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公开(公告)号：US11110398B2
公开(公告)日：2021-09-07
申请号：US15750218
申请日：2016-08-17
Applicant: Cytiva Sweden AB
Inventor： Sasi Kumar Nutalapati , Klaus Gebauer , Karl Axel Jakob Liderfelt , Nachiket Karmarkar , Ajit S. Vernekar , Amit Kumar Sharma , Fredrik Oskar Lundstrom , Sangeetha Raghu Ramachandran
Abstract: The disclosure generally relates to methods and apparatus for the efficient quantitative recovery of valuable biological fluids from filtration systems, more particularly to efficient quantitative recovery of valuable biological fluids from high precision separation systems suitable for use in the pharmaceutical and biotechnology industries.
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公开(公告)号：US12169034B2
公开(公告)日：2024-12-17
申请号：US16077779
申请日：2017-02-21
Applicant: Cytiva Sweden AB
Inventor： Klaus Gebauer , Sudheer Mygapula , Nachiket Karmarkar , Sasikumar Arumugam , Bashkar Hv , Ajit S. Vernekar , Nityananda Maiya , Prashanth Hosabettu Mohan , Sasi Kumar Nutalapati , Sameera Simha Hindupur , Shashidhar Hedge
Abstract: The invention discloses a method of controlling a transmembrane pressure (TMP) in a crossflow filtration apparatus, comprising the steps of: a) providing a crossflow filtration apparatus comprising a pump (21) fluidically connected via a retentate compartment (33) of a crossflow filter (32) and a length of flexible tubing to a regulator valve (1; 101) acting on the flexible tubing, wherein the regulator valve is a high precision pinch valve. The apparatus further comprises a first pressure transducer (22) adapted to measure a pressure between the retentate compartment and the regulator valve, a second pressure transducer (39) adapted to measure a pressure between the pump and the retentate compartment and a third pressure transducer (40) adapted to measure a pressure at a permeate outlet (36) of the crossflow filter, and a control unit (23) electrically or electromagnetically connected to said regulator valve, the first, second and third pressure transducers and optionally to the pump; b) pumping a liquid with the pump via the second pressure transducer, through the retentate compartment via the length of flexible tubing, the first pressure transducer and the regulator valve; c) controlling the regulator valve with the control unit, such that a TMP calculated by formula (I) TMP=(Pinlet+Poutlet)/2−Pperm corresponds to a predetermined TMP value or to an interval between two predetermined TMP values, wherein Pinlet is a pressure reading from the second pressure transducer, Poutlet is a pressure reading from the first pressure transducer and Pperm is a pressure reading from the third pressure transducer.
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公开(公告)号：US11850391B2
公开(公告)日：2023-12-26
申请号：US17174533
申请日：2021-02-12
Applicant: Cytiva Sweden AB
Inventor： Eric Faldt , Klaus Gebauer
CPC classification number: A61M39/105 , A61M39/16 , A61M39/18 , F16L39/00 , F16L2201/44
Abstract: Aseptic connectors are described. An aseptic connector includes a first connection unit and a second connection unit provided with at least one first and second openings orientated to substantially coincide when said first and second connection units are connected to each other. The first and second openings are sealed by at least one film, so that the contact between the film and each connection unit is aseptic. The at least one film is adapted to be mated with a corresponding film on the other connection unit; and the mated films are adapted to be pulled out together two and two after mating such that corresponding first and second openings are mated aseptically.
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公开(公告)号：US11781659B2
公开(公告)日：2023-10-10
申请号：US16981114
申请日：2019-03-21
Applicant: Cytiva Sweden AB
Inventor： Klaus Gebauer
IPC: F16K7/04 , F16K7/12 , F16K31/12 , F16K31/122 , F16K31/126
CPC classification number: F16K7/04 , F16K7/12 , F16K31/12 , F16K31/122 , F16K31/126
Abstract: A method for controlling at least one valve provided to a tube in a bioprocess flow system, said method comprising the steps of: —controlling the at least one valve to be in a first state, which is an open state when a flow through the tube should be allowed; —controlling the at least one valve to be in a second state during some parts of a process run in the system, said second state is a closed state were a first closing force is provided; and—controlling the at least one valve to be in a third state during some parts of a process run in the system, said third state is a closed state were a second closing force is provided which is a higher force than the first closing force.
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公开(公告)号：US11643627B2
公开(公告)日：2023-05-09
申请号：US16474626
申请日：2017-12-27
Applicant: CYTIVA SWEDEN AB
Inventor： Klaus Gebauer , Nagaraj Raghavendra Rao , Anindya Kanti De , Anindya Sengupta , Mats Olsson , Colin R. Tuohey , Jonathan A. Kenney , Richard Lee Damren , Ralph Stankowski , Nirmal Kumar Thanikachalam
Abstract: A support housing for a flexible bioprocess bag, the housing comprising at least one side wall having a first segment and a second segment, the first segment movable in relation to the second segment between an open and a closed position, wherein at least a supporting part of the housing is translatable from an operating position to a bag loading position, wherein the supporting part comprises one or more retainers for holding the flexible bioprocess bag upon re-translation of the supporting part to the operating position and movement of the first segment to the closed position, and wherein the first segment comprises a first drive unit for connecting and driving a first mixing unit in the flexible bioprocess bag.
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Patent Agency Ranking
公开(公告)号：US20220275798A1
公开(公告)日：2022-09-01
申请号：US17634455
申请日：2020-06-24
Applicant: Cytiva Sweden AB
Inventor： Klaus Gebauer , Andreas Lundin , Andreas Marcstrom , David Gronowitz , Bjorn Johansson , Mats Nilsson , Bjorn Olovsson
Abstract: A diapharagm pump for a bioprocess system comprises a pump head (1; 101; 201; 301) comprising: a common inlet (3); a common outlet (5); a plurality of pump cavities (7) each including at least one cooperating pair of one-way valves, the at least one pair of one-way valves including an inlet valve (9) and an outlet valve (11), wherein the respective inlet valves (9) are in fluid communication with the common inlet (3) and the respective outlet valves (11) are in fluid communication with the common outlet (5) and wherein a centre of the outlet valve (11) for each pump cavity is positionable above a centre of the inlet valve (9) for the same pump cavity when the diaphragm pump is oriented for use to inhibit trapped gas; and a plurality of moveable diaphragms (13) each respectively provided in a respective of said pump cavities (7) for varying a volume of the pump cavities. The system further comprises a pump drive (31) which is configured to transfer a motion to the diaphragms (13) of the pump head (1; 101; 201) for accomplishing a fluid displacement from the common inlet (3) to the common outlet (5) of the pump head (1; 101; 201; 301) as a result of said varying of the volume of the pump cavities (7).
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公开(公告)号：US20220275317A1
公开(公告)日：2022-09-01
申请号：US17763135
申请日：2020-09-30
Applicant: Cytiva Sweden AB
Inventor： Klas Marteleur , Andreas Marcstrom , Mats Olsson , Klaus Gebauer
Abstract: Disclosed is a bioprocess system (1) comprising a flow path (3; 3a, 3) comprising: a plurality of inlets (7); at least one bio-processing device inlet connection (9a) and at least one bioprocessing device outlet connection (9b); a plurality of outlets (11); and flow path parts (5a′, 5b′, 5c′, 5d′, 5e′) of at least some active components (5a, 5b, 5c, 5d, 5e) comprised in the bioprocess system; and active parts (5a″, 5b″, 5c″, 5d″, 5e″) of said active components (5a, 5b, 5c, 5d, 5e). The flow path (3; 3a, 3b) of the bioprocess system is positioned centrally within the bioprocess system (1) and in a vertical orientation, whereby the active parts (5a″, 5b″, 5c″, 5d″, 5e″) are positioned around the flow path (3; 3a, 3b) being accessible from outside the bioprocess system (1) and each in connection with a corresponding flow path part (5a′, 5b′, 5c′, 5d′, 5e′) of an active component (5a, 5b, 5c, 5d, 5e).
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公开(公告)号：US20220184527A1
公开(公告)日：2022-06-16
申请号：US17686157
申请日：2022-03-03
Applicant: Cytiva Sweden AB
Inventor： Johan Avallin , Klaus Gebauer
Abstract: A method and a system and a container system for transferring separation resin from at least one first container (3; 3′; 3a, 3b; 3a′, 3b′, 3c′, 3d′) to a second container (5; 5′), wherein said first container is a deformable, single-use separation resin storage container, said method comprising the steps of:
preparing (S1) the at least one first container by providing a deformable, single-use container comprising an outlet port (4′) with a predefined volume of separation resin in a storage solution;
fluidizing (S3) the separation resin in the at least one first container to provide a resin slurry, said fluidizing being performed by mechanical interaction to the first container from an outside of the first container to provide a deformation of said first container;
fluidically connecting (S5) the outlet port (4′) of the at least one first container to an inlet port (103) of the second container;
transferring (S7) separation resin from the at least one first container to the second container by generating a pressure difference between an interior of the second container and an interior of the first container where the pressure is lower in the second container.-
公开(公告)号：US11291929B2
公开(公告)日：2022-04-05
申请号：US16481655
申请日：2018-01-30
Applicant: Cytiva Sweden AB
Inventor： Johan Avallin , Klaus Gebauer
Abstract: A method and a system and a container system for transferring separation resin from at least one first container (3; 3; 3a, 3b; 3a′, 3b′, 3c′, 3d′) to a second container (5; 5′), wherein said first container is a deformable, single-use separation resin storage container, said method comprising the steps of:—preparing (S1) the at least one first container by providing a deformable, single-use container comprising an outlet port (4′) with a predefined volume of separation resin in a storage solution;—fluidizing (S3) the separation resin in the at least one first container to provide a resin slurry, said fluidizing being performed by mechanical interaction to the first container from an outside of the first container to provide a deformation of said first container;—fluidically connecting (S5) the outlet port (4′) of the at least one first container to an inlet port (103) of the second container;—transferring (S7) separation resin from the at least one first container to the second container by generating a pressure difference between an interior of the second container and an interior of the first container where the pressure is lower in the second container.
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公开(公告)号：US20220025313A1
公开(公告)日：2022-01-27
申请号：US17296711
申请日：2019-12-10
Applicant: Cytiva Sweden AB
Inventor： Bjorn Olovsson , Andreas Lundin , Klaus Gebauer , Tim Francois , Kerstin Erickson
IPC: C12M1/00
Abstract: A flow distribution device for bioprocess systems, comprising: ⋅—a flow distribution manifold (12; 112; 212; 312) comprising: ⋅o at least four fluid connection tubes (14), wherein each fluid connection tube (14) comprises a first end (18) for fluid connection and an opposite second end (20) ⋅o a central common compartment (30; 130; 230; 330) to which the second ends (20) of each of the fluid connection tubes (14) are connected, whereby the first ends (18) of each of the fluid connection tubes (14) can be in fluid communication with the central common compartment (30; 130; 230; 330) ⋅—at least three pinching members (41) which are provided in connection with one fluid connection tube (14) of the flow distribution manifold (12; 112; 212; 312) each, wherein each of said pinching members (41) can be controlled into at least a first and a second position, wherein in the first position for each of the pinching members (41) the pinching member pinches one of the fluid connection tubes (14) such that fluid flow is prevented between the first end (18) and the second end (20) of this fluid connection tube (14)
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