公开(公告)号：US20110109911A1

公开(公告)日：2011-05-12

申请号：US12919026

申请日：2009-02-24

Applicant: Adrian Podoleanu

Inventor： Adrian Podoleanu

IPC: G01B9/02

CPC classification number: G01B9/02014 ,  A61B3/102 ,  A61B5/0059 ,  A61B5/0066 ,  A61B5/7257 ,  G01B9/02002 ,  G01B9/02028 ,  G01B9/02044 ,  G01B9/02087 ,  G01B9/02091 ,  G01B2290/35 ,  G01B2290/45 ,  G01B2290/70 ,  G01N21/4795

Abstract: The invention discloses an optical interferometer which can be used to provide simultaneous measurements over multiple path lengths and methods to employ such an interferometer as to achieve a variety of functions covering simultaneous measurements at different depths separated by an increment of a multiple differential delay matched in the interferometer as well as imaging. Optical sensors, optical coherence tomography (OCT) set-ups, optical sensing methods and OCT methods are disclosed which can provide: (i) multiple en-face images at several depths with dynamic dispersion compensation, (ii) fast acquisition of cross sections, (iii) fast acquisition of 3D volumes of a scattering object while maintaining dynamic focus; (iv) fast acquisition of long axial measurement profiles, non mechanical, with dynamic focus, range scalable, with applications in tracking and OTDR. Methods are disclosed on the combination of scanning regimes and modes of operation to achieve versatile functionality in measurements, in the 3D imaging of moving tissue such as the eye, heart, or moving embryos or functional/low noise imaging by making use of angular compounding or polarisation. A method for elimination of axial movement effects in measuring the flow profile is also disclosed.

Abstract translation: 本发明公开了一种光干涉仪，其可用于提供多路径长度上的同时测量以及采用这种干涉仪的方法，以实现各种功能，覆盖在不同深度处的同时测量，所述多个不同深度由在 干涉仪以及成像。 公开了光学传感器，光学相干断层扫描（OCT）设置，光学感测方法和OCT方法，其可以提供：（i）在几个深度处具有动态色散补偿的多个面部图像，（ii）快速获取横截面， （iii）快速获取散射物体的3D体积，同时保持动态聚焦; （iv）快速获取长轴向测量轮廓，非机械，具有动态聚焦，范围可扩展，应用于跟踪和OTDR。 在扫描方式和操作模式的组合中公开了方法，以在测量中进行多功能功能，在移动组织例如眼睛，心脏或移动胚胎或功能/低噪声成像的3D成像中，通过使用角配合或 极化。 还公开了一种在测量流动剖面中消除轴向运动效应的方法。

公开(公告)号：US07466423B2

公开(公告)日：2008-12-16

申请号：US11239677

申请日：2005-09-30

Applicant: Adrian Podoleanu ,  Adrian Bradu ,  Chris Dainty ,  David Merino

Inventor： Adrian Podoleanu ,  Adrian Bradu ,  Chris Dainty ,  David Merino

IPC: G01B9/02

CPC classification number: A61B3/102 ,  A61B3/1025 ,  A61B3/14

Abstract: Optical mapping apparatus for imaging an object, comprising an optical coherence tomography (OCT) system including an OCT source, an OCT reference path leading from the OCT source to an OCT receiver, an OCT object path leading from the object to the OCT coupler, an OCT depth scanner adapted to alter at least one of the OCT reference path and the OCT receiver path. A confocal system is provided including a confocal optical receiver a confocal path leading from the object to the confocal optical receiver via a confocal input aperture. An adaptive optics (AO) system is provided to correct optical aberrations in the OCT object path and the confocal path.

Abstract translation: 用于对物体成像的光学映射设备，包括包括OCT源，从OCT源引导到OCT接收器的OCT参考路径的光学相干断层摄影（OCT）系统，从对象引导到OCT耦合器的OCT对象路径， OCT深度扫描器适于改变OCT参考路径和OCT接收器路径中的至少一个。 提供了共焦系统，其包括共聚焦光学接收器，其经由共焦输入孔从物体引导到共焦光学接收器。 提供自适应光学（AO）系统来校正OCT对象路径和共焦路径中的光学像差。

公开(公告)号：US20070076223A1

公开(公告)日：2007-04-05

申请号：US11561682

申请日：2006-11-20

Applicant: Adrian Podoleanu ,  David Jackson ,  John Rogers ,  George Dobre ,  Radu Cucu

Inventor： Adrian Podoleanu ,  David Jackson ,  John Rogers ,  George Dobre ,  Radu Cucu

IPC: G01B9/02 ,  G01B11/02

CPC classification number: A61B3/102 ,  A61B5/0066 ,  G01B9/0201 ,  G01B9/02027 ,  G01B9/0203 ,  G01B9/02058 ,  G01B9/02063 ,  G01B9/02091 ,  G01B2290/45 ,  G01B2290/70 ,  G01N21/23 ,  G01N21/4795

Abstract: OCT apparatus includes an interferometer, having an input beam splitter and a 50/50 output splitter. The splitting ratio of the input splitter may be optimized depending on the source power of light source and on the mismatch of the balanced receiver. The input splitter is a plate beam-splitter to minimize the stray reflected light in the interferometer and allow sequential operation of the apparatus in the OCT or in the confocal regime. The switching between the two regimes may be at will, or synchronous with the en-face scanning which results in quasi-simultaneous OCT/confocal imaging or in alternatives frames, confocal and OCT. By using polarization sensitive elements, two channels are provided in each regime, OCT and confocal. The two confocal polarization sensitive channels may allow adjustments of compensators prior to OCT measurements or OCT imaging.

Abstract translation: OCT设备包括具有输入分束器和50/50输出分离器的干涉仪。 输入分路器的分频比可以根据光源的功率和平衡接收机的不匹配进行优化。 输入分路器是平板分光器，以最小化干涉仪中的杂散反射光，并允许在OCT或共聚焦状态下对装置的顺序操作。 两种方案之间的切换可以是随意的，或者与进行准同时OCT /共聚焦成像或替代帧，共聚焦和OCT的正面扫描同步。 通过使用极化敏感元件，在每个方案中提供了两个通道，OCT和共聚焦。 两个共焦极化敏感通道可以允许在OCT测量或OCT成像之前调整补偿器。

公开(公告)号：US08514404B2

公开(公告)日：2013-08-20

申请号：US12919026

申请日：2009-02-24

Applicant: Adrian Podoleanu

Inventor： Adrian Podoleanu

IPC: G01B9/02 ,  G01B11/02

CPC classification number: G01B9/02014 ,  A61B3/102 ,  A61B5/0059 ,  A61B5/0066 ,  A61B5/7257 ,  G01B9/02002 ,  G01B9/02028 ,  G01B9/02044 ,  G01B9/02087 ,  G01B9/02091 ,  G01B2290/35 ,  G01B2290/45 ,  G01B2290/70 ,  G01N21/4795

Abstract: The invention discloses an optical interferometer which can be used to provide simultaneous measurements over multiple path lengths and methods to employ such an interferometer as to achieve a variety of functions covering simultaneous measurements at different depths separated by an increment of a multiple differential delay matched in the interferometer as well as imaging. Optical sensors, optical coherence tomography (OCT) set-ups, optical sensing methods and OCT methods are disclosed which can provide: (i) multiple en-face images at several depths with dynamic dispersion compensation, (ii) fast acquisition of cross sections, (iii) fast acquisition of 3D volumes of a scattering object while maintaining dynamic focus; (iv) fast acquisition of long axial measurement profiles, non mechanical, with dynamic focus, range scalable, with applications in tracking and OTDR. Methods are disclosed on the combination of scanning regimes and modes of operation to achieve versatile functionality in measurements, in the 3D imaging of moving tissue such as the eye, heart, or moving embryos or functional/low noise imaging by making use of angular compounding or polarisation. A method for elimination of axial movement effects in measuring the flow profile is also disclosed.

Abstract translation: 本发明公开了一种光干涉仪，其可用于提供多路径长度上的同时测量以及采用这种干涉仪的方法，以实现各种功能，覆盖在不同深度处的同时测量，所述多个不同深度由在 干涉仪以及成像。 公开了光学传感器，光学相干断层扫描（OCT）设置，光学感测方法和OCT方法，其可以提供：（i）在几个深度处具有动态色散补偿的多个面部图像，（ii）快速获取横截面， （iii）快速获取散射物体的3D体积，同时保持动态聚焦; （iv）快速获取长轴向测量轮廓，非机械，具有动态聚焦，范围可扩展，应用于跟踪和OTDR。 在扫描方式和操作模式的组合中公开了方法，以在测量中进行多功能功能，在移动组织例如眼睛，心脏或移动胚胎或功能/低噪声成像的3D成像中，通过使用角配合或 极化。 还公开了一种在测量流动剖面中消除轴向运动效应的方法。

公开(公告)号：US07594730B2

公开(公告)日：2009-09-29

申请号：US11547922

申请日：2005-03-11

Applicant: Adrian Podoleanu

Inventor： Adrian Podoleanu

IPC: A61B3/00 ,  A61B3/02 ,  A61B3/10

CPC classification number: G01B9/02091 ,  A61B3/102 ,  G01B9/02083

Abstract: OCT cross section images of a part of a curved object are displayed by creating a series of image points and placing each image point into a corrected image in such a way that the positions of scattering points within the image coincide with or are at least closer to their real spatial distribution within the curved object.

Abstract translation: 通过创建一系列图像点并将每个图像点放置在校正图像中，使得图像内的散射点的位置与图像中的位置一致或至少更接近于图像点来显示弯曲物体的一部分的OCT截面图像 它们在曲线对象内的实际空间分布。

公开(公告)号：US20070046948A1

公开(公告)日：2007-03-01

申请号：US11239677

申请日：2005-09-30

Applicant: Adrian Podoleanu ,  Adrian Bradu ,  Chris Dainty ,  David Merino

Inventor： Adrian Podoleanu ,  Adrian Bradu ,  Chris Dainty ,  David Merino

IPC: G01B11/02

CPC classification number: A61B3/102 ,  A61B3/1025 ,  A61B3/14

Abstract: Optical mapping apparatus for imaging an object, comprising an optical coherence tomography (OCT) system including an OCT source, an OCT reference path leading from the OCT source to an OCT receiver, an OCT object path leading from the object to the OCT coupler, an OCT depth scanner adapted to alter at least one of the OCT reference path and the OCT receiver path. A confocal system is provided including a confocal optical receiver a confocal path leading from the object to the confocal optical receiver via a confocal input aperture. An adaptive optics (AO) system is provided to correct optical aberrations in the OCT object path and the confocal path.

Abstract translation: 用于对物体成像的光学映射设备，包括包括OCT源，从OCT源引导到OCT接收器的OCT参考路径的光学相干断层摄影（OCT）系统，从对象引导到OCT耦合器的OCT对象路径， OCT深度扫描器适于改变OCT参考路径和OCT接收器路径中的至少一个。 提供了共焦系统，其包括共聚焦光学接收器，其经由共焦输入孔从物体引导到共焦光学接收器。 提供自适应光学（AO）系统来校正OCT对象路径和共焦路径中的光学像差。

公开(公告)号：US20060055938A1

公开(公告)日：2006-03-16

申请号：US11216403

申请日：2005-08-31

Applicant: Adrian Podoleanu ,  John Rogers

Inventor： Adrian Podoleanu ,  John Rogers

IPC: G01B11/02

CPC classification number: A61B3/102 ,  G01B9/0201 ,  G01B9/02091 ,  G01B2290/20 ,  G01B2290/35 ,  G01B2290/65 ,  G01N21/4795 ,  G02B17/023 ,  G02B26/06

Abstract: A method for axial scanning to be used in transmission in one of the arms of OCT interferometers, with reduced walk-off and loss. Procedures are disclosed of using the scanning delay line in conjunction with the transverse scanners to generate B and C-scan OCT images.

Abstract translation: 一种用于在OCT干涉仪的一个臂中的透射中的轴向扫描的方法，具有减小的偏离和损失。 公开了使用与横向扫描仪结合的扫描延迟线以产生B和C扫描OCT图像的程序。

公开(公告)号：US08619184B2

公开(公告)日：2013-12-31

申请号：US12866304

申请日：2009-02-06

Applicant: Adrian Podoleanu

Inventor： Adrian Podoleanu

IPC: H04N5/225

CPC classification number: H04N5/232 ,  A61B3/102 ,  A61B3/14 ,  G01B9/02007 ,  G01B9/0203 ,  G01B9/02049 ,  G01B9/02069 ,  G01B9/02079 ,  G01B9/02091 ,  G01B2290/35 ,  G01B2290/70 ,  G02B21/0056 ,  G02B21/0064 ,  H04N5/2252 ,  H04N5/33

Abstract: An adapter which can make use of the devices in any commercially available digital cameras to accomplish different functions, the invention admits addition of confocal detection and provides simultaneous measurements or imaging in at least two channels, confocal and OCT, where the confocal channel provides an en-face image simultaneous with the acquisition of OCT cross sections, to guide the acquisition as well as to be used subsequently in the visualization of OCT images. Different technical solutions are provided for the assembly of one or two digital cameras which together with such adapters lead to modular and portable high resolution imaging systems which can accomplish various functions with a minimum of extra components while adapting the elements in the digital camera.

Abstract translation: 可以使用任何市售数码相机中的装置来实现不同功能的适配器，本发明允许加入共聚焦检测，并且在至少两个通道，共聚焦和OCT中提供同时测量或成像，其中共聚焦通道提供en 同时采集OCT横截面，以指导采集以及随后在OCT图像的可视化中使用。 提供了不同的技术解决方案，用于组装一个或两个数字照相机，这些数字照相机与这些适配器一起导致模块化和便携式的高分辨率成像系统，其可以在使数字照相机中的元件适应的同时以最小额外的成分完成各种功能。

公开(公告)号：US08472027B2

公开(公告)日：2013-06-25

申请号：US13178695

申请日：2011-07-08

Applicant: Adrian Podoleanu

Inventor： Adrian Podoleanu

IPC: G01B9/02

CPC classification number: A61B3/102 ,  A61B5/0064 ,  A61B5/0066 ,  A61B5/0073 ,  A61B5/441 ,  A61B5/7203 ,  A61B5/7257 ,  G01B9/02044 ,  G01B9/02069 ,  G01B9/02091 ,  G01N21/4795

Abstract: A spectral interferometry apparatus and method is provided to supply unambiguous profiles (A-scans free of mirror terms) of the reflectivity versus optical path difference and make difference between the positive and negative optical path difference or provide output in a selected interval of optical path differences. The apparatus comprises object optics that transfer a beam from an optical source to a target object (55) to produce an object beam and reference optics that produce a reference beam. Displacing means (57) are provided to produce a gap (g) between the object beam (41′) and the reference beam (42′). Optical spectrum dispersing means (7) such as a grating or a prism receive the two relatively displaced beams, and disperse their spectral content onto a reading element such as a CCD. The combination of the displacing means and the optical spectrum dispersing means creates an intrinsic optical delay between the wavetrains of the object beam and the reference beam which can be used with the optical path difference in the interferometer to generate a channelled spectrum for the optical path difference in the interferometer on the reading element.

Abstract translation: 提供了一种光谱干涉测量装置和方法来提供反射率相对于光程差的明确分布（无镜像的A扫描），并使得在正和负光程差之间产生差异，或者在所选择的光程差间隔中提供输出 。 该装置包括将光束从光源传输到目标物体（55）以产生物体光束和产生参考光束的参考光学器件的物体光学器件。 设置位移装置（57）以在物体光束（41'）和参考光束（42'）之间产生间隙（g）。 诸如光栅或棱镜的光谱分散装置（7）接收两个相对移动的光束，并将其光谱含量分散到诸如CCD的读取元件上。 位移装置和光谱分散装置的组合在物体光束的波长与参考光束之间产生固有的光学延迟，该参考光束可与干涉仪中的光程差用于产生用于光程差的通道光谱 在干涉仪上读取元件。

公开(公告)号：US20110134436A1

公开(公告)日：2011-06-09

申请号：US12764510

申请日：2010-04-21

Applicant: Adrian Podoleanu ,  Simon Tuohy

Inventor： Adrian Podoleanu ,  Simon Tuohy

IPC: G01B11/02

CPC classification number: G01B9/02004 ,  A61B3/1015 ,  A61B3/102 ,  A61B3/156 ,  G01B9/02002 ,  G01B9/0201 ,  G01B9/02027 ,  G01B9/02038 ,  G01B9/02063 ,  G01B9/02068 ,  G01B9/0209 ,  G01B9/02091 ,  G01B2290/45 ,  G01B2290/70

Abstract: Methods and devices are disclosed for acquiring depth resolved aberration information using principles of low coherence interferometry and perform coherence gated wavefront sensing (CG-WFS). The wavefront aberrations is collected using spectral domain low coherence interferometry (SD-LCI) or time domain low coherence interferometry (TD-LCI) principles. When using SD-LCI, chromatic aberrations can also be evaluated. Methods and devices are disclosed in using a wavefront corrector to compensate for the aberration information provided by CG-WFS, in a combined imaging system, that can use one or more channels from the class of (i) optical coherence tomography (OCT), (ii) scanning laser ophthalmoscopy, (iii) microscopy, such as confocal or phase microscopy, (iv) multiphoton microscopy, such as harmonic generation and multiphoton absorption. In particular, a swept source (SS) is used that drives both an OCT channel and a coherence gated wavefront sensor, where: a) both channels operate according to SS-OCT principles; b) OCT channel integrates over at least one tuning scan of the swept source to provide a TD-OCT image of the object; c) CG-WFS integrates over at least one tuning scan of the swept source to provide an en-face TD-OCT mapping of the wavefront. For some implementations, simultaneous and dynamic aberration measurements/correction with the imaging process is achieved. The methods and devices for depth resolved aberrations disclosed, will find applications in wavefront sensing and adaptive optics imaging systems that are more tolerant to stray reflections from optical interfaces, such as reflections from the microscope objectives and cover slip in microscopy and when imaging the eye, the reflection from the cornea.

Abstract translation: 公开了使用低相干干涉测量原理获取深度分辨像差信息并执行相干门控波前检测（CG-WFS）的方法和装置。 使用频域低相干干涉测量（SD-LCI）或时域低相干干涉测量（TD-LCI）原理收集波前像差。 当使用SD-LCI时，也可以评估色差。 在使用波前校正器来补偿在组合成像系统中由CG-WFS提供的像差信息的方法和装置被公开，该组合成像系统可以使用来自（i）光学相干断层扫描（OCT）的一个或多个通道， ii）扫描激光眼底镜检查，（iii）显微镜，如共焦或相位显微镜，（iv）多光子显微镜，如谐波产生和多光子吸收。 特别地，使用驱动OCT通道和相干门控波前传感器的扫频源（SS），其中：a）两个通道根据SS-OCT原理操作; b）OCT信道在扫描源的至少一次调谐扫描上进行积分以提供对象的TD-OCT图像; c）CG-WFS集成了扫描源的至少一个调谐扫描，以提供波前的面向TD-OCT映射。 对于一些实施方案，实现了通过成像过程的同步和动态像差测量/校正。 所公开的用于深度分辨像差的方法和装置将会在波前感测和自适应光学成像系统中应用，这些系统对光学界面的杂散反射更为宽容，例如来自显微镜物镜的反射和显微镜下的盖滑动以及当成像眼睛时， 角膜的反射。