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公开(公告)号：US20190233375A1
公开(公告)日：2019-08-01
申请号：US16342741
申请日：2017-10-18
Applicant: Constellation Pharmaceuticals, Inc.
Inventor： Rishi G. Vaswani , Michael Charles Hewitt
IPC: C07D211/28 , C07D401/06 , C07D401/14
CPC classification number: C07D211/28 , C07D211/26 , C07D401/06 , C07D401/14
Abstract: Provided herein are synthetic methods for the preparation of EZH2 inhibitors.
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公开(公告)号：US20180290976A1
公开(公告)日：2018-10-11
申请号：US15567978
申请日：2016-04-22
Applicant: Constellation Pharmaceuticals, Inc.
Inventor： Brian K. Albrecht , James Edmund Audia , Alexandre Côté , Martin Duplessis , Victor S. Gehling , Jean-Christophe Harmange , Rishi G. Vaswani
IPC: C07D211/26 , C07D211/58 , C07C211/40 , C07D213/38 , C07C229/10 , C07D213/73 , C07C255/58 , C07D211/76 , C07D401/06 , C07C215/42 , C07C233/41 , C07C217/08 , C07C237/06 , C07D295/195 , C07C229/38 , C07C255/30 , C07D213/69 , C07D305/06
CPC classification number: C07D211/26 , A61P35/00 , C07B2200/07 , C07C211/09 , C07C211/36 , C07C211/40 , C07C215/14 , C07C215/42 , C07C215/44 , C07C217/08 , C07C229/10 , C07C229/38 , C07C229/46 , C07C233/41 , C07C237/06 , C07C255/24 , C07C255/30 , C07C255/58 , C07C2601/02 , C07C2601/04 , C07C2601/14 , C07C2602/44 , C07D205/12 , C07D207/32 , C07D211/22 , C07D211/36 , C07D211/58 , C07D211/76 , C07D213/38 , C07D213/64 , C07D213/69 , C07D213/73 , C07D215/44 , C07D239/30 , C07D263/32 , C07D295/195 , C07D305/06 , C07D309/20 , C07D317/28 , C07D401/04 , C07D401/06 , C07D403/04 , C07D403/06 , C07D403/10 , C07D405/04 , C07D417/06
Abstract: Provided are novel compounds of Formula (I): and pharmaceutically acceptable salts thereof, which are useful for treating a variety of diseases, disorders or conditions, associated with LSD1. Also provided are pharmaceutical compositions comprising the novel compounds of Formula (I), pharmaceutically acceptable salts thereof, and methods for their use in treating one or more diseases, disorders or conditions, associated with LSD1.
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公开(公告)号：US09980952B2
公开(公告)日：2018-05-29
申请号：US15155749
申请日：2016-05-16
Applicant: Constellation Pharmaceuticals, Inc.
Inventor： Brian K. Albrecht , James Edmund Audia , Andrew Cook , Les A. Dakin , Martin Duplessis , Victor S. Gehling , Jean-Christophe Harmange , Christopher G. Nasveschuk , Rishi G. Vaswani
IPC: C07D471/04 , A61K31/4545 , C07D401/14 , C07D401/12 , C07D417/04 , C07D487/04 , C07D417/14 , C07D405/14 , C07D409/06
CPC classification number: A61K31/4545 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/06 , C07D417/04 , C07D417/14 , C07D471/04 , C07D487/04
Abstract: Agents for modulating methyl modifying enzymes, compositions and uses thereof are provided herein.
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![BENZO [C] ISOXAZOLOAZEPINE BROMODOMAIN INHIBITORS AND USES THEREOF](/abs-image/US/2015/05/28/US20150148337A1/abs.jpg.150x150.jpg)
14.发明申请BENZO [C] ISOXAZOLOAZEPINE BROMODOMAIN INHIBITORS AND USES THEREOF 有权BENZO [C] ISOXAZOLOAZEPINE BROMODOMAIN抑制剂及其用途公开(公告)号：US20150148337A1
公开(公告)日：2015-05-28
申请号：US14405209
申请日：2013-06-06
Applicant: Constellation Pharmaceuticals, Inc.
Inventor： Brian K. Albrecht , Michael Charles Hewitt , Victor S. Gehling , Rishi G. Vaswani
IPC: C07D498/04
CPC classification number: A61K31/55 , C07D498/04
Abstract: The present invention relates to compounds useful as inhibitors of bromodomain-containing proteins. The invention also provides pharmaceutically acceptable compositions comprising compounds of the present invention and methods of using said compositions in the treatment of various disorders.
Abstract translation: 本发明涉及可用作含溴结构域蛋白质的抑制剂的化合物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用所述组合物治疗各种疾病的方法。
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公开(公告)号：US10457640B2
公开(公告)日：2019-10-29
申请号：US16342741
申请日：2017-10-18
Applicant: Constellation Pharmaceuticals, Inc.
Inventor： Rishi G. Vaswani , Michael Charles Hewitt
IPC: C07D211/28 , C07D401/06 , C07D401/14
Abstract: Provided herein are synthetic methods for the preparation of EZH2 inhibitors.
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Patent Agency Ranking
公开(公告)号：US10301253B2
公开(公告)日：2019-05-28
申请号：US15658219
申请日：2017-07-24
Applicant: GENENTECH, INC. , CONSTELLATION PHARMACEUTICALS, INC.
Inventor： Brian K. Albrecht , James Edmund Audia , Alexandre Cote , Martin Duplessis , Victor S. Gehling , Andrew Charles Good , Jean-Christophe Harmange , Yves LeBlanc , Christopher G. Nasveschuk , Alexander M. Taylor , Rishi G. Vaswani
IPC: C07C211/39 , C07C211/38 , C07C211/17 , C07C211/19 , A61K31/137 , A61K31/136 , A61K31/135 , A61K31/4465 , C07C211/42 , C07D231/12 , C07D401/12 , C07D405/12 , C07D211/78 , C07D213/38 , C07C255/58 , C07C217/74 , C07C229/50 , C07C237/48 , A61K31/166 , A61K31/196 , A61K31/277 , A61K31/337 , A61K31/351 , A61K31/397 , A61K31/40 , A61K31/415 , A61K31/4155 , A61K31/437 , A61K31/4406 , A61K31/445 , A61K31/4545 , A61K31/4747 , A61K31/495 , A61K31/517 , A61K45/06 , C07C317/36 , C07D205/04 , C07D205/12 , C07D207/06 , C07D211/26 , C07D211/46 , C07D215/08 , C07D295/185 , C07D305/08 , C07D309/04
Abstract: Provided herein are compounds of formula I: and salts thereof and compositions and uses thereof. The compounds are useful as inhibitors of LSD1. Also included are pharmaceutical compositions comprising a compound of formula I or a pharmaceutically acceptable salt thereof, and methods of using such compounds and salts in the treatment of various LSD1-mediated disorders.
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![Benzo [C] isoxazoloazepine bromodomain inhibitors and uses thereof](/abs-image/US/2018/03/27/US09925197B2/abs.jpg.150x150.jpg)
公开(公告)号：US09925197B2
公开(公告)日：2018-03-27
申请号：US15277854
申请日：2016-09-27
Applicant: Constellation Pharmaceuticals, Inc.
Inventor： Brian K. Albrecht , Michael Charles Hewitt , Victor S. Gehling , Rishi G. Vaswani
IPC: A61K31/55 , C07D498/04
CPC classification number: A61K31/55 , C07D498/04
Abstract: The present invention relates to compounds useful as inhibitors of bromodomain-containing proteins. The invention also provides pharmaceutically acceptable compositions comprising compounds of the present invention and methods of using said compositions in the treatment of various disorders.
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公开(公告)号：US20170056388A1
公开(公告)日：2017-03-02
申请号：US15257275
申请日：2016-09-06
Applicant: Constellation Pharmaceuticals, Inc.
Inventor： Brian K. Albrecht , James Edmund Audia , Andrew Cook , Les A. Dakin , Martin Duplessis , Victor S. Gehling , Jean-Christophe Harmange , Christopher G. Nasveschuk , Rishi G. Vaswani
IPC: A61K31/4545
CPC classification number: A61K31/4545 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/06 , C07D417/04 , C07D417/14 , C07D471/04 , C07D487/04
Abstract: Agents for modulating methyl modifying enzymes, compositions and uses thereof are provided herein.
Abstract translation: 本文提供了用于调节甲基修饰酶的组合物及其用途。
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公开(公告)号：US09522920B2
公开(公告)日：2016-12-20
申请号：US14313148
申请日：2014-06-24
Applicant: Constellation Pharmaceuticals, Inc.
Inventor： Brian K. Albrecht , James Edmund Audia , Alexandre Côté , Victor S. Gehling , Jean-Christophe Harmange , Michael Charles Hewitt , Yves Leblanc , Christopher G. Nasveschuk , Alexander M. Taylor , Rishi G. Vaswani
IPC: A61K31/55 , C07D498/04 , C07D498/14 , C07D498/20 , C07D498/22 , C07K14/47 , A61K31/424
CPC classification number: C07D498/04 , A61K31/424 , A61K31/55 , C07D498/14 , C07D498/20 , C07D498/22 , C07K14/4702
Abstract: The present invention relates to compounds useful as inhibitors of bromodomain-containing proteins. The invention also provides pharmaceutically acceptable compositions comprising compounds of the present invention and methods of using said compositions in the treatment of various disorders.
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公开(公告)号：US20160333016A1
公开(公告)日：2016-11-17
申请号：US15155749
申请日：2016-05-16
Applicant: Constellation Pharmaceuticals, Inc.
Inventor： Brian K. Albrecht , James Edmund Audia , Andrew Cook , Les A. Dakin , Martin Duplessis , Victor S. Gehling , Jean-Christophe Harmange , Christopher G. Nasveschuk , Rishi G. Vaswani
IPC: C07D487/04 , C07D405/14 , C07D401/14 , C07D401/12 , C07D471/04
CPC classification number: A61K31/4545 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/06 , C07D417/04 , C07D417/14 , C07D471/04 , C07D487/04
Abstract: Agents for modulating methyl modifying enzymes, compositions and uses thereof are provided herein.
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