公开(公告)号：US20050261301A1

公开(公告)日：2005-11-24

申请号：US10507925

申请日：2003-03-20

申请人： Jonathan Baell ,  Heike Wulff ,  Andrew Harvey ,  Raymond Norton ,  George Chandy

发明人： Jonathan Baell ,  Heike Wulff ,  Andrew Harvey ,  Raymond Norton ,  George Chandy

IPC分类号： A61K31/343 ,  A61P29/00 ,  A61P37/00 ,  A61P37/06 ,  C07D307/86 ,  C07D405/14 ,  C07D409/14 ,  C07D417/14 ,  A61K31/506 ,  A61K31/381 ,  A61K31/427 ,  A61K31/4433 ,  A61K31/497 ,  A61K31/501 ,  C07D45/14

CPC分类号： C07D417/14 ,  C07D307/86 ,  C07D405/14 ,  C07D409/14

摘要： Various divalent ligands based on khellinone derivatives are described. These derivatives can be useful in the modulation of potassium channel activity in cells, including among others Kv1.3 channels found in T-cells. The compounds may also be useful in the treatment or prevention of autoimmune and inflammatory diseases, including multiple sclerosis.

摘要翻译： 描述了基于凯芬酮衍生物的各种二价配体。 这些衍生物可用于细胞中钾通道活性的调节，包括在T细胞中发现的Kv1.3通道。 所述化合物还可用于治疗或预防自身免疫性和炎性疾病，包括多发性硬化。

公开(公告)号：US08369642B2

公开(公告)日：2013-02-05

申请号：US12482251

申请日：2009-06-10

申请人： Ewan Findlay ,  Andrew Harvey ,  Bertrand Lucotte ,  Gonzalo Muyo ,  Mads Demenikov

发明人： Ewan Findlay ,  Andrew Harvey ,  Bertrand Lucotte ,  Gonzalo Muyo ,  Mads Demenikov

IPC分类号： G06K9/40

CPC分类号： G06T5/003

摘要： PSF coding has become well known in recent years. Although it enables significant increases in the depth of field, defocus introduces artifacts in images that are a major detraction from the final image quality. A method is described that enables the deduction or defocus and consequently the removal of these artifacts. The principle of the disclosed techniques involves iteratively adjusting the restoration algorithm according to a chosen image or artifact metric and choosing the defocus parameter that yields the image the lowest level of artifact.

摘要翻译： 近年来，PSF编码已经成为众所周知的。 虽然它能够显着提高景深，但散焦会在图像中引入伪像，这是最终图像质量的主要障碍。 描述了一种能够减少或散焦并因此去除这些伪影的方法。 所公开技术的原理涉及根据所选择的图像或伪影度量迭代地调整恢复算法，并且选择产生图像最低级别的伪像的散焦参数。

公开(公告)号：US20100008597A1

公开(公告)日：2010-01-14

申请号：US12482251

申请日：2009-06-10

申请人： Ewan Findlay ,  Andrew Harvey ,  Bertrand Lucotte ,  Gonzalo Muyo ,  Mads Demenikov

发明人： Ewan Findlay ,  Andrew Harvey ,  Bertrand Lucotte ,  Gonzalo Muyo ,  Mads Demenikov

IPC分类号： G06K9/40

CPC分类号： G06T5/003

摘要： PSF coding has become well known in recent years. Although it enables significant increases in the depth of field, defocus introduces artifacts in images that are a major detraction from the final image quality. A method is described that enables the deduction or defocus and consequently the removal of these artifacts. The principle of the disclosed techniques involves iteratively adjusting the restoration algorithm according to a chosen image or artifact metric and choosing the defocus parameter that yields the image the lowest level of artifact.

摘要翻译： 近年来，PSF编码已经成为众所周知的。 虽然它能够显着提高景深，但散焦会在图像中引入伪像，这是最终图像质量的主要障碍。 描述了一种能够减少或散焦并因此去除这些伪影的方法。 所公开技术的原理涉及根据所选择的图像或伪影度量迭代地调整恢复算法，并且选择产生图像最低级别的伪像的散焦参数。

公开(公告)号：US20070253621A1

公开(公告)日：2007-11-01

申请号：US11416404

申请日：2006-05-01

申请人： Giacomo Balestriere ,  Gilbert Woodman ,  Andrew Harvey

发明人： Giacomo Balestriere ,  Gilbert Woodman ,  Andrew Harvey

IPC分类号： G06K9/00

CPC分类号： G06K9/00026 ,  G06F17/2247 ,  G06F17/272

摘要： A method and system is described to process a data string (e.g., an XML data string). The method comprises accessing the data string to identify a plurality of data segments and a plurality of predefined reference character sequences. Each predefined reference character sequence may be located between adjacent data segments. The method further comprises creating a data structure to identify a location and length of each data segment within the data string, and a location of each predefined reference character sequences within the data string. A method and system to provide an output data string for transmission to a destination device is also described. The method comprises accessing a data structure to identify a sequence of data segments and a plurality of predefined reference character sequences. The data segments and the predefined reference character sequences are then combined based on the data structure to provide the output data string.

摘要翻译： 描述了处理数据串（例如，XML数据串）的方法和系统。 该方法包括访问数据串以识别多个数据段和多个预定义的参考字符序列。 每个预定义的参考字符序列可以位于相邻数据段之间。 该方法还包括创建数据结构以识别数据串中的每个数据段的位置和长度，以及数据串中每个预定义参考字符序列的位置。 还描述了提供用于传输到目的地设备的输出数据串的方法和系统。 该方法包括访问数据结构以识别数据段的序列和多个预定义的参考字符序列。 然后基于数据结构组合数据段和预定义的参考字符序列以提供输出数据串。

公开(公告)号：US07054924B1

公开(公告)日：2006-05-30

申请号：US09675921

申请日：2000-09-29

申请人： Andrew Harvey ,  Ikramullah Mohammad ,  Leo Pereira ,  Tohru Kao

发明人： Andrew Harvey ,  Ikramullah Mohammad ,  Leo Pereira ,  Tohru Kao

IPC分类号： G06F15/16 ,  G06F15/177

CPC分类号： H04L67/303 ,  H04L67/025 ,  H04L67/125

摘要： A method is disclosed for carrying out network device provisioning and configuration, and communication of other information to a network device, automatically and in an assured manner. A configuration service receives a request from a network device to provide configuration information. The configuration service retrieves a template representing the configuration from a storage location, e.g., a directory service. The configuration service also retrieves one or more parameter values specific to the device. Device-specific values are instantiated for the generic parameters in the template, based on the retrieved values. The resulting configuration is stored in XML format using XML tags to delimit configuration commands, tested for well-formed-ness, and syntax checked. A reliable transport protocol carries the configuration information to the device. At the device, a configuration agent syntax checks the embedded configuration information, and then applies the configuration information to the device. As a result, automatic network provisioning may be accomplished remotely, without requiring a skilled technician to visit customer premises to carry out configuration. The process may be integrated with an event service to enable multiple devices to concurrently receive re-configuration without special synchronization logic.

摘要翻译： 公开了一种用于执行网络设备供应和配置的方法，以及自动和以可靠的方式将其他信息传送到网络设备。 配置服务从网络设备接收请求以提供配置信息。 配置服务从存储位置例如目录服务检索表示配置的模板。 配置服务还检索特定于设备的一个或多个参数值。 基于检索到的值，为模板中的通用参数实例化设备特定的值。 最终的配置使用XML标签以XML格式存储，以分隔配置命令，经过验证，检查格式和语法。 可靠的传输协议将配置信息携带到设备。 在设备上，配置代理语法检查嵌入式配置信息，然后将配置信息应用于设备。 因此，可以远程完成自动网络配置，而不需要技术熟练的技术人员访问客户驻地来执行配置。 该过程可以与事件服务集成，以使多个设备能够同时接收重新配置而无需特殊的同步逻辑。

公开(公告)号：US4363572A

公开(公告)日：1982-12-14

申请号：US292808

申请日：1981-08-14

申请人： Andrew Harvey

发明人： Andrew Harvey

IPC分类号： B65G53/32 ,  E21F13/04 ,  F04D7/04 ,  B65G53/30 ,  B65G53/48

CPC分类号： B65G53/32 ,  E21F13/042 ,  F04D7/045

摘要： An injector for a material transport system includes a helical inducer having a housing with a fluid input port, a material input port and a discharge port, each port is open to an internal chamber of the housing. A rotor with a helical blade is mounted to the housing and constrained for rotation within the chamber. A fluid entering the fluid input port is formed into a fluid vortex having a ventilated core by the rotating rotor blade. A feeder assembly feeds the material to be transported into the material input port where it is carried by the fluid vortex to the discharge port for transmission to a hydraulic transport line.

摘要翻译： 用于材料输送系统的注射器包括具有带有流体输入端口的壳体的螺旋形诱导器，材料输入端口和排出口，每个端口对壳体的内部室进行开口。 具有螺旋叶片的转子安装到壳体并被限制为在腔室内旋转。 进入流体输入口的流体通过旋转的转子叶片形成具有通风芯的流体涡流。 馈送器组件将待传输的材料馈送到材料输入端口，在那里它被流体涡流携带到排出口以传输到液压输送管线。

公开(公告)号：US09493451B2

公开(公告)日：2016-11-15

申请号：US14118170

申请日：2012-05-16

申请人： Andrew Harvey ,  Agnes Bombrun ,  Rachel Cooke ,  Isabelle Jeanclaude-Etter ,  Nathan Kuchel ,  Jerome Molette ,  Jorgen Mould ,  Dharam Paul ,  Rajinder Singh ,  Cristina Donini ,  Veronique Colovray ,  Thomas Avery ,  Julia Crossman ,  Justin Ripper

发明人： Andrew Harvey ,  Agnes Bombrun ,  Rachel Cooke ,  Isabelle Jeanclaude-Etter ,  Nathan Kuchel ,  Jerome Molette ,  Jorgen Mould ,  Dharam Paul ,  Rajinder Singh ,  Cristina Donini ,  Veronique Colovray ,  Thomas Avery ,  Julia Crossman ,  Justin Ripper

IPC分类号： A61K31/497 ,  C07D451/04 ,  C07D309/14 ,  C07D213/89 ,  C07D231/12 ,  C07D233/56 ,  C07D401/12 ,  C07D237/08 ,  C07D239/24 ,  C07D405/12 ,  C07D411/12 ,  C07C217/90 ,  C07D413/12 ,  C07D241/12 ,  C07D209/52 ,  C07D211/16 ,  C07D211/26 ,  C07D211/38 ,  C07D213/16 ,  C07D213/61 ,  C07D213/64 ,  C07D213/70 ,  C07D213/40 ,  C07D241/18

CPC分类号： C07D213/40 ,  C07C217/90 ,  C07D209/52 ,  C07D211/16 ,  C07D211/26 ,  C07D211/38 ,  C07D213/16 ,  C07D213/61 ,  C07D213/64 ,  C07D213/70 ,  C07D213/89 ,  C07D231/12 ,  C07D233/56 ,  C07D237/08 ,  C07D239/24 ,  C07D239/34 ,  C07D241/12 ,  C07D241/18 ,  C07D309/14 ,  C07D401/12 ,  C07D405/12 ,  C07D411/12 ,  C07D413/12 ,  C07D451/04

摘要： The present invention relates to compounds useful in the modulation of potassium channel activity in cells, in particular the activity of Kv1.3 channels found in T cells. The invention also relates to the use of these compounds in the treatment or prevention of autoimmune and inflammatory diseases, including multiple sclerosis, pharmaceutical compositions containing these compounds and methods for their preparation.

摘要翻译： 本发明涉及可用于调节细胞中钾通道活性的化合物，特别是在T细胞中发现的Kv1.3通道的活性。 本发明还涉及这些化合物在治疗或预防自身免疫性和炎性疾病，包括多发性硬化症中的用途，含有这些化合物的药物组合物及其制备方法。

公开(公告)号：US07395322B2

公开(公告)日：2008-07-01

申请号：US11404397

申请日：2006-04-14

申请人： Andrew Harvey ,  Ikramullah Mohammad ,  Leo Pereira ,  Tohru Kao

发明人： Andrew Harvey ,  Ikramullah Mohammad ,  Leo Pereira ,  Tohru Kao

IPC分类号： G06F15/16 ,  G06F15/173 ,  G06F15/177

CPC分类号： H04L67/303 ,  H04L67/025 ,  H04L67/125

摘要： A system and an apparatus are disclosed for carrying out automatic network device provisioning and configuration. A configuration service receives a request from a network device to provide configuration information. The configuration service retrieves a template describing the device configuration, where the template associates one symbolic reference to one parameter that may receive values specific to particular devices. Based at least on the symbolic reference and the request, the configuration service retrieves a value of the parameter that is specific to the network device. A device-specific instance of the configuration information is created and stored based at least one the template and the value of the parameter. The configuration information is stored in XML format and conforms to an XML DTD.

摘要翻译： 公开了一种用于执行自动网络设备供应和配置的系统和装置。 配置服务从网络设备接收请求以提供配置信息。 配置服务检索描述设备配置的模板，其中模板将一个符号引用与可能接收特定设备特定值的一个参数相关联。 至少基于符号引用和请求，配置服务检索特定于网络设备的参数的值。 基于模板和参数值中的至少一个创建并存储配置信息的设备特定实例。 配置信息以XML格式存储，并符合XML DTD。

公开(公告)号：US20070192498A1

公开(公告)日：2007-08-16

申请号：US11697726

申请日：2007-04-07

申请人： Petre Dini ,  Andrew Harvey ,  Cosmin Dini ,  Manuela Popescu

发明人： Petre Dini ,  Andrew Harvey ,  Cosmin Dini ,  Manuela Popescu

IPC分类号： G06F15/16

CPC分类号： G06F9/468

摘要： A method is disclosed for adaptively coupling processing components in a distributed system. In one aspect, a second component requests an interaction with a first component by sending a service access request to access a first service of the first component. The service access request specifies parameters relating to a proposed level of coupling between the first component and the second component. The second component receives a service response from the first component; the service response specifies counter-proposed parameters relating to a proposed level of coupling between the first component and the second component. The second component determines whether the service response indicates that the first service may be provided. If so, then an agreed-upon level of coupling is established between the first component and second component, and the components interact to receive the service. The level of coupling among the components may be re-negotiated at any time by exchanging values in a coupling context. As a result, a component can selectively and with fine granularity allow other components to access its data or services.

公开(公告)号：US20060033237A1

公开(公告)日：2006-02-16

申请号：US10919132

申请日：2004-08-16

申请人： Lawrence Graham ,  Andrew Harvey ,  Ponnattu Joseph ,  Edward Ouellette

发明人： Lawrence Graham ,  Andrew Harvey ,  Ponnattu Joseph ,  Edward Ouellette

IPC分类号： B29C43/22

CPC分类号： B29C43/222

摘要： An improved dough sheeting system and method which allow for improved selection of sheeter gap size and which provide a quick release mechanism to prevent damage to sheeter rollers. Hydraulic actuators, attached to a movable roller, hold the roller in a fixed position relative to an opposing roller. The actuators are engaged with a closing force in excess of the force exerted by the sheeted material against the rollers thereby ensuring that the rollers maintain a gap of fixed width. Thermal expansion blocks mounted to the frame or housing of the opposing roller provide a means for fine adjustments in the sheeter gap.

摘要翻译： 改进的面团系统和方法，其允许改进选择片材间隙尺寸，并提供快速释放机构以防止损伤片材辊。 安装在可动辊上的液压执行器将辊子相对于相对的辊保持在固定位置。 致动器的接合力超过由片状材料施加在辊上的力，从而确保辊保持固定宽度的间隙。 安装到相对辊的框架或壳体上的热膨胀块提供了在片材间隙中精细调节的装置。