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    Surface Energy Gradient Films for Analytical Devices
    11.
    发明申请
    Surface Energy Gradient Films for Analytical Devices 审中-公开
    用于分析设备的表面能量梯度膜

    公开(公告)号：US20140295565A1

    公开(公告)日：2014-10-02

    申请号：US14258132

    申请日：2014-04-22

    Applicant: Brian David Babcock

    Inventor： Brian David Babcock

    IPC: B01L3/00 ,  G01N33/68

    CPC classification number: B01L3/502753 ,  B82Y30/00 ,  C12Q1/6837 ,  G01N33/6803 ,  C12Q2527/15 ,  C12Q2527/125 ,  C12Q2523/308

    Abstract: A device comprising a channel comprising at least one surface wherein the surface comprises a fluid-impervious base surface covered by a coating beginning at a proximal location and ending at a distal location along the at least one surface of the channel, the coating forming a surface energy gradient from the proximal location to the distal location on the surface, wherein the coating comprises a species having a functional group M1 and a species having a functional group M2 where M1 and M2 have different surface energies, wherein the functional group M2 comprises an amide or amine group, and the concentration of the species comprising functional group M2 in the coating increases relative to the concentration of the species comprising functional group M1 from the proximal location to the distal location on the surface.

    Abstract translation: 一种包括通道的装置，所述通道包括至少一个表面，其中所述表面包括不透液体的基部表面，所述基底表面被覆盖在最近位置处的涂层，并且沿着所述通道的至少一个表面终止于远端位置，所述涂层形成表面 能量梯度从表面上的近端位置到远端位置，其中涂层包括具有官能团M1的物质和具有官能团M2的物质，其中M1和M2具有不同的表面能，其中官能团M2包含酰胺 或胺基，并且包含官能团M2的物质在涂层中的浓度相对于从表面上的近端位置到远端位置的包含官能团M1的物质的浓度增加。

    Microfluidic diagnostics with controlled fluid flow
    16.
    发明授权
    Microfluidic diagnostics with controlled fluid flow 有权

    公开(公告)号：US10821438B2

    公开(公告)日：2020-11-03

    申请号：US15973882

    申请日：2018-05-08

    Applicant: Brian David Babcock

    Inventor： Brian David Babcock

    IPC: B01L3/00 ,  G01N15/06 ,  G01N33/00 ,  G01N33/48 ,  G01N35/00 ,  B81C1/00

    Abstract: A microfluidic product utilizing gradient surface energy coatings for fluid control comprising a plurality of fluid passages wherein at least one fluid passage comprises a coating configured to control liquid flow wherein the coating configured to control liquid flow comprises a gradient surface energy coating from a proximal location to a distal location on a surface of the fluid passage. The product can include uniform regions and surface gradient regions in the same passage. Coating compositions and product dimensions can be selected to provide control over different flow properties including fluid velocity, reduction and acceleration of fluid flow, and starting and stopping fluid flow.

    Biopolymer resistant devices using coatings with surface energy gradient
    17.
    发明申请
    Biopolymer resistant devices using coatings with surface energy gradient 审中-公开
    使用具有表面能梯度的涂层的生物聚合物抗性装置

    公开(公告)号：US20110034785A1

    公开(公告)日：2011-02-10

    申请号：US12803612

    申请日：2010-06-30

    Applicant: Brian David Babcock

    Inventor： Brian David Babcock

    IPC: A61B5/145

    CPC classification number: B01L3/502753 ,  B82Y30/00 ,  C12Q1/6837 ,  G01N33/6803 ,  C12Q2527/15 ,  C12Q2527/125 ,  C12Q2523/308

    Abstract: A medical device or analytical device comprising a fluid-impervious surface comprising a base surface, at least one distinct region of the base surface covered by a mixed monolayer film, the mixed monolayer film comprising a species having a functional group M1 and a species having a functional group M2 where M1 and M2 have different surface energies, the mixed monolayer forming a surface energy gradient wherein at least one of the species used to form the monolayer on the surface comprises a biopolymer-resistant domain.

    Abstract translation: 一种医疗装置或分析装置，其包括不透液体表面，其包含基底表面，所述基底表面的至少一个不同区域被混合单层膜覆盖，所述混合单层膜包含具有官能团M1的物质和具有 官能团M2，其中M1和M2具有不同的表面能，所述混合单层形成表面能梯度，其中用于在表面上形成单层的物质中的至少一种包含生物聚合物抗性结构域。

    Methods for creating a surface energy gradient
    18.
    发明申请
    Methods for creating a surface energy gradient 审中-公开
    创建表面能量梯度的方法

    公开(公告)号：US20110024391A1

    公开(公告)日：2011-02-03

    申请号：US12803603

    申请日：2010-06-30

    Applicant: Brian David Babcock

    Inventor： Brian David Babcock

    IPC: B05D3/10 ,  B05D3/00 ,  B05D3/06 ,  B05D3/12

    CPC classification number: B01L3/502753 ,  B82Y30/00 ,  C12Q1/6837 ,  G01N33/6803 ,  C12Q2527/15 ,  C12Q2527/125 ,  C12Q2523/308

    Abstract: A method of derivatizing a fluid-impervious surface with a mixed monolayer to create a surface energy gradient comprising the steps of a) Exposing a base surface to a first solution comprising a plurality of molecules of the formula X1-J1-M1 wherein X1 and M1 represent separate functional groups and J1 represents a spacer moiety that, together, are able to promote formation from solution of a self-assembled monolayer for sufficient time to form a monolayer surface having a substantially uniform surface energy on the base surface. b) Removing a portion of the monolayer formed in (a) such that a portion of the base surface is again fully or partially exposed. c) Exposing the portion of the base surface from (b) to a second solution comprising a plurality of molecules of the formula X2-J2-M2 wherein the functional group M2 has a different surface energy from that of the functional group M1 such that a surface energy gradient is formed.

    Abstract translation: 一种用混合单层衍生流体不透过表面以产生表面能梯度的方法，包括以下步骤：a）将基底表面暴露于包含多个分子式X1-J1-M1的第一溶液，其中X1和M1 代表分开的官能团，并且J 1表示间隔部分，其一起能够促进从自组装单层的溶液形成足够的时间以形成在基底表面上具有基本均匀的表面能的单层表面。 b）去除在（a）中形成的单层的一部分，使得基底表面的一部分再次完全或部分暴露。 c）将基底表面从（b）的部分暴露于包含多个式X2-J2-M2分子的第二溶液中，其中官能团M2具有与官能团M1不同的表面能，使得 形成表面能梯度。

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