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    Determination of a lipid water ratio
    1.
    发明授权
    Determination of a lipid water ratio 有权
    脂质水比的测定

    公开(公告)号：US09468379B2

    公开(公告)日：2016-10-18

    申请号：US13641229

    申请日：2011-04-18

    申请人： Bernardus Hendrikus Wilhelmus Hendriks ,  Jeroen Jan Lambertus Horikx ,  Gerhardus Wilhelmus Lucassen ,  Rami Nachabe ,  Marjolein Van Der Voort

    发明人： Bernardus Hendrikus Wilhelmus Hendriks ,  Jeroen Jan Lambertus Horikx ,  Gerhardus Wilhelmus Lucassen ,  Rami Nachabe ,  Marjolein Van Der Voort

    IPC分类号： G01N21/359 ,  A61B5/00

    CPC分类号： A61B5/0059 ,  A61B5/4869 ,  G01N21/359

    摘要： The present invention relates to an apparatus, a method and a computer program for determining a lipid-water ratio and a scattering parameter of a sample. In particular, the invention relates to an apparatus comprising a light source and a detector arranged to measure an optical parameter at various wavelengths, where the wavelengths are selected so that at two of the wavelengths the absorption coefficients for both water and lipids are substantially identical. This enables determination of a scattering parameter. A further measurement at a third wavelength enables determination of a water-lipid ratio. According to a specific embodiment, the light source and the detector are arranged in relation to an interventional device, so as to be able to examine a tissue in terms of lipid-water ratio and scattering during an intervention.

    摘要翻译： 本发明涉及一种用于确定样品的脂质 - 水比和散射参数的装置，方法和计算机程序。 具体地，本发明涉及一种包括光源和检测器的设备，其被布置成测量各种波长的光学参数，其中选择波长使得在两个波长处，水和脂质的吸收系数基本相同。 这使得能够确定散射参数。 在第三波长处的进一步测量使得能够测定水 - 油比。 根据具体实施例，光源和检测器相对于介入装置布置，以便能够在干预期间根据脂质 - 水比和散射来检查组织。

    APPARATUS FOR OPTICAL ANALYSIS OF AN ASSOCIATED TISSUE
    3.
    发明申请
    APPARATUS FOR OPTICAL ANALYSIS OF AN ASSOCIATED TISSUE 审中-公开
    用于相关组织的光学分析的装置

    公开(公告)号：US20140200459A1

    公开(公告)日：2014-07-17

    申请号：US13995967

    申请日：2011-12-22

    申请人： Bernardus Hendrikus Wilhelmus Hendriks ,  Rami Nachabe ,  Gerhardus Wilhelmus Lucassen ,  Adrien Emmanuel Desjardins ,  Theodoor Jacques Marie Ruers

    发明人： Bernardus Hendrikus Wilhelmus Hendriks ,  Rami Nachabe ,  Gerhardus Wilhelmus Lucassen ,  Adrien Emmanuel Desjardins ,  Theodoor Jacques Marie Ruers

    IPC分类号： A61B5/00 ,  A61B18/18

    CPC分类号： A61B5/0075 ,  A61B1/00 ,  A61B5/0084 ,  A61B5/4836 ,  A61B18/18 ,  G01N21/25

    摘要： The present invention relates to an apparatus 100 and, a method and a computer program for determining a parameter indicative of a tissue type of an associated tissue 116. In particular, the invention relates to an apparatus 100 comprising a spectrometer 102, which spectrometer comprises a light source 104 and a detector 106, 108 arranged to measure an optical spectrum. This enables determination of a first parameter being indicative of a bile concentration. As the inventors of the present invention have made the insight that bile concentration may serve as a discriminative feature for different tissue types, the apparatus is arranged to determine a second parameter indicative of a tissue type based on a concentration of bile. According to a specific embodiment, the apparatus further comprises an interventional device 112.

    摘要翻译： 本发明涉及一种用于确定指示相关组织116的组织类型的参数的装置100和方法和计算机程序。特别地，本发明涉及一种包括分光计102的装置100，该分光计包括： 光源104和被布置成测量光谱的检测器106,108。 这使得能够确定指示胆汁浓度的第一参数。 本发明的发明人已经认识到胆汁浓度可以用作不同组织类型的鉴别特征，该装置被设置为基于胆汁的浓度来确定指示组织类型的第二参数。 根据具体实施例，该装置还包括介入装置112。

    DETERMINATION OF A LIPID WATER RATIO
    4.
    发明申请
    DETERMINATION OF A LIPID WATER RATIO 有权
    脂肪水比的测定

    公开(公告)号：US20130026367A1

    公开(公告)日：2013-01-31

    申请号：US13641229

    申请日：2011-04-18

    申请人： Bernardus Hendrikus Wilhelmus Hendriks ,  Jeroen Jan Lambertus Horikx ,  Gerhardus Wilhelmus Lucassen ,  Rami Nachabe ,  Marjolein Van Der Voort

    发明人： Bernardus Hendrikus Wilhelmus Hendriks ,  Jeroen Jan Lambertus Horikx ,  Gerhardus Wilhelmus Lucassen ,  Rami Nachabe ,  Marjolein Van Der Voort

    IPC分类号： G01N21/59 ,  G01N21/49

    CPC分类号： A61B5/0059 ,  A61B5/4869 ,  G01N21/359

    摘要： The present invention relates to an apparatus, a method and a computer program for determining a lipid-water ratio and a scattering parameter of a sample. In particular, the invention relates to an apparatus comprising a light source and a detector arranged to measure an optical parameter at various wavelengths, where the wavelengths are selected so that at two of the wavelengths the absorption coefficients for both water and lipids are substantially identical. This enables determination of a scattering parameter. A further measurement at a third wavelength enables determination of a water-lipid ratio. According to a specific embodiment, the light source and the detector are arranged in relation to an interventional device, so as to be able to examine a tissue in terms of lipid-water ratio and scattering during an intervention.

    摘要翻译： 本发明涉及一种用于确定样品的脂质 - 水比和散射参数的装置，方法和计算机程序。 具体地，本发明涉及一种包括光源和检测器的设备，其被布置成测量各种波长的光学参数，其中选择波长使得在两个波长处，水和脂质的吸收系数基本相同。 这使得能够确定散射参数。 在第三波长处的进一步测量使得能够测定水 - 油比。 根据具体实施例，光源和检测器相对于介入装置布置，以便能够在干预期间根据脂质 - 水比和散射来检查组织。

    Classification of tumor tissue with a personalized threshold
    5.
    发明授权
    Classification of tumor tissue with a personalized threshold 有权
    具有个性化阈值的肿瘤组织分类

    公开(公告)号：US09498136B2

    公开(公告)日：2016-11-22

    申请号：US14112555

    申请日：2012-04-10

    申请人： Gerhardus Wilhelmus Lucassen ,  Bernardus Hendrikus Wilhelmus Hendriks ,  Rami Nachabe

    发明人： Gerhardus Wilhelmus Lucassen ,  Bernardus Hendrikus Wilhelmus Hendriks ,  Rami Nachabe

    IPC分类号： A61B5/00 ,  A61B1/00 ,  G01N21/64

    CPC分类号： A61B5/0075 ,  A61B1/00 ,  A61B5/0071 ,  A61B5/0084 ,  A61B5/0091 ,  A61B5/4887 ,  A61B5/6848 ,  A61B5/6852 ,  G01N21/64 ,  G01N2021/6421

    摘要： The present invention deals with discrimination of malignant tissue from normal and benign tissue in a single patient on the basis of optical spectroscopic measurements. Starting from spectroscopic measurements in normal tissue, reference values are obtained for the normal class. With spectroscopic measurements in other tissues data points can be assigned to new class(es) when the spectral characteristics fall outside a threshold defining the reference class. Thresholds between different classes can also be defined. Finding (the transition to) malignant tissue is based on comparing the spectroscopic values to the classification threshold discriminating normal and benign versus malignant tissue. Thus, the basis of normal spectroscopic measurements is tuned to the individual patient characteristic. Discriminating the normal plus benign and malignant from that reference is more efficient compared to the reference of the all patient database.

    摘要翻译： 本发明基于光学光谱测量法处理单个患者中恶性组织与正常和良性组织的鉴别。 从正常组织中的光谱测量开始，获得正常类的参考值。 通过在其他组织中的光谱测量，当光谱特性落在定义参考类的阈值之外时，可以将数据点分配给新类。 也可以定义不同类之间的阈值。 寻找（过渡到）恶性组织是基于将光谱值与鉴别正常和良性与恶性组织的分类阈值进行比较。 因此，正常光谱测量的基础被调整到个体患者的特征。 与所有患者数据库的参考相比，从该参考文献中区分正常和良性和恶性的效果更高。

    APPRATUS FOR OPTICAL ANALYSIS OF AN ASSOCIATED TISSUE SAMPLE
    8.
    发明申请
    APPRATUS FOR OPTICAL ANALYSIS OF AN ASSOCIATED TISSUE SAMPLE 审中-公开
    用于相关组织样品的光学分析的规定

    公开(公告)号：US20140117256A1

    公开(公告)日：2014-05-01

    申请号：US14127719

    申请日：2012-06-21

    申请人： Manfred Mueller ,  Bernardus Hendrikus Wilhelmus Hendriks ,  Waltherus Cornelis Jozef Bierhoff ,  Gerhardus Wilhelmus Lucassen ,  Jeroen Jan Lambertus Horikx ,  Rami Nachabe ,  Marjolein Van Der Voort

    发明人： Manfred Mueller ,  Bernardus Hendrikus Wilhelmus Hendriks ,  Waltherus Cornelis Jozef Bierhoff ,  Gerhardus Wilhelmus Lucassen ,  Jeroen Jan Lambertus Horikx ,  Rami Nachabe ,  Marjolein Van Der Voort

    IPC分类号： A61B5/00

    CPC分类号： A61B5/0071 ,  A61B5/0075 ,  A61B5/0084

    摘要： In order to improve fluorescence measurements, there is provided an apparatus and, a method and a computer program for optical analysis of an associated tissue sample, the apparatus comprising a spectrometer comprising an optical detector, a light source, a first light emitter 219 arranged for emitting photons into the associated tissue sample, a first light collector 221 arranged for receiving photons from the associated tissue sample, a second light emitter 223, a second light collector 225, wherein a reflectance spectrum is obtained via the first light emitter 219 and collector 221 and a fluorescence spectrum is obtained via the second light emitter 223 and collector 225, and where a first distance d1 between the first light emitter and collector is larger than a second distance d2 between the second light emitter and collector. By combining the data thus obtained, an intrinsic fluorescence spectrum may be obtained.

    摘要翻译： 为了改进荧光测量，提供了一种用于相关组织样本的光学分析的装置和方法以及计算机程序，该装置包括光谱仪，该光谱仪包括光学检测器，光源，第一光发射器219， 将光子发射到相关联的组织样本中，布置成从相关联的组织样本接收光子的第一光收集器221，第二光发射器223，第二光收集器225，其中通过第一光发射器219和集电极221获得反射光谱 并且通过第二光发射器223和集电极225获得荧光光谱，并且其中第一光发射器和集电极之间的第一距离d1大于第二发光体和集电极之间的第二距离d2。 通过组合由此获得的数据，可以获得固有的荧光光谱。

    CLASSIFICATION OF TUMOR TISSUE WITH A PERSONALIZED THRESHOLD
    9.
    发明申请
    CLASSIFICATION OF TUMOR TISSUE WITH A PERSONALIZED THRESHOLD 有权
    具有个性化THRESHOLD的肿瘤组织分类

    公开(公告)号：US20140046197A1

    公开(公告)日：2014-02-13

    申请号：US14112555

    申请日：2012-04-10

    申请人： Gerhardus Wilhelmus Lucassen ,  Bernardus Hendrikus Wilhelmus Hendriks ,  Rami Nachabe

    发明人： Gerhardus Wilhelmus Lucassen ,  Bernardus Hendrikus Wilhelmus Hendriks ,  Rami Nachabe

    IPC分类号： A61B5/00 ,  A61B1/00

    CPC分类号： A61B5/0075 ,  A61B1/00 ,  A61B5/0071 ,  A61B5/0084 ,  A61B5/0091 ,  A61B5/4887 ,  A61B5/6848 ,  A61B5/6852 ,  G01N21/64 ,  G01N2021/6421

    摘要： The present invention deals with discrimination of malignant tissue from normal and benign tissue in a single patient on the basis of optical spectroscopic measurements. Starting from spectroscopic measurements in normal tissue, reference values are obtained for the normal class. With spectroscopic measurements in other tissues data points can be assigned to new class(es) when the spectral characteristics fall outside a threshold defining the reference class. Thresholds between different classes can also be defined. Finding (the transition to) malignant tissue is based on comparing the spectroscopic values to the classification threshold discriminating normal and benign versus malignant tissue. Thus, the basis of normal spectroscopic measurements is tuned to the individual patient characteristic. Discriminating the normal plus benign and malignant from that reference is more efficient compared to the reference of the all patient database.

    摘要翻译： 本发明基于光学光谱测量法处理单个患者中恶性组织与正常和良性组织的鉴别。 从正常组织中的光谱测量开始，获得正常类的参考值。 通过在其他组织中的光谱测量，当光谱特性落在定义参考类的阈值之外时，可以将数据点分配给新类。 也可以定义不同类之间的阈值。 寻找（过渡到）恶性组织是基于将光谱值与鉴别正常和良性与恶性组织的分类阈值进行比较。 因此，正常光谱测量的基础被调整到个体患者的特征。 与所有患者数据库的参考相比，从该参考文献中区分正常和良性和恶性的效果更高。