-
公开(公告)号：US20230408526A1
公开(公告)日：2023-12-21
申请号：US18058458
申请日：2022-11-23
发明人： Daniel T. Chiu , Changfeng Wu , Xuanjun Zhang , Jiangbo Yu , Fangmao Ye
IPC分类号： G01N33/58 , B82Y30/00 , B82Y40/00 , B82Y15/00 , H10K85/10 , C09K11/06 , C08G61/12 , C08J3/11 , C09K11/02
CPC分类号： G01N33/588 , C09K2211/1425 , B82Y40/00 , B82Y15/00 , H10K85/115 , C09K11/06 , C08G61/126 , C08J3/11 , C09K11/025 , C08G2261/12 , C08G2261/1426 , C08G2261/228 , C08G2261/3142 , C08G2261/3246 , C08G2261/522 , C08G2261/54 , C08G2261/72 , C08G2261/94 , C08J2327/22 , B82Y30/00
摘要： The present invention provides, among other aspects, stabilized chromophoric nanoparticles. In certain embodiments, the chromophoric nanoparticles provided herein are rationally functionalized with a pre-determined number of functional groups. In certain embodiments, the stable chromophoric nanoparticles provided herein are modified with a low density of functional groups. In yet other embodiments, the chromophoric nanoparticles provided herein are conjugated to one or more molecules. Also provided herein are methods for making rationally functionalized chromophoric nanoparticles.
-
公开(公告)号：US11835526B2
公开(公告)日：2023-12-05
申请号：US17672586
申请日：2022-02-15
发明人： Daniel T. Chiu , Changfeng Wu , Jason McNeill , Jiangbo Yu
CPC分类号： G01N33/587 , C09K11/06 , G01N33/582
摘要： The present invention provides, among other aspects, functionalized chromophoric polymer dots comprising a hydrophobic core and a hydrophilic cap, and bioconjugates thereof. Also provided are improved methods for preparing functionalized chromophoric polymer dots. Methods for in vivo imaging and molecular labeling are also disclosed.
-
公开(公告)号：US11674964B2
公开(公告)日：2023-06-13
申请号：US17538447
申请日：2021-11-30
发明人： Daniel T. Chiu , Changfeng Wu , Jiangbo Yu
CPC分类号： G01N33/58 , C09K11/02 , C09K11/06 , G01N21/6408 , G01N21/6428 , G01N33/582 , G01N33/587 , G01N33/588 , C09K2211/1007 , C09K2211/1011 , C09K2211/1044 , C09K2211/1416 , C09K2211/182 , G01N2021/6417 , G01N2021/6439 , G01N2021/6441 , G01N2201/12
摘要： The present disclosure provides encoded chromophoric polymer particles that are capable of, for example, optical and/or biomolecular encoding of analytes. The present disclosure also provides suspensions comprising a plurality of encoded chromophoric polymer particles. The present disclosure also provides methods of using the encoded chromophoric polymer particles and systems for performing multiplex analysis with encoded chromophoric polymer particles.
-
公开(公告)号：US11585818B2
公开(公告)日：2023-02-21
申请号：US16989491
申请日：2020-08-10
发明人： Daniel T. Chiu , Changfeng Wu , Xuanjun Zhang , Jiangbo Yu , Fangmao Ye
IPC分类号： C09K11/02 , G01N33/58 , B82Y30/00 , B82Y40/00 , B82Y15/00 , C09K11/06 , H01L51/00 , C08G61/12 , C08J3/11
摘要： The present invention provides, among other aspects, stabilized chromophoric nanoparticles. In certain embodiments, the chromophoric nanoparticles provided herein are rationally functionalized with a pre-determined number of functional groups. In certain embodiments, the stable chromophoric nanoparticles provided herein are modified with a low density of functional groups. In yet other embodiments, the chromophoric nanoparticles provided herein are conjugated to one or more molecules. Also provided herein are methods for making rationally functionalized chromophoric nanoparticles.
-
公开(公告)号：US10444243B2
公开(公告)日：2019-10-15
申请号：US15100056
申请日：2014-11-25
发明人： Daniel T. Chiu , Changfeng Wu , Jiangbo Yu
摘要： The present disclosure provides encoded chromophoric polymer particles that are capable of, for example, optical and/or biomolecular encoding of analytes. The present disclosure also provides suspensions comprising a plurality of encoded chromophoric polymer particles. The present disclosure also provides methods of using the encoded chromophoric polymer particles and systems for performing multiplex analysis with encoded chromophoric polymer particles.
-
公开(公告)号：US11697713B2
公开(公告)日：2023-07-11
申请号：US16138732
申请日：2018-09-21
发明人： Daniel T. Chiu , Changfeng Wu , Yu Rong , Yong Zhang , Yi-Che Wu , Yang-Hsiang Chan , Xuanjun Zhang , Jiangbo Yu , Wei Sun
IPC分类号： A61K47/32 , C08G77/00 , C08G77/398 , C08G75/32 , G01N33/58 , A61K49/00 , C09B69/10 , H10K85/10 , C08G79/00 , B82Y40/00 , B82Y30/00 , G01N21/64 , H10K50/11
CPC分类号： C08G75/32 , A61K49/0019 , A61K49/0067 , C08G79/00 , C09B69/105 , G01N33/582 , G01N33/587 , H10K85/10 , H10K85/113 , H10K85/115 , H10K85/151 , B82Y30/00 , B82Y40/00 , G01N2021/6439 , H10K50/11
摘要： Polymers, monomers, chromophoric polymer dots and related methods are provided. Highly fluorescent chromophoric polymer dots with narrow-band emissions are provided. Methods for synthesizing the chromophoric polymers, preparation methods for forming the chromophoric polymer dots, and biological applications using the unique properties of narrow-band emissions are also provided.
-
公开(公告)号：US20230077385A1
公开(公告)日：2023-03-16
申请号：US18058530
申请日：2022-11-23
发明人： Daniel T. Chiu , Jiangbo Yu , Changfeng Wu , Kai Sun
摘要： The present disclosure provides nanoparticle transducers and methods of use thereof for the detection of analyte concentrations in a fluid. Nanoparticle transducers can comprise a nanoparticle, such as a Pdot, coupled to an enzyme that catalyzes a reaction with the analyte. The nanoparticle transducers further comprise chromophores that emit fluorescence that varies as a function of the concentration of one of the elements of the reaction. The nanoparticle transducer thus changes fluorescence as the analyte concentration changes, transforming analyte concentration values into fluorescence intensities. The measurement of these intensities provides a measurement of the analyte concentration. The nanoparticle transducers are biocompatible, allowing for use in vivo, for the monitoring of analyte blood concentrations such as blood glucose concentrations.
-
公开(公告)号：US11249073B2
公开(公告)日：2022-02-15
申请号：US14434200
申请日：2013-10-08
发明人： Daniel T. Chiu , Wei Sun , Jiangbo Yu , Changfeng Wu
摘要： The present disclosure provides metal-containing (MC) semiconducting (SC) Pdots (MC-SC-Pdots) with beneficial functionalities in both cellular imaging and manipulation, among other applications. The Pdots comprise at least one nanoparticle comprising at least one metal, and a semiconducting polymer associated with the nanoparticle.
-
公开(公告)号：US11087900B2
公开(公告)日：2021-08-10
申请号：US16900809
申请日：2020-06-12
发明人： Daniel T. Chiu , Jiangbo Yu , Yu Rong , Changfeng Wu
摘要： The present disclosure provides organic-inorganic hybrid polymer particles, which have desirable surface chemistry and optical properties that make them particularly suitable for biological and optical applications. The present disclosure also provides methods of making organic-inorganic hybrid polymer particles. The present disclosure also provides methods of using the organic-inorganic hybrid polymer particles for biological and optical applications.
-
公开(公告)号：US10150841B2
公开(公告)日：2018-12-11
申请号：US14366863
申请日：2012-12-27
发明人： Daniel T. Chiu , Changfeng Wu , Yu Rong , Yong Zhang , Yi-Che Wu , Yang-Hsiang Chan , Xuanjun Zhang , Jiangbo Yu , Wei Sun
IPC分类号： C08G75/32 , C08G79/00 , G01N33/58 , H01L51/00 , A61K49/00 , C09B69/10 , G01N21/64 , H01L51/50 , B82Y40/00 , B82Y30/00
摘要： Polymers, monomers, chromophoric polymer dots and related methods are provided. Highly fluorescent chromophoric polymer dots with narrow-band emissions are provided. Methods for synthesizing the chromophoric polymers, preparation methods for forming the chromophoric polymer dots, and biological applications using the unique properties of narrow-band emissions are also provided.
-
-
-
-
-
-
-
-
-
搜索结果
36 条记录 (耗时 0.022 秒)
