公开(公告)号：US11364070B2

公开(公告)日：2022-06-21

申请号：US16254879

申请日：2019-01-23

Applicant: BOSTON SCIENTIFIC SCIMED, INC.

Inventor： Bruce R. Forsyth ,  Matthew Ryan Dewitt ,  Hong Cao ,  Timothy A. Ostroot

IPC: A61B18/14 ,  A61N1/32 ,  A61M5/158 ,  A61B18/00

Abstract: Novel and versatile apparatuses for delivering one or more of thermal ablation and irreversible electroporation therapies to target tissue. In some examples, a device includes at its distal end a plurality of electrodes that can be advanced or retracted to pierce patient tissue, with a variable position and size shaft electrode provided near the distal end of the device to allow manipulation of therapy fields to achieve various tissue destruction field shapes. A number of method of use examples are described as well.

公开(公告)号：US20210290300A1

公开(公告)日：2021-09-23

申请号：US17204150

申请日：2021-03-17

Applicant: Boston Scientific Scimed, Inc. ,  REGENTS OF THE UNIVERSITY OF MINNESOTA

Inventor： Bruce R. Forsyth ,  Chun Wang ,  Samuel Hanson

IPC: A61B18/14 ,  A61L27/36

Abstract: In some aspects, the present disclosure pertains to methods of treating a tissue volume comprising (a) administering an implantable composition comprising a releasable membrane-active agent to a target site such that the membrane-active agent is locally released to the tissue volume and (b) performing irreversible, reversible and/or thermal treatment by application of a pulsed electric field to the tissue volume. In other aspects, the present disclosure pertains to embolic compositions that comprise releasable membrane-active agents.

公开(公告)号：US20210204874A1

公开(公告)日：2021-07-08

申请号：US17115503

申请日：2020-12-08

Applicant: Boston Scientific Scimed, Inc.

Inventor： Pramodsingh Hirasingh Thakur ,  Jeffrey E. Stahmann ,  Viktoria A. Averina ,  Deepa Mahajan ,  Bruce R. Forsyth

IPC: A61B5/00 ,  A61B5/0205 ,  A61B5/0537 ,  A61B5/11 ,  A61B7/00

Abstract: Systems and methods to determine an indication of patient dehydration are disclosed, including receiving first and second physiologic information of a patient, the first physiologic information including heart sound information of the patient and the second physiologic information different than the first physiologic information, and determining the indication of patient dehydration using the received first and second physiologic information.

公开(公告)号：US20190350703A1

公开(公告)日：2019-11-21

申请号：US16526150

申请日：2019-07-30

Applicant: Boston Scientific Scimed, Inc.

Inventor： Jan Weber ,  Haiying Zhou ,  Bruce R. Forsyth

IPC: A61F2/24 ,  B32B27/02 ,  C08K3/22 ,  A61L27/14 ,  A61L27/30

Abstract: Examples herein include prosthetic valves, valve leaflets and related methods. In an example, a prosthetic valve is included having a plurality of leaflets. The leaflets can each have a root portion and an edge portion substantially opposite the root portion and movable relative to the root portion. The leaflets can include a fibrous matrix including polymeric fibers having an average diameter of about 10 nanometers to about 10 micrometers. A coating can surround the polymeric fibers within the fibrous matrix. The coating can have a thickness of about 3 to about 30 nanometers. The coating can be formed of a material selected from the group consisting of a metal oxide, a nitride, a carbide, a sulfide, or fluoride. In an example, a method of making a valve is included.Other examples are also included herein.

公开(公告)号：US10368982B2

公开(公告)日：2019-08-06

申请号：US15595176

申请日：2017-05-15

Applicant: Boston Scientific Scimed Inc.

Inventor： Jan Weber ,  Haiying Zhou ,  Bruce R. Forsyth

IPC: A61F2/24 ,  B32B27/02 ,  C08K3/22 ,  A61L27/14 ,  A61L27/30 ,  D04H1/541 ,  D01F8/00 ,  D04H3/147

Abstract: Examples herein include prosthetic valves, valve leaflets and related methods. In an example, a prosthetic valve is included having a plurality of leaflets. The leaflets can each have a root portion and an edge portion substantially opposite the root portion and movable relative to the root portion. The leaflets can include a fibrous matrix including polymeric fibers having an average diameter of about 10 nanometers to about 10 micrometers. A coating can surround the polymeric fibers within the fibrous matrix. The coating can have a thickness of about 3 to about 30 nanometers. The coating can be formed of a material selected from the group consisting of a metal oxide, a nitride, a carbide, a sulfide, or fluoride. In an example, a method of making a valve is included. Other examples are also included herein.

公开(公告)号：US12114919B2

公开(公告)日：2024-10-15

申请号：US16660498

申请日：2019-10-22

Applicant: Boston Scientific Scimed, Inc.

Inventor： Bruce R. Forsyth ,  Larry D. Canady, Jr. ,  Hong Cao ,  Timothy A. Ostroot ,  Jonathan Tyler Gorzycki

IPC: A61B18/14 ,  A61M25/00 ,  A61B18/00

CPC classification number: A61B18/1492 ,  A61B18/14 ,  A61M25/0023 ,  A61B2018/0016 ,  A61B2018/00196 ,  A61B2018/00202 ,  A61B2018/00577 ,  A61B2018/00613 ,  A61B2018/00875 ,  A61B2018/143 ,  A61B2018/1435 ,  A61B2018/144 ,  A61B2018/1467 ,  A61B2018/1475 ,  A61M2025/0024

Abstract: A system for ablation is described herein including an inner electrode assembly with an inner elongate shaft and a distal electrode, an outer electrode assembly having an outer elongate shaft and a proximal electrode, wherein the outer electrode assembly defines a central passage configured to slidably receive the inner electrode assembly, wherein the distal electrode or the proximal electrode is axially moveable with respect to the other, and an energy source configured to be electrically connected to the distal electrode and the proximal electrode and configured to deliver a pulsed electric field (PEF). One of the distal electrode and proximal electrode is part of a first expandable electrode array comprising two or more electrode elements moveable between an unexpanded position and an expanded position.

公开(公告)号：US12076070B2

公开(公告)日：2024-09-03

申请号：US16818014

申请日：2020-03-13

Applicant: BOSTON SCIENTIFIC SCIMED, INC.

Inventor： Bruce R. Forsyth ,  Larry D. Canady, Jr. ,  Jonathan Tyler Gorzycki ,  Timothy A Ostroot ,  Hong Cao

IPC: A61B18/12 ,  A61B18/00

CPC classification number: A61B18/1206 ,  A61B18/12 ,  A61B2018/00577 ,  A61B2018/00613 ,  A61B2018/1246

Abstract: Methods and devices for performing ablation using time multiplexed waveforms are disclosed. The increased efficacy of monophasic waveforms is combined with the reduced side effects of biphasic waveforms by distributing components of the waveform across over a broader time interval than that typically used in a conventional biphasic waveform. Charge balancing occurs upon completion of therapy delivery within a time period that avoids muscle stimulation, while allowing unbalanced waveforms to be delivered during stimulation.

公开(公告)号：US11944372B2

公开(公告)日：2024-04-02

申请号：US16659111

申请日：2019-10-21

Applicant: Boston Scientific Scimed, Inc.

Inventor： Hong Cao ,  Larry D. Canady, Jr. ,  Timothy A. Ostroot ,  Bruce R. Forsyth ,  Jonathan Tyler Gorzycki

IPC: A61B18/14 ,  A61B8/12 ,  A61B10/02 ,  A61B18/00 ,  A61B18/18

CPC classification number: A61B18/1492 ,  A61B8/12 ,  A61B18/1477 ,  A61B18/1482 ,  A61B10/0233 ,  A61B2018/0016 ,  A61B2018/00214 ,  A61B2018/00577 ,  A61B2018/00613 ,  A61B2018/00636 ,  A61B2018/143 ,  A61B2018/1432 ,  A61B2018/1475 ,  A61B2018/1823 ,  A61B2018/1861

Abstract: One general aspect includes a system for ablation including a catheter including a sheath defining a sheath lumen and a distal end, and an elongate electrode assembly axially moveable within the sheath lumen. The electrode assembly includes a shaft defining a central channel and a distal central channel opening. The electrode assembly also includes an expandable electrode array including two or more electrode elements positioned at the distal portion of the electrode assembly, where the electrode array is moveable between a retracted position contained within the sheath lumen and an expanded position protruding from the sheath.

公开(公告)号：US11931094B2

公开(公告)日：2024-03-19

申请号：US17070649

申请日：2020-10-14

Applicant: BOSTON SCIENTIFIC SCIMED, INC.

Inventor： Bruce R. Forsyth ,  Jonathan Tyler Gorzycki ,  Larry D. Canady, Jr. ,  Hong Cao ,  Timothy A. Ostroot

IPC: A61B18/12 ,  A61B18/14 ,  A61B18/00

CPC classification number: A61B18/1206 ,  A61B18/1492 ,  A61B2018/00351 ,  A61B2018/00577 ,  A61B2018/00613 ,  A61B2018/00702 ,  A61B2018/00839 ,  A61B2018/00875 ,  A61B2018/00958 ,  A61B2018/00982

Abstract: Electrosurgical generators having improved functionality and user interface. In an example, the user may modify therapy output parameters without interrupting therapy delivery within a therapy regimen. In an example, the display shows both therapy amplitudes and encountered impedances for a plurality of therapy pulses in different portions of a display. In an example, the electrosurgical generator is operable in a triggered mode using a cardiac signal trigger and provides the operator with an estimate of remaining time that is calculated in light of a calculated cardiac rate.

公开(公告)号：US11559394B2

公开(公告)日：2023-01-24

申请号：US16526150

申请日：2019-07-30

Applicant: Boston Scientific Scimed, Inc.

Inventor： Jan Weber ,  Haiying Zhou ,  Bruce R. Forsyth

IPC: A61F2/24 ,  A61L27/14 ,  A61L27/30 ,  D04H1/541 ,  B32B27/02 ,  C08K3/22 ,  D01F8/00 ,  D04H3/147

Abstract: Examples herein include prosthetic valves, valve leaflets and related methods. In an example, a prosthetic valve is included having a plurality of leaflets. The leaflets can each have a root portion and an edge portion substantially opposite the root portion and movable relative to the root portion. The leaflets can include a fibrous matrix including polymeric fibers having an average diameter of about 10 nanometers to about 10 micrometers. A coating can surround the polymeric fibers within the fibrous matrix. The coating can have a thickness of about 3 to about 30 nanometers. The coating can be formed of a material selected from the group consisting of a metal oxide, a nitride, a carbide, a sulfide, or fluoride. In an example, a method of making a valve is included. Other examples are also included herein.