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11.发明申请DERIVATIVES OF 1-PHENYL-2-PYRIDINYL ALKYL ALCOHOLS AS PHOSPHODIESTERASE INHIBITORS 审中-公开1-苯基-2-吡啶基亚胺醇作为磷酸二酯酶抑制剂的衍生物公开(公告)号：US20140135301A1
公开(公告)日：2014-05-15
申请号：US14161285
申请日：2014-01-22
IPC分类号： C07D213/30 , C07D401/12 , A61K31/4545 , C07D213/79 , A61K31/444 , A61K31/4439 , A61K31/5377 , C07D405/12 , A61K31/4433 , C07D473/04 , A61K31/522 , A61K31/4709 , C07D417/12 , A61K31/538 , A61K45/06 , A61K31/44
CPC分类号： C07D213/30 , A61K31/44 , A61K31/4433 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/455 , A61K31/4709 , A61K31/522 , A61K31/5377 , A61K31/538 , A61K45/06 , C07D213/38 , C07D213/61 , C07D213/79 , C07D213/80 , C07D213/89 , C07D401/12 , C07D405/12 , C07D417/12 , C07D473/04 , C07D473/08
摘要： Derivatives of 1-phenyl-2-pyridinyl alkyl alcohols are useful as inhibitors of the phosphodiesterase 4 (PDE4) enzyme.
摘要翻译： 1-苯基-2-吡啶基烷基醇的衍生物可用作磷酸二酯酶4（PDE4）酶的抑制剂。
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公开(公告)号：US20130137648A1
公开(公告)日：2013-05-30
申请号：US13747812
申请日：2013-01-23
IPC分类号： C07D213/61 , A61K45/06 , C07D213/89 , A61K31/4545 , A61K31/444 , C07D401/12 , A61K31/4439 , A61K31/5377 , A61K31/538 , C07H15/26 , A61K31/706 , A61K31/4709 , C07D473/08 , A61K31/522 , C07J43/00 , A61K31/58 , C07D405/12 , A61K31/4433 , C07D417/12 , A61K31/443 , A61K31/44
CPC分类号： C07D213/30 , A61K31/44 , A61K31/4433 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/455 , A61K31/4709 , A61K31/522 , A61K31/5377 , A61K31/538 , A61K45/06 , C07D213/38 , C07D213/61 , C07D213/79 , C07D213/80 , C07D213/89 , C07D401/12 , C07D405/12 , C07D417/12 , C07D473/04 , C07D473/08
摘要： Derivatives of 1-phenyl-2-pyridinyl alkyl alcohols are useful as inhibitors of the phosphodiesterase 4 (PDE4) enzyme.
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公开(公告)号：US09944612B2
公开(公告)日：2018-04-17
申请号：US14097445
申请日：2013-12-05
IPC分类号： A61K31/44 , A61K31/435 , A61K31/425 , C07D295/155 , A61M15/00 , A61M16/14 , C07D213/89 , C07D401/12 , C07D407/12 , C07D417/12 , C07D213/61
CPC分类号： C07D295/155 , A61M15/0065 , A61M15/009 , A61M16/14 , C07D213/61 , C07D213/89 , C07D401/12 , C07D407/12 , C07D417/12
摘要： Compounds of formula (I) described herein are inhibitors of the phosphodiesterase 4 (PDE4) enzyme and are useful for the prevention and/or treatment of an allergic disease state or a disease of the respiratory tract characterized by airway obstruction.
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公开(公告)号：US09931327B2
公开(公告)日：2018-04-03
申请号：US14863915
申请日：2015-09-24
发明人： Elisabetta Armani , Gabriele Amari , Laura Carzaniga , Carmelida Capaldi , Oriana Esposito , Gino Villetti , Renato De Fanti
IPC分类号： A61K31/4425 , C07D213/89 , C07D401/12 , C07D401/14 , C07D405/14 , C07D413/12 , C07D417/12 , C07D417/14 , A61K45/06 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/496 , A61K31/5377 , A61K31/538 , A61K31/541 , C07D213/30 , A61K31/517 , A61K31/635 , C07D471/04 , C07D498/04
CPC分类号： A61K31/4425 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/496 , A61K31/517 , A61K31/5377 , A61K31/538 , A61K31/541 , A61K31/635 , A61K45/06 , C07D213/30 , C07D213/89 , C07D401/12 , C07D401/14 , C07D405/14 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/04 , C07D498/04
摘要： Derivatives of 1-phenyl-2-pyridinyl alkyl alcohols are useful as inhibitors of the phosphodiesterase 4 (PDE4) enzyme and the treatment of certain conditions such as COPD.
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公开(公告)号：US20160008338A1
公开(公告)日：2016-01-14
申请号：US14863915
申请日：2015-09-24
发明人： Elisabetta ARMANI , Gabriele Amari , Laura Carzaniga , Carmelida Capaldi , Oriana Esposito , Gino Villetti , Renato De Fanti
IPC分类号： A61K31/4425 , C07D401/12 , A61K31/4439 , C07D417/12 , C07D413/12 , A61K31/5377 , A61K31/4545 , A61K31/541 , A61K31/496 , C07D405/14 , C07D417/14 , A61K31/517 , A61K31/538 , C07D498/04 , C07D471/04 , A61K31/635 , A61K45/06 , C07D213/89
CPC分类号： A61K31/4425 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/496 , A61K31/517 , A61K31/5377 , A61K31/538 , A61K31/541 , A61K31/635 , A61K45/06 , C07D213/30 , C07D213/89 , C07D401/12 , C07D401/14 , C07D405/14 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/04 , C07D498/04
摘要： Derivatives of 1-phenyl-2-pyridinyl alkyl alcohols are useful as inhibitors of the phosphodiesterase 4 (PDE4) enzyme and the treatment of certain conditions such as COPD.
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公开(公告)号：US09102619B2
公开(公告)日：2015-08-11
申请号：US14496136
申请日：2014-09-25
IPC分类号： A61K31/44 , C07D213/61 , C07D213/30 , C07D213/89 , C07D401/12 , A61K31/4433 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/522 , A61K31/5377 , A61K31/538 , A61K45/06 , C07D213/79 , C07D405/12 , C07D417/12 , C07D473/04 , A61K31/455 , C07D213/38 , C07D213/80 , C07D473/08
CPC分类号： C07D213/30 , A61K31/44 , A61K31/4433 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/455 , A61K31/4709 , A61K31/522 , A61K31/5377 , A61K31/538 , A61K45/06 , C07D213/38 , C07D213/61 , C07D213/79 , C07D213/80 , C07D213/89 , C07D401/12 , C07D405/12 , C07D417/12 , C07D473/04 , C07D473/08
摘要： Derivatives of 1-phenyl-2-pyridinyl alkyl alcohols are useful as inhibitors of the phosphodiesterase 4 (PDE4) enzyme.
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公开(公告)号：US20140155373A1
公开(公告)日：2014-06-05
申请号：US14097397
申请日：2013-12-05
IPC分类号： C07D453/02 , A61K31/4545 , A61K31/444
CPC分类号： C07D453/02 , C07D401/12 , C07D401/14 , C07D417/12 , C07D417/14 , C07D453/00
摘要： Compounds of formula (I) described herein are both inhibitors of the phosphodiesterase 4 (PDE4) enzyme and muscarinic M3 receptor antagonists, and are useful for the prevention and/or treatment of diseases of the respiratory tract characterized by airway obstruction.
摘要翻译： 本文所述的式（I）化合物既是磷酸二酯酶4（PDE4）酶和毒蕈碱M3受体拮抗剂的抑制剂，并且可用于预防和/或治疗以气道阻塞为特征的呼吸道疾病。
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18.发明授权1-phenyl-2-pyridinyl alkyl alcohol compounds as phosphodiesterase inhibitors 有权1-苯基-2-吡啶基烷基醇化合物作为磷酸二酯酶抑制剂公开(公告)号：US08648204B2
公开(公告)日：2014-02-11
申请号：US13930304
申请日：2013-06-28
IPC分类号： C07D211/82 , A61K31/435
CPC分类号： A61M15/0065 , A61K31/44 , A61K31/4704 , A61K45/06 , A61M16/14 , C07D213/30 , C07D213/61 , C07D213/89
摘要： 1-Phenyl-2-pyridinyl alkyl alcohol compounds are effective as inhibitors of the phosphodiesterase 4 (PDE4) enzyme and may be used to prevent and/or treat certain diseases or conditions.
摘要翻译： 1-苯基-2-吡啶基烷基醇化合物作为磷酸二酯酶4（PDE4）酶的抑制剂是有效的，可用于预防和/或治疗某些疾病或病症。
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公开(公告)号：US20130196978A1
公开(公告)日：2013-08-01
申请号：US13827101
申请日：2013-03-14
IPC分类号： C07D453/02 , C07D207/12 , C07D223/08 , C07D491/08 , C07C233/80 , C07D333/24 , C07D211/44 , C07D209/02
CPC分类号： C07D453/02 , C07C233/80 , C07D207/12 , C07D209/02 , C07D211/42 , C07D211/44 , C07D211/46 , C07D223/08 , C07D333/24 , C07D451/10 , C07D491/08
摘要： Alkaloid aminoester compounds which act as muscarinic receptor antagonists are useful for the prevention and/or treatment of a broncho-obstructive or inflammatory diseases.
摘要翻译： 作为毒蕈碱受体拮抗剂的生物碱类氨基酯化合物可用于预防和/或治疗支气管阻塞性或炎性疾病。
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20.发明授权公开(公告)号：US10087176B2
公开(公告)日：2018-10-02
申请号：US15316401
申请日：2014-06-04
发明人： Gabriele Amari , Elisabetta Armani , Mauro Riccaboni , Andrea Rizzi , Charles Baker-Glenn , Wesley Blackaby , Herve Van De Poel , Ben Whittaker
IPC分类号： C07D453/02
摘要： The invention relates to novel 3,5-dichloro,4-(3,4-(cyclo-) alkoxyphenyl)-2-carbonyloxy)ethyl)pyridine compounds which are inhibitors of the phosphodiesterase 4 (PDE4) enzyme and muscarinic M3 receptor antagonists, methods of preparing such compounds, compositions containing them and therapeutic use thereof.
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