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公开(公告)号：US09572824B2
公开(公告)日：2017-02-21
申请号：US14874600
申请日：2015-10-05
Applicant: Biogen MA Inc.
Inventor： Jermaine Thomas , Xiaogao Liu , Edward Yin-Shiang Lin , Guo Zhu Zheng , Bin Ma , Richard D. Caldwell , Kevin M. Guckian , Gnanasambandam Kumaravel , Arthur G. Taveras
IPC: A61K31/695 , A61K31/11 , A61K31/18 , A61K31/216 , A61K31/197 , A61K31/397 , A61K31/40 , A61K31/445 , A61K31/683 , A61K31/662 , A61K31/47 , A61K31/277 , A61K31/41 , A61K31/4709 , A61K31/472 , A61K31/337 , A61K31/517 , A61K31/428 , A61K31/404 , A61K45/06 , A61K31/085 , C07C229/14 , C07C229/22 , C07C229/46 , C07C229/48 , C07C237/08 , C07C237/52 , C07C309/14 , C07C311/51 , C07D205/04 , C07D207/16 , C07D209/08 , C07D211/60 , C07D211/62 , C07D215/20 , C07D217/24 , C07D257/04 , C07D305/08 , C07D403/06 , C07D417/06 , C07F9/38 , C07F9/40 , C07C43/247 , C07C47/575 , C07C255/54 , C07D215/227 , C07D217/04 , C07D239/74 , C07D277/64 , C07D401/06 , C07F7/08
CPC classification number: A61K31/695 , A61K31/085 , A61K31/11 , A61K31/137 , A61K31/165 , A61K31/18 , A61K31/185 , A61K31/197 , A61K31/198 , A61K31/216 , A61K31/222 , A61K31/223 , A61K31/235 , A61K31/277 , A61K31/337 , A61K31/397 , A61K31/40 , A61K31/401 , A61K31/404 , A61K31/41 , A61K31/428 , A61K31/445 , A61K31/47 , A61K31/4709 , A61K31/472 , A61K31/517 , A61K31/662 , A61K31/683 , A61K45/06 , C07C43/247 , C07C47/575 , C07C229/14 , C07C229/22 , C07C229/46 , C07C229/48 , C07C237/08 , C07C237/52 , C07C255/54 , C07C309/14 , C07C311/51 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/16 , C07D205/04 , C07D207/16 , C07D209/08 , C07D211/60 , C07D211/62 , C07D215/20 , C07D215/227 , C07D217/04 , C07D217/24 , C07D239/74 , C07D257/04 , C07D277/64 , C07D305/08 , C07D401/06 , C07D403/06 , C07D417/06 , C07F7/081 , C07F9/3808 , C07F9/3834 , C07F9/4006
Abstract: Compounds that have agonist activity at one or more of the S1P receptors are provided. The compounds are sphin-gosine analogs that, after phosphorylation, can behave as agonists at S1P receptors.
Abstract translation: 提供了在一种或多种S1P受体上具有激动剂活性的化合物。 化合物是肌氨酸 - 甙类似物，磷酸化后，可以作为S1P受体的激动剂。
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公开(公告)号：US10894040B2
公开(公告)日：2021-01-19
申请号：US16542746
申请日：2019-08-16
Applicant: BIOGEN MA INC.
Inventor： Jermaine Thomas , Sha Mi , Edward Yin-Shiang Lin , Guo Zhu Zheng , Bin Ma , Richard D. Caldwell , Kevin Guckian , Gnanasambandam Kumaravel
IPC: A61K31/445 , C07D211/34 , C07D211/60 , C07D211/62 , C07D405/12 , C07D401/06 , C07D215/20 , A61K31/225 , A61K31/4545 , A61K31/4709 , A61K31/498 , A61K31/517 , A61K31/55 , A61K31/695 , A61K38/21 , A61K39/395 , C07K16/28
Abstract: The present invention provides compounds of formula (I) or (II) or a pharmaceutically acceptable salt thereof and their use in modulating the activity of S1P) receptors. Also provided is a pharmaceutical composition comprising the compounds of formula (I) or (II) or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable excipient or carrier.
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公开(公告)号：US20190209592A1
公开(公告)日：2019-07-11
申请号：US16182845
申请日：2018-11-07
Applicant: BIOGEN MA INC.
Inventor： Jermaine Thomas , Xiaogao Liu , Edward Yin-Shiang Lin , Guo Zhu Zheng , Bin Ma , Richard D. Caldwell , Kevin M. Guckian , Gnanasambandam Kumaravel , Arthur G. Taveras
IPC: A61K31/695 , A61K31/11 , C07F7/08 , A61K31/165 , A61K31/137 , A61K31/235 , A61K31/223 , C07D401/06 , C07D277/64 , C07D239/74 , C07D217/04 , C07D215/227 , C07C255/54 , C07C47/575 , C07C43/247 , A61K45/06 , A61K31/683 , A61K31/662 , A61K31/517 , A61K31/472 , A61K31/4709 , A61K31/47 , A61K31/445 , A61K31/428 , A61K31/41 , A61K31/404 , A61K31/40 , A61K31/397 , A61K31/337 , A61K31/277 , A61K31/216 , A61K31/197 , A61K31/18 , C07F9/38 , A61K31/085 , C07F9/40 , C07D417/06 , C07D403/06 , C07D305/08 , C07D257/04 , C07D217/24 , C07D215/20 , C07D211/62 , C07D211/60 , C07D209/08 , C07D207/16 , C07D205/04 , C07C311/51 , C07C309/14 , C07C237/52 , C07C237/08 , C07C229/48 , C07C229/46 , C07C229/22 , C07C229/14 , A61K31/401 , A61K31/185 , A61K31/198 , A61K31/222
CPC classification number: A61K31/695 , A61K31/085 , A61K31/11 , A61K31/137 , A61K31/165 , A61K31/18 , A61K31/185 , A61K31/197 , A61K31/198 , A61K31/216 , A61K31/222 , A61K31/223 , A61K31/235 , A61K31/277 , A61K31/337 , A61K31/397 , A61K31/40 , A61K31/401 , A61K31/404 , A61K31/41 , A61K31/428 , A61K31/445 , A61K31/47 , A61K31/4709 , A61K31/472 , A61K31/517 , A61K31/662 , A61K31/683 , A61K45/06 , C07C43/247 , C07C47/575 , C07C229/14 , C07C229/22 , C07C229/46 , C07C229/48 , C07C237/08 , C07C237/52 , C07C255/54 , C07C309/14 , C07C311/51 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/16 , C07D205/04 , C07D207/16 , C07D209/08 , C07D211/60 , C07D211/62 , C07D215/20 , C07D215/227 , C07D217/04 , C07D217/24 , C07D239/74 , C07D257/04 , C07D277/64 , C07D305/08 , C07D401/06 , C07D403/06 , C07D417/06 , C07F7/081 , C07F9/3808 , C07F9/3834 , C07F9/4006
Abstract: Compounds that have agonist activity at one or more of the S1P receptors are provided. The compounds are sphingosine analogs that, after phosphorylation, can behave as agonists at S1P receptors.
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公开(公告)号：US20180133233A1
公开(公告)日：2018-05-17
申请号：US15783809
申请日：2017-10-13
Applicant: BIOGEN MA INC.
Inventor： Jermaine Thomas , Xiaogao Liu , Edward Yin-Shiang Lin , Guo Zhu Zheng , Bin Ma , Richard D. Caldwell , Kevin M. Guckian , Gnanasambandam Kumaravel , Arthur G. Taveras
IPC: A61K31/695 , A61K31/11 , C07F7/08 , C07D401/06 , C07D277/64 , C07D239/74 , C07D217/04 , C07D215/227 , C07C255/54 , C07C47/575 , C07C43/247 , A61K45/06 , A61K31/683 , A61K31/662 , A61K31/517 , A61K31/472 , A61K31/4709 , A61K31/47 , A61K31/445 , A61K31/428 , A61K31/41 , A61K31/404 , A61K31/40 , A61K31/397 , A61K31/337 , A61K31/277 , A61K31/216 , A61K31/197 , A61K31/18 , C07F9/38 , A61K31/085 , C07F9/40 , C07D417/06 , C07D403/06 , C07D305/08 , C07D257/04 , C07D217/24 , C07D215/20 , C07D211/62 , C07D211/60 , C07D209/08 , C07D207/16 , C07D205/04 , C07C311/51 , C07C309/14 , C07C237/52 , C07C237/08 , C07C229/48 , C07C229/46 , C07C229/22 , C07C229/14 , A61K31/401 , A61K31/185 , A61K31/198 , A61K31/222 , A61K31/223 , A61K31/235 , A61K31/137 , A61K31/165
CPC classification number: A61K31/695 , A61K31/085 , A61K31/11 , A61K31/137 , A61K31/165 , A61K31/18 , A61K31/185 , A61K31/197 , A61K31/198 , A61K31/216 , A61K31/222 , A61K31/223 , A61K31/235 , A61K31/277 , A61K31/337 , A61K31/397 , A61K31/40 , A61K31/401 , A61K31/404 , A61K31/41 , A61K31/428 , A61K31/445 , A61K31/47 , A61K31/4709 , A61K31/472 , A61K31/517 , A61K31/662 , A61K31/683 , A61K45/06 , C07C43/247 , C07C47/575 , C07C229/14 , C07C229/22 , C07C229/46 , C07C229/48 , C07C237/08 , C07C237/52 , C07C255/54 , C07C309/14 , C07C311/51 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/16 , C07D205/04 , C07D207/16 , C07D209/08 , C07D211/60 , C07D211/62 , C07D215/20 , C07D215/227 , C07D217/04 , C07D217/24 , C07D239/74 , C07D257/04 , C07D277/64 , C07D305/08 , C07D401/06 , C07D403/06 , C07D417/06 , C07F7/081 , C07F9/3808 , C07F9/3834 , C07F9/4006
Abstract: Compounds that have agonist activity at one or more of the S1P receptors are provided. The compounds are sphin-gosine analogs that, after phosphorylation, can behave as agonists at S1P receptors.
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![PYRAZOLO[1,5-A]PYRAZINE DERIVATIVES AS BTK INHIBITORS](/abs-image/US/2024/03/14/US20240083900A1/abs.jpg.150x150.jpg)
公开(公告)号：US20240083900A1
公开(公告)日：2024-03-14
申请号：US18036853
申请日：2021-11-12
Applicant: BIOGEN MA INC.
Inventor： Brian T. Hopkins , Bin Ma , Isaac Marx , Jürgen Schulz , George Vandeveer , Robin Prince , Marta Nevalainen , TeYu Chen , Zain Yousaf , Martin Himmelbauer , Vatee Pattaropong , John Howard Jones , Edward Yin-Shiang Lin , Felix Gonzalez Lopez de Turiso , Thomas Purgett , Andrew George Capacci , Simone Sciabola
IPC: C07D487/04 , C07D471/04 , C07D519/00
CPC classification number: C07D487/04 , C07D471/04 , C07D519/00
Abstract: Provided are compounds of Formula (I′): or pharmaceutically acceptable salts thereof, wherein the variables in the formula are as defined herein; and methods for their use and production.
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Patent Agency Ranking
公开(公告)号：US10968181B2
公开(公告)日：2021-04-06
申请号：US16473667
申请日：2017-12-27
Applicant: BIOGEN MA INC.
Inventor： Brian Stuart Lucas , Edward Yin-Shiang Lin , Andrew George Capacci , Zhili Xin , Istvan Enyedy , TeYu Chen , John H. Jones , Kurt D. van Vloten
IPC: C07D311/76 , C07D217/04 , C07D217/08 , C07D223/16 , C07D498/14 , A61K31/352 , A61K31/47 , C07D217/20 , C07D217/22 , C07D223/14 , C07D311/74 , C07D401/04 , C07D401/06 , C07D405/04 , C07D405/06 , C07D413/06 , C07D498/04
Abstract: Provided are compounds of Formula I, or pharmaceutically acceptable salts thereof, and methods for their use and production.
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公开(公告)号：US20190389830A1
公开(公告)日：2019-12-26
申请号：US16481743
申请日：2018-01-26
Applicant: BIOGEN MA INC.
Inventor： Andrew George Capacci , Edward Yin-Shiang Lin , Brian Stuart Lucas
IPC: C07D311/74
Abstract: Provided are compounds of Formula I, or pharmaceutically acceptable salts thereof, which are activators of nuclear factor erythroid 2 (NF-E2)-related factor 2 (Nrf2) and are useful to treat diseases caused by oxidative stress, such as neurodegenerative diseases or inflammation. Also provided are methods for their use and production.
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公开(公告)号：US10406144B2
公开(公告)日：2019-09-10
申请号：US16020696
申请日：2018-06-27
Applicant: BIOGEN MA INC.
Inventor： Jermaine Thomas , Sha Mi , Edward Yin-Shiang Lin , Guo Zhu Zheng , Bin Ma , Richard D. Caldwell , Kevin M. Guckian , Gnanasambandam Kumaravel
IPC: A61K31/445 , A61K31/225 , A61K31/4545 , A61K31/4709 , A61K31/498 , A61K31/517 , A61K31/55 , A61K31/695 , A61K39/395 , A61K38/21 , C07D211/34 , C07D211/60 , C07D211/62 , C07D401/06 , C07D405/12 , C07D215/20 , C07K16/28
Abstract: Compounds of formula (I) or (II) can modulate the activity of S1P receptors.
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公开(公告)号：US20180369215A1
公开(公告)日：2018-12-27
申请号：US16020696
申请日：2018-06-27
Applicant: BIOGEN MA INC.
Inventor： Jermaine Thomas , Sha Mi , Edward Yin-Shiang Lin , Guo Zhu Zheng , Bin Ma , Richard D. Caldwell , Kevin M. Guckian , Gnanasambandam Kumaravel
IPC: A61K31/445 , A61K31/517 , C07D211/34 , A61K31/4545 , A61K31/4709 , A61K31/498 , A61K31/55 , A61K31/225 , A61K31/695 , C07K16/28 , A61K38/21 , A61K39/395 , C07D215/20 , C07D405/12 , C07D401/06 , C07D211/62 , C07D211/60
CPC classification number: A61K31/445 , A61K31/225 , A61K31/4545 , A61K31/4709 , A61K31/498 , A61K31/517 , A61K31/55 , A61K31/695 , A61K38/21 , A61K39/3955 , C07D211/34 , C07D211/60 , C07D211/62 , C07D215/20 , C07D401/06 , C07D405/12 , C07K16/2842
Abstract: Compounds of formula (I) or (II) can modulate the activity of S1P receptors.
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公开(公告)号：US20180002356A1
公开(公告)日：2018-01-04
申请号：US15621665
申请日：2017-06-13
Applicant: BIOGEN MA INC.
Inventor： Richard D. Caldwell , Kevin M. Guckian , Gnanasambandam Kumaravel , Wen-Cherng Lee , Edward Yin-Shiang Lin , Xiaogao Liu , Bin Ma , Daniel M. Scott , Zhan Shi , Jermaine Thomas , Arthur G. Taveras , Guo Zhu Zheng
IPC: C07F9/6512 , C07D263/24 , C07D215/20 , C07C217/58 , C07C233/47 , C07C229/36 , C07F9/60 , C07D239/80
CPC classification number: C07F9/6512 , C07C217/58 , C07C217/74 , C07C229/36 , C07C233/47 , C07C2602/10 , C07D215/06 , C07D215/20 , C07D215/227 , C07D233/32 , C07D239/74 , C07D239/80 , C07D263/24 , C07D277/64 , C07D401/04 , C07F9/091 , C07F9/60 , C07F9/65744
Abstract: Compounds that have agonist activity at one or more of the S1P receptors are provided. The compounds are sphingosine analogs that, after phosphorylation, can behave as agonists at S1P receptors.
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