Abuse-resistant opioid solid dosage form
    1.
    发明申请
    Abuse-resistant opioid solid dosage form 审中-公开
    滥用阿片类固体剂型

    公开(公告)号:US20060073102A1

    公开(公告)日:2006-04-06

    申请号:US10514387

    申请日:2003-05-13

    CPC classification number: A61K45/06 A61K9/2081 A61K31/485 A61K2300/00

    Abstract: The present invention pertains to a solid dosage form comprising an analgesically effective amount of opioid analgesic and an opioid abuse-deterring amount of a nontoxic N-methyl-D-aspartate receptor antagonist contained in a carrier which isolates, or separates, the antagonist from the opioid analgesic. The nontoxic N-methyl-D-aspartate receptor antagonist is released and made available only when the dosage form is misused, as would be the case when the dosage form is crushed or dissolved and thereafter administered in a manner other than that indicated, e.g., by injection or intranasally.

    Abstract translation: 本发明涉及一种固体剂型,其包含镇痛有效量的阿片类止痛剂和阿片样物质滥用 - 限制剂量的载体中含有的无毒N-甲基-D-天冬氨酸受体拮抗剂,其将拮抗剂与 阿片类止痛药。 无毒的N-甲基-D-天冬氨酸受体拮抗剂被释放,并且仅当剂型被滥用时才能使用,如在剂型被粉碎或溶解的情况下,然后以不同于所指示的方式给药, 通过注射或鼻内。

    Target aiming system
    2.
    发明授权
    Target aiming system 有权
    目标瞄准系统

    公开(公告)号:US06260466B1

    公开(公告)日:2001-07-17

    申请号:US09269890

    申请日:1999-04-02

    CPC classification number: F41G3/2611 F41G3/08 F41G3/142

    Abstract: Assessing the accuracy with which a round fired from a gun hits an intended target is achieved and alignment of the gun is corrected by monitoring the target with an image sensor which is associated with a computer enabling a frame by frame analysis and comparison of the fired round's trajectory with computer-generated alternative trajectories.

    Abstract translation: 通过使用与计算机相关联的图像传感器监视目标,可以评估从枪击中预定目标射击的圆度的准确性,从而可以逐帧分析并比较发射枪的对准 轨迹与计算机生成的替代轨迹。

    Processor Implemented Systems and Methods for Using the Catalog Part of an SQL Identifier to Expose/Access Heterogeneous Data
    3.
    发明申请
    Processor Implemented Systems and Methods for Using the Catalog Part of an SQL Identifier to Expose/Access Heterogeneous Data 有权
    处理器实现的系统和使用目录的方法部分SQL标识符来暴露/访问异构数据

    公开(公告)号:US20110213778A1

    公开(公告)日:2011-09-01

    申请号:US13035630

    申请日:2011-02-25

    CPC classification number: G06F17/30545

    Abstract: Systems and methods are provided for providing data from a plurality of databases stored on a plurality of disparate servers. A query is received for data from a plurality of databases stored on a plurality of disparate servers. An address for a first server is resolved that stores a first database identified by the catalog field in the query using a logical name-to-connection metadata map. A first sub-query is transmitted to the first server based on the received query, and a first sub-query response is received from the first server. The resolving, transmitting, and receiving are repeated for a second server. The first sub-query response and the second sub-query response are combined to generate a query response according to the received query, and the query response is transmitted.

    Abstract translation: 提供了用于从存储在多个不同服务器上的多个数据库提供数据的系统和方法。 接收来自存储在多个不同服务器上的多个数据库的数据的查询。 第一个服务器的地址被解析为使用逻辑名称到连接元数据映射存储由查询中的目录字段标识的第一个数据库。 基于接收的查询将第一子查询发送到第一服务器,并且从第一服务器接收第一子查询响应。 第二个服务器重复解析,发送和接收。 第一子查询响应和第二子查询响应被组合以根据接收到的查询生成查询响应,并且发送查询响应。

    Method of etching vias without sputtering of underlying electrically
conductive layer
    4.
    发明授权
    Method of etching vias without sputtering of underlying electrically conductive layer 失效
    蚀刻通孔而不溅射底层导电层的方法

    公开(公告)号:US5269879A

    公开(公告)日:1993-12-14

    申请号:US777611

    申请日:1991-10-16

    CPC classification number: H01L21/76802 H01L21/31116

    Abstract: A process for etching of silicon oxide/nitride such as silicon dioxide, silicon nitride or oxynitride. The process includes etching a silicon oxide/nitride layer to expose an underlying electrically conductive layer and provide a via extending through the silicon oxide/nitride layer to the electrically conductive layer. The etching is performed by exposing the silicon oxide/nitride layer to an etching gas in an ionized state in a reaction chamber of a plasma generating device. The etching gas includes a fluoride-containing gas and a passivating gas which is present in an amount effective to suppress sputtering of the electrically conductive layer when it is exposed to the etching gas during the etching step. The passivating gas can be nitrogen gas and the fluoride-containing gas can be CF.sub.4, CHF.sub.3, C.sub.2 F.sub.6, CH.sub.2 F.sub.2, SF.sub.6, other Freons and mixtures thereof. The etching gas can also include a carrier gas such as Ar, He, Ne, Kr or mixtures thereof. The etching can be reactive ion etching or plasma etching and the etching gas can be exposed to a microwave electric field and/or a magnetic field during the etching step. The etching gas can achieve 350% overetching while preventing sputtering of the electrically conductive layer which can be Al, Al alloys, Ti, TiN, TiW and Mo.

    Abstract translation: 氧化硅/氮化物如二氧化硅,氮化硅或氧氮化物的蚀刻方法。 该方法包括蚀刻氧化硅/氮化物层以暴露下面的导电层,并提供穿过氧化硅/氮化物层延伸到导电层的通孔。 通过在等离子体产生装置的反应室中将氧化硅/氮化物层以离子化状态的蚀刻气体曝光来进行蚀刻。 蚀刻气体包括含氟化物气体和钝化气体,其在蚀刻步骤中暴露于蚀刻气体时有效地抑制导电层的溅射。 钝化气体可以是氮气,含氟化物气体可以是CF4,CHF3,C2F6,CH2F2,SF6,其他氟利昂及其混合物。 蚀刻气体还可以包括载气如Ar,He,Ne,Kr或其混合物。 蚀刻可以是反应离子蚀刻或等离子体蚀刻,并且蚀刻气体可以在蚀刻步骤期间暴露于微波电场和/或磁场。 蚀刻气体可以防止可以为Al,Al合金,Ti,TiN,TiW和Mo的导电层的溅射,达到350%的过蚀刻。

    Phase-stepping interferometry
    5.
    发明授权
    Phase-stepping interferometry 失效
    相位干涉测量

    公开(公告)号:US5048964A

    公开(公告)日:1991-09-17

    申请号:US469480

    申请日:1990-04-11

    CPC classification number: G01B9/0201 G01B9/02094

    Abstract: An interferometric procedure, such as electronic speckle pattern interferometry, involves generating two signals representing the point-by-point variations in intensity of respective patterns of electromagnetic radiation resulting from the interference of first and second beams of such radiation derived from a coherent source, with at least the first beam from each pattern being scattered, before interference with its respective second beam, from a common object surface, and with a corresponding pair of the beams, one for each pattern, having a predetermined relative phase difference of other than a multiple of .pi.; and determining from the two signals values for a datum phase of the radiation at the object surface. Preferably, as a preliminary to this last determination. DC components are removed from the two signals. Conveniently, to simplify the determination, the phase difference is an odd multiple of .pi./4 or .pi./2.

    Abstract translation: PCT No.PCT / GB89 / 01030 Sec。 371日期1990年04月11日 102(e)1990年4月11日PCT PCT 1989年9月4日PCT公布。 出版物WO90 / 02930 日期1990年3月22日。干涉测量程序,例如电子散斑图案干涉测量,涉及产生两个信号,表示由这种辐射的第一和第二波束的干涉导致的各种电磁辐射模式的逐点变化的信号 衍生自相干光源,至少来自每个图案的第一光束在与其相应的第二光束干涉之前,从公共物体表面散射,并且与对应的一对光束一一对应于每个图案,具有预定的相对 相位差不同于pi的倍数; 并根据两个信号确定物体表面上的辐射的基准相位值。 优选地,作为该最后确定的初步。 从两个信号中去除直流分量。 方便地,为了简化确定,相位差是pi / 4或pi / 2的奇数倍。

    Automatic laser shutdown and recovery in response to a link break
    6.
    发明授权
    Automatic laser shutdown and recovery in response to a link break 有权
    自动激光关机和恢复响应链路断开

    公开(公告)号:US09264134B2

    公开(公告)日:2016-02-16

    申请号:US12239857

    申请日:2008-09-29

    CPC classification number: H04B10/0773 H04B10/071

    Abstract: A communication system may include a first control circuit to detect a break on a first optical link; a first optical source to supply a first optical signal on a second optical link in response to detecting the break on the first optical link, the first optical signal propagating in a first direction on the second optical link; a second control circuit to detect a presence of the first optical signal on the second optical link, and output a control signal in response to detecting the presence of the first optical signal; and a second optical source to supply a second optical signal on the second optical link, the second optical signal propagating in a second direction opposite the first direction, where the Raman pump is disabled in response to the control signal.

    Abstract translation: 通信系统可以包括用于检测第一光链路上的断点的第一控制电路; 第一光源,用于响应于检测到第一光链路上的断裂而在第二光链路上提供第一光信号,第一光信号在第二光链路上沿第一方向传播; 第二控制电路,用于检测所述第二光链路上的所述第一光信号的存在,并且响应于检测到所述第一光信号的存在而输出控制信号; 以及第二光源,用于在所述第二光链路上提供第二光信号,所述第二光信号在与所述第一方向相反的第二方向上传播,其中所述拉曼泵响应于所述控制信号被禁用。

    METHOD AND APPARATUS FOR VERIFYING SEAL INTEGRITY
    8.
    发明申请
    METHOD AND APPARATUS FOR VERIFYING SEAL INTEGRITY 审中-公开
    验证密封完整性的方法和装置

    公开(公告)号:US20100018941A1

    公开(公告)日:2010-01-28

    申请号:US11721663

    申请日:2005-12-14

    CPC classification number: G01M3/38

    Abstract: A method of verifying the integrity of a seal in a sealing region between a container and a sealing film applied to the container comprises viewing at least the sealing region to detect the presence of a detectable predetermined feature in the sealing region. The presence of the detectable predetermined feature in the sealing region is indicative of an improper seal between the container and the sealing film whilst the absence of the detectable predetermined feature in the sealing region is indicative of an integral seal between the container and the sealing film.

    Abstract translation: 验证在容器和施加到容器上的密封膜之间的密封区域中密封件的完整性的方法包括至少观察密封区域以检测密封区域中可检测到的预定特征的存在。 密封区域中可检测的预定特征的存在表示容器和密封膜之间的不正确的密封,而在密封区域中不存在可检测的预定特征指示容器和密封膜之间的整体密封。

    Treatment of staphylococcus infections
    9.
    发明授权
    Treatment of staphylococcus infections 有权
    葡萄球菌感染的治疗

    公开(公告)号:US07091332B1

    公开(公告)日:2006-08-15

    申请号:US09698579

    申请日:2000-10-27

    CPC classification number: C12N9/52 A61K48/00 C12N15/86 C12N2710/10343

    Abstract: The present invention relates to an improved approach for the treatment of microbial infections in mammals. Specifically, the invention provides methods and reagents for expressing in mammalian cells proteins that have anti-microbial activity. The invention provides both genes which have been modified to allow expression and preferably secretion of active protein in desired mammalian cells or tissues, and methods of introducing such modified genes into desired mammalian cells and/or tissues. Most specifically, genes encode anti-staphylococcal proteins are delivered to mammalian cells and/or tissues by methods of gene delivery, including gene therapy and the production of transgenic animals, for the treatment of mastitis in ruminant animals.

    Abstract translation: 本发明涉及用于治疗哺乳动物微生物感染的改进方法。 具体地,本发明提供用于在哺乳动物细胞中表达具有抗微生物活性的蛋白质的方法和试剂。 本发明提供了已被修饰以允许在期望的哺乳动物细胞或组织中表达和优选分泌活性蛋白质的两个基因,以及将这些修饰的基因导入所需的哺乳动物细胞和/或组织的方法。 最具体地,编码抗葡萄球菌蛋白的基因通过基因递送方法(包括基因治疗和转基因动物的产生)被递送到哺乳动物细胞和/或组织,用于治疗反刍动物的乳腺炎。

    Treatment of Staphylococcus infections
    10.
    发明授权
    Treatment of Staphylococcus infections 失效
    治疗葡萄球菌感染

    公开(公告)号:US06875903B2

    公开(公告)日:2005-04-05

    申请号:US10087667

    申请日:2002-02-28

    Abstract: The present invention relates to an improved approach for the treatment of microbial infections in mammals. Specifically, the invention provides methods and reagents for expressing in mammalian cells, proteins having anti-microbial activity. The invention provides both genes, which have been modified to allow expression and preferably secretion of active protein in desired mammalian cells or tissues, and methods of introducing such modified genes into desired mammalian cells and/or tissues. Most specifically, genes encoding anti-staphylococcal proteins are delivered to mammalian cells and/or tissues by methods of gene delivery, including gene therapy and the production of transgenic animals, for the treatment of mastitis in ruminant animals.

    Abstract translation: 本发明涉及用于治疗哺乳动物微生物感染的改进方法。 具体地,本发明提供用于在哺乳动物细胞中表达具有抗微生物活性的蛋白质的方法和试剂。 本发明提供了已经被修饰以允许在期望的哺乳动物细胞或组织中表达和优选分泌活性蛋白质的两个基因,以及将这些修饰的基因导入所需的哺乳动物细胞和/或组织的方法。 最具体地,编码抗葡萄球菌蛋白的基因通过基因递送的方法(包括基因治疗和转基因动物的产生)被递送到哺乳动物细胞和/或组织,用于治疗反刍动物的乳腺炎。

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