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公开(公告)号：US11891435B2
公开(公告)日：2024-02-06
申请号：US17558032
申请日：2021-12-21
Applicant: AMGEN INC.
Inventor： Neeraj Jagdish Agrawal , Kevin Graham , Agnes Eva Hamburger , Christopher Mohr , Derek E. Piper , Kenneth William Walker , Zhulun Wang , Cen Xu
IPC: C07K16/00 , A61K39/395 , A61K39/00 , A61K49/00 , A61K49/16 , C12P21/08 , G01N33/53 , C07K16/18 , C07K16/28 , A61P25/06 , A61K38/22 , A61K47/68 , A61K38/17 , A61K51/10 , C07K14/575 , C07K16/26 , C07K14/72 , C07K14/47 , G01N33/74 , G01N33/68
CPC classification number: C07K16/18 , A61K38/2278 , A61P25/06 , C07K16/2869 , A61K38/1796 , A61K38/22 , A61K47/6843 , A61K47/6849 , A61K51/10 , A61K2039/505 , A61K2039/545 , A61K2300/00 , C07K14/47 , C07K14/575 , C07K14/57563 , C07K14/72 , C07K16/00 , C07K16/26 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/34 , C07K2317/51 , C07K2317/515 , C07K2317/52 , C07K2317/522 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/70 , C07K2317/72 , C07K2317/76 , C07K2317/90 , C07K2317/92 , C12N2501/30 , G01N33/6854 , G01N33/6896 , G01N33/74 , G01N2333/575 , G01N2333/5757 , Y02A50/30
Abstract: The present invention relates to neutralizing antibodies of the human pituitary adenylate cyclase activating polypeptide type I receptor (PAC1) and pharmaceutical compositions comprising such antibodies. Methods of treating or preventing headache conditions, such as migraine and cluster headache, using the neutralizing antibodies are also described.
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公开(公告)号：US11541103B2
公开(公告)日：2023-01-03
申请号：US16054035
申请日：2018-08-03
Applicant: AMGEN INC.
Inventor： Khaled M. K. Z. Ali , Neeraj Jagdish Agrawal , Gunasekaran Kannan , Ian Foltz , Zhulun Wang , Darren Bates , Marissa Mock , Shunsuke Takenaka
Abstract: Provided herein are IL-21 muteins and fusion proteins comprising the same for use in methods of treating a disease. Related conjugates, nucleic acids, vectors, host cells, pharmaceutical compositions and kits are also provided herein. Methods of making the IL-21 muteins and fusion proteins comprising the same, as well as methods of treating a subject in need thereof, are provided by the present disclosure. Further provided are PD-1 antigen-binding proteins.
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公开(公告)号：US10465009B2
公开(公告)日：2019-11-05
申请号：US14649469
申请日：2013-12-05
Applicant: Amgen Inc.
Inventor： Richard J. Armitage , Michelle Blake , William C. Fanslow, III , Jason Charles O'Neill , Gunasekaran Kannan , Jiangchun Xu , Mark Edward Tometsko , Zhulun Wang , Athena Sudom
Abstract: The present invention relates to BCMA (B-Cell Maturation Antigen) antigen binding proteins, such as antibodies, polynucleotide sequences encoding said antigen binding proteins, and compositions and methods for diagnosing and treating diseases. The present invention also relates to BCMA antibody drug conjugates and uses thereof.
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公开(公告)号：US10227414B2
公开(公告)日：2019-03-12
申请号：US15601868
申请日：2017-05-22
Applicant: Amgen Inc.
Inventor： Dirk E. Smith , Ian Foltz , Chadwick T. King , Ai Ching Lim , Rutilio Clark , Michael R. Comeau , Randal R. Ketchem , Donghui Shi , Xiaoshan Min , Zhulun Wang
Abstract: Described herein are compositions and methods related to antigen binding proteins that bind to human ST2, including antibodies. In particular embodiments, the disclosure provides fully human anti-ST2 antibodies and deriviatives and variants thereof. Further provided are nucleic acids encoding such antibodies and antibody fragments, variants, and derivatives. Also, provided are methods of making and using such antibodies including methods of treating and preventing autoimmune and inflammatory disorders.
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公开(公告)号：US09862752B2
公开(公告)日：2018-01-09
申请号：US14908459
申请日：2014-07-31
Applicant: Amgen Inc.
Inventor： Yumei Xiong , Yi Zhang , Jackie Z. Sheng , Agnes Eva Hamburger , Murielle Veniant-Ellison , Grant Shimamoto , Xiaoshan Min , Zhulun Wang , Jie Tang , Gunasekaran Kannan , Marissa Mock , Kenneth Walker
IPC: C07K14/00 , C07K14/475
CPC classification number: C07K14/475 , C07K2319/30
Abstract: Constructs comprising GDF15, and mutants thereof are provided. In various embodiments the constructs comprising GDF15, and mutants thereof, can be of use in the treatment or ameliorating a metabolic disorder. In various embodiments the metabolic disease or disorder is type 2 diabetes, obesity, dyslipidemia, elevated glucose levels, elevated insulin levels and diabetic nephropathy.
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Patent Agency Ranking
公开(公告)号：US09382318B2
公开(公告)日：2016-07-05
申请号：US13897096
申请日：2013-05-17
Applicant: Amgen Inc.
Inventor： Dirk E. Smith , Ian Foltz , Chadwick T. King , Ai Ching Lim , Rutilio Clark , Michael R. Comeau , Randal R. Ketchem , Donghui Shi , Xiaoshan Min , Zhulun Wang
CPC classification number: C07K16/2866 , A61K2039/505 , C07K16/244 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/51 , C07K2317/515 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C12N15/11
Abstract: Described herein are compositions and methods related to antigen binding proteins that bind to human ST2, including antibodies. In particular embodiments, the disclosure provides fully human anti-ST2 antibodies and deriviatives and variants thereof. Further provided are nucleic acids encoding such antibodies and antibody fragments, variants, and derivatives. Also, provided are methods of making and using such antibodies including methods of treating and preventing autoimmune and inflammatory disorders.
Abstract translation: 本文描述的是与抗原结合蛋白相关的组合物和方法，其结合人ST2，包括抗体。 在具体实施方案中，本公开提供完全人抗-ST2抗体及其衍生物及其变体。 还提供了编码这种抗体和抗体片段，变体和衍生物的核酸。 此外，提供制备和使用这些抗体的方法，包括治疗和预防自身免疫性和炎症性疾病的方法。
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公开(公告)号：US20140378665A1
公开(公告)日：2014-12-25
申请号：US14374885
申请日：2013-01-28
Applicant: AMGEN INC.
Inventor： Yumei Xiong , Yi Zhang , Jackie Zeqi Sheng , Agnes Eva Hamburger , Murielle Veniant-Ellison , Grant Shimamoto , Xiaoshan Min , Zhulun Wang , Jie Tang , Gunasekaran Kannan , Kenneth W. Walker , Bryan Lemon
IPC: C07K14/475
CPC classification number: C07K14/475 , A61K39/0005 , A61K2039/6056 , C07K2319/30
Abstract: GDF15 polypeptides, constructs comprising GDF15, and mutants thereof are provided. In various embodiments the GDF15 polypeptides, constructs comprising GDF15, and mutants thereof, can be of use in the treatment or ameliorating a metabolic disorder. In various embodiments the metabolic disease or disorder is type 2 diabetes, obesity, dyslipidemia, elevated glucose levels, elevated insulin levels and diabetic nephropathy.
Abstract translation: 提供GDF15多肽，包含GDF15的构建体及其突变体。 在各种实施方案中，GDF15多肽，包含GDF15的构建体及其突变体可用于治疗或改善代谢紊乱。 在各种实施方案中，代谢疾病或病症是2型糖尿病，肥胖症，血脂异常，升高的葡萄糖水平，升高的胰岛素水平和糖尿病性肾病。
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公开(公告)号：US11739131B2
公开(公告)日：2023-08-29
申请号：US16416050
申请日：2019-05-17
Applicant: Amgen Inc.
Inventor： Yumei Xiong , Yi Zhang , Jackie Z. Sheng , Agnes Eva Hamburger , Murielle M. Veniant-Ellison , Grant Shimamoto , Xiaoshan Min , Zhulun Wang , Jie Tang , Gunasekaran Kannan , Kenneth W. Walker , Bryan Lemon
IPC: C07K14/475 , C07K14/495 , C07K14/51 , A61K38/16 , A61K38/00 , A61K38/18 , A61K38/17 , A61K39/00
CPC classification number: C07K14/475 , A61K38/00 , A61K38/16 , A61K38/17 , A61K38/18 , A61K39/0005 , C07K14/495 , C07K14/51 , A61K2039/6056 , C07K2319/30
Abstract: GDF15 polypeptides, constructs comprising GDF15, and mutants thereof are provided. In various embodiments the GDF15 polypeptides, constructs comprising GDF15, and mutants thereof, can be of use in the treatment or ameliorating a metabolic disorder. In various embodiments the metabolic disease or disorder is type 2 diabetes, obesity, dyslipidemia, elevated glucose levels, elevated insulin levels and diabetic nephropathy.
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公开(公告)号：US11518808B2
公开(公告)日：2022-12-06
申请号：US16245733
申请日：2019-01-11
Applicant: AMGEN INC.
Inventor： Khaled M. K. Z. Ali , Neeraj Jagdish Agrawal , Gunasekaran Kannan , Ian Foltz , Zhulun Wang , Daren Bates , Marissa Mock , Shunsuke Takenaka
IPC: C07K16/28 , A61P35/00 , A61K39/395 , C07K16/06 , C12N15/85
Abstract: Provided herein are PD-1 antigen-binding proteins and related nucleic acids, vectors, host cells, kits and pharmaceutical compositions. Methods of making PD-1 antigen-binding proteins and methods of treating a subject are further provided.
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公开(公告)号：US11059895B2
公开(公告)日：2021-07-13
申请号：US16242278
申请日：2019-01-08
Applicant: Amgen Inc.
Inventor： Dirk E. Smith , Ian Foltz , Chadwick T. King , Ai Ching Lim , Rutilio Clark , Michael R. Comeau , Randal R. Ketchem , Donghui Shi , Xiaoshan Min , Zhulun Wang
Abstract: Described herein are compositions and methods related to antigen binding proteins that bind to human ST2, including antibodies. In particular embodiments, the disclosure provides fully human anti-ST2 antibodies and derivatives and variants thereof. Further provided are nucleic acids encoding such antibodies and antibody fragments, variants, and derivatives. Also, provided are methods of making and using such antibodies including methods of treating and preventing autoimmune and inflammatory disorders.
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