公开(公告)号：US20220112156A1

公开(公告)日：2022-04-14

申请号：US17418940

申请日：2020-01-03

Applicant: AMOREPACIFIC CORPORATION

Inventor： Yunghyup JOO ,  Jaeyoung KO ,  Jaewon YOU ,  Yong Jin KIM ,  Tae Ryong LEE

IPC: C07C233/60 ,  C07C231/02 ,  A61K8/42 ,  A61Q19/02 ,  A61K9/00

Abstract: The present specification relates to an adamantanecarboxylic acid benzyl amide derivative compound, an isomer thereof, a pharmaceutically acceptable salt thereof, a hydrate thereof or a solvate thereof, and a skin whitening composition comprising the same as an active ingredient. Specifically, the compound, according to the present specification, is a compound having a novel structure having adamantanecarboxylic acid bound to an amine compound, and exhibits a skin whitening effect by inhibiting the production of melanin, and thus may be used in various ways as a pharmaceutical composition, a cosmetic composition or a skin preparation for external use.

公开(公告)号：US20210177919A1

公开(公告)日：2021-06-17

申请号：US16759892

申请日：2018-10-05

Applicant: AMOREPACIFIC CORPORATION

Inventor： Eun-Gyung CHO ,  Wanil KIM ,  Tae Ryong LEE

IPC: A61K35/747 ,  A61K8/14 ,  A23L33/135 ,  A61K8/99

Abstract: The present specification discloses an immunomodulatory composition comprising Lactobacillus-derived extracellular vesicles as an active ingredient. The Lactobacillus may be Lactobacillus plantarum. The composition has the effects of inducing differentiation into M2-type macrophages and reducing expression of at least one member selected from the group consisting of CCR2, SOCS3 and HLA-DRα, which are M1-type macrophage differentiation markers.

公开(公告)号：US20200276154A1

公开(公告)日：2020-09-03

申请号：US16650140

申请日：2018-09-20

Applicant: AMOREPACIFIC CORPORATION

Inventor： Pil Joon PARK ,  Tae Ryong LEE ,  Eungyung CHO

IPC: A61K31/351 ,  A61K8/67 ,  A61K8/49 ,  A61Q19/00 ,  A23L29/00 ,  A23L33/155 ,  A61K47/10

Abstract: The present disclosure relates to a composition for promoting adipocyte differentiation or adiponectin production, including a trimethoxy phenyl compound, an isomer thereof, a pharmaceutically acceptable salt thereof, a hydrate thereof or a solvate thereof as an effective ingredient. A composition according to the present specification promotes adipocyte differentiation or adiponectin production, thereby exhibiting the effect of making the skin plump or increasing skin elasticity. Hence, the composition of the present specification can find various applications as a pharmaceutical composition or cosmetic composition in the field such as that concerning skin damage.

公开(公告)号：US20200246413A1

公开(公告)日：2020-08-06

申请号：US16648946

申请日：2018-08-13

Applicant: AMOREPACIFIC CORPORATION

Inventor： Hyoung-June KIM ,  Jinsup SHIM ,  Tae Ryong LEE

IPC: A61K36/736 ,  A61K8/9789 ,  A61Q19/00 ,  A23L33/105 ,  B01D11/02

Abstract: Disclosed in the present specification is a composition comprising a Prunus mume flower extract as an effective ingredient for treating fine dust-caused skin damage, wherein the expression of IL-36G (NM 019618), which is a gene having an expression level affected by fine dust in skin cells, is regulated to a novel level. By using the composition for treating fine dust-caused skin damage, gene expression changed by fine dust can return to a normal level to treat skin cell damage.

公开(公告)号：US20190004034A1

公开(公告)日：2019-01-03

申请号：US16023045

申请日：2018-06-29

Applicant: AMOREPACIFIC CORPORATION

Inventor： Sunghoon LEE ,  Il-Hong BAE ,  Daejin MIN ,  Soojung OH ,  Tae Ryong LEE ,  Eungyung CHO

IPC: G01N33/50 ,  C12N5/071

Abstract: According to an embodiment, a method of producing artificial skin includes mixing fibroblasts and collagen to form a dermis simulating layer, applying keratinocytes on the dermis simulating layer and culturing the same, culturing the dermis simulating layer in a first medium that is a keratinocyte medium, and culturing the dermis simulating layer that is cultured in the first medium in a second medium including a DMEM medium and a F12 medium.

公开(公告)号：US20180263871A1

公开(公告)日：2018-09-20

申请号：US15760819

申请日：2016-09-23

Applicant: AMOREPACIFIC CORPORATION

Inventor： Suh-Yeon CHOI ,  Eun-Jeong CHOI ,  Bum-Ho BIN ,  Kyeonghwan HWANG ,  Eun-Gyung CHO ,  Tae Ryong LEE

IPC: A61K8/14 ,  A61Q19/02 ,  A61K8/9789

CPC classification number: A61K8/14 ,  A61K8/9789 ,  A61K36/258 ,  A61K2800/413 ,  A61Q19/02

Abstract: Disclosed are: a lightening composition comprising ginseng-derived exosome-like vesicles; and a method for producing the ginseng-derived exosome-like vesicles. The ginseng-derived exosome-like vesicles may have a diameter of between 20 and 500 nm, and may be isolated from ginseng root. Because the composition comprises the ginseng-derived exosome-like vesicles as an active ingredient, said composition is effective in preventing, improving or treating skin pigmentation conditions such as liver spots, freckles, lentigo, birth marks and melanoma by effectively suppressing the production of melanin.

公开(公告)号：US20180256490A1

公开(公告)日：2018-09-13

申请号：US15760908

申请日：2016-09-26

Applicant: AMOREPACIFIC CORPORATION

Inventor： Sung Tae KIM ,  Yonghee LEE ,  Seung Hyun SHIN ,  Hyun Gee LEE ,  Eun-Gyung CHO ,  Tae Ryong LEE

IPC: A61K8/99 ,  A61Q7/00 ,  A61K8/14

CPC classification number: A61K8/99 ,  A61K8/14 ,  A61K35/744 ,  A61K35/745 ,  A61K35/747 ,  A61P17/14 ,  A61Q7/00

Abstract: The present specification discloses a composition for preventing hair loss or promoting hair growth comprising, as an active ingredient, extracellular follicles derived from lactic acid bacteria, and a method for preparing the extracellular follicles derived from lactic acid bacteria. The composition has an effect of preventing and prohibiting hair from falling off from the scalp or becoming thin or tapered. In addition, the composition has an effect of implementing a hair growth function for generating new hair, or a function for promoting the hair growth, as well as a function of promoting a delay from an anagen to a catagen phase of a hair cycle and a function of growing the existing hair healthy.

公开(公告)号：US20170182104A1

公开(公告)日：2017-06-29

申请号：US15305012

申请日：2015-04-29

Applicant: AMOREPACIFIC CORPORATION

Inventor： Pil Joon PARK ,  So Hee LEE ,  Eun Gyung CHO ,  Tae Ryong LEE

IPC: A61K36/23 ,  A61K9/20 ,  A61K9/00 ,  A23L33/105 ,  A61K9/107 ,  A61K8/97 ,  A61Q19/00 ,  A61K9/48 ,  A61K9/14

CPC classification number: A61K36/23 ,  A23L33/105 ,  A23V2002/00 ,  A61K8/97 ,  A61K9/0014 ,  A61K9/0019 ,  A61K9/0056 ,  A61K9/0095 ,  A61K9/107 ,  A61K9/14 ,  A61K9/20 ,  A61K9/48 ,  A61K2236/333 ,  A61Q19/00 ,  A61Q19/08

Abstract: The present invention relates to a composition containing a masterwort (Peucedanum Ostruthium) extract as an active ingredient. The composition of the present invention exhibits effects of reducing the amount of endothelin 1 by containing a masterwort extract, and reducing the overexpression of NK1R and EDN1 genes. Therefore, the masterwort extract of the present invention can exhibit, by said effects, skin homeostasis maintenance and anti-stress effects, and thus can be widely used as acomposition for maintaining skin homeostasis in the pharmaceutical or cosmetic field.

公开(公告)号：US20170128354A1

公开(公告)日：2017-05-11

申请号：US15323177

申请日：2015-06-26

Applicant: AMOREPACIFIC CORPORATION

Inventor： Pil Joon PARK ,  So Hee LEE ,  Eun Gyung CHO ,  Tae Ryong LEE

IPC: A61K8/97 ,  A61Q19/02

CPC classification number: A61K8/97 ,  A61K8/9789 ,  A61K36/23 ,  A61Q19/02

Abstract: The present specification discloses a composition comprising an umbel (masterwort, Peucedanum ostruthium) extract as an active ingredient. The composition disclosed in the present specification exhibits the effect of reducing melanogenesis or inhibiting tyrosinase activity by comprising the umbel (masterwort, Peucedanum ostruthium) extract. As a result of the effect, the umbel (masterwort, Peucedanum ostruthium) extract of the present specification can exhibit a whitening effect and thus can be widely used as a whitening composition in the field of pharmaceuticals or cosmetics.

公开(公告)号：US20170014333A1

公开(公告)日：2017-01-19

申请号：US15300736

申请日：2015-03-23

Applicant: AMOREPACIFIC CORPORATION

Inventor： Pil Joon PARK ,  So Hee LEE ,  Eun Gyung CHO ,  Tae Ryong LEE

IPC: A61K8/97 ,  A61K8/34 ,  A61Q19/00 ,  A23L2/52 ,  A23L33/105 ,  A23L33/15 ,  A23L33/155 ,  A23L33/16 ,  A61Q19/02 ,  A61K36/282

Abstract: Disclosed is a composition containing an extract of alpine wormwood (Artemisia Umbelliformis) as an active ingredient. The composition disclosed in the present specification has the effect of reducing melanin generation, or inhibiting activation of tyrosinase due to the composition containing the extract of an alpine wormwood (Artemisia Umbelliformis). Accordingly, due to such effects, the alpine wormwood (Artemisia Umbelliformis) extract of the present specification can exhibit a whitening effect, and thus can be widely used in the pharmaceutical or cosmetics fields as a whitening composition.

Abstract translation: 公开了含有高山蒿木（艾蒿）作为活性成分的提取物的组合物。 本说明书中公开的组合物具有由于含有高山蒿木（艾蒿（Artemisia Umbelliformis））提取物的组合物而减少黑色素产生或抑制酪氨酸酶活化的作用。 因此，由于这样的效果，本说明书的高山蒿（Artemisia Umbelliformis）提取物可以呈现美白效果，因此可以广泛用于作为美白组合物的药物或化妆品领域。