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公开(公告)号：US20060194036A1
公开(公告)日：2006-08-31
申请号：US10551545
申请日：2004-03-30
申请人： Keiichi Miyamoto , Eiichi Kitazono , Takanori Miyoshi , Hiroaki Kaneko , Yoshihiko Sumi , Hitoshi Hirata
发明人： Keiichi Miyamoto , Eiichi Kitazono , Takanori Miyoshi , Hiroaki Kaneko , Yoshihiko Sumi , Hitoshi Hirata
IPC分类号： B32B3/00
CPC分类号： A61L27/58 , A61L27/227 , A61L27/48 , Y10T428/249971 , C08L67/04
摘要： There is provided an elastin molded article having flexibility, a biological absorption property and tear strength which is practically suturable by using a fiber structure comprising aliphatic polyester fibers having an average fiber diameter of 0.05 to 50 μm as a supporting base material. The elastin molded article is useful as a raw material for a tube or artificial blood vessel to be implanted in a body that has a biological absorption property and has tear strength and flexibility which allow the tube or artificial blood vessel to endure suture at the time of operation or the like.
摘要翻译： 提供弹性蛋白模制品，其具有柔软性，生物吸收性和撕裂强度，其通过使用包含平均纤维直径为0.05至50μm的脂族聚酯纤维作为支撑基材的纤维结构实际上可切割。 弹性蛋白模塑制品可用作管或人造血管的原料，其被植入具有生物吸收性的身体中并具有撕裂强度和柔软性，其允许管或人造血管在缝合时耐受缝合 操作等。
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12.发明申请Pharmaceutical composition having inhibitory effect on overproduction and accumulation of extracellular matrix 审中-公开对细胞外基质过量产生和积累具有抑制作用的药物组合物公开(公告)号：US20050032675A1
公开(公告)日：2005-02-10
申请号：US10928407
申请日：2004-08-30
申请人： Satoshi Sasaki , Yoshihiko Sumi , Reginald Hughes
发明人： Satoshi Sasaki , Yoshihiko Sumi , Reginald Hughes
IPC分类号： A61K31/739 , A61K38/17 , A61K38/39 , A61K38/40 , A61K38/16
CPC分类号： A61K31/739 , A61K38/1741
摘要： A pharmaceutical composition having an inhibitory effect on the overproduction and the accumulation of extracellular matrix, said composition comprising as an active ingredient a compound that inhibits the biological activity of galectin-3, which pharmaceutical composition can serve as a therapeutic or preventive agent for glomerular nephritis, diabetic nephropathy or tissue fibrosis, as well as the use of said compound for the production of pharmaceuticals for the above-mentioned use, and a method for inhibition of the overproduction and accumulation of the extracellular matrix.
摘要翻译： 一种药物组合物，其对细胞外基质的过度产生和积累具有抑制作用，所述组合物包含抑制半乳凝素-3生物活性的化合物作为活性成分，该组合物可用作肾小球性肾炎的治疗或预防剂 ，糖尿病性肾病或组织纤维化，以及所述化合物用于制备上述用途的药物的用途，以及抑制细胞外基质过量产生和积累的方法。
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公开(公告)号：US5463025A
公开(公告)日：1995-10-31
申请号：US185162
申请日：1994-01-24
申请人： Yoshihiko Sumi , Yataro Ichikawa , Nobuo Aoki , Masami Muramatsu
发明人： Yoshihiko Sumi , Yataro Ichikawa , Nobuo Aoki , Masami Muramatsu
IPC分类号： C12N9/99 , A61K38/00 , A61K38/55 , A61P7/04 , C07K1/22 , C07K14/00 , C07K14/81 , C12N9/64 , C12N15/09 , C12N15/15 , C12P21/02 , C12R1/91 , C07K14/47 , A61K38/17
CPC分类号： C07K14/8121 , A61K38/00
摘要： A protein having human plasmin inhibiting activity, substantially equivalent reactivity with human plasmin to a human .alpha..sub.2 -plasmin inhibitor derived from plasma, a binding ability to human fibrin about 1/4 to about 1/3 of that of the human .alpha..sub.2 -plasmin inhibitor derived from plasma, and a molecular weight of about 50,000 to about 77,000.
摘要翻译： 具有人纤维蛋白酶抑制活性的蛋白质，与人类纤溶酶基本上等同于对来自血浆的人α2-纤溶酶抑制剂的反应性，人纤维蛋白的结合能力约为人α2-纤溶酶的约1/4至约1/3 来自血浆的抑制剂，分子量约为50,000至约77,000。
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公开(公告)号：US08097273B2
公开(公告)日：2012-01-17
申请号：US10552685
申请日：2004-04-08
申请人： Yukako Fukuhira , Eiichi Kitazono , Hiroaki Kaneko , Yoshihiko Sumi , Masatsugu Shimomura , Masaru Tanaka
发明人： Yukako Fukuhira , Eiichi Kitazono , Hiroaki Kaneko , Yoshihiko Sumi , Masatsugu Shimomura , Masaru Tanaka
摘要： The invention relates to a honeycomb film made of a biodegradable polymer which has biodegradation properties as an anti-adhesion membrane for preventing adhesion after an operation, is excellent in handling properties, and exhibits a satisfactory adhesion preventive effect stably over a desired period of time, and to a production process of the same. Above all, the invention provides an anti-adhesion membrane of a honeycomb film made of polylactic acid as a biodegradable polymer and a phospholipid and a production process of the same.
摘要翻译： 本发明涉及一种由生物降解性聚合物制成的蜂窝膜，其具有生物降解性，作为防止粘合后的防粘膜，操作性优异，并且在期望的时间段内稳定地表现出令人满意的粘合防止效果， 以及其生产过程。 其中，本发明提供了由聚乳酸作为生物降解性聚合物和磷脂制成的蜂窝膜的防粘膜及其制造方法。
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15.发明授权Tissue regeneration substrate, complex thereof with cells, and method for its production 有权组织再生底物，与细胞的复合物及其制备方法公开(公告)号：US07915028B2
公开(公告)日：2011-03-29
申请号：US10580029
申请日：2004-11-19
申请人： Yukako Fukuhira , Masaya Ito , Hiroaki Kaneko , Yoshihiko Sumi , Masatsugu Shimomura , Masaru Tanaka
发明人： Yukako Fukuhira , Masaya Ito , Hiroaki Kaneko , Yoshihiko Sumi , Masatsugu Shimomura , Masaru Tanaka
CPC分类号： A61L27/3817 , A61L27/3852 , A61L27/446 , A61L27/50 , A61L27/56 , A61L2430/06
摘要： A tissue regeneration substrate comprising a film with a honeycomb structure composed primarily of a polymer compound and a phospholipid. A tissue regeneration complex comprising the tissue regeneration substrate and cells held in the tissue regeneration substrate. The substrate is particularly suitable for regeneration of cartilage tissue, and allows growth of cartilage tissue in a three-dimensional fashion.
摘要翻译： 一种组织再生基材，其包含主要由高分子化合物和磷脂构成的蜂窝结构体的膜。 一种组织再生复合体，其包含组织再生基质和保持在组织再生基质中的细胞。 该底物特别适用于软骨组织的再生，并允许以三维方式生长软骨组织。
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16.发明申请公开(公告)号：US20080193538A1
公开(公告)日：2008-08-14
申请号：US10577154
申请日：2004-10-27
申请人： Eiichi Kitazono , Hiroaki Kaneko , Masaya Ito , Chiaki Fukutomi , Saki Tsuzuki , Yoshihiko Sumi
发明人： Eiichi Kitazono , Hiroaki Kaneko , Masaya Ito , Chiaki Fukutomi , Saki Tsuzuki , Yoshihiko Sumi
IPC分类号： A61K9/00 , C08F251/00
CPC分类号： C08B37/0072 , A61L27/20 , A61L27/52 , C08L5/08
摘要： A hyaluronic acid compound which is a reaction product between hyaluronic acid and a phosphatidyl ethanolamine. This compound has biocompatibility and bio-safety, and can be formed into a hydrogel or molded form having a certain shape. Making use of these properties, it is used to treat a knee joint, prevent the accretion of a tissue after an operation and keep a skin wet.
摘要翻译： 透明质酸化合物，其是透明质酸和磷脂酰乙醇胺之间的反应产物。 该化合物具有生物相容性和生物安全性，可以形成为具有一定形状的水凝胶或成型体。 利用这些性质，它用于治疗膝关节，防止手术后组织的积累并保持皮肤湿润。
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17.发明申请Tissue regeneration substrate, complex thereof with cells, and method for its production 有权组织再生底物，与细胞的复合物及其制备方法公开(公告)号：US20070112438A1
公开(公告)日：2007-05-17
申请号：US10580029
申请日：2004-11-19
申请人： Yukako Fukuhira , Masaya Ito , Hiroaki Kaneko , Yoshihiko Sumi , Masatsugu Shimomura , Masaru Tanaka
发明人： Yukako Fukuhira , Masaya Ito , Hiroaki Kaneko , Yoshihiko Sumi , Masatsugu Shimomura , Masaru Tanaka
IPC分类号： A61F2/02
CPC分类号： A61L27/3817 , A61L27/3852 , A61L27/446 , A61L27/50 , A61L27/56 , A61L2430/06
摘要： A tissue regeneration substrate comprising a film with a honeycomb structure composed primarily of a polymer compound and a phospholipid. A tissue regeneration complex comprising the tissue regeneration substrate and cells held in the tissue regeneration substrate. The substrate is particularly suitable for regeneration of cartilage tissue, and allows growth of cartilage tissue in a three-dimensional fashion.
摘要翻译： 一种组织再生基材，其包含主要由高分子化合物和磷脂构成的蜂窝结构体的膜。 一种组织再生复合体，其包含组织再生基质和保持在组织再生基质中的细胞。 该底物特别适用于软骨组织的再生，并允许以三维方式生长软骨组织。
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公开(公告)号：US20060286886A1
公开(公告)日：2006-12-21
申请号：US10550912
申请日：2004-03-30
CPC分类号： D04H3/02 , D01D5/0038 , D01D5/247 , D01D5/253 , D01F1/08 , D01F6/625 , D04H1/4382 , D04H1/4391 , Y10T442/608 , Y10T442/614
摘要： A process for production of a nonwoven fabric, which comprises a step wherein a thermoplastic polymer is dissolved in a mixed solvent composed of a volatile good solvent and a volatile poor solvent, a step wherein the resulting solution is spun by an electrospinning method and a step wherein a nonwoven fabric accumulated on a collecting sheet is obtained, is employed to provide a nonwoven fabric having a surface area sufficiently large as a matrix for cell culturing in the field of regenerative medicine, with large gaps between filaments and a low apparent density suitable for cell culturing.
摘要翻译： 一种无纺布的制造方法，其特征在于，包括将热塑性聚合物溶解在由挥发性良溶剂和挥发性不良溶剂组成的混合溶剂中的工序，其中所得溶液通过静电纺丝法和步骤 其中收集在收集片上的无纺织物用于提供表面积足够大的无纺织物作为再生医学领域的细胞培养基质，细丝间隙大，表观密度低 细胞培养。
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公开(公告)号：US20060189911A1
公开(公告)日：2006-08-24
申请号：US10552685
申请日：2004-04-08
申请人： Yukako Fukuhira , Eiichi Kitazono , Hiroaki Kaneko , Yoshihiko Sumi , Masatsugu Shimomura , Masaru Tanaka
发明人： Yukako Fukuhira , Eiichi Kitazono , Hiroaki Kaneko , Yoshihiko Sumi , Masatsugu Shimomura , Masaru Tanaka
摘要： The invention relates to a honeycomb film made of a biodegradable polymer which has biodegradation properties as an anti-adhesion membrane for preventing adhesion after an operation, is excellent in handling properties, and exhibits a satisfactory adhesion preventive effect stably over a desired period of time, and to a production process of the same. Above all, the invention provides an anti-adhesion membrane of a honeycomb film made of polylactic acid as a biodegradable polymer and a phospholipid and a production process of the same.
摘要翻译： 本发明涉及一种由生物降解性聚合物制成的蜂窝膜，其具有生物降解性，作为防止粘合后的防粘膜，操作性优异，并且在期望的时间段内稳定地表现出令人满意的粘合防止效果， 以及其生产过程。 其中，本发明提供了由聚乳酸作为生物降解性聚合物和磷脂制成的蜂窝膜的防粘膜及其制造方法。
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20.发明授权Composite of support matrix and collagen, and method for production of support matrix and composite 有权支撑基质和胶原的复合物，以及支撑基质和复合材料的生产方法公开(公告)号：US08263187B2
公开(公告)日：2012-09-11
申请号：US13031934
申请日：2011-02-22
CPC分类号： A61F2/06 , A61F2210/0004 , A61L27/34 , C08L89/06
摘要： A cylindrical body is produced which is composed of a fiber structure with a basis weight of 1-50 g/m2 and having a diameter of 0.5-50 mm and a bellows-shaped section, wherein the crest-to-crest spacing of the bellows-shaped section is no greater than 2 mm and the crest-to-valley depth of the bellows-shaped section is 0.01-1 mm; collagen is added to the cylindrical body to produce a composite including the cylindrical body and collagen.
摘要翻译： 制造圆筒体，其由基重为1-50g / m 2且直径为0.5-50mm的纤维结构和波纹管状部分组成，其中波纹管的峰间距 形状截面不大于2mm，波纹状截面的波谷深度为0.01-1mm; 将胶原蛋白加入到圆柱体中以产生包括圆柱体和胶原蛋白的复合物。
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