公开(公告)号：US11059895B2

公开(公告)日：2021-07-13

申请号：US16242278

申请日：2019-01-08

Applicant: Amgen Inc.

Inventor： Dirk E. Smith ,  Ian Foltz ,  Chadwick T. King ,  Ai Ching Lim ,  Rutilio Clark ,  Michael R. Comeau ,  Randal R. Ketchem ,  Donghui Shi ,  Xiaoshan Min ,  Zhulun Wang

IPC: C07K16/28 ,  C07K16/24 ,  A61K39/00 ,  C12N15/11

Abstract: Described herein are compositions and methods related to antigen binding proteins that bind to human ST2, including antibodies. In particular embodiments, the disclosure provides fully human anti-ST2 antibodies and derivatives and variants thereof. Further provided are nucleic acids encoding such antibodies and antibody fragments, variants, and derivatives. Also, provided are methods of making and using such antibodies including methods of treating and preventing autoimmune and inflammatory disorders.

公开(公告)号：US20200181255A1

公开(公告)日：2020-06-11

申请号：US16793610

申请日：2020-02-18

Applicant: AMGEN INC.

Inventor： Jennifer E. Towne ,  Janet D. Cheng ,  Jason C. O'Neill ,  Yu Zhang ,  Yu Sun ,  Heather Cerne ,  Derek E. Piper ,  Randal R. Ketchem

IPC: C07K16/24 ,  A61K39/395 ,  A61K47/68

Abstract: Antigen binding proteins that bind to human IL-23 protein are provided. Nucleic acids encoding the antigen binding protein, vectors, and cells encoding the same as well as use of IL-23 antigen binding proteins for diagnostic and therapeutic purposes are also provided.

公开(公告)号：US20190071498A1

公开(公告)日：2019-03-07

申请号：US16194896

申请日：2018-11-19

Applicant: AMGEN INC.

Inventor： Jennifer E. Towne ,  Janet D. Cheng ,  Jason C. O'Neill ,  Yu Zhang ,  Yu Sun ,  Heather Cerne ,  Derek E. Piper ,  Randal R. Ketchem

IPC: C07K16/24 ,  A61K39/395 ,  A61K47/68 ,  A61K39/00

Abstract: Antigen binding proteins that bind to human IL-23 protein arc provided. Nucleic acids encoding the antigen binding protein, vectors, and cells encoding the same as well as use of IL-23 antigen binding proteins for diagnostic and therapeutic purposes arc also provided.

公开(公告)号：US12012449B2

公开(公告)日：2024-06-18

申请号：US17525421

申请日：2021-11-12

Applicant: AMGEN INC.

Inventor： Jennifer E. Towne ,  Janet D. Cheng ,  Jason C. O'Neill ,  Yu Zhang ,  Yu Sun ,  Heather Cerne ,  Derek E. Piper ,  Randal R. Ketchem

IPC: A61K39/395 ,  A61K47/68 ,  C07K16/24 ,  A61K39/00

CPC classification number: C07K16/244 ,  A61K39/395 ,  A61K47/6845 ,  C07K16/24 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/626 ,  C07K2317/76 ,  C07K2317/92

Abstract: Antigen binding proteins that bind to human IL-23 protein are provided. Nucleic acids encoding the antigen binding protein, vectors, and cells encoding the same as well as use of IL-23 antigen binding proteins for diagnostic and therapeutic purposes are also provided.

公开(公告)号：US11427627B2

公开(公告)日：2022-08-30

申请号：US14916993

申请日：2014-09-05

Applicant: AMGEN INC.

Inventor： Zhimei Du ,  Pranhitha Reddy ,  Randal B. Bass ,  Feng He ,  William C. Fanslow, III ,  Yuling Zhang ,  Da Ren ,  Randal R. Ketchem

IPC: C07K1/00 ,  C07K16/00 ,  A61K39/395 ,  A61K39/40

Abstract: The present invention relates to variant Fc-containing molecules, such as antibodies and Fc-fusion molecules, having glycosylation characteristics favorable to largescale production of therapeutic molecules containing such variant Fc. Described herein are compositions and methods to improve glycosylation maturation of and to minimize the culture process-dependent effects of Fc-containing molecules, e.g., Fc-fusion molecules and antibodies. Creating single and multiple amino acid substitutions within the Fc domain with the aim to improve high mannose processing and glycosylation maturation.

公开(公告)号：US20210230267A1

公开(公告)日：2021-07-29

申请号：US17229607

申请日：2021-04-13

Applicant: AMGEN INC.

Inventor： Jennifer E. Towne ,  Janet D. Cheng ,  Jason C. O'Neill ,  Yu Zhang ,  Yu Sun ,  Heather Cerne ,  Derek E. Piper ,  Randal R. Ketchem

IPC: C07K16/24 ,  A61K47/68 ,  A61K39/395

Abstract: Antigen binding proteins that bind to human IL-23 protein are provided. Nucleic acids encoding the antigen binding protein, vectors, and cells encoding the same as well as use of IL-23 antigen binding proteins for diagnostic and therapeutic purposes are also provided.

公开(公告)号：US10227414B2

公开(公告)日：2019-03-12

申请号：US15601868

申请日：2017-05-22

Applicant: Amgen Inc.

Inventor： Dirk E. Smith ,  Ian Foltz ,  Chadwick T. King ,  Ai Ching Lim ,  Rutilio Clark ,  Michael R. Comeau ,  Randal R. Ketchem ,  Donghui Shi ,  Xiaoshan Min ,  Zhulun Wang

IPC: A61K39/00 ,  C07K16/24 ,  C07K16/28

Abstract: Described herein are compositions and methods related to antigen binding proteins that bind to human ST2, including antibodies. In particular embodiments, the disclosure provides fully human anti-ST2 antibodies and deriviatives and variants thereof. Further provided are nucleic acids encoding such antibodies and antibody fragments, variants, and derivatives. Also, provided are methods of making and using such antibodies including methods of treating and preventing autoimmune and inflammatory disorders.

公开(公告)号：US20180030116A1

公开(公告)日：2018-02-01

申请号：US15547730

申请日：2015-08-26

Applicant: AMGEN INC.

Inventor： Jason C. O'Neill ,  Randal R. Ketchem ,  Taeweon Lee ,  Vishnu Chintalgattu ,  Jennitte Leann Stevens

IPC: C07K14/81

CPC classification number: C07K14/8146 ,  A61K38/00

Abstract: The application concerns tissue inhibitor of metalloproteinase 3 (TIMP-3) muteins, variants and derivatives, nucleic acids encoding them, and methods of making and using them; in particular, muteins of TIMP-3 with specific amino acid substitutions in order to introduce N-linked glycosylation sites.

公开(公告)号：US09464139B2

公开(公告)日：2016-10-11

申请号：US14472116

申请日：2014-08-28

Applicant: AMGEN INC.

Inventor： Courtney Beers ,  Jason C. O'Neill ,  Ian Foltz ,  Randal R. Ketchem ,  Julia C. Piasecki

IPC: C07K16/28 ,  A61K45/06 ,  A61K39/00

CPC classification number: C07K16/2878 ,  A61K45/06 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/41 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/565 ,  C07K2317/71 ,  C07K2317/74 ,  C07K2317/75 ,  C07K2317/76 ,  C07K2317/77 ,  C07K2317/94

Abstract: Antigen binding proteins that activate GITR are provided. Nucleic acids encoding the antigen binding proteins and vectors and cells containing such nucleic acids are also provided. The antigen binding proteins have value in therapeutic methods in which it is useful to stimulate GITR signaling, thereby inducing or enhancing an immune response in a subject. Accordingly, the antigen binding proteins have utility in a variety of immunotherapy treatments, including treatment of various cancers and infections.

Abstract translation: 提供激活GITR的抗原结合蛋白。 还提供了编码抗原结合蛋白的核酸和含有此类核酸的载体和细胞。 抗原结合蛋白在治疗方法中具有价值，其中它可用于刺激GITR信号传导，从而诱导或增强受试者的免疫应答。 因此，抗原结合蛋白具有多种免疫治疗方法的用途，包括治疗各种癌症和感染。

公开(公告)号：US09382318B2

公开(公告)日：2016-07-05

申请号：US13897096

申请日：2013-05-17

Applicant: Amgen Inc.

Inventor： Dirk E. Smith ,  Ian Foltz ,  Chadwick T. King ,  Ai Ching Lim ,  Rutilio Clark ,  Michael R. Comeau ,  Randal R. Ketchem ,  Donghui Shi ,  Xiaoshan Min ,  Zhulun Wang

IPC: C07K16/24 ,  C12N15/11 ,  C07K16/28 ,  A61K39/00

CPC classification number: C07K16/2866 ,  A61K2039/505 ,  C07K16/244 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  C12N15/11

Abstract: Described herein are compositions and methods related to antigen binding proteins that bind to human ST2, including antibodies. In particular embodiments, the disclosure provides fully human anti-ST2 antibodies and deriviatives and variants thereof. Further provided are nucleic acids encoding such antibodies and antibody fragments, variants, and derivatives. Also, provided are methods of making and using such antibodies including methods of treating and preventing autoimmune and inflammatory disorders.

Abstract translation: 本文描述的是与抗原结合蛋白相关的组合物和方法，其结合人ST2，包括抗体。 在具体实施方案中，本公开提供完全人抗-ST2抗体及其衍生物及其变体。 还提供了编码这种抗体和抗体片段，变体和衍生物的核酸。 此外，提供制备和使用这些抗体的方法，包括治疗和预防自身免疫性和炎症性疾病的方法。