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36 条记录 (耗时 0.027 秒)

    G-protein-conjugated receptor agonist
    11.
    发明授权
    G-protein-conjugated receptor agonist 失效
    G蛋白偶联受体激动剂

    公开(公告)号：US08318781B2

    公开(公告)日：2012-11-27

    申请号：US12597281

    申请日：2008-04-25

    申请人： Gozoh Tsujimoto ,  Akira Hirasawa ,  Naoki Miyata ,  Takayoshi Suzuki ,  Yoshiyuki Takahara ,  Masaji Ishiguro ,  Mie Hata

    发明人： Gozoh Tsujimoto ,  Akira Hirasawa ,  Naoki Miyata ,  Takayoshi Suzuki ,  Yoshiyuki Takahara ,  Masaji Ishiguro ,  Mie Hata

    IPC分类号： A01N43/40 ,  A01N43/78 ,  A01N37/12 ,  A01N37/44 ,  A01N43/00 ,  A61K31/445 ,  A61K31/425 ,  A61K31/33 ,  C07D213/72 ,  C07D213/78 ,  C07D277/82 ,  C07C63/00 ,  C07C65/00

    CPC分类号： C07C311/51 ,  C07C217/18 ,  C07D213/74 ,  C07D215/12 ,  C07D257/04

    摘要： Disclosed is a novel aralkyl carboxylic acid compound which has an agonistic activity on GPR-120 and/or GPR-40, particularly GPR-120, and is therefore useful as an appetite regulator, an anti-obesity agent, a therapeutic agent for diabetes, a pancreatic beta differentiating cell growth enhancer, a therapeutic agent for metabolic syndrome, a therapeutic agent for a gastrointestinal disease, a therapeutic agent for a neuropathy, a therapeutic agent for a mental disorder, a therapeutic agent for a pulmonary disease, a therapeutic agent for a pituitary hormone secretion disorder or a lipid flavoring/seasoning agent. The aralkyl carboxylic acid compound is represented by the general formula (I). (I) wherein the ring Q represents a pyridyl or the like; R1 represents a C1-6 alkyl group or the like; R2 represents a hydrogen atom, a C1-4 alkyl group or a C1-4 alkoxy group; m and n independently represent an integer of 1 to 5; and X represents an oxygen atom, a sulfur atom or —NR3— [wherein R3 represents a hydrogen atom or a C1-4 alkyl group].

    摘要翻译： 公开了一种对GPR-120和/或GPR-40，特别是GPR-120具有激动作用的新的芳烷基羧酸化合物，因此可用作食欲调节剂，抗肥胖剂，糖尿病治疗剂， 胰腺β分化细胞生长增强剂，代谢综合征治疗剂，胃肠道疾病治疗剂，神经病变治疗剂，精神障碍治疗剂，肺病治疗剂，治疗剂 垂体激素分泌障碍或脂质调味剂/调味剂。 芳烷基羧酸化合物由通式（I）表示。 （I）其中环Q表示吡啶基等; R1表示C1-6烷基等; R2表示氢原子，C1-4烷基或C1-4烷氧基; m和n独立地表示1〜5的整数。 X表示氧原子，硫原子或-NR 3 - [其中R 3表示氢原子或C 1-4烷基]。

    Head-And-Neck Tumor Proliferation Inhibitor
    12.
    发明申请
    Head-And-Neck Tumor Proliferation Inhibitor 失效
    头颈肿瘤增生抑制剂

    公开(公告)号：US20120088816A1

    公开(公告)日：2012-04-12

    申请号：US13263800

    申请日：2010-04-16

    申请人： Takeru Zama ,  Koichiro Saito ,  Akira Hirasawa ,  Koji Inagaki

    发明人： Takeru Zama ,  Koichiro Saito ,  Akira Hirasawa ,  Koji Inagaki

    IPC分类号： A61K31/713 ,  A61P35/00 ,  A61P35/04 ,  C07H21/02

    CPC分类号： A61K31/7088 ,  A61K31/713 ,  C12N15/113 ,  C12N2310/113 ,  C12N2310/141

    摘要： It is to provide a novel head-and-neck tumor proliferation inhibitor, head-and-neck tumor metastasis inhibitor and pharmaceutical composition for treating a head-and-neck tumor. The present invention is characterized by using an inhibitory substance of a microRNA whose expression increases in a head-and-neck tumor and/or a promoting substance of a microRNA whose expression decreases in a head-and-neck tumor. Preferred examples of the microRNA whose expression increases in a head-and-neck tumor include miR-455-3p, miR-455-5p, miR-130b, miR-130b*, miR-801, miR-196a, miR-21 and miR-31. Preferred examples of the microRNA whose expression decreases in a head-and-neck tumor include miR-133b, miR-145 and miR-375.

    摘要翻译： 它提供了一种新型的头颈部肿瘤增殖抑制剂，头颈部肿瘤转移抑制剂和用于治疗头颈部肿瘤的药物组合物。 本发明的特征在于使用在头颈部肿瘤中其表达降低的头颈部肿瘤和/或其表达降低的促进物质的微小RNA的抑制物质。 在头颈部肿瘤中表达增加的微小RNA的优选实例包括miR-455-3p，miR-455-5p，miR-130b，miR-130b *，miR-801，miR-196a，miR-21和 miR-31。 在头颈部肿瘤中表达降低的微小RNA的优选实例包括miR-133b，miR-145和miR-375。

    Diagnosis/Therapeutic Strategy For Gynecological Cancer by Utilizing Micro-RNA as Biomarker
    13.
    发明申请
    Diagnosis/Therapeutic Strategy For Gynecological Cancer by Utilizing Micro-RNA as Biomarker 审中-公开
    通过利用微RNA作为生物标志物进行妇科癌症诊断/治疗策略

    公开(公告)号：US20110166041A1

    公开(公告)日：2011-07-07

    申请号：US12999124

    申请日：2009-06-25

    申请人： Takeru Zama ,  Akira Hirasawa ,  Koichiro Saito ,  Tomoko Akahane

    发明人： Takeru Zama ,  Akira Hirasawa ,  Koichiro Saito ,  Tomoko Akahane

    IPC分类号： C40B40/06 ,  C12Q1/68

    CPC分类号： C12N15/113 ,  C12N2310/113 ,  C12N2310/141 ,  C12N2330/10 ,  C12Q1/6886 ,  C12Q2600/136 ,  C12Q2600/158 ,  C12Q2600/178

    摘要： Disclosed are: a method for using a particular microRNA as a biomarker for gynecological cancer; a method for the determination of gynecological cancer; a kit for the determination of gynecological cancer, and the like. The present invention is characterized in that at least one microRNA selected from the group of microRNAs consisting of miR-592, miR-629*, miR-517a, miR-205, miR-184, miR-509-5p, miR-135a*, miR-137, miR-602, miR-186*, miR-181a-2*, miR-193b*, miR-377*, miR-449b, miR-449a, miR-369-3p, miR-323-3p, miR-329, miR-299-5p, miR-34b, miR-411, miR-34c-5p, miR-376b, miR-885-5p, miR-337-3p, miR-337-5p, miR-127-3p, miR-138, miR-203, miR-488, miR-489, miR-643, miR-888, miR-424, miR-432, miR-433, miR-450a, miR-503, miR-542-3p, miR-542-5p and miR-584 is used as a biomarker for gynecological cancer.

    摘要翻译： 公开的是：使用特定微小RNA作为妇科癌症生物标志物的方法; 确定妇科癌症的方法; 用于确定妇科癌症的试剂盒等。 本发明的特征在于，至少一种选自miR-592，miR-629 *，miR-517a，miR-205，miR-184，miR-509-5p，miR-135a * ，miR-137，miR-602，miR-186 *，miR-181a-2 *，miR-193b *，miR-377 *，miR-449b，miR-449a，miR-369-3p，miR-323-3p ，miR-329，miR-299-5p，miR-34b，miR-411，miR-34c-5p，miR-376b，miR-885-5p，miR-337-3p，miR-337-5p，miR-127 -3p，miR-138，miR-203，miR-488，miR-489，miR-643，miR-888，miR-424，miR-432，miR-433，miR-450a，miR-503，miR-542 -3p，miR-542-5p和miR-584用作妇科癌症的生物标志物。

    Sanitary paper
    14.
    发明授权
    Sanitary paper 有权
    卫生纸

    公开(公告)号：US07815769B2

    公开(公告)日：2010-10-19

    申请号：US11973695

    申请日：2007-10-09

    申请人： Akira Hirasawa

    发明人： Akira Hirasawa

    IPC分类号： D21F11/00

    CPC分类号： D21H21/22 ,  A47K10/16 ,  D21H21/14 ,  D21H21/38 ,  D21H27/002

    摘要： It is intended to provide sanitary paper which is excellent in texture such as moistness and softness and scarcely causes skin irritation or blushing even if it is brought into contact with the skin frequently. Namely, sanitary paper having an oil absorbance specified in JIS P8141 of 7 mm or less and a moisture content of from 9.50 to 15.00% (measured in accordance with JIS P8127 after conditioning in accordance with JIS P8111); carrying a solution, which contains a moistening agent, a softener, an antioxidant and so on, coated in a dose of 46.0 to 160.0 mg/cm3 of the paper base; and having a bending hardness B measured with the use of a pure bending machine of from 0.0040 to 0.0060 g·cm2/cm.

    摘要翻译： 其目的在于提供湿度和柔软度等质地优异的卫生纸，即使经常与皮肤接触，也几乎不引起皮肤刺激或白化。 即，JIS P8141中规定的吸油量为7mm以下，湿度为9.50〜15.00％（根据JIS P8127，按照JIS P8111调理后测定）的卫生纸; 携带含有作为纸基的46.0〜160.0mg / cm3的剂量的润湿剂，软化剂，​​抗氧化剂等的溶液。 并且具有使用纯度为0.0040〜0.0060g·cm 2 / cm的纯弯曲机测定的弯曲硬度B。

    Household Sanitary Tissue Paper Container
    16.
    发明申请
    Household Sanitary Tissue Paper Container 有权
    家用卫生巾纸容器

    公开(公告)号：US20080257903A1

    公开(公告)日：2008-10-23

    申请号：US11579792

    申请日：2005-05-06

    申请人： Akira Hirasawa ,  Hiroshi Ono

    发明人： Akira Hirasawa ,  Hiroshi Ono

    IPC分类号： A47K10/24 ,  B65H1/00

    CPC分类号： B65D83/0894 ,  B65D83/0805

    摘要： In a household sanitary tissue paper container 1 that has a slender taking-out opening 2 where a film for supporting a household sanitary tissue paper 10 is not provided at the taking-out opening 2, the taking-out opening 2 having finger inserting portions 2B and supporting portions 2A for supporting a pulled-out household sanitary tissue paper 10 is provided, and in outside positions of edges of the supporting portions 2A in a width direction, crush portions for raising 5 along a longitudinal direction are formed respectively so as to continue into the taking-out opening 2.

    摘要翻译： 在取出开口2上没有设置有用于支撑家用卫生薄页纸10的薄片的细长的取出开口2的家用卫生纸容器1中，具有手指插入部分2的取出开口2 B和用于支撑拉出的家用卫生薄页纸10的支撑部分2A设置在支撑部分2A的沿宽度方向的边缘的外侧位置，分别形成沿着纵向方向升高5的挤压部分 继续进入出口2。

    LIGHTING APPARATUS AND LIGHT EMISSION CONTROL METHOD
    18.
    发明申请
    LIGHTING APPARATUS AND LIGHT EMISSION CONTROL METHOD 有权
    照明装置和发光控制方法

    公开(公告)号：US20140292223A1

    公开(公告)日：2014-10-02

    申请号：US14241847

    申请日：2011-08-31

    申请人： Akira Hirasawa ,  Yuhki Terao

    发明人： Akira Hirasawa ,  Yuhki Terao

    IPC分类号： H05B33/08

    CPC分类号： H05B33/0896 ,  H01L27/3211 ,  H01L2251/5361 ,  H05B33/0857

    摘要： A lighting apparatus includes: a plurality of light emission units that respectively emit lights in luminescent colors different from each other; and a control unit that controls in luminance the respective light, which are emitted from said plurality of light emission units, for the respective luminescent colors. In response to a control input, said control unit switches between a first light emission mode that it makes said light emission units emit light with luminance set for the respective luminescent colors and a second light emission mode that makes it light emission units corresponding to at least one luminescent color turn off or emit light with luminance lower than the luminance in the first light emission mode.

    摘要翻译： 照明装置包括：多个发光单元，其分别发射彼此不同的发光颜色的光; 以及控制单元，其控制从所述多个发光单元发射的各个发光颜色的各个亮度的亮度。 响应于控制输入，所述控制单元在其使得所述发光单元发光的第一发光模式与针对各个发光颜色设定的亮度之间切换，并且使其使得至少对应于发光单元的第二发光模式 一种发光颜色在亮度低于第一发光模式下的亮度时熄灭或发光。

    METHOD FOR MANUFACTURING TOILET ROLL PRODUCTS AND TOILET ROLL PRODUCTS
    19.
    发明申请
    METHOD FOR MANUFACTURING TOILET ROLL PRODUCTS AND TOILET ROLL PRODUCTS 审中-公开
    制造厕所产品和厕所产品的方法

    公开(公告)号：US20130323453A1

    公开(公告)日：2013-12-05

    申请号：US14000724

    申请日：2012-02-14

    申请人： Akira Hirasawa

    发明人： Akira Hirasawa

    IPC分类号： A47K10/16 ,  B31F1/07

    CPC分类号： B31F1/07 ,  A47K10/16 ,  B31B70/006 ,  B31F2201/0761 ,  B65H2301/41484 ,  B65H2701/1762 ,  D21H23/48 ,  D21H27/005 ,  D21H27/30 ,  D21H27/40 ,  Y10T428/15

    摘要： Provided are an electrolytic cathode structure that can suppress the degradation of an activated cathode even if a reverse current flows upon the stoppage of operation of an electrolyzer in an electrode structure allowing the distance between the electrode and an electrode current collector to be maintained at an approximately constant value, and an electrolyzer using the same.The electrolytic cathode structure includes a metal elastic cushion member 1 compressed and accommodated between an activated cathode 2 and a cathode current collector 3. At least a surface layer of the cathode current collector 3 consumes a larger oxidation current per unit area than the activated cathode. The electrolyzer is partitioned by an ion exchange membrane into an anode chamber for accommodating an anode and a cathode chamber for accommodating a cathode. The electrolytic cathode structure is used for the cathode.

    摘要翻译： 提供了一种电解阴极结构，即使在电极结构中的电解槽停止操作时反向电流也能够抑制活性阴极的劣化，使电极和电极集电体之间的距离保持在约 恒定值，以及使用该值的电解槽。 电解阴极结构包括压缩并容纳在活性阴极2和阴极集电体3之间的金属弹性缓冲构件1.至少阴极集电体3的表面层消耗比活化阴极更大的每单位面积的氧化电流。 电解槽被离子交换膜分隔成阳极室，用于容纳用于容纳阴极的阳极和阴极室。 电解阴极结构用于阴极。