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公开(公告)号：US20230408526A1
公开(公告)日：2023-12-21
申请号：US18058458
申请日：2022-11-23
Inventor： Daniel T. Chiu , Changfeng Wu , Xuanjun Zhang , Jiangbo Yu , Fangmao Ye
IPC: G01N33/58 , B82Y30/00 , B82Y40/00 , B82Y15/00 , H10K85/10 , C09K11/06 , C08G61/12 , C08J3/11 , C09K11/02
CPC classification number: G01N33/588 , C09K2211/1425 , B82Y40/00 , B82Y15/00 , H10K85/115 , C09K11/06 , C08G61/126 , C08J3/11 , C09K11/025 , C08G2261/12 , C08G2261/1426 , C08G2261/228 , C08G2261/3142 , C08G2261/3246 , C08G2261/522 , C08G2261/54 , C08G2261/72 , C08G2261/94 , C08J2327/22 , B82Y30/00
Abstract: The present invention provides, among other aspects, stabilized chromophoric nanoparticles. In certain embodiments, the chromophoric nanoparticles provided herein are rationally functionalized with a pre-determined number of functional groups. In certain embodiments, the stable chromophoric nanoparticles provided herein are modified with a low density of functional groups. In yet other embodiments, the chromophoric nanoparticles provided herein are conjugated to one or more molecules. Also provided herein are methods for making rationally functionalized chromophoric nanoparticles.
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公开(公告)号：US11835526B2
公开(公告)日：2023-12-05
申请号：US17672586
申请日：2022-02-15
Inventor： Daniel T. Chiu , Changfeng Wu , Jason McNeill , Jiangbo Yu
CPC classification number: G01N33/587 , C09K11/06 , G01N33/582
Abstract: The present invention provides, among other aspects, functionalized chromophoric polymer dots comprising a hydrophobic core and a hydrophilic cap, and bioconjugates thereof. Also provided are improved methods for preparing functionalized chromophoric polymer dots. Methods for in vivo imaging and molecular labeling are also disclosed.
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公开(公告)号：US11674964B2
公开(公告)日：2023-06-13
申请号：US17538447
申请日：2021-11-30
Inventor： Daniel T. Chiu , Changfeng Wu , Jiangbo Yu
CPC classification number: G01N33/58 , C09K11/02 , C09K11/06 , G01N21/6408 , G01N21/6428 , G01N33/582 , G01N33/587 , G01N33/588 , C09K2211/1007 , C09K2211/1011 , C09K2211/1044 , C09K2211/1416 , C09K2211/182 , G01N2021/6417 , G01N2021/6439 , G01N2021/6441 , G01N2201/12
Abstract: The present disclosure provides encoded chromophoric polymer particles that are capable of, for example, optical and/or biomolecular encoding of analytes. The present disclosure also provides suspensions comprising a plurality of encoded chromophoric polymer particles. The present disclosure also provides methods of using the encoded chromophoric polymer particles and systems for performing multiplex analysis with encoded chromophoric polymer particles.
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公开(公告)号：US11585818B2
公开(公告)日：2023-02-21
申请号：US16989491
申请日：2020-08-10
Inventor： Daniel T. Chiu , Changfeng Wu , Xuanjun Zhang , Jiangbo Yu , Fangmao Ye
IPC: C09K11/02 , G01N33/58 , B82Y30/00 , B82Y40/00 , B82Y15/00 , C09K11/06 , H01L51/00 , C08G61/12 , C08J3/11
Abstract: The present invention provides, among other aspects, stabilized chromophoric nanoparticles. In certain embodiments, the chromophoric nanoparticles provided herein are rationally functionalized with a pre-determined number of functional groups. In certain embodiments, the stable chromophoric nanoparticles provided herein are modified with a low density of functional groups. In yet other embodiments, the chromophoric nanoparticles provided herein are conjugated to one or more molecules. Also provided herein are methods for making rationally functionalized chromophoric nanoparticles.
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公开(公告)号：US11219896B2
公开(公告)日：2022-01-11
申请号：US14900926
申请日：2014-06-25
Inventor： Daniel T. Chiu , Thomas Schneider , Jason E. Kreutz
IPC: B01L3/00 , B01L7/00 , G01N27/447
Abstract: Devices, systems and apparatuses for the discretization and manipulation of sample volumes are provided. Related methods are also provided.
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Patent Agency Ranking
公开(公告)号：US20210172957A1
公开(公告)日：2021-06-10
申请号：US17175408
申请日：2021-02-12
Applicant: University of Washington
Inventor： Daniel T. Chiu
Abstract: Methods, systems, compositions and kits are provided for the analysis of target molecules using chromophoric polymer dots conjugated to biomolecules. The use of chromophoric polymer dots improves detection sensitivity and stability when compared with existing techniques. In some aspects, methods, systems, and kits are provided for detecting a target protein using chromophoric polymer dots conjugated to biomolecules in a Western blot analysis. Related methods, systems, compositions and kits are also provided.
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公开(公告)号：US20200208202A1
公开(公告)日：2020-07-02
申请号：US16812173
申请日：2020-03-06
Inventor： Daniel T. Chiu , Jason E. Kreutz , Gloria S. Yen , Bryant S. Fujimoto
Abstract: Methods, devices, and systems for performing digital assays are provided. In certain aspects, the methods, devices, and systems can be used for the amplification and detection of nucleic acids. In certain aspects, the methods, devices, and systems can be used for the recognition, detection, and sizing of droplets in a volume. Also provided are compositions and kits suitable for use with the methods and devices of the present disclosure.
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公开(公告)号：US10590470B2
公开(公告)日：2020-03-17
申请号：US15962944
申请日：2018-04-25
Inventor： Daniel T. Chiu , Bryant S. Fujimoto , Alexander R. Gansen , Gloria S. Yen , Robert M. Lorenz
IPC: C12Q1/68 , C12Q1/6851 , C12Q1/6806
Abstract: Methods, devices and systems for performing digital measurements are provided.
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公开(公告)号：US20200057060A1
公开(公告)日：2020-02-20
申请号：US16347502
申请日：2017-11-16
Applicant: University of Washington
Inventor： Daniel T. Chiu , Chun-Ting Kuo , Li Wu
IPC: G01N33/554 , G01N21/64 , G01N15/14 , G01N33/533 , B01L3/00
Abstract: Methods and systems for improved labeling and/or de-labeling a molecule or cell in the context of scientific experimentation, industrial applications, and clinical investigation, including the means to repeat the process of labeling and de-labeling in an efficient manner.
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公开(公告)号：US10444243B2
公开(公告)日：2019-10-15
申请号：US15100056
申请日：2014-11-25
Inventor： Daniel T. Chiu , Changfeng Wu , Jiangbo Yu
Abstract: The present disclosure provides encoded chromophoric polymer particles that are capable of, for example, optical and/or biomolecular encoding of analytes. The present disclosure also provides suspensions comprising a plurality of encoded chromophoric polymer particles. The present disclosure also provides methods of using the encoded chromophoric polymer particles and systems for performing multiplex analysis with encoded chromophoric polymer particles.
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