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公开(公告)号：US10286110B2
公开(公告)日：2019-05-14
申请号：US15398288
申请日：2017-01-04
Applicant: Agency for Science, Technology and Research
Inventor： Charlotte Hauser , Wei Yang Seow
IPC: A61K38/00 , A01N25/00 , A61K47/00 , C12N5/00 , C12N5/02 , A61L27/38 , A61K47/42 , A61K38/02 , A61L27/22 , A61L27/50 , A61L27/52 , A61L26/00 , A61K9/06 , A61K35/33 , C12N5/071
Abstract: The present invention relates to hydrogels comprising a plurality of amphiphilic peptides and/or peptoids capable of self-assembling into three-dimensional macromolecular nanofibrous networks, which entrap water and form said hydrogels, wherein at least a portion of said plurality of amphiphilic peptides and/or peptoids is chemically cross-linked. The present invention further relates to methods for preparing such hydrogels and to various uses of such hydrogels, e.g. as cell culture substrates, for drug and gene delivery, as wound dressing, as an implant, as an injectable agent that gels in situ, in pharmaceutical or cosmetic compositions, in regenerative medicine, in tissue engineering and tissue regeneration, or in electronic devices. It also relates to a method of tissue regeneration or tissue replacement using a hydrogel in accordance with the present invention.
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公开(公告)号：US20170182217A1
公开(公告)日：2017-06-29
申请号：US15398254
申请日：2017-01-04
Applicant: Agency for Science, Technology and Research
Inventor： Charlotte Hauser , Wei Yang Seow
CPC classification number: A61L27/3804 , A61K9/06 , A61K35/33 , A61K38/02 , A61K47/42 , A61L26/0028 , A61L26/0061 , A61L26/008 , A61L27/22 , A61L27/38 , A61L27/50 , A61L27/52 , A61L2300/412 , A61L2300/426 , A61L2400/06 , A61L2430/00 , A61L2430/06 , A61L2430/38 , C12N5/0018 , C12N5/0062 , C12N5/0068 , C12N5/0671 , C12N5/0691 , C12N2513/00 , C12N2533/50 , C12N2533/54 , C12N2537/10
Abstract: The present invention relates to hydrogels comprising a plurality of amphiphilic peptides and/or peptoids capable of self-assembling into three-dimensional macromolecular nanofibrous networks, which entrap water and form said hydrogels, wherein at least a portion of said plurality of amphiphilic peptides and/or peptoids is chemically cross-linked. The present invention further relates to methods for preparing such hydrogels and to various uses of such hydrogels, e.g. as cell culture substrates, for drug and gene delivery, as wound dressing, as an implant, as an injectable agent that gels in situ, in pharmaceutical or cosmetic compositions, in regenerative medicine, in tissue engineering and tissue regeneration, or in electronic devices. It also relates to a method of tissue regeneration or tissue replacement using a hydrogel in accordance with the present invention.
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公开(公告)号：US20170182113A1
公开(公告)日：2017-06-29
申请号：US15398379
申请日：2017-01-04
Applicant: Agency for Science, Technology and Research
Inventor： Charlotte Hauser , Wei Yang Seow
CPC classification number: A61L27/3804 , A61K9/06 , A61K35/33 , A61K38/02 , A61K47/42 , A61L26/0028 , A61L26/0061 , A61L26/008 , A61L27/22 , A61L27/38 , A61L27/50 , A61L27/52 , A61L2300/412 , A61L2300/426 , A61L2400/06 , A61L2430/00 , A61L2430/06 , A61L2430/38 , C12N5/0018 , C12N5/0062 , C12N5/0068 , C12N5/0671 , C12N5/0691 , C12N2513/00 , C12N2533/50 , C12N2533/54 , C12N2537/10
Abstract: The present invention relates to hydrogels comprising a plurality of amphiphilic peptides and/or peptoids capable of self-assembling into three-dimensional macromolecular nanofibrous networks, which entrap water and form said hydrogels, wherein at least a portion of said plurality of amphiphilic peptides and/or peptoids is chemically cross-linked. The present invention further relates to methods for preparing such hydrogels and to various uses of such hydrogels, e.g. as cell culture substrates, for drug and gene delivery, as wound dressing, as an implant, as an injectable agent that gels in situ, in pharmaceutical or cosmetic compositions, in regenerative medicine, in tissue engineering and tissue regeneration, or in electronic devices. It also relates to a method of tissue regeneration or tissue replacement using a hydrogel in accordance with the present invention.
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14.发明申请公开(公告)号：US20150320908A1
公开(公告)日：2015-11-12
申请号：US14639035
申请日：2015-03-04
Applicant: Agency for Science, Technology and Research
Inventor： Charlotte Hauser , Wei Yang Seow
CPC classification number: A61L27/52 , A61L26/0028 , A61L26/0061 , A61L26/008 , A61L27/22 , A61L27/38 , A61L27/50 , A61L27/60 , A61L2430/06 , A61L2430/16 , C12N5/0068 , C12N2533/50 , C12N2533/54 , C12N2537/10
Abstract: The present invention relates to hydrogel membranes comprising a hydrogel, said hydrogel comprising a plurality of tetramer amphiphilic peptides and/or peptoids capable of self-assembling into three-dimensional macromolecular nanofibrous networks, which entrap water and form said hydrogels, wherein at least a portion of said plurality of tetramer amphiphilic peptides and/or peptoids is chemically cross-linked. The present invention further relates to stratisfied biostructures and devices comprising at least two hydrogel membranes of the invention, which can be used e.g. to rebuild human skin and for tissue engineering of organs and tissues. The present invention further relates to corneal implants and devices comprising a hydrogel membrane of the invention.
Abstract translation: 本发明涉及包含水凝胶的水凝胶膜，所述水凝胶包括能够自组装成三维大分子纳米纤维网络的多个四聚体两亲肽和/或拟肽，其捕获水并形成所述水凝胶，其中至少一部分 的所述多个四聚体两亲肽和/或拟肽化学交联。 本发明还涉及包含本发明的至少两种水凝胶膜的粘合生物结构和装置，其可以例如使用。 重建人体皮肤和器官和组织的组织工程。 本发明还涉及角膜植入物和包含本发明的水凝胶膜的装置。
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