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    Out of order millicode control operation
    11.
    发明授权
    Out of order millicode control operation 失效
    无序控制操作

    公开(公告)号：US08683261B2

    公开(公告)日：2014-03-25

    申请号：US13186953

    申请日：2011-07-20

    申请人： Michael Cremer ,  Guenter Gerwig ,  Frank Lehnert ,  Peter Probst

    发明人： Michael Cremer ,  Guenter Gerwig ,  Frank Lehnert ,  Peter Probst

    IPC分类号： G06F11/00

    CPC分类号： G06F9/30076 ,  G06F9/30101 ,  G06F9/3838 ,  G06F9/3863

    摘要： Instructions within a processor are managed by receiving, at a recovery unit of the processor, an instruction that modifies a control register residing within the recovery unit. The recovery unit receives a first set of data associated with the instruction from a general register. A second set of data associated with the instruction is retrieved from the control register by the recovery unit. The recovery unit performs at least one binary logic operation on the first set of data and the second data.

    摘要翻译： 在处理器中的指令通过在处理器的恢复单元处接收修改驻留在恢复单元内的控制寄存器的指令来管理。 恢复单元从通用寄存器接收与该指令相关联的第一组数据。 与指令相关联的第二组数据由恢复单元从控制寄存器检索。 恢复单元对第一组数据和第二数据执行至少一个二进制逻辑运算。

    COMPOUNDS AND METHODS FOR TREATMENT AND DIAGNOSIS OF CHLAMYDIAL INFECTION
    13.
    发明申请
    COMPOUNDS AND METHODS FOR TREATMENT AND DIAGNOSIS OF CHLAMYDIAL INFECTION 有权
    用于治疗和诊断CHLAMYDIAL感染的化合物和方法

    公开(公告)号：US20080299142A1

    公开(公告)日：2008-12-04

    申请号：US11929665

    申请日：2007-10-30

    申请人： Ajay Bhatia ,  Yasir A.W. Skeiky ,  Peter Probst

    发明人： Ajay Bhatia ,  Yasir A.W. Skeiky ,  Peter Probst

    IPC分类号： A61K39/00 ,  A61P31/00

    CPC分类号： C07K14/295 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  A61K2039/505 ,  A61K2039/51 ,  A61K2039/515 ,  A61K2039/5154 ,  A61K2039/53 ,  C07K2319/00

    摘要： Compounds and methods for the diagnosis and treatment of Chlamydial infection are disclosed. The compounds provided include polypeptides that contain at least one antigenic portion of a Chlamydia antigen and DNA sequences encoding such polypeptides. Pharmaceutical compositions and vaccines comprising such polypeptides or DNA sequences are also provided, together with antibodies directed against such polypeptides. Diagnostic kits containing such polypeptides or DNA sequences and a suitable detection reagent may be used for the detection of Chlamydial infection in patients and in biological samples.

    摘要翻译： 公开了用于诊断和治疗衣原体感染的化合物和方法。 提供的化合物包括含有衣原体抗原的至少一个抗原部分的多肽和编码这些多肽的DNA序列。 还提供了包含此类多肽或DNA序列的药物组合物和疫苗以及针对这些多肽的抗体。 含有此类多肽或DNA序列的诊断试剂盒和合适的检测试剂可用于检测患者和生物样品中的衣原体感染。

    Immunomodulatory compositions and uses therefor
    15.
    发明申请
    Immunomodulatory compositions and uses therefor 审中-公开
    免疫调节组合物及其用途

    公开(公告)号：US20070134234A1

    公开(公告)日：2007-06-14

    申请号：US11541449

    申请日：2006-09-29

    申请人： Craig Smith ,  Steven Wiley ,  Ajamete Kaykas ,  Jalal Vakili ,  Peter Probst

    发明人： Craig Smith ,  Steven Wiley ,  Ajamete Kaykas ,  Jalal Vakili ,  Peter Probst

    IPC分类号： A61K39/395 ,  C07H21/04 ,  C12P21/06 ,  C07K16/46 ,  C12N5/06 ,  C12P21/08

    CPC分类号： C12N9/16 ,  A61K38/162 ,  C07K14/005 ,  C07K14/70539 ,  C07K16/2803 ,  C07K2319/30 ,  C12N2710/24022 ,  C12N2710/24122

    摘要： The poxvirus proteins designated A41L and 130L bind to three receptor-like protein tyrosine phosphatases (RPTP), leukocyte common antigen related protein (LAR), RPTP-δ, and RPTP-σ, that are present on the cell surface of immune cells. When a host is infected with the poxvirus, binding of A41L to cell surface proteins on the host cells results in suppression of the immune response. The present invention provides agents such as antibodies, and antigen-binding fragments thereof, small molecules, aptamers, small interfering RNAs, and peptide-IgFc fusion polypeptides that interact with one or more of LAR, RPTP-δ, and RPTP-σ expressed by immune cells or interact with a polynucleotide encoding the RPTP. Also provided are RPTP Ig domain oligomers and Fc fusion polypeptides. Such agents are useful for treating an immunological disorder in a subject according to the methods described herein.

    摘要翻译： 命名为A41L和130L的痘病毒蛋白与存在于免疫细胞的细胞表面上的三种受体样蛋白酪氨酸磷酸酶（RPTP），白细胞常见抗原相关蛋白（LAR），RPTP-delta和RPTP-sigma结合。 当宿主感染痘病毒时，A41L与宿主细胞上的细胞表面蛋白的结合导致免疫应答的抑制。 本发明提供诸如抗体及其抗原结合片段，小分子，适体，小干扰RNA和肽-IgFc融合多肽的试剂，其与LAR，RPTP-δ和RPTP-sigma中的一种或多种相互作用， 免疫细胞或与编码RPTP的多核苷酸相互作用。 还提供了RPTP Ig结构域寡聚体和Fc融合多肽。 根据本文所述的方法，这样的试剂可用于治疗受试者的免疫学障碍。

    IMMUNOMODULATORY COMPOSITIONS AND USES THEREFOR
    19.
    发明申请
    IMMUNOMODULATORY COMPOSITIONS AND USES THEREFOR 审中-公开
    免疫组化及其用途

    公开(公告)号：US20090117112A1

    公开(公告)日：2009-05-07

    申请号：US12246291

    申请日：2008-10-06

    申请人： Craig A. Smith ,  Steven Wiley ,  Ajamete Kaykas ,  Jalal Vakili ,  Peter Probst

    发明人： Craig A. Smith ,  Steven Wiley ,  Ajamete Kaykas ,  Jalal Vakili ,  Peter Probst

    IPC分类号： A61K39/395 ,  C07K16/00 ,  A61P37/02

    CPC分类号： C12N9/16 ,  A61K38/162 ,  C07K14/005 ,  C07K14/70539 ,  C07K16/2803 ,  C07K2319/30 ,  C12N2710/24022 ,  C12N2710/24122

    摘要： The poxvirus proteins designated A41L and 130L bind to three receptor-like protein tyrosine phosphatases (RPTP), leukocyte common antigen related protein (LAR), RPTP-δ, and RPTP-σ, that are present on the cell surface of immune cells. When a host is infected with the poxvirus, binding of A41L to cell surface proteins on the host cells results in suppression of the immune response. The present invention provides agents such as antibodies, and antigen-binding fragments thereof, small molecules, aptamers, small interfering RNAs, and peptide-IgFc fusion polypeptides that interact with one or more of LAR, RPTP-δ, and RPTP-σ expressed by immune cells or interact with a polynucleotide encoding the RPTP. Also provided are RPTP Ig domain oligomers and Fc fusion polypeptides. Such agents are useful for treating an immunological disorder in a subject according to the methods described herein.

    摘要翻译： 命名为A41L和130L的痘病毒蛋白与存在于免疫细胞的细胞表面上的三种受体样蛋白酪氨酸磷酸酶（RPTP），白细胞常见抗原相关蛋白（LAR），RPTP-delta和RPTP-sigma结合。 当宿主感染痘病毒时，A41L与宿主细胞上的细胞表面蛋白的结合导致免疫应答的抑制。 本发明提供诸如抗体及其抗原结合片段，小分子，适体，小干扰RNA和肽-IgFc融合多肽的试剂，其与LAR，RPTP-δ和RPTP-sigma中的一种或多种相互作用， 免疫细胞或与编码RPTP的多核苷酸相互作用。 还提供了RPTP Ig结构域寡聚体和Fc融合多肽。 根据本文所述的方法，这样的试剂可用于治疗受试者的免疫学障碍。