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    Method of preparing metal diboride dispersions and films
    13.
    发明授权
    Method of preparing metal diboride dispersions and films 有权

    公开(公告)号：US10711210B2

    公开(公告)日：2020-07-14

    申请号：US15775735

    申请日：2016-11-11

    Applicant: Arizona Board of Regents on Behalf of Arizona State University

    Inventor： Alexander Green ,  Ahmed Yousaf ,  Abhishek Debnath

    IPC: C10L3/10 ,  C08K3/38 ,  C08J3/21 ,  C08L29/04 ,  C01B35/04 ,  C08J3/215 ,  C08J5/18 ,  B01D53/047 ,  B01D53/26 ,  B82Y30/00 ,  B82Y40/00

    Abstract: Some embodiments include a method of producing metal diboride nanomaterials having thickness down to the atomic scale and lateral areas from 10 nm to over 1 μm by preparing a mixture of a metal diboride and a suspending solution. The suspending solution can be an organic solvent or a solution containing water, and optionally can include a dispersion agent, such as a surfactant, a polymer, small molecule, or biopolymer. Further, the method includes exfoliating the metal diboride by exposing the mixture to ultrasonic energy, centrifuging the mixture forming supernatant that includes a dispersion of exfoliated metal diborides, and extracting the dispersion from the supernatant. Some embodiments include extracting the supernatant and casting the solution by diluting the dispersion with a second suspending solution that includes dissolved polymer. This can result in a composite film includes a dispersion of the exfoliated metal diborides and provides improved mechanical properties.

    Method for functionalizing transition metal dichalcogenides
    15.
    发明授权
    Method for functionalizing transition metal dichalcogenides 有权

    公开(公告)号：US10155782B2

    公开(公告)日：2018-12-18

    申请号：US15288952

    申请日：2016-10-07

    Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY

    Inventor： Qing Hua Wang ,  Ximo Chu ,  Alexander Green ,  Ahmed Yousaf

    IPC: C07F11/00 ,  C09K11/06 ,  C09K11/02 ,  C09K11/68

    Abstract: Embodiments of the invention provide a lithium-free metal dichalcogenides functionalization method where a metal dichalcogenide including a surface of predominantly semiconducting 2H phase is reacted with an aryl diazonium salt by exposing at least a portion of transition metal dichalcogenide to the aryl diazonium salt in the absence of alkyl lithium or alkyl lithium. A substantial portion of the reaction of the at least one aryl diazonium salt with the at least one transition metal dichalcogenide occurs with the semiconducting 2H phase. The aryl diazonium salt can be 4-nitrobenzenediazonium tetrafluoroborate or 4-carboxybenzene diazonium tetrafluoroborate, and the metal dichalcogenide can be MoS2. The semiconducting 2H phase of the transition metal dichalcogenide is derived directly from mechanical exfoliation such as mechanical cleaving and/or sonication.

    Ultraspecific nucleic acid sensors for low-cost liquid biopsies
    18.
    发明授权
    Ultraspecific nucleic acid sensors for low-cost liquid biopsies 有权

    公开(公告)号：US11434540B2

    公开(公告)日：2022-09-06

    申请号：US16349752

    申请日：2017-11-15

    Applicant: Arizona Board of Regents on Behalf of Arizona State University

    Inventor： Alexander Green ,  Fan Hong ,  Soma Chaudhary ,  Anli Tang ,  Hao Yan

    IPC: C12Q1/6858 ,  C12Q1/6897

    Abstract: Ultraspecific, programmable nucleic acid sensors capable of detecting and preferentially amplifying target DNA molecules comprising a particular SNP or mutation are provided. In some cases, the ultraspecific programmable nucleic acid sensors are useful for detecting SNP-containing DNA molecules indicative of cancer such as cell-free DNA circulating in the blood or indicative of organ transplant rejection Also provided are methods for construction of such ultraspecific nucleic acid sensors and methods for preferential amplification of target DNA molecules containing a mutation of interest, as well as testing systems for early cancer screening and routine monitoring of circulating cancer DNA using liquid biological samples such as serum, plasma, or saliva.

    Synthetic Near-Threshold Translational Repressors
    20.
    发明申请
    Synthetic Near-Threshold Translational Repressors 有权

    公开(公告)号：US20210147846A1

    公开(公告)日：2021-05-20

    申请号：US17155387

    申请日：2021-01-22

    Applicant: Arizona Board of Regents on behalf of Arizona State University

    Inventor： Alexander Green ,  Yu Zhou

    IPC: C12N15/113 ,  C12N15/67 ,  H03K19/20

    Abstract: Provided herein are synthetic nucleic acid molecules and methods of using such synthetic nucleic acid molecules for strong repression of target gene expression. In particular, provided herein are methods for altering expression of a protein in a cell, where the method comprises introducing into a cell a protein coding sequence operably linked to a near-threshold translational repressor having first and second trigger recognition sequences that are fully or partially complementary to a repressing trigger RNA; and introducing into a cell the repressing trigger RNA.

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