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11.发明申请ISOFLAVONE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME 有权ISOFLAVONE衍生物和包含其的药物组合物公开(公告)号：US20090215767A1
公开(公告)日：2009-08-27
申请号：US12241671
申请日：2008-09-30
申请人： Cherng-Chyi TZENG , Yeh-Long Chen , Gwo-Jaw Wang , Mei-Ling Ho , Je-Ken Chang , Yin-Chih Fu
发明人： Cherng-Chyi TZENG , Yeh-Long Chen , Gwo-Jaw Wang , Mei-Ling Ho , Je-Ken Chang , Yin-Chih Fu
IPC分类号： A61K31/5377 , C07D311/28 , C07D407/02 , C07D409/02 , A61K31/38 , A61K31/353 , A61K31/496 , C07D405/02 , C07D413/12
CPC分类号： C07D407/12 , C07D311/36
摘要： An isoflavone derivative is provided. The isoxazole derivative has following formula: wherein R1 and R2, independently, include C1-C12 alkyl optionally substituted with oxirane, thiirane, aziridine, amino, cycloamino, aminohydroxy or cycloaminohydroxy, and R3 includes hydrogen, hydroxy or C1-C12 alkoxy optionally substituted with oxirane, thiirane, aziridine, amino, cycloamino, aminohydroxy or cycloaminohydroxy. The invention also provides a pharmaceutical composition for treatment of osteoporosis including an isoflavone derivative or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier.
摘要翻译： 提供异黄酮衍生物。 异恶唑衍生物具有下式：其中R1和R2独立地包括任选地被环氧乙烷，硫杂环丁烷，氮丙啶，氨基，环氨基，氨基羟基或环氨基羟基取代的C1-C12烷基，R3包括氢，羟基或任选被 环氧乙烷，硫杂环丁烷，氮丙啶，氨基，环氨基，氨基羟基或环氨基羟基。 本发明还提供了用于治疗骨质疏松症的药物组合物，其包括异黄酮衍生物或其药学上可接受的盐和药学上可接受的载体。
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公开(公告)号：US08586533B2
公开(公告)日：2013-11-19
申请号：US12638816
申请日：2009-12-15
申请人： Mei-Ling Ho , Gwo-Jaw Wang , Je-Ken Chang , Yin-Chih Fu , Chung-Hwan Chen
发明人： Mei-Ling Ho , Gwo-Jaw Wang , Je-Ken Chang , Yin-Chih Fu , Chung-Hwan Chen
CPC分类号： A61K38/29
摘要： A method for treating early-stage osteoarthritis in an animal is provided. The method comprises delivery of a therapeutically effective amount of a parathyroid hormone (PTH) or a PTH derived substance to an affected joint cavity of the patient. Methods for inhibiting articular chondrocytes apoptosis and for inhibiting a degenerative process of articular chondrocytes in an afflicted animal are also provided.
摘要翻译： 提供了一种治疗动物早期骨关节炎的方法。 该方法包括将治疗有效量的甲状旁腺激素（PTH）或PTH衍生物质递送至患者的受影响的关节腔。 还提供了在受影响的动物中抑制关节软骨细胞凋亡和抑制关节软骨细胞退行过程的方法。
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13.发明申请METHOD FOR CONTROLLED RELEASE OF PARATHYROID HORMONE FROM CROSS-LINKED HYALURONIC ACID HYDROGEL 有权从交联羟丙酸水合物中控制释放天冬酰胺的方法公开(公告)号：US20130183349A1
公开(公告)日：2013-07-18
申请号：US13349533
申请日：2012-01-12
申请人： Mei-Ling Ho , Rajalakshmanan Eswaramoorthy , Shun-Cheng Wu , Gwo-Jaw Wang , Je-Ken Chang , Yin-Chih Fu , Cherng-Chyi Tzeng , Hui-Ting Chen , Yao-Hsien Wang
发明人： Mei-Ling Ho , Rajalakshmanan Eswaramoorthy , Shun-Cheng Wu , Gwo-Jaw Wang , Je-Ken Chang , Yin-Chih Fu , Cherng-Chyi Tzeng , Hui-Ting Chen , Yao-Hsien Wang
摘要： A method for locally controlled release of an effective amount of PTH(1-34) by a hyaluronic acid based hydrogel that can injected intra-articularly for the treatment of osteoarthritis is provided.
摘要翻译： 提供了一种通过可关节内注射用于治疗骨关节炎的透明质酸基水凝胶局部控制释放有效量的PTH（1-34）的方法。
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14.发明授权公开(公告)号：US08138184B2
公开(公告)日：2012-03-20
申请号：US12243376
申请日：2008-10-01
申请人： Cherng-Chyi Tzeng , Yeh-Long Chen , Gwo-Jaw Wang , Mei-Ling Ho , Je-Ken Chang , Yin-Chih Fu
发明人： Cherng-Chyi Tzeng , Yeh-Long Chen , Gwo-Jaw Wang , Mei-Ling Ho , Je-Ken Chang , Yin-Chih Fu
IPC分类号： A61K31/5377 , A61K31/4525 , A61K31/42 , C07D413/02 , C07D413/12 , C07D261/06
CPC分类号： C07D261/08
摘要： An isoxazole derivative is provided. The isoxazole derivative has following formula: wherein R1, R2, R3, R4 and R5, independently, include hydrogen, hydroxy or C1-C12 alkoxy optionally substituted with oxirane, thiirane, aziridine, amino, cycloamino, aminohydroxy or cycloaminohydroxy. The invention also provides a pharmaceutical composition for treatment of osteoporosis and cancer including an isoxazole derivative or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier.
摘要翻译： 提供异恶唑衍生物。 异恶唑衍生物具有下式：其中R 1，R 2，R 3，R 4和R 5独立地包括任选被环氧乙烷，硫杂环丁烷，氮丙啶，氨基，环氨基，氨基羟基或环氨基羟基取代的氢，羟基或C 1 -C 12烷氧基。 本发明还提供了用于治疗骨质疏松症和癌症的药物组合物，包括异恶唑衍生物或其药学上可接受的盐和药学上可接受的载体。
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公开(公告)号：US08889828B2
公开(公告)日：2014-11-18
申请号：US13278844
申请日：2011-10-21
申请人： Hui-Ting Chen , Kuang-Chan Hsieh , Je-Ken Chang , Gwo-Jaw Wang , Yin-Chih Fu , Mei-Ling Ho , Cherng-Chyi Tzeng
发明人： Hui-Ting Chen , Kuang-Chan Hsieh , Je-Ken Chang , Gwo-Jaw Wang , Yin-Chih Fu , Mei-Ling Ho , Cherng-Chyi Tzeng
CPC分类号： A61K47/48207 , A61K38/06 , A61K47/595 , C07K5/0815 , C08G69/48 , C08G73/028
摘要： A series of peptides with divergent confirmations including structures of formula (1A), (1B), (2) and (3) are provided. In the formula, wherein U, G, A, B, R1, R2 and T are as defined in the specification. The divergent peptides disclosed in the present invention are characterized in a mineral binding affinity function.
摘要翻译： 提供了包括式（1A），（1B），（2）和（3）结构的发散确认的一系列肽。 在其中U，G，A，B，R 1，R 2和T如说明书中所定义的式中。 本发明中公开的发散肽的特征在于矿物结合亲和力。
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公开(公告)号：US08530420B2
公开(公告)日：2013-09-10
申请号：US12336209
申请日：2008-12-16
申请人： Mei-Ling Ho , Gwo-Jaw Wang , Je-Ken Chang , Yin-Chih Fu , Chung-Hwan Chen
发明人： Mei-Ling Ho , Gwo-Jaw Wang , Je-Ken Chang , Yin-Chih Fu , Chung-Hwan Chen
CPC分类号： A61K38/29 , A61K31/663 , A61K45/06 , A61K2300/00
摘要： A method for treating and/or inhibiting arthritis is provided. The method includes administering an effective amount of a composition including a parathyroid hormone and a pharmaceutically acceptable carrier or salt to a subject with arthritis. Additionally, a method for inhibiting and/or rescuing terminal differentiation of cells is also provided.
摘要翻译： 提供了治疗和/或抑制关节炎的方法。 该方法包括向患有关节炎的受试者施用有效量的包括甲状旁腺激素和药学上可接受的载体或盐的组合物。 此外，还提供了用于抑制和/或挽救细胞末端分化的方法。
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公开(公告)号：US20130171197A1
公开(公告)日：2013-07-04
申请号：US13338800
申请日：2011-12-28
申请人： Mei-Ling Ho , Rajalakshmanan Eswaramoorthy , Shun-Cheng Wu , Gwo-Jaw Wang , Je-Ken Chang , Yin-Chih Fu , Cherng-Chyi Tzeng , Chau-Zen Wang
发明人： Mei-Ling Ho , Rajalakshmanan Eswaramoorthy , Shun-Cheng Wu , Gwo-Jaw Wang , Je-Ken Chang , Yin-Chih Fu , Cherng-Chyi Tzeng , Chau-Zen Wang
CPC分类号： C12N5/0068 , A61K47/36 , C12N5/0667 , C12N2533/40 , C12N2533/80 , C12N2537/10
摘要： The present invention provides a hydrogel comprising a poly(N-isopropylacrylamide) cross-linked hyaluronic acid. The present invention also provides a method of synthesizing a hydrogel comprising poly(N-isopropylacrylamide) cross-linked hyaluronic acid, which comprises (a) synthesizing methacrylated hyaluronic acid; and (b) copolymerizing methacrylated hyaluronic acid with N-isopropylacrylamide.
摘要翻译： 本发明提供包含聚（N-异丙基丙烯酰胺）交联透明质酸的水凝胶。 本发明还提供一种合成包含聚（N-异丙基丙烯酰胺）交联透明质酸的水凝胶的方法，其包括（a）合成甲基丙烯酸酯化的透明质酸; 和（b）将甲基丙烯酸酯化的透明质酸与N-异丙基丙烯酰胺共聚。
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公开(公告)号：US09314503B2
公开(公告)日：2016-04-19
申请号：US12832248
申请日：2010-07-08
申请人： Yin-Chin Fu , Chih-Kuang Wang , Gwo-Jaw Wang , Mei-Ling Ho , Je-Ken Chang , Cherng-Chyi Tzeng
发明人： Yin-Chin Fu , Chih-Kuang Wang , Gwo-Jaw Wang , Mei-Ling Ho , Je-Ken Chang , Cherng-Chyi Tzeng
CPC分类号： A61K38/1875 , A61K9/146 , A61K9/5031 , A61K38/1825 , A61K38/1841 , A61K38/1858 , A61K38/29 , A61K38/30
摘要： The present invention relates to a hydrophilic drug and β-tricalcium phosphate (β-TCP) coating on a surface area of biopolymer matrix to form a sustained release system. The present invention also provides a method for preparing a sustained release system, comprising providing a surface are of biopolymer matrix coated with a hydrophilic drug and β-TCP.
摘要翻译： 本发明涉及生物聚合物基质表面上的亲水药物和磷酸三钙（＆bgr-TCP）涂层，以形成持续释放系统。 本发明还提供了一种制备持续释放系统的方法，其包括提供涂覆有亲水药物和重组体的生物聚合物基质的表面。
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公开(公告)号：US20110052691A1
公开(公告)日：2011-03-03
申请号：US12832248
申请日：2010-07-08
申请人： Yin-Chin Fu , Chih-Kuang Wang , Gwo-Jaw Wang , Mei-Ling Ho , Je-Ken Chang , Cherng-Chyi Tzeng
发明人： Yin-Chin Fu , Chih-Kuang Wang , Gwo-Jaw Wang , Mei-Ling Ho , Je-Ken Chang , Cherng-Chyi Tzeng
CPC分类号： A61K38/1875 , A61K9/146 , A61K9/5031 , A61K38/1825 , A61K38/1841 , A61K38/1858 , A61K38/29 , A61K38/30
摘要： The present invention relates to a hydrophilic drug and β-tricalcium phosphate (β-TCP) coating on a surface area of biopolymer matrix to form a sustained release system. The present invention also provides a method for preparing a sustained release system, comprising providing a surface are of biopolymer matrix coated with a hydrophilic drug and β-TCP.
摘要翻译： 本发明涉及生物聚合物基质表面上的亲水药物和磷酸三钙（＆bgr-TCP）涂层，以形成持续释放系统。 本发明还提供了一种制备持续释放系统的方法，其包括提供涂覆有亲水药物和重组体的生物聚合物基质的表面。
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公开(公告)号：US09173969B2
公开(公告)日：2015-11-03
申请号：US13443996
申请日：2012-04-11
申请人： Hui-Min Wang , Mei-Ling Ho , Gwo-Jaw Wang , Je-Ken Chang , Yi-Ting Chou , Ching-Ying Wu , Su-Shin Lee
发明人： Hui-Min Wang , Mei-Ling Ho , Gwo-Jaw Wang , Je-Ken Chang , Yi-Ting Chou , Ching-Ying Wu , Su-Shin Lee
CPC分类号： A61L15/28 , A61L15/32 , A61L15/325 , A61L15/425 , A61L27/3813 , A61L27/3886 , A61L27/60 , C08L5/08
摘要： The present invention provides a biomaterial comprising a scaffold consisting of collagen, hyaluronic acid, and gelatin, which are cross-linked via ethyl-3-[3-dimethylaminopropyl]carbodiimide (EDC) between any two of collagen, hyaluronic acid, and gelatin. The present invention further provides a method for preparing the biomaterial and a method for enhancing wound healing with the biomaterial.
摘要翻译： 本发明提供一种生物材料，其包含由胶原，透明质酸和明胶组成的支架，其通过任何两种胶原，透明质酸和明胶之间的乙基-3- [3-二甲基氨基丙基]碳二亚胺（EDC）进行交联。 本发明还提供了一种用于制备生物材料的方法和用生物材料增强伤口愈合的方法。
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