18359740
申请日：2023-07-26
Applicant: UNIVERSITY OF WASHINGTON
Inventor： Sean C. Murphy , Bradley C. Stone
Abstract: An immunogenic composition is provided herein. The immunogenic compositions are used to identify and select immunogenic antigens that elicit immune responses in a subject and may be subsequently used in multi-antigen vaccine compositions against one or more diseases or conditions. According to some embodiments, the immunogenic composition may include a plurality of nucleic acid fragments or minigenes derived from a nucleic acid library, wherein each nucleic acid fragment encodes a different antigen or functional portion thereof, and wherein the different antigens or functional portions thereof are associated with one or more disease or condition. The immunogenic composition may also include a delivery medium loaded with the plurality of nucleic acid fragments and in some embodiments, the delivery medium is loaded with nucleic acid fragments in such a way that individual antigen presenting cells receive only a subset of the nucleic acids within a vaccine in order to minimize antigenic competition.
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17.发明授权公开(公告)号：US12231830B2
公开(公告)日：2025-02-18
申请号：US17765317
申请日：2020-09-30
Applicant: University of Washington
Inventor： Ruikang K. Wang , Qinghua He
Abstract: In some embodiments, a computer-implemented method of generating a visualization of wavelength-dependent surface characteristics is provided. A computing device receives an input image captured by a camera, wherein the input image includes information in a low-dimensional color space. The computing device processes the input image to determine spectrum band information in a high-dimensional color space that corresponds to the input image. The computing device extracts subtractive information from the spectrum band information to obtain wavelength-dependent surface characteristic information, The computing device generates the visualization using the wavelength-dependent surface characteristic information. In some embodiments, the computing device may be a smartphone.
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公开(公告)号：US12227553B2
公开(公告)日：2025-02-18
申请号：US18187639
申请日：2023-03-21
Applicant: UNIVERSITY OF WASHINGTON , THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
Inventor： Daniel Adriano Silva Manzano , Shawn Yu , Umut Ulge , David Baker , Kenan Christopher Garcia , Jamie Spangler , Carl Walkey
Abstract: De novo designed polypeptides that bind to IL-2 receptor βγc heterodimer (IL-2Rβγc), IL-4 receptor αγc heterodimer (IL-4Rαγc), or IL-13 receptor α subunit (IL-13Rα) are disclosed, as are methods for using and designing the polypeptides.
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公开(公告)号：US20250051407A1
公开(公告)日：2025-02-13
申请号：US18799107
申请日：2024-08-09
Applicant: University of Washington
Inventor： David Baker , Cameron Glasscock , Robert Pecoraro , Ryan McHugh , Christoffer Norn , Frank DiMaio , David Benjamin Turitz Cox , Brian Coventry , Hugh Haddox , Gyu Rie Lee
Abstract: Polypeptides are provided that include an amino acid sequence at least 50% identical, not including any amino acid insertions at identified insertion sites, to the amino acid sequence selected from the group consisting of SEQ ID NO: 1-52, wherein the polypeptide is a sequence-specific DNA-binding polypeptide, fusion proteins comprising such polypeptides, nucleic acids encoding such polypeptides and fusion proteins, and expression vectors and host cells comprising such nucleic acids.
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公开(公告)号：US20250049843A1
公开(公告)日：2025-02-13
申请号：US18723132
申请日：2022-12-21
Applicant: University of Washington
Inventor： Miqin ZHANG , Peter A. CHIARELLI , Richard REVIA , Zachary STEPHEN , Forrest M. KIEVIT , Kui WANG , Richard G. ELLENBOGEN
Abstract: Method for nanoparticle-mediated deposition of radiation (NMDR) and targeted radiation therapies using a biodegradable and bioabsorbable iron oxide nanoparticle with a biocompatible coating that is effective to overcome various extra- and intra-cellular barriers and selectively accumulate in solid and metastatic tumors to improve the energy transfer of conventional radiotherapy
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