公开(公告)号：US12083108B2

公开(公告)日：2024-09-10

申请号：US17752683

申请日：2022-05-24

Applicant: CHDI Foundation, Inc.

Inventor： Celia Dominguez ,  Jonathan Bard ,  Matthew R. Lee ,  Longbin Liu ,  Michael Edward Prime ,  Samuel Coe

IPC: A61K31/454 ,  A61K31/165 ,  A61K31/427 ,  A61K47/54

CPC classification number: A61K31/454 ,  A61K31/165 ,  A61K31/427 ,  A61K47/555

Abstract: The present disclosure relates generally to compounds that simultaneously bind both mutant huntingtin protein (mHTT) and an ubiquitin E3 ligase and their use as therapeutic agents, for example, in treating diseases, such as neurodegenerative disorders caused by aggregation of mHTT.

公开(公告)号：US12036292B2

公开(公告)日：2024-07-16

申请号：US17395055

申请日：2021-08-05

Applicant: CHDI Foundation, Inc.

Inventor： Longbin Liu ,  Celia Dominguez ,  Xuemei Chen ,  John E. Mangette

IPC: A61K51/04 ,  C07D239/28 ,  C07D401/12 ,  C07D401/14 ,  C07D403/06 ,  C07D471/04

CPC classification number: A61K51/0459 ,  C07D239/28 ,  C07D401/12 ,  C07D401/14 ,  C07D403/06 ,  C07D471/04 ,  C07B2200/05

Abstract: Provided herein are certain compounds and imaging agents useful for detecting a disease or condition associated with protein aggregation, compositions thereof, and methods of their use.

公开(公告)号：US11806346B2

公开(公告)日：2023-11-07

申请号：US17318693

申请日：2021-05-12

Applicant: CHDI Foundation, Inc.

Inventor： Celia Dominguez ,  Elizabeth M. Doherty ,  Longbin Liu ,  Matthew Lee ,  Mark Stuart Chambers ,  Karine Fabienne Malagu ,  Perla Breccia ,  Alan F. Haughan ,  Huw D. Vater ,  Andrew J. Stott ,  William R. K. Esmieu ,  Stephen John Webster ,  Amanda J. Van De Poël

IPC: A61K31/497 ,  A61P25/28 ,  A61K31/4985 ,  A61K31/501 ,  A61K31/506 ,  C07D403/14 ,  C07D413/14 ,  C07D471/04 ,  C07D487/04 ,  C07D519/00

CPC classification number: A61K31/497 ,  A61K31/4985 ,  A61K31/501 ,  A61K31/506 ,  A61P25/28 ,  C07D403/14 ,  C07D413/14 ,  C07D471/04 ,  C07D487/04 ,  C07D519/00

Abstract: Provided herein are certain compounds useful as HTT modulators. Such compound are useful in the treatment of Huntington's disease.

公开(公告)号：US20230159531A1

公开(公告)日：2023-05-25

申请号：US17988340

申请日：2022-11-16

Applicant: CHDI Foundation, Inc.

Inventor： Longbin Liu ,  Celia Dominguez ,  Nikolay V. Plotnikov ,  Alan Haughan ,  Andrew Stott ,  Brett Cosgrove ,  Cole Clissold ,  Huw Vater ,  Jonathan Spencer ,  William Esmieu ,  Karine Malagu ,  Mark Chambers

IPC: C07D471/10 ,  C07D413/14 ,  C07D405/14 ,  C07D403/14 ,  C07D471/04 ,  A61K45/06

CPC classification number: C07D471/10 ,  C07D413/14 ,  C07D405/14 ,  C07D403/14 ,  C07D471/04 ,  A61K45/06

Abstract: Provided herein are certain compounds useful as HTT modulators. Such compound are useful in the treatment of Huntington's disease.