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    APPRATUS FOR OPTICAL ANALYSIS OF AN ASSOCIATED TISSUE SAMPLE
    11.
    发明申请
    APPRATUS FOR OPTICAL ANALYSIS OF AN ASSOCIATED TISSUE SAMPLE 审中-公开
    用于相关组织样品的光学分析的规定

    公开(公告)号：US20140117256A1

    公开(公告)日：2014-05-01

    申请号：US14127719

    申请日：2012-06-21

    申请人： Manfred Mueller ,  Bernardus Hendrikus Wilhelmus Hendriks ,  Waltherus Cornelis Jozef Bierhoff ,  Gerhardus Wilhelmus Lucassen ,  Jeroen Jan Lambertus Horikx ,  Rami Nachabe ,  Marjolein Van Der Voort

    发明人： Manfred Mueller ,  Bernardus Hendrikus Wilhelmus Hendriks ,  Waltherus Cornelis Jozef Bierhoff ,  Gerhardus Wilhelmus Lucassen ,  Jeroen Jan Lambertus Horikx ,  Rami Nachabe ,  Marjolein Van Der Voort

    IPC分类号： A61B5/00

    CPC分类号： A61B5/0071 ,  A61B5/0075 ,  A61B5/0084

    摘要： In order to improve fluorescence measurements, there is provided an apparatus and, a method and a computer program for optical analysis of an associated tissue sample, the apparatus comprising a spectrometer comprising an optical detector, a light source, a first light emitter 219 arranged for emitting photons into the associated tissue sample, a first light collector 221 arranged for receiving photons from the associated tissue sample, a second light emitter 223, a second light collector 225, wherein a reflectance spectrum is obtained via the first light emitter 219 and collector 221 and a fluorescence spectrum is obtained via the second light emitter 223 and collector 225, and where a first distance d1 between the first light emitter and collector is larger than a second distance d2 between the second light emitter and collector. By combining the data thus obtained, an intrinsic fluorescence spectrum may be obtained.

    摘要翻译： 为了改进荧光测量，提供了一种用于相关组织样本的光学分析的装置和方法以及计算机程序，该装置包括光谱仪，该光谱仪包括光学检测器，光源，第一光发射器219， 将光子发射到相关联的组织样本中，布置成从相关联的组织样本接收光子的第一光收集器221，第二光发射器223，第二光收集器225，其中通过第一光发射器219和集电极221获得反射光谱 并且通过第二光发射器223和集电极225获得荧光光谱，并且其中第一光发射器和集电极之间的第一距离d1大于第二发光体和集电极之间的第二距离d2。 通过组合由此获得的数据，可以获得固有的荧光光谱。

    CLASSIFICATION OF TUMOR TISSUE WITH A PERSONALIZED THRESHOLD
    12.
    发明申请
    CLASSIFICATION OF TUMOR TISSUE WITH A PERSONALIZED THRESHOLD 有权
    具有个性化THRESHOLD的肿瘤组织分类

    公开(公告)号：US20140046197A1

    公开(公告)日：2014-02-13

    申请号：US14112555

    申请日：2012-04-10

    申请人： Gerhardus Wilhelmus Lucassen ,  Bernardus Hendrikus Wilhelmus Hendriks ,  Rami Nachabe

    发明人： Gerhardus Wilhelmus Lucassen ,  Bernardus Hendrikus Wilhelmus Hendriks ,  Rami Nachabe

    IPC分类号： A61B5/00 ,  A61B1/00

    CPC分类号： A61B5/0075 ,  A61B1/00 ,  A61B5/0071 ,  A61B5/0084 ,  A61B5/0091 ,  A61B5/4887 ,  A61B5/6848 ,  A61B5/6852 ,  G01N21/64 ,  G01N2021/6421

    摘要： The present invention deals with discrimination of malignant tissue from normal and benign tissue in a single patient on the basis of optical spectroscopic measurements. Starting from spectroscopic measurements in normal tissue, reference values are obtained for the normal class. With spectroscopic measurements in other tissues data points can be assigned to new class(es) when the spectral characteristics fall outside a threshold defining the reference class. Thresholds between different classes can also be defined. Finding (the transition to) malignant tissue is based on comparing the spectroscopic values to the classification threshold discriminating normal and benign versus malignant tissue. Thus, the basis of normal spectroscopic measurements is tuned to the individual patient characteristic. Discriminating the normal plus benign and malignant from that reference is more efficient compared to the reference of the all patient database.

    摘要翻译： 本发明基于光学光谱测量法处理单个患者中恶性组织与正常和良性组织的鉴别。 从正常组织中的光谱测量开始，获得正常类的参考值。 通过在其他组织中的光谱测量，当光谱特性落在定义参考类的阈值之外时，可以将数据点分配给新类。 也可以定义不同类之间的阈值。 寻找（过渡到）恶性组织是基于将光谱值与鉴别正常和良性与恶性组织的分类阈值进行比较。 因此，正常光谱测量的基础被调整到个体患者的特征。 与所有患者数据库的参考相比，从该参考文献中区分正常和良性和恶性的效果更高。

    Classification of tumor tissue with a personalized threshold
    14.
    发明授权
    Classification of tumor tissue with a personalized threshold 有权
    具有个性化阈值的肿瘤组织分类

    公开(公告)号：US09498136B2

    公开(公告)日：2016-11-22

    申请号：US14112555

    申请日：2012-04-10

    申请人： Gerhardus Wilhelmus Lucassen ,  Bernardus Hendrikus Wilhelmus Hendriks ,  Rami Nachabe

    发明人： Gerhardus Wilhelmus Lucassen ,  Bernardus Hendrikus Wilhelmus Hendriks ,  Rami Nachabe

    IPC分类号： A61B5/00 ,  A61B1/00 ,  G01N21/64

    CPC分类号： A61B5/0075 ,  A61B1/00 ,  A61B5/0071 ,  A61B5/0084 ,  A61B5/0091 ,  A61B5/4887 ,  A61B5/6848 ,  A61B5/6852 ,  G01N21/64 ,  G01N2021/6421

    摘要： The present invention deals with discrimination of malignant tissue from normal and benign tissue in a single patient on the basis of optical spectroscopic measurements. Starting from spectroscopic measurements in normal tissue, reference values are obtained for the normal class. With spectroscopic measurements in other tissues data points can be assigned to new class(es) when the spectral characteristics fall outside a threshold defining the reference class. Thresholds between different classes can also be defined. Finding (the transition to) malignant tissue is based on comparing the spectroscopic values to the classification threshold discriminating normal and benign versus malignant tissue. Thus, the basis of normal spectroscopic measurements is tuned to the individual patient characteristic. Discriminating the normal plus benign and malignant from that reference is more efficient compared to the reference of the all patient database.

    摘要翻译： 本发明基于光学光谱测量法处理单个患者中恶性组织与正常和良性组织的鉴别。 从正常组织中的光谱测量开始，获得正常类的参考值。 通过在其他组织中的光谱测量，当光谱特性落在定义参考类的阈值之外时，可以将数据点分配给新类。 也可以定义不同类之间的阈值。 寻找（过渡到）恶性组织是基于将光谱值与鉴别正常和良性与恶性组织的分类阈值进行比较。 因此，正常光谱测量的基础被调整到个体患者的特征。 与所有患者数据库的参考相比，从该参考文献中区分正常和良性和恶性的效果更高。

    Apparatus for depth-resolved measurements of properties of tissue
    18.
    发明授权
    Apparatus for depth-resolved measurements of properties of tissue 失效
    用于深度分辨测量组织性质的装置

    公开(公告)号：US08417323B2

    公开(公告)日：2013-04-09

    申请号：US12302053

    申请日：2007-05-30

    申请人： Natallia Uzunbajakava ,  Rachel Estelle Thilwind ,  Joachim Kahlert ,  Gerhardus Wilhelmus Lucassen

    发明人： Natallia Uzunbajakava ,  Rachel Estelle Thilwind ,  Joachim Kahlert ,  Gerhardus Wilhelmus Lucassen

    IPC分类号： A61B6/00

    CPC分类号： A61B5/0086 ,  A61B5/0084 ,  A61B5/1459 ,  A61B18/24 ,  A61B2562/0242

    摘要： An apparatus for depth-resolved measurements of properties of tissue includes an illuminator that illuminates the tissue with light, a collector for collecting light which has not been absorbed by the tissue, and a determination device configured to determine properties of the tissue in different depths from the collected light. A casing for advancing into a hollow object includes at least a part of the illuminator and collector. The illuminator and collector are configured to collect light depth-resolved, and the determination device is configured to determine depth-resolved properties of the tissue from the light which has been collected depth-resolved.

    摘要翻译： 用于对组织性质进行深度分辨测量的装置包括用光照射组织的照明器，用于收集未被组织吸收的光的收集器;以及确定装置，其被配置为确定不同深度的组织的性质 收集的光。 用于前进到中空物体的壳体包括照明器和收集器的至少一部分。 照明器和收集器被配置为收集深度分辨的光，并且确定装置被配置为确定已经被深度分辨的光的组织的深度分辨特性。

    Depth selective pH measurement and UV exposure measurement
    19.
    发明授权
    Depth selective pH measurement and UV exposure measurement 有权
    深度选择性pH测量和紫外线曝光测量

    公开(公告)号：US07656522B2

    公开(公告)日：2010-02-02

    申请号：US10506056

    申请日：2002-02-28

    申请人： Gerwin Jan Puppels ,  Peter Jacobus Caspers ,  Gerhardus Wilhelmus Lucassen

    发明人： Gerwin Jan Puppels ,  Peter Jacobus Caspers ,  Gerhardus Wilhelmus Lucassen

    IPC分类号： G01J3/44

    CPC分类号： A61B5/14539 ,  A61B5/0059 ,  A61B5/0064 ,  A61B5/441 ,  A61B2562/0242 ,  G01N21/65

    摘要： A Raman spectrum is measured inside animal tissue, such us human skin tissue, at a selected depth from a surface the tissue. A pH value is computed using a function that assigns a pH value as a function of the measured Raman spectrum. The computation may involve computing a number representing a ratio of concentrations of a protonated and a deprotonated version of a chemical substance from the Raman spectrum and generating pH information on the basis of said number. The chemical substance is for example a form of Urocanic acid (UCA). UV exposure is measured from the weight of the spectrum of cis-UCA.

    摘要翻译： 在动物组织内测量拉曼光谱，例如人类皮肤组织，从表面的选定深度组织。 使用赋予pH值作为测量的拉曼光谱的函数的函数来计算pH值。 该计算可以涉及计算表示来自拉曼光谱的化学物质的质子化和去质子化版本的浓度比的数量，并且基于所述数量产生pH信息。 化学物质例如是一种形式的尿布酸（UCA）。 紫外线照射是从顺式UCA光谱的重量测定的。