公开(公告)号：US06875903B2

公开(公告)日：2005-04-05

申请号：US10087667

申请日：2002-02-28

Applicant: A. John Bramley ,  Karen I. Plaut ,  David Kerr

Inventor： A. John Bramley ,  Karen I. Plaut ,  David Kerr

IPC: A01K67/027 ,  A61K48/00 ,  C12N9/52 ,  C12N15/85 ,  C12N15/861 ,  G01N33/00 ,  A01K67/00 ,  A01K67/033 ,  C12N15/00

CPC classification number: C12N15/8509 ,  A01K67/0275 ,  A01K2217/072 ,  A01K2227/101 ,  A01K2227/105 ,  A01K2267/02 ,  A01K2267/0337 ,  A61K48/00 ,  C12N9/52 ,  C12N15/86 ,  C12N2710/10343

Abstract: The present invention relates to an improved approach for the treatment of microbial infections in mammals. Specifically, the invention provides methods and reagents for expressing in mammalian cells, proteins having anti-microbial activity. The invention provides both genes, which have been modified to allow expression and preferably secretion of active protein in desired mammalian cells or tissues, and methods of introducing such modified genes into desired mammalian cells and/or tissues. Most specifically, genes encoding anti-staphylococcal proteins are delivered to mammalian cells and/or tissues by methods of gene delivery, including gene therapy and the production of transgenic animals, for the treatment of mastitis in ruminant animals.

Abstract translation: 本发明涉及用于治疗哺乳动物微生物感染的改进方法。 具体地，本发明提供用于在哺乳动物细胞中表达具有抗微生物活性的蛋白质的方法和试剂。 本发明提供了已经被修饰以允许在期望的哺乳动物细胞或组织中表达和优选分泌活性蛋白质的两个基因，以及将这些修饰的基因导入所需的哺乳动物细胞和/或组织的方法。 最具体地，编码抗葡萄球菌蛋白的基因通过基因递送的方法（包括基因治疗和转基因动物的产生）被递送到哺乳动物细胞和/或组织，用于治疗反刍动物的乳腺炎。

公开(公告)号：US20100080553A1

公开(公告)日：2010-04-01

申请号：US12239857

申请日：2008-09-29

Applicant: David Kerr ,  Mark Laliberte ,  Avery Van Gieson ,  John Lai ,  Kim Jepsen ,  Wei Lu ,  Yan Han ,  Marc Placidet ,  Ulrik Gliese ,  David Copeland ,  Guangning Yang

Inventor： David Kerr ,  Mark Laliberte ,  Avery Van Gieson ,  John Lai ,  Kim Jepsen ,  Wei Lu ,  Yan Han ,  Marc Placidet ,  Ulrik Gliese ,  David Copeland ,  Guangning Yang

IPC: H04B10/00

CPC classification number: H04B10/0773 ,  H04B10/071

Abstract: A communication system may include a first control circuit to detect a break on a first optical link; a first optical source to supply a first optical signal on a second optical link in response to detecting the break on the first optical link, the first optical signal propagating in a first direction on the second optical link; a second control circuit to detect a presence of the first optical signal on the second optical link, and output a control signal in response to detecting the presence of the first optical signal; and a second optical source to supply a second optical signal on the second optical link, the second optical signal propagating in a second direction opposite the first direction, where the Raman pump is disabled in response to the control signal.

Abstract translation: 通信系统可以包括用于检测第一光链路上的断点的第一控制电路; 第一光源，用于响应于检测到第一光链路上的断裂而在第二光链路上提供第一光信号，第一光信号在第二光链路上沿第一方向传播; 第二控制电路，用于检测所述第二光链路上的所述第一光信号的存在，并且响应于检测到所述第一光信号的存在而输出控制信号; 以及第二光源，用于在所述第二光链路上提供第二光信号，所述第二光信号在与所述第一方向相反的第二方向上传播，其中所述拉曼泵响应于所述控制信号被禁用。

公开(公告)号：US20070112261A1

公开(公告)日：2007-05-17

申请号：US11466532

申请日：2006-08-23

Applicant: Bradley Enegren ,  David Kerr

Inventor： Bradley Enegren ,  David Kerr

IPC: A61B5/00

CPC classification number: A61B5/0002 ,  A61B5/18 ,  A61B5/7445 ,  B60K28/063 ,  G06F19/3418

Abstract: An automobile monitoring system is for monitoring patient body characteristics. The automobile monitoring system includes at least one sensor to monitor at least one patient body characteristic, at least one transmitter operatively coupled to the at least one sensor to communicate sensor data, at least one monitor operatively coupled to the at least one transmitter to receive the sensor data, and automobile electronics operatively coupled to the at least one transmitter to receive sensor data. The at least one monitor and the automobile electronics display the sensor data to the patient. The at least one transmitter communicates with the at least one monitor and the automobile electronics using at least one wireless protocol including Bluetooth, infrared, radio frequency, 802.11a, 802.11b, or 802.11g. The automobile electronics include at least one of a GPS navigation system, a DVD entertainment system, an on-system computer, or a stereo system.

Abstract translation: 汽车监控系统用于监测患者的身体特征。 所述汽车监控系统包括至少一个用于监测至少一个患者身体特征的传感器，至少一个发射器，可操作地耦合到所述至少一个传感器以传送传感器数据;至少一个监视器，可操作地耦合到所述至少一个发射器， 传感器数据和可操作地耦合到所述至少一个发射器的汽车电子装置以接收传感器数据。 至少一个监视器和汽车电子装置将传感器数据显示给患者。 至少一个发射机使用至少一个包括蓝牙，红外，射频，802.11a，802.11b或802.11g的无线协议与至少一个监视器和汽车电子通信。 汽车电子产品包括GPS导航系统，DVD娱乐系统，系统计算机或立体声系统中的至少一个。

公开(公告)号：US06941816B2

公开(公告)日：2005-09-13

申请号：US10722029

申请日：2003-11-25

Applicant: Anthony D. Kurtz ,  David Kerr

Inventor： Anthony D. Kurtz ,  David Kerr

IPC: G01L9/00 ,  G01L19/08 ,  G01L7/00

CPC classification number: G01L19/003 ,  G01L19/0038 ,  G01L19/086

Abstract: There is disclosed a transducer with an integral switch for wireless electronics. Essentially, the transducer contains a housing which includes a sensor device. The sensor device may be a piezoresistive Wheatstone bridge arranged in a conventional manner. The output of the bridge is coupled to a typical amplifying circuit or an analog-to-digital converter whose signal is coupled to a suitable transmitting means. The signal provided by the Wheatstone bridge is transmitted through RF, infrared or some other wireless transmission scheme to a remote location. Such transmissions schemes are well known. Associated with the sensor and secured to the sensor housing, is a push button switch which is wired in series with a battery. The battery operates to energize the sensor, including all the electronics when the sensor is in placed in a pressure sensing position. When the pressure is placed in a pressure sensing position, the push button switch, is actuated to apply operating bias to the transducer device.

Abstract translation: 公开了一种具有用于无线电子装置的集成开关的换能器。 本质上，换能器包含一个包括传感器装置的壳体。 传感器装置可以是以常规方式布置的压阻式惠斯通电桥。 桥的输出耦合到典型的放大电路或其信号耦合到合适的发射装置的模数转换器。 惠斯通电桥提供的信号通过RF，红外或其他无线传输方案传输到远程位置。 这样的传输方案是众所周知的。 与传感器相关联并固定到传感器外壳上的是按钮开关，其与电池串联。 当传感器处于压力感测位置时，电池用于对传感器通电，包括所有电子元件。 当压力被置于压力感测位置时，按钮开关被致动以向换能器装置施加操作偏压。

公开(公告)号：US5658425A

公开(公告)日：1997-08-19

申请号：US474003

申请日：1995-06-07

Applicant: Mark Halman ,  Paul Rhoades ,  David Kerr

Inventor： Mark Halman ,  Paul Rhoades ,  David Kerr

IPC: H01L21/311 ,  H01L21/768 ,  H01L21/00

CPC classification number: H01L21/76802 ,  H01L21/31116

Abstract: A process for etching of silicon oxide such as silicon dioxide, or oxynitride. The process includes etching a silicon oxide layer to expose an underlying electrically conductive titanium silicide layer and provide a contact opening extending through the silicon oxide layer to the electrically conductive titanium silicide layer. The etching is performed by exposing the silicon oxide layer to an etching gas in an ionized state in a reaction chamber of a plasma generating device. The etching gas includes a fluoride-containing gas and a passivating nitrogen gas which is present in an amount effective to suppress a removal rate of the electrically conductive titanium silicide layer when it is exposed to the etching gas during the etching step. The fluoride-containing gas can be CF.sub.4, CHF.sub.3, C.sub.2 F.sub.6, CH.sub.2 F.sub.2, SF.sub.6, other Freons and mixtures thereof. The etching gas can also include a carrier gas such as Ar, He, Ne, Kr or mixtures thereof. The etching can be reactive ion etching or plasma etching and the etching gas can be exposed to a microwave electric field and/or a magnetic field during the etching step. The etching gas reduces the amount of the titanium silicide layer etched during overetching thereof compared to the same etching gas without nitrogen.

Abstract translation: 蚀刻二氧化硅或氧氮化硅等氧化硅的工序。 该方法包括蚀刻氧化硅层以暴露下面的导电硅化钛层，并提供延伸穿过氧化硅层的导电硅化钛层的接触开口。 通过在等离子体产生装置的反应室中将氧化硅层暴露于离子化状态的蚀刻气体来进行蚀刻。 蚀刻气体包括含氟化物气体和钝化氮气，其在蚀刻步骤中暴露于蚀刻气体时有效地抑制导电硅化钛层的去除速率。 含氟化物气体可以是CF 4，CHF 3，C 2 F 6，CH 2 F 2，SF 6，其它氟利昂及其混合物。 蚀刻气体还可以包括载气如Ar，He，Ne，Kr或其混合物。 蚀刻可以是反应离子蚀刻或等离子体蚀刻，并且蚀刻气体可以在蚀刻步骤期间暴露于微波电场和/或磁场。 与没有氮气的相同的蚀刻气体相比，蚀刻气体减少了在其过蚀刻期间蚀刻的硅化钛层的量。