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公开(公告)号:US20140121538A1
公开(公告)日:2014-05-01
申请号:US14127692
申请日:2012-06-13
申请人: Bernardus Hendrikus Wilhelmus Hendriks , Waltherus Cornelis Jozef Bierhoff , Gerhardus Wilhelmus Lucassen , Jeroen Jan Lambertus Horiks , Susanne Dorien Van Den Bergdams , Christian Reich , Stephan Voss , Axel Winkel , Rami Nachabe , Manfred Muller , Marjolein Van Der Voort
发明人: Bernardus Hendrikus Wilhelmus Hendriks , Waltherus Cornelis Jozef Bierhoff , Gerhardus Wilhelmus Lucassen , Jeroen Jan Lambertus Horiks , Susanne Dorien Van Den Bergdams , Christian Reich , Stephan Voss , Axel Winkel , Rami Nachabe , Manfred Muller , Marjolein Van Der Voort
CPC分类号: A61B1/00009 , A61B1/0646 , A61B1/0684 , A61B1/07 , A61B5/0071 , A61B5/0073 , A61B5/0075 , A61B5/0084 , A61B5/6848 , A61B10/0233 , F04C2270/0421 , Y10T29/49826
摘要: A needle is proposed including a cannula or hollow shaft with a multilumen insert inside. The insert comprises at least two lumen. Both the insert as well as the cannula have bevelled ends. In the insert substantially straight cleaved fibers are present that may be connected at the proximal end to a console. At least one of the distal fiber ends in the insert may protrude more than half the fiber diameter out of the insert. Furthermore, the bevel angle of the insert is different from the bevel angle of the cannula such that combination cannula and insert is such that the fiber ends do not protrude the bevel surface of the cannula.
摘要翻译: 提出了一种针头,其中包括插入件或空心轴,其中具有多孔插入件。 插入件包括至少两个内腔。 插入件以及套管均具有倾斜端部。 在插入件中,存在基本上直的切割的纤维,其可以在近端连接到控制台。 插入件中的远端纤维端部中的至少一个可以突出超过插入件的纤维直径的一半以上。 此外,插入件的斜角与插管的斜角不同,使得组合插管和插入件使得纤维端部不突出套管的斜面。
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公开(公告)号:US20140117256A1
公开(公告)日:2014-05-01
申请号:US14127719
申请日:2012-06-21
申请人: Manfred Mueller , Bernardus Hendrikus Wilhelmus Hendriks , Waltherus Cornelis Jozef Bierhoff , Gerhardus Wilhelmus Lucassen , Jeroen Jan Lambertus Horikx , Rami Nachabe , Marjolein Van Der Voort
发明人: Manfred Mueller , Bernardus Hendrikus Wilhelmus Hendriks , Waltherus Cornelis Jozef Bierhoff , Gerhardus Wilhelmus Lucassen , Jeroen Jan Lambertus Horikx , Rami Nachabe , Marjolein Van Der Voort
IPC分类号: A61B5/00
CPC分类号: A61B5/0071 , A61B5/0075 , A61B5/0084
摘要: In order to improve fluorescence measurements, there is provided an apparatus and, a method and a computer program for optical analysis of an associated tissue sample, the apparatus comprising a spectrometer comprising an optical detector, a light source, a first light emitter 219 arranged for emitting photons into the associated tissue sample, a first light collector 221 arranged for receiving photons from the associated tissue sample, a second light emitter 223, a second light collector 225, wherein a reflectance spectrum is obtained via the first light emitter 219 and collector 221 and a fluorescence spectrum is obtained via the second light emitter 223 and collector 225, and where a first distance d1 between the first light emitter and collector is larger than a second distance d2 between the second light emitter and collector. By combining the data thus obtained, an intrinsic fluorescence spectrum may be obtained.
摘要翻译: 为了改进荧光测量,提供了一种用于相关组织样本的光学分析的装置和方法以及计算机程序,该装置包括光谱仪,该光谱仪包括光学检测器,光源,第一光发射器219, 将光子发射到相关联的组织样本中,布置成从相关联的组织样本接收光子的第一光收集器221,第二光发射器223,第二光收集器225,其中通过第一光发射器219和集电极221获得反射光谱 并且通过第二光发射器223和集电极225获得荧光光谱,并且其中第一光发射器和集电极之间的第一距离d1大于第二发光体和集电极之间的第二距离d2。 通过组合由此获得的数据,可以获得固有的荧光光谱。
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公开(公告)号:US20140142563A1
公开(公告)日:2014-05-22
申请号:US14131518
申请日:2012-07-05
申请人: Bernardus Hendrikus Wilhelmus Hendriks , Nicolaas Jan Noordhoek , Gerhardus Wilhelmus Lucassen , Pieter Maria Mielekamp , Rami Nachabé , Marjolein Van Der Voort , Waltherus Cornelis Jozef Bierhoff
发明人: Bernardus Hendrikus Wilhelmus Hendriks , Nicolaas Jan Noordhoek , Gerhardus Wilhelmus Lucassen , Pieter Maria Mielekamp , Rami Nachabé , Marjolein Van Der Voort , Waltherus Cornelis Jozef Bierhoff
CPC分类号: A61B34/10 , A61B18/14 , A61B2018/00577 , A61B2034/101
摘要: The invention relates to an energy application planning apparatus for planning an application of energy to an object (3) like a tumor. An energy application element representation represents an energy application element (5) like an ablation needle including an energy application part for applying energy and a sensing part (7). An arrangement of the energy application element (5) with respect to the object (3) is determined depending on the positions of the energy application part and the sensing part (7) with respect to the energy application element (5) as defined by the energy application element representation and depending on the object representation. The application of energy can therefore not only be planned such that the application of energy is performed as desired, but also such that the object and/or a surrounding of the object are sensible as desired. In this way, the planning procedure can be improved.
摘要翻译: 本发明涉及一种能量应用计划装置,用于规划能量到诸如肿瘤的物体(3)的应用。 能量应用元件表示代表诸如包括用于施加能量的能量施加部分和感测部分(7)的消融针的能量施加元件(5)。 能量施加元件(5)相对于物体(3)的布置根据能量施加部分和感测部分(7)相对于能量施加元件(5)的位置来确定,如由 能量应用元素表示,并取决于对象表示。 因此,能量的施加不仅可以被规划,使得能量的应用按照需要执行,而且还使得物体和/或物体的周围是期望的。 这样可以提高规划程序。
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公开(公告)号:US09757201B2
公开(公告)日:2017-09-12
申请号:US14131518
申请日:2012-07-05
申请人: Bernardus Hendrikus Wilhelmus Hendriks , Nicolaas Jan Noordhoek , Gerhardus Wilhelmus Lucassen , Pieter Maria Mielekamp , Rami Nachabė , Marjolein Van Der Voort , Waltherus Cornelis Jozef Bierhoff
发明人: Bernardus Hendrikus Wilhelmus Hendriks , Nicolaas Jan Noordhoek , Gerhardus Wilhelmus Lucassen , Pieter Maria Mielekamp , Rami Nachabė , Marjolein Van Der Voort , Waltherus Cornelis Jozef Bierhoff
CPC分类号: A61B34/10 , A61B18/14 , A61B2018/00577 , A61B2034/101
摘要: The invention relates to an energy application planning apparatus for planning an application of energy to an object (3) like a tumor. An energy application element representation represents an energy application element (5) like an ablation needle including an energy application part for applying energy and a sensing part (7). An arrangement of the energy application element (5) with respect to the object (3) is determined depending on the positions of the energy application part and the sensing part (7) with respect to the energy application element (5) as defined by the energy application element representation and depending on the object representation. The application of energy can therefore not only be planned such that the application of energy is performed as desired, but also such that the object and/or a surrounding of the object are sensible as desired. In this way, the planning procedure can be improved.
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公开(公告)号:US09072475B2
公开(公告)日:2015-07-07
申请号:US13881379
申请日:2011-10-17
申请人: Bernardus Hendrikus Wilhelmus Hendriks , Waltherus Cornelis Jozef Bierhoff , Gerhardus Wilhelmus Lucassen , Rami Nachabe , Theodoor Jacques Marie Ruers
发明人: Bernardus Hendrikus Wilhelmus Hendriks , Waltherus Cornelis Jozef Bierhoff , Gerhardus Wilhelmus Lucassen , Rami Nachabe , Theodoor Jacques Marie Ruers
IPC分类号: A61B5/1459 , A61B5/00 , A61M25/06
CPC分类号: A61B5/1459 , A61B5/0075 , A61B5/0084 , A61B5/6848 , A61B5/6882 , A61M25/065
摘要: A needle comprises an elongated first shaft element with a C-shaped cross section and an elongated second shaft element with a C-shaped cross section. The first shaft element and the second shaft element are adapted to be detachably connected to each other. This is achieved by an overlap of respective end sections of the first and second shaft elements. Within the channel formed by the shaft elements, an optical probe may be accommodated from which the shaft elements may be removed by separating the two shaft elements from each other.
摘要翻译: 针包括具有C形横截面的细长的第一轴元件和具有C形横截面的细长的第二轴元件。 第一轴元件和第二轴元件适于彼此可拆卸地连接。 这通过第一和第二轴元件的相应端部部分的重叠来实现。 在由轴元件形成的通道内,可以容纳光学探针,通过将两个轴元件彼此分离,可以从中移除轴元件。
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公开(公告)号:US20130217989A1
公开(公告)日:2013-08-22
申请号:US13881379
申请日:2011-10-17
申请人: Bernardus Hendrikus Wilhelmus Hendriks , Waltherus Cornelis Jozef Bierhoff , Gerhardus Wilhelmus Lucassen , Rami Nachabe , Theodoor Jacques Marie Ruers
发明人: Bernardus Hendrikus Wilhelmus Hendriks , Waltherus Cornelis Jozef Bierhoff , Gerhardus Wilhelmus Lucassen , Rami Nachabe , Theodoor Jacques Marie Ruers
IPC分类号: A61B5/1459
CPC分类号: A61B5/1459 , A61B5/0075 , A61B5/0084 , A61B5/6848 , A61B5/6882 , A61M25/065
摘要: A needle comprises an elongated first shaft element with a C-shaped cross section and an elongated second shaft element with a C-shaped cross section. The first shaft element and the second shaft element are adapted to be detachably connected to each other. This is achieved by an overlap of respective end sections of the first and second shaft elements. Within the channel formed by the shaft elements, an optical probe may be accommodated from which the shaft elements may be removed by separating the two shaft elements from each other.
摘要翻译: 针包括具有C形横截面的细长的第一轴元件和具有C形横截面的细长的第二轴元件。 第一轴元件和第二轴元件适于彼此可拆卸地连接。 这通过第一和第二轴元件的相应端部部分的重叠来实现。 在由轴元件形成的通道内,可以容纳光学探针,通过将两个轴元件彼此分离,可以从中移除轴元件。
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公开(公告)号:US20120316558A1
公开(公告)日:2012-12-13
申请号:US13578883
申请日:2011-02-22
申请人: Bernardus Hendrikus Wilhelmus Hendriks , Gerhrdus Wilhelmus Lucassen , Rami Nachabe , Waltherus Cornelis Jozef Bierhoff , Adrien Emmanuel Desjardins
发明人: Bernardus Hendrikus Wilhelmus Hendriks , Gerhrdus Wilhelmus Lucassen , Rami Nachabe , Waltherus Cornelis Jozef Bierhoff , Adrien Emmanuel Desjardins
IPC分类号: A61B18/14
CPC分类号: A61B18/1477 , A61B5/0066 , A61B5/0075 , A61B5/0084 , A61B8/0841 , A61B18/02 , A61B2017/00057 , A61B2017/00061 , A61B2017/00084 , A61B2017/00106 , A61B2018/00577 , A61B2034/2063 , A61B2090/378
摘要: An interventional ablation device (1) is proposed to comprise an ablation needle (3) with an elongated body (5) and a handle (7). Adjacent to an ablation element (9) provided on the body (5), at least one or preferably two or more sensors (11-21) are provided, preferably at both of opposing sides of the ablation element (9). The ablation device (1) is adapted for detecting physiological information of tissue (27, 29, 31) surrounding an ablation site (33) based on measurement values provided by the sensors. E.g., optical sensors may be used to measure a reflectance spectrum indicating whether the adjacent tissue is healthy tissue (31), tumorous tissue (27) or ablated tissue (29). Using such information, an ablation process may be controlled.
摘要翻译: 提出介入消融装置(1)包括具有细长主体(5)和手柄(7)的消融针(3)。 设置在主体(5)上的消融元件(9)附近,优选地在消融元件(9)的相对两侧提供至少一个或优选两个或更多个传感器(11-21)。 消融装置(1)适于基于由传感器提供的测量值来检测围绕消融部位(33)的组织(27,29,31)的生理信息。 例如,光学传感器可用于测量反映光谱,其指示相邻组织是健康组织(31),肿瘤组织(27)还是消融组织(29)。 使用这种信息,可以控制消融过程。
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公开(公告)号:US09687156B2
公开(公告)日:2017-06-27
申请号:US14342442
申请日:2012-09-07
申请人: Waltherus Cornelis Jozef Bierhoff , Bernardus Hendrikus Wilhelmus Hendriks , Franciscus Marinus Antonius Maria Van Gaal
发明人: Waltherus Cornelis Jozef Bierhoff , Bernardus Hendrikus Wilhelmus Hendriks , Franciscus Marinus Antonius Maria Van Gaal
CPC分类号: A61B5/0084 , A61B5/0071 , A61B5/0075 , A61B5/0086 , A61B5/6844 , A61B5/6848
摘要: A needle device includes a hollow shaft, an elongated insert and an operating lever. The hollow shaft has a first distal end portion with a bevel, the elongated insert has a second distal end portion and is movably arranged within the hollow shaft, and the operating lever is shiftable between a first condition and a second condition. Furthermore, the operating lever is interconnected with the elongated insert such that the second distal end portion is located within the hollow shaft and proximally to the bevel when the operating lever is in the first condition, and that the second distal end portion is located outside the hollow shaft and distally to the bevel when the operating lever is in the second condition.
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公开(公告)号:US20120113491A1
公开(公告)日:2012-05-10
申请号:US13320601
申请日:2010-05-10
申请人: Cornelius Antonius Hezemans , Bernardus Hendrikus Wilhelmus Hendriks , Waltherus Cornelis Jozef Bierhoff , Augustinus Laurentius Braun , Nenad Mihajlovic
发明人: Cornelius Antonius Hezemans , Bernardus Hendrikus Wilhelmus Hendriks , Waltherus Cornelis Jozef Bierhoff , Augustinus Laurentius Braun , Nenad Mihajlovic
IPC分类号: G02B26/10
CPC分类号: A61B5/6848 , A61B5/0068 , A61B5/0084 , G02B21/0012 , G02B21/0036 , G02B23/2423 , G02B23/26 , G02B26/103
摘要: The present invention relates to an optical probe (1) suitable for miniature applications. An example application is a fibre-based confocal miniaturized microscope. The optical probe comprises a coil-based actuation system (9, 10) comprising drive coils (9) capable of displacing the distal end (3) of an optical guide (2) housed (4) by the optical probe. The probe makes use of a feedback loop which alternate between driving the displacement of the optical guide by driving a current through the drive coils and switching off the current through the drive coils, and while the drive current being switched off, measure the speed of the distal end of the optical guide. The measured speed is compared to the set-point speed, and if a difference is detected, the drive current is adjusted to eliminate, or at least bring down, this difference.
摘要翻译: 本发明涉及适合于微型应用的光学探头(1)。 一个示例应用是基于光纤的共聚焦微型显微镜。 光探头包括基于线圈的致动系统(9,10),其包括驱动线圈(9),该驱动线圈能够移动由光学探头容纳(4)的光导(2)的远端(3)。 探头利用反馈回路,通过驱动通过驱动线圈的电流驱动光导的位移和切断通过驱动线圈的电流之间的交替,并且在驱动电流被切断时,测量速度 光导的远端。 将测量的速度与设定点速度进行比较,并且如果检测到差异,则调节驱动电流以消除或至少降低该差异。
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公开(公告)号:US20110201941A1
公开(公告)日:2011-08-18
申请号:US13125392
申请日:2009-10-19
申请人: Franciscus Martinus Antonius Maria Van Gaal , Bernardus Hendrikus Wilhelmus Hendriks , Augustinus Laurentius Braun , Cornelius Antonius Hezemans , Waltherus Cornelis Jozef Bierhoff
发明人: Franciscus Martinus Antonius Maria Van Gaal , Bernardus Hendrikus Wilhelmus Hendriks , Augustinus Laurentius Braun , Cornelius Antonius Hezemans , Waltherus Cornelis Jozef Bierhoff
IPC分类号: A61B6/00
CPC分类号: A61B5/0062 , A61B5/0084 , G02B23/2461 , G02B26/103
摘要: The present invention relates to an optical scanning probe assembly for microscopic guide optic scanning and inspection of tissues suitable for application in, e.g. in vivo medical inspection and biopsy. The assembly comprises an outer housing (3) comprising: i) a spring element for a scanning motor, the spring element formed as a hollow tube (5) adapted to receive an optical guide, the hollow tube having mechanical stiffness larger than the optical guide to be received, ii) a lens system (7) and iii) N means for deflecting (6) the distal end of the hollow tube in directions transverse to the longitudinal extension of the hollow tube, so as to form an optical scan pattern. The optical assembly is particularly advantageous as it increases the freedom to optimize the optical and mechanical performance of the system which is defined respectively by the optical guide and by the hollow tube. The probe can be used in resonant and non-resonant scanning modes.
摘要翻译: 本发明涉及一种光学扫描探针组件,用于微观引导光学扫描和检查适用于例如, 体内检查和活检。 该组件包括外壳(3),包括:i)用于扫描电机的弹簧元件,弹簧元件形成为适于容纳光导的中空管(5),所述中空管的机械刚度大于光导 ii)透镜系统(7),以及iii)用于使中空管的远端沿垂直于中空管的纵向延伸的方向偏转(6)的装置,以形成光学扫描图案。 光学组件是特别有利的,因为它增加了由光导和中空管分别限定的优化系统的光学和机械性能的自由度。 探头可用于谐振和非谐振扫描模式。
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