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公开(公告)号：US20150140006A1
公开(公告)日：2015-05-21
申请号：US14614311
申请日：2015-02-04
Applicant: AbbVie, Inc.
Inventor： Natarajan RAMASUBRAMANYAN , Lihua Yang , Matthew Omon Herigstad , Hong Yang , Kartik Subramanian , Xiaobei Zeng , Diane D. Dong , Wen Chung Lim , Kathreen A. Gifford , Zehra Kaymakcalan , Christopher Chumsae
IPC: C07K16/24
CPC classification number: C07K16/241 , A61K39/39591 , A61K47/183 , A61K47/26 , A61K2039/505 , C07K16/00 , C07K2317/10 , C07K2317/14 , C07K2317/21 , C07K2317/41 , C07K2317/76
Abstract: The instant invention relates to low acidic species (AR) compositions comprising a protein, e.g., an antibody, or antigen-binding portion thereof, and methods, e.g., cell culture and/or protein purification methods, for producing such low AR compositions. Methods for using such compositions to treat a disorder, e.g., a disorder in which TNFα is detrimental, are also provided.
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公开(公告)号：US09683033B2
公开(公告)日：2017-06-20
申请号：US15008895
申请日：2016-01-28
Applicant: AbbVie Inc.
Inventor： Kartik Subramanian , Xiaobei Zeng , Diane D. Dong , Wen Chung Lim , Kathreen A. Gifford , Christopher Chumsae
IPC: C07K16/00 , C07K1/00 , C07K16/24 , C07K1/16 , C07K1/18 , A61K39/395 , C12P21/00 , C07K1/20 , C07K1/22
CPC classification number: C07K16/241 , A61K39/39591 , C07K1/165 , C07K1/18 , C07K1/20 , C07K1/22 , C07K16/00 , C07K2317/14 , C07K2317/21 , C12P21/00
Abstract: The instant invention relates to the field of protein production and purification, and in particular to compositions and processes for controlling the amount of acidic species expressed by host cells, as well as to compositions and processes for controlling the amount of acidic species present in purified preparations.
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公开(公告)号：US09522953B2
公开(公告)日：2016-12-20
申请号：US15009286
申请日：2016-01-28
Applicant: AbbVie, Inc.
Inventor： Natarajan Ramasubramanyan , Lihua Yang , Matthew Omon Herigstad , Hong Yang , Kartik Subramanian , Xiaobei Zeng , Diane D. Dong , Wen Chung Lim , Kathreen A. Gifford , Zehra Kaymakcalan , Christopher Chumsae
CPC classification number: C07K16/241 , A61K39/39591 , A61K47/183 , A61K47/26 , A61K2039/505 , C07K16/00 , C07K2317/10 , C07K2317/14 , C07K2317/21 , C07K2317/41 , C07K2317/76
Abstract: The instant invention relates to low acidic species (AR) compositions comprising a protein, e.g., an antibody, or antigen-binding portion thereof, and methods, e.g., cell culture and/or protein purification methods, for producing such low AR compositions. Methods for using such compositions to treat a disorder, e.g., a disorder in which TNFα is detrimental, are also provided.
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14.发明授权公开(公告)号：US09499616B2
公开(公告)日：2016-11-22
申请号：US14923966
申请日：2015-10-27
Applicant: AbbVie Inc.
Inventor： Kartik Subramanian , Mayda Perez Thiele , Xiaobei Zeng , Chee Furng Wong , Zehra Kaymakcalan , Ying Jing , Christopher M. Chumsae
CPC classification number: C07K16/241 , A61K2039/505 , C07K2317/14 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C12P21/005
Abstract: The instant invention relates to modulated lysine variant species compositions comprising a protein, e.g., an antibody, or antigen-binding portion thereof, and methods, e.g., cell culture and/or protein purification methods, for producing such modulated lysine variant species compositions. Methods for using such compositions to treat a disorder, e.g., a disorder in which TNFα is detrimental, are also provided.
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公开(公告)号：US09359434B2
公开(公告)日：2016-06-07
申请号：US14842933
申请日：2015-09-02
Applicant: AbbVie Inc.
Inventor： Kartik Subramanian , Xiaobei Zeng , Diane D. Dong , Wen Chung Lim , Kathreen A. Gifford , Christopher Chumsae
IPC: C07K1/18 , C07K16/00 , A61K39/00 , C12P21/00 , C07K16/24 , C07K1/16 , A61K39/395 , C07K1/20 , C07K1/22
CPC classification number: C07K16/241 , A61K39/39591 , C07K1/165 , C07K1/18 , C07K1/20 , C07K1/22 , C07K16/00 , C07K2317/14 , C07K2317/21 , C12P21/00
Abstract: The instant invention relates to the field of protein production and purification, and in particular to compositions and processes for controlling the amount of acidic species expressed by host cells, as well as to compositions and processes for controlling the amount of acidic species present in purified preparations.
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Patent Agency Ranking
16.发明申请Methods of Reducing Methylglyoxal (MGO) Modification of Recombinant Proteins in Cell Culture 审中-公开减少甲基乙二醛（MGO）细胞培养重组蛋白修饰的方法公开(公告)号：US20160115225A1
公开(公告)日：2016-04-28
申请号：US14922088
申请日：2015-10-23
Applicant: AbbVie Inc.
Inventor： Christopher M. Chumsae , Kartik Subramanian , Yun ("Frank") Zhang
IPC: C07K16/24
CPC classification number: C07K16/241 , C07K2317/14
Abstract: Methods are provided for controlling the levels of acidic species when a protein of interest is expressed by host cells. One particular example of an acidic species is methylglyoxal (MGO). Reduction of acidic species such as MGO may be achieved by regulating the glucose consumption of the cell culture or by modulating the cysteine/glutathione metabolic pathways.
Abstract translation: 当由宿主细胞表达感兴趣的蛋白质时，提供了控制酸性物质水平的方法。 酸性物质的一个具体实例是甲基乙二醛（MGO）。 通过调节细胞培养物的葡萄糖消耗或通过调节半胱氨酸/谷胱甘肽代谢途径，可以实现诸如MGO的酸性物质的还原。
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公开(公告)号：US20130280274A1
公开(公告)日：2013-10-24
申请号：US13830976
申请日：2013-03-14
Applicant: ABBVIE INC.
Inventor： Kartik Subramanian , Mayda Perez , Xiaobei Zeng , Chee Furng Wong
IPC: C12P21/00
CPC classification number: C07K16/241 , C07K16/00 , C07K16/2803 , C07K2317/14 , C07K2317/21 , C07K2317/40 , C07K2317/526 , C12N5/0018 , C12N2500/22 , C12N2500/32 , C12N2511/00 , C12P21/00
Abstract: The instant invention relates to the field of protein production and purification, and in particular to compositions and processes for controlling the distribution or amount of lysine variants expressed by host cells, as well as to compositions and processes for controlling the amount of lysine variants present in purified preparations.
Abstract translation: 本发明涉及蛋白质生产和纯化领域，特别涉及用于控制由宿主细胞表达的赖氨酸变体的分布或数量的组合物和方法，以及用于控制宿主细胞中存在的赖氨酸变体的量的组合物和方法 纯化制剂。
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公开(公告)号：US20170355761A1
公开(公告)日：2017-12-14
申请号：US15601945
申请日：2017-05-22
Applicant: AbbVie Inc.
Inventor： Kartik Subramanian , Xiaobei Zeng , Diane D. Dong , Wen Chung Lim , Kathreen A. Gifford , Christopher CHUMSAE
CPC classification number: C07K16/241 , A61K39/39591 , C07K1/165 , C07K1/18 , C07K1/20 , C07K1/22 , C07K16/00 , C07K2317/14 , C07K2317/21 , C12P21/00
Abstract: The instant invention relates to the field of protein production and purification, and in particular to compositions and processes for controlling the amount of acidic species expressed by host cells, as well as to compositions and processes for controlling the amount of acidic species present in purified preparations.
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19.发明申请公开(公告)号：US20160237150A1
公开(公告)日：2016-08-18
申请号：US14923966
申请日：2015-10-27
Applicant: AbbVie Inc.
Inventor： Kartik Subramanian , Mayda Perez Thiele , Xiaobei Zeng , Chee Furng Wong , Zehra Kaymakcalan , Ying Jing , Christopher M. Chumsae
CPC classification number: C07K16/241 , A61K2039/505 , C07K2317/14 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C12P21/005
Abstract: The instant invention relates to modulated lysine variant species compositions comprising a protein, e.g., an antibody, or antigen-binding portion thereof, and methods, e.g., cell culture and/or protein purification methods, for producing such modulated lysine variant species compositions. Methods for using such compositions to treat a disorder, e.g., a disorder in which TNFα is detrimental, are also provided.
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公开(公告)号：US20160145331A1
公开(公告)日：2016-05-26
申请号：US15008895
申请日：2016-01-28
Applicant: AbbVie Inc.
Inventor： Kartik Subramanian , Xiaobei Zeng , Diane D. Dong , Wen Chung Lim , Kathreen A. Gifford , Christopher CHUMSAE
IPC: C07K16/24
CPC classification number: C07K16/241 , A61K39/39591 , C07K1/165 , C07K1/18 , C07K1/20 , C07K1/22 , C07K16/00 , C07K2317/14 , C07K2317/21 , C12P21/00
Abstract: The instant invention relates to the field of protein production and purification, and in particular to compositions and processes for controlling the amount of acidic species expressed by host cells, as well as to compositions and processes for controlling the amount of acidic species present in purified preparations.
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