公开(公告)号：US20230190461A1

公开(公告)日：2023-06-22

申请号：US18109937

申请日：2023-02-15

Applicant: Cardiovalve Ltd.

Inventor： Ilia HARITON ,  Meni Iamberger ,  Aviram Baum ,  Boaz Harari

IPC: A61F2/24

CPC classification number: A61F2/2427 ,  A61F2/2454 ,  A61F2/2463 ,  A61F2/2445 ,  A61F2/2436 ,  A61F2/243 ,  A61F2/2409 ,  A61F2220/0008 ,  A61F2/246 ,  A61F2210/0014 ,  A61F2250/007 ,  A61F2/2466 ,  A61F2/2418

Abstract: An expandable prosthetic valve is implantable within a native mitral valve by terminal ends of ventricular anchors of the prosthetic valve moving outwardly from a constrained delivery position of the ventricular anchors, while the ventricular anchors are positioned within the atrium. Then, a portion of the expandable prosthetic valve containing the ventricular anchors is advanced through the native mitral valve into the ventricle. Terminal ends of atrial anchors of the prosthetic valve move outwardly relative to a portion of an annular valve body of the prosthetic valve while the atrial anchors are at least partially positioned within the atrium. Next, the annular valve body is radially expanded while the ventricular anchors are in the ventricle and the atrial anchors are in the atrium, thereby anchoring native heart valve tissue between the atrial anchors and ventricular anchors. Other embodiments are also described.

公开(公告)号：US20200163761A1

公开(公告)日：2020-05-28

申请号：US16776581

申请日：2020-01-30

Applicant: CARDIOVALVE LTD.

Inventor： Ilia HARITON ,  Boaz HARARI

IPC: A61F2/24

Abstract: Embodiments of the present disclosure include apparatus including a percutaneous delivery capsule and prosthetic valve. The prosthetic valve includes a frame assembly that includes a tubular portion, and a plurality of atrial arms that extend away from the tubular portion. A plurality of prosthetic leaflets are attached to the tubular portion, and are disposed within a lumen defined by the tubular portion. When the prosthetic valve is in a compressed state and is housed by the capsule, each of the atrial arms extends, in a serpentine shape, along the capsule and away from the tubular portion. Other embodiments are also described.

公开(公告)号：US20200163760A1

公开(公告)日：2020-05-28

申请号：US16637166

申请日：2018-08-07

Applicant: CARDIOVALVE LTD.

Inventor： Ilia HARITON ,  Meni IAMBERGER ,  Aviram BAUM

IPC: A61F2/24 ,  B23P15/00

Abstract: A unitary flexible sheet is folded to defines a panel, and first and second tabs. Each of the tabs has an inner layer and an outer layer. Commissural portions of prosthetic leaflets are sandwiched between inner layers of the first and second tabs. The tabs protrude from a first side of the panel, and are shaped such that progressively downstream parts of each tab protrude progressively further away from the panel portion. Other embodiments are also described.

公开(公告)号：US20200046497A1

公开(公告)日：2020-02-13

申请号：US16660231

申请日：2019-10-22

Applicant: CARDIOVALVE LTD.

Inventor： Ilia HARITON ,  Boaz HARARI

IPC: A61F2/24

Abstract: Prosthetic valves and methods of use of prosthetic valves may be provided. In one implementation, a method of implanting a prosthetic valve within a native heart valve may be provided. The method may include delivering the prosthetic valve into a heart chamber while the prosthetic valve is constrained in a radially-contracted delivery configuration. The method may also include unconstraining ventricular tissue anchors and atrial tissue anchors of the prosthetic valve while maintaining an annular valve body of the prosthetic valve in the delivery configuration. The method may also include unconstraining the annular valve body from the delivery configuration while the unconstrained atrial tissue anchors and ventricular tissue anchors are positioned within an atrium and a ventricle, respectively. Unconstraining the annular valve body may decrease a longitudinal distance between the ventricular tissue anchors and atrial tissue anchors to secure the prosthetic valve within the native heart valve.

公开(公告)号：US20200046496A1

公开(公告)日：2020-02-13

申请号：US16656790

申请日：2019-10-18

Applicant: CARDIOVALVE LTD.

Inventor： Tal HAMMER ,  Meni IAMBERGER ,  Yaron HERMAN ,  Yuval ZIPORY ,  Eran HOFFER ,  Michael ALBITOV ,  Natalia KRUGLOVA ,  Tal REICH ,  Ilia HARITON ,  Aviram BAUM

IPC: A61F2/24

Abstract: A prosthetic valve includes a tubular valve body, snares, and an upstream support. A native valve of a heart of a subject is disposed between an atrium and a ventricle of the heart, and has an annulus and leaflets. The prosthetic valve is advanced to the heart while in a compressed state. The prosthetic valve is positioned within the heart such that the snares are disposed upstream of the annulus and leaflets. The snares are expanded radially outwardly upstream of the leaflets. Subsequently, the prosthetic valve is moved in a downstream direction such that the snares become disposed downstream of the leaflets. While the snares remain downstream of the leaflets, the upstream support is expanded within the atrium, and the upstream support is placed against an upstream surface of the annulus. Other embodiments are also described.

公开(公告)号：US20190083251A1

公开(公告)日：2019-03-21

申请号：US16136082

申请日：2018-09-19

Applicant: CARDIOVALVE LTD.

Inventor： Ilia HARITON ,  Meni IAMBERGER ,  Aviram BAUM ,  Boaz HARARI

IPC: A61F2/24

Abstract: Prosthetic valves and methods of implanting prosthetic valves may be provided, including an expandable prosthetic valve for implantation within a native heart valve. The prosthetic valve may include an annular valve body and atrial anchoring arms configured to extend radially outward from the annular valve body. Each atrial anchoring arm may have a proximal arm end and a distal arm end. The flexibility of at least one atrial anchoring arm may vary substantially from the proximal arm end thereof to the distal arm end thereof. The prosthetic valve may also include a plurality of ventricular anchoring legs configured to extend radially outward from the annular valve body. Each ventricular anchoring leg may have a proximal leg end and a distal leg end. Each ventricular anchoring leg may have a substantially constant flexibility from the proximal leg end to the distal leg end.

公开(公告)号：US20190083250A1

公开(公告)日：2019-03-21

申请号：US16136074

申请日：2018-09-19

Applicant: CARDIOVALVE LTD.

Inventor： Ilia HARITON ,  Meni IAMBERGER ,  Aviram BAUM ,  Boaz HARARI

IPC: A61F2/24

Abstract: A prosthetic valve for implantation within a native heart valve may be provided. The prosthetic valve may include an annular valve body, as well as a plurality of ventricular anchoring legs and a plurality of atrial anchoring arms configured to extend radially outward from the annular valve body. The ventricular anchoring legs and grasping segments of the atrial anchoring arms may be configured to substantially restrict axial movement of the annular valve body within the native heart valve. In addition, anchoring segments of the atrial anchoring arms may be configured for lateral deformation relative to the native heart valve.

公开(公告)号：US20190083244A1

公开(公告)日：2019-03-21

申请号：US16135599

申请日：2018-09-19

Applicant: CARDIOVALVE LTD.

Inventor： Ilia HARITON ,  Meni IAMBERGER ,  Aviram BAUM ,  Boaz HARARI

IPC: A61F2/24

Abstract: An expandable prosthetic valve for implantation within a native mitral valve may be provided. The prosthetic valve may include an expandable valve body having an atrial end, a ventricular end opposite the atrial end, and an intermediate portion extending between the atrial end and the ventricular end. The valve body may include a plurality of struts intersecting at junctions. The prosthetic valve may also include a plurality of tissue anchoring legs extending from junctions within the intermediate portion of the valve body. At least one of the tissue anchoring legs may have a cross-sectional area which is larger by at least 20% than a cross-sectional area of a strut extending between the at least one tissue anchoring leg and an adjacent tissue anchoring leg.

公开(公告)号：US20240423796A1

公开(公告)日：2024-12-26

申请号：US18765724

申请日：2024-07-08

Applicant: CARDIOVALVE LTD.

Inventor： Ilia HARITON ,  Boaz Harari ,  Maxim Karalnik ,  Michael Albitov ,  Meni Iamberger

IPC: A61F2/24 ,  A61F2/958 ,  A61F2/966

Abstract: A method includes delivering an implant to a heart of a patient using a delivery tool that includes a nosepiece that is fixed to a shaft and distal to an implant, and an expandable element proximal to the nosepiece. Maximally-expanded, the expandable element (i) has an expanded external diameter at its widest part that is smaller than the expanded internal diameter of a lumen of the frame of the implant and (ii) tapers proximally away from the widest part and from the nosepiece. In a compressed state of the implant a portion of the expandable element is disposed within the lumen of the frame. The method includes, following implantation of the implant, withdrawing the expandable element proximally through the lumen of the implant, between leaflets of the implant, and out of the lumen. Other applications are also described.

公开(公告)号：US20230293293A1

公开(公告)日：2023-09-21

申请号：US18125350

申请日：2023-03-23

Applicant: CARDIOVALVE LTD.

Inventor： Maxim KARALNIK ,  Michael ALBITOV ,  Oren SHUA ,  Meni IAMBERGER ,  Ilia HARITON

IPC: A61F2/24 ,  B21D39/04 ,  A61F2/95

CPC classification number: A61F2/2415 ,  A61F2/2427 ,  B21D39/048 ,  A61F2/9522 ,  A61F2/9525 ,  Y10T29/49865 ,  A61F2210/0014

Abstract: An assembly (10) for crimping a frame (56) of an implant (58) comprises a crimping device (20) with a base (22) and a crimping mechanism (24) that defines a crimping aperture (26). A bath (28) having a floor (30), and one or more side-walls (32) extending upward from the floor to a side-wall height defines a receptacle (18) that is shaped to receive a portion of the crimping device. The apparatus has an assembled state in which the portion of the crimping device has been received by the receptacle, the crimping device is held securely by the bath, and the aperture is below the side-wall height. Other embodiments are also described.