-
公开(公告)号：US20210130892A1
公开(公告)日：2021-05-06
申请号：US17084481
申请日：2020-10-29
Applicant: 10X Genomics, Inc.
Inventor： Phillip Belgrader , Zachary Bent , Rajiv Bharadwaj , Vijay Kumar Sreenivasa Gopalan , Josephine Harada , Christopher Hindson , Mohammad Rahimi Lenji , Michael Ybarra Lucero , Geoffrey McDermott , Elliott Meer , Tarjei Sigurd Mikkelsen , Christopher Joachim O'Keeffe , Katherine Pfeiffer , Andrew D. Price , Paul Ryvkin , Serge Saxonov , John R. Stuelpnagel , Jessica Michele Terry , Tobias Daniel Wheeler , Indira Wu , Solongo Batjargal Ziraldo , Stephane Claude Boutet , Sarah Taylor , Niranjan Srinivas
IPC: C12Q1/6874 , C12Q1/683 , C12Q1/6806
Abstract: The present disclosure provides compositions, methods, systems, and devices for polynucleotide processing and analyte characterization. Such polynucleotide processing may be useful for a variety of applications, including analyte characterization by polynucleotide sequencing. The compositions, methods, systems, and devices disclosed herein generally describe barcoded oligonucleotides, which can be bound to a bead, such as a gel bead, useful for characterizing one or more analytes including, for example, protein (e.g., cell surface or intracellular proteins), genomic DNA, and RNA (e.g., mRNA or CRISPR guide RNAs). Also described herein, are barcoded labelling agents and oligonucleotide molecules useful for “tagging” analytes for characterization.
-
公开(公告)号：US10688494B2
公开(公告)日：2020-06-23
申请号：US16325922
申请日：2017-08-23
Applicant: 10X Genomics, Inc.
Inventor： Rajiv Bharadwaj , Tobias Daniel Wheeler , Kevin Ness , Benjamin Hindson
Abstract: A microfluidic emulsion droplet generation system and methods of use thereof are provided. The system may include a microfluidic substrate having a flow path configured and arranged for emulsion droplet generation, at least one textured surface in the flow path configured and arranged for inducing surface-mediated coalescence of emulsion droplets; and at least one channel junction in the flow path for emulsion droplet formation.
-
公开(公告)号：US20200165603A1
公开(公告)日：2020-05-28
申请号：US16419461
申请日：2019-05-22
Applicant: 10X Genomics, Inc.
Inventor： Kamila Belhocine , Rajiv Bharadwaj , Christopher Hindson , Michael Schnall-Levin , Bill Kengli Lin , Anthony Makarewicz , Pranav Patel , Katherine Pfeiffer , Andrew D. Price , Mohammad Rahimi Lenji , Tobias Daniel Wheeler , Yifeng Yin
IPC: C12N15/10 , C12Q1/6869 , C12Q1/6806
Abstract: Methods and systems are provided for sample preparation techniques and sequencing of macromolecular constituents of cells and other biological materials.
-
公开(公告)号：US20200024596A1
公开(公告)日：2020-01-23
申请号：US16419428
申请日：2019-05-22
Applicant: 10X Genomics, Inc.
Inventor： Kamila Belhocine , Rajiv Bharadwaj , Christopher Hindson , Michael Schnall-Levin , Bill Kengli Lin , Anthony Makarewicz , Pranav Patel , Katherine Pfeiffer , Andrew D. Price , Mohammad Rahimi Lenji , Tobias Daniel Wheeler , Yifeng Yin
IPC: C12N15/10 , C12Q1/6806 , C12Q1/6869
Abstract: Methods and systems are provided for sample preparation techniques and sequencing of macromolecular constituents of cells and other biological materials.
-
公开(公告)号：US11584954B2
公开(公告)日：2023-02-21
申请号：US16855177
申请日：2020-04-22
Applicant: 10X GENOMICS, INC.
Inventor： Zahra Kamila Belhocine , Josephine Lee , Francesca Meschi , Luz Montesclaros , Katherine Pfeiffer , Andrew D. Price , Jerald Sapida , David Sukovich , Tobias Daniel Wheeler , Yifeng Yin
IPC: C12Q1/6806
Abstract: The present disclosure provides methods and systems for sample preparation and/or analysis. Samples may be cells, or may be derived from one or more cells. Sample preparation may comprise conducting one or more reactions on a target. Such reactions may be conducted in one or more partitions. One or more reactions may be performed in one or more successive operations.
-
Patent Agency Ranking
公开(公告)号：US20220195420A1
公开(公告)日：2022-06-23
申请号：US17517282
申请日：2021-11-02
Applicant: 10x Genomics, Inc.
Inventor： Zahra Kamila Belhocine , Rajiv Bharadwaj , Christopher Hindson , Michael Schnall-Levin , Bill Kengli Lin , Anthony Makarewicz , Pranav Patel , Katherine Pfeiffer , Andrew D. Price , Mohammad Rahimi Lenji , Tobias Daniel Wheeler , Yifeng Yin
IPC: C12N15/10 , C12Q1/6806 , C12Q1/6869
Abstract: Methods and systems are provided for sample preparation techniques and sequencing of macromolecular constituents of cells and other biological materials.
-
公开(公告)号：US11241688B2
公开(公告)日：2022-02-08
申请号：US16704610
申请日：2019-12-05
Applicant: 10X Genomics, Inc.
Inventor： Tobias Daniel Wheeler , Rajiv Bharadwaj
IPC: B01L3/00
Abstract: A microfluidic system includes a microfluidic chip having a plurality of fluid channels, each fluid channel having an opening providing access to an interior of the fluid channel, and a gasket disposable on the microfluidic chip in an aligned configuration, the gasket including a first side configured to face the microfluidic chip in the aligned configuration, a second side opposite the first side, and an aperture extending through the gasket from the first side to the second side, the aperture being sized and positioned to allow a communication of pressure from the second side of the gasket to the openings of at least two fluid channels when the gasket is in the aligned configuration.
-
公开(公告)号：US20210372998A1
公开(公告)日：2021-12-02
申请号：US17209045
申请日：2021-03-22
Applicant: 10X Genomics, Inc.
Inventor： Zahra Kamila Belhocine , Jason Bell , Zachary Bent , Rajiv Bharadwaj , Christopher Hindson , Mohammad Rahimi Lenji , Bill Kengli Lin , Anthony Makarewicz , Geoffrey McDermott , Elliott Meer , Francesca Meschi , Tarjei Sigurd Mikkelsen , Christopher Joachim O'Keeffe , Katherine Pfeiffer , Andrew D. Price , Paul Ryvkin , Michael Schnall-Levin , Sarah Taylor , Jessica Michele Terry , Tobias Daniel Wheeler , Yifeng Yin , Xinying Zheng , Solongo Batjargal Ziraldo , Eswar Prasad Ramachandran Iyer , Luigi Jhon Alvarado Martinez
IPC: G01N33/532 , C07K14/74 , C12N15/85 , G01N33/543 , G01N33/548 , C12N15/10 , C12Q1/6804 , C12Q1/6806 , G01N33/50 , G01N33/53 , G01N33/58 , C12Q1/6818 , C12Q1/6827 , C12Q1/6881 , C12N15/11 , G01N33/569
Abstract: The present disclosure provides compositions, methods, systems, and devices for polynucleotide processing and antigen screening. Polynucleotide processing may be useful for a variety of applications. Antigen screening may comprise the use of one or more engineered cells. Engineered cells may be useful for characterizing one or more analytes including, for example, a polypeptide antigen.
-
公开(公告)号：US20200002764A1
公开(公告)日：2020-01-02
申请号：US16443638
申请日：2019-06-17
Applicant: 10X Genomics, Inc.
Inventor： Phillip Belgrader , Zachary Bent , Rajiv Bharadwaj , Vijay Kumar Sreenivasa Gopalan , Josephine Harada , Christopher Hindson , Mohammad Rahimi Lenji , Michael Ybarra Lucero , Geoffrey McDermott , Elliott Meer , Tarjei Sigurd Mikkelsen , Christopher Joachim O'Keeffe , Katherine Pfeiffer , Andrew D. Price , Paul Ryvkin , Serge Saxonov , John R. Stuelpnagel , Jessica Michele Terry , Tobias Daniel Wheeler , Indira Wu , Solongo Batjargal Ziraldo , Stephane Claude Boutet , Sarah Taylor , Niranjan Srinivas
IPC: C12Q1/6874 , C12Q1/683 , C12Q1/6806
Abstract: The present disclosure provides compositions, methods, systems, and devices for polynucleotide processing and analyte characterization. Such polynucleotide processing may be useful for a variety of applications, including analyte characterization by polynucleotide sequencing. The compositions, methods, systems, and devices disclosed herein generally describe barcoded oligonucleotides, which can be bound to a bead, such as a gel bead, useful for characterizing one or more analytes including, for example, protein (e.g., cell surface or intracellular proteins), genomic DNA, and RNA (e.g., mRNA or CRISPR guide RNAs). Also described herein, are barcoded labelling agents and oligonucleotide molecules useful for “tagging” analytes for characterization.
-
公开(公告)号：US20190134633A1
公开(公告)日：2019-05-09
申请号：US16180356
申请日：2018-11-05
Applicant: 10X GENOMICS,INC.
Inventor： Rajiv Bharadwaj , Kevin Ness , Tobias Daniel Wheeler
IPC: B01L3/00
Abstract: Microfluidic channels networks and systems are provided. One network includes a first fluid channel having a first depth dimension; at least a second channel intersecting the first channel at a first intersection; at least a third channel in fluid communication with the first intersection, at least one of the first intersection and the third channel having a depth dimension that is greater than the first depth dimension. Also provided is a flow control system for directing fluids in the network. Systems are additionally provided for flowing disrupted particles into a droplet formation junction, whereby a portion of the disrupted particles or the contents thereof are encapsulated into one or more droplets. Further provided is a method for controlling filling of a microfluidic network by controlling passive valving microfluidic channel network features.
-
-
-
-
-
-
-
-
-
Search Results
42
records
(took 0.025 seconds)
