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    Process for the continuous production of high purity phenolic glycol ether
    13.
    发明授权
    Process for the continuous production of high purity phenolic glycol ether 有权
    连续生产高纯度酚醛二醇醚的方法

    公开(公告)号：US08558029B2

    公开(公告)日：2013-10-15

    申请号：US12745648

    申请日：2008-12-08

    申请人： Max Tirtowidjojo ,  Edward D. Daugs

    发明人： Max Tirtowidjojo ,  Edward D. Daugs

    IPC分类号： C07C43/23

    CPC分类号： C07C41/03 ,  Y02P20/582 ,  C07C43/23

    摘要： Phenolic glycol ethers, e.g., ethylene glycol phenyl ether, are prepared by a continuous, nonaqueous process comprising the steps of (A) contacting under isothermal reactive conditions in a first reactor or reaction zone an alkylene oxide, e.g., ethylene oxide, with (i) a stoichiometric molar excess of a phenolic compound, e.g., phenol, and (ii) a catalytic amount of a base, e.g., sodium hydroxide, homogeneously dispersed throughout the phenolic compound, to form a first intermediate phenolic glycol ether product, (Bj transferring the first intermediate phenolic glycol ether product to a second reactor or reaction zone, and (C) subjecting the first intermediate phenolic glycol ether product to adiabatic reactive conditions in the second reactor or reaction zone to form a second intermediate phenolic glycol ether product comprising phenolic glycol ether, unreacted phenolic compound, catalyst, water and byproduct glycols. In addition, the mono-/di-product weight ratio can be adjusted by increasing or decreasing the amount of base catalyst employed.

    摘要翻译： 酚醛二醇醚，例如乙二醇苯基醚，通过连续的非水性方法制备，包括以下步骤：（A）在等温反应条件下在第一反应器或反应区中接触环氧烷，例如环氧乙烷与（i ）化学计量摩尔过量的酚类化合物，例如苯酚，和（ii）催化量的碱，例如均匀分散在整个酚类化合物中的氢氧化钠，形成第一中间体酚二醇醚产物（Bj转移 将第一中间体酚二醇醚产物加入到第二反应器或反应区中，和（C）使第一中间体酚二醇醚产物在第二反应器或反应区中进行绝热反应条件以形成包含酚二醇的第二中间体酚二醇醚产物 醚，未反应的酚类化合物，催化剂，水和副产物二醇，另外，单/二产物重量比可以通过 增加或减少所用的碱催化剂的量。

    Process for Reducing Inorganics from and Concentrating Anionic Surfactant Solutions
    14.
    发明申请
    Process for Reducing Inorganics from and Concentrating Anionic Surfactant Solutions 有权
    减少阴离子表面活性剂溶液无机物浓缩的方法

    公开(公告)号：US20120078008A1

    公开(公告)日：2012-03-29

    申请号：US13242963

    申请日：2011-09-23

    申请人： Edward D. Daugs

    发明人： Edward D. Daugs

    IPC分类号： C07C303/44

    CPC分类号： C07C303/44 ,  C07C309/10

    摘要： A process including contacting one or more Strecker sulfonation reaction products of one or more halogenated alkyl ethers in the presence of sulfite with one or more polar water soluble organic solvents selected from acetone, methyl ethyl ketone, the C2-C5 alkyl alcohols, and the like, to form an extraction mixture; allowing the extraction mixture to separate into an aqueous phase and an organic phase; and separating the aqueous phase from the organic phase; wherein the one or more Strecker sulfonation reaction products each comprise at least 30 percent by weight of one or more inorganic salts and the organic phase following separation comprises less than 20 percent by weight of one or more inorganic salts, is provided.

    摘要翻译： 一种方法，包括在亚硫酸盐存在下使一种或多种卤代烷基醚的一种或多种磺化反应产物与一种或多种选自丙酮，甲基乙基酮，C 2 -C 5烷基醇等的极性水溶性有机溶剂接触 ，形成提取混合物; 使萃取混合物分离成水相和有机相; 并将水相与有机相分离; 其中一个或多个Strecker磺化反应产物各自包含至少30重量％的一种或多种无机盐，分离后的有机相包含小于20重量％的一种或多种无机盐。

    Process for making amino acids
    15.
    发明授权
    Process for making amino acids 失效
    制备氨基酸的方法

    公开(公告)号：US07671231B2

    公开(公告)日：2010-03-02

    申请号：US11333937

    申请日：2006-01-18

    申请人： Michael C. Lloyd ,  Edward D. Daugs ,  Cynthia L. Rand ,  Wei-Jun Peng

    发明人： Michael C. Lloyd ,  Edward D. Daugs ,  Cynthia L. Rand ,  Wei-Jun Peng

    IPC分类号： C07C227/12

    CPC分类号： C07C227/32 ,  C07D317/30 ,  C12P13/04 ,  C12P41/006

    摘要： A process for making an amino acid by the steps of: (a) contacting a compound of formula I with a hydroformylation catalyst and synthesis gas to produce a mixture of aldehyde compounds comprising the formulas IIa, IIb and IIc; (b) reacting the mixture of aldehyde compounds from step (a) to produce a mixture of derivative compounds; (c) contacting the mixture of derivative compounds from step (b) with an enantioselective hydrolase enzyme in the presence of water to produce an L-amino acid having the formula IV; (d) isolating the amino acid having the formula IV in substantially pure form, wherein in formulas I, IIa, IIb, IIc, IIIa, IIIb, IIIc and IV, R is H, alkyl or aryl and R1 and R2 are the same or different alkyl groups and wherein R1 and R2 may be fused.

    摘要翻译： 通过以下步骤制备氨基酸的方法：（a）使式I化合物与加氢甲酰化催化剂和合成气接触以产生包含式IIa，IIb和IIc的醛化合物的混合物; （b）使来自步骤（a）的醛化合物的混合物反应以产生衍生化合物的混合物; （c）在水存在下将来自步骤（b）的衍生化合物的混合物与对映选择性水解酶接触以产生具有式IV的L-氨基酸; （d）以基本上纯的形式分离具有式IV的氨基酸，其中在式I，IIa，IIb，IIc，IIIa，IIIb，IIIc和IV中，R是H，烷基或芳基，R 1和R 2相同或 不同的烷基，其中R 1和R 2可以稠合。

    Process for reducing inorganics from anionic surfactant solutions
    16.
    发明授权
    Process for reducing inorganics from anionic surfactant solutions 有权
    从阴离子表面活性剂溶液中降低无机物的方法

    公开(公告)号：US09315404B2

    公开(公告)日：2016-04-19

    申请号：US13989929

    申请日：2011-12-05

    申请人： Mark R. Smit ,  Edward D. Daugs ,  Raymond M. Collins

    发明人： Mark R. Smit ,  Edward D. Daugs ,  Raymond M. Collins

    IPC分类号： C07C309/00 ,  C02F9/00 ,  B01D61/02 ,  C07C303/44

    CPC分类号： C02F9/00 ,  B01D61/027 ,  C07C303/44 ,  C07C309/10

    摘要： A process comprising contacting deionized water with one or more Strecker sulfonation reaction products of one or more halogenated alkyl ethers in the presence of sulfite, wherein the one or more Strecker sulfonation reaction products each comprise one or more inorganic salts on a dry basis and one or more surfactant components, form a filtration mixture; loading the filtration mixture into a high pressure filtration system containing a membrane having a membrane molecular weight cutoff allowing preferential passage of the inorganic salts, for example, of greater than or equal to 200 Daltons; wherein the high pressure filtration system is operated at a pressure greater than ambient pressure and is configured to cause crossflow of the filtration mixture along a surface of the membrane resulting in a permeate solution which substantially passes through the membrane and a retentate solution which substantially does not pass through the membrane; wherein the permeate comprises less than or equal to 15 weight percent surfactant component, based on the weight of the filtration mixture is provided.

    摘要翻译： 一种方法，其包括在亚硫酸盐存在下使去离子水与一种或多种卤化烷基醚的一种或多种降解性磺化反应产物接触，其中所述一种或多种Strecker磺化反应产物各自包含一个或多个基于干基的无机盐， 更多的表面活性剂组分，形成过滤混合物; 将过滤混合物装入含有具有膜分子量截留的膜的高压过滤系统，允许无机盐优先通过，例如大于或等于200道尔顿; 其中所述高压过滤系统在大于环境压力的压力下操作并且被配置成使所述过滤混合物沿所述膜的表面交叉流动，导致基本上通过所述膜的渗透液和基本上不通过所述膜的渗余物溶液 通过膜; 其中所述渗透物包含基于所述过滤混合物的重量的小于或等于15重量％的表面活性剂组分。

    Crystalline solid and amorphous forms of (−)- halofenate and methods related thereto
    17.
    发明授权
    Crystalline solid and amorphous forms of (−)- halofenate and methods related thereto 有权
    （ - ） - 卤化物的结晶固体和无定形形式及其相关方法

    公开(公告)号：US08203019B2

    公开(公告)日：2012-06-19

    申请号：US11408609

    申请日：2006-04-20

    申请人： Edward D. Daugs ,  Eric J. Hagen ,  Jason A. Hanko ,  David H. Louks

    发明人： Edward D. Daugs ,  Eric J. Hagen ,  Jason A. Hanko ,  David H. Louks

    IPC分类号： C07C69/76 ,  C07C69/63 ,  C07C67/02 ,  A61K31/235 ,  A61K31/22

    CPC分类号： C07C233/18 ,  A61K9/0053 ,  A61K31/216 ,  C07B2200/07 ,  C07B2200/13 ,  C07C235/78

    摘要： The present invention provides crystalline solid and amorphous forms of (−)-halofenate. The crystalline solid forms may be used in various pharmaceutical compositions, and are particularly effective for the prevention and/or treatment of conditions associated with blood lipid deposition in a mammal, particularly those diseases related to Type 2 diabetes and hyperlipidemia. The invention also relates to a method for preventing or treating Type 2 diabetes and hyperlipidemia in a mammal comprising the step of administering a therapeutically effective amount of crystalline solid and amorphous forms of (−)-halofenate.

    摘要翻译： 本发明提供（ - ） - 卤代苯甲酸酯的结晶固体和无定形形式。 结晶固体形式可以用于各种药物组合物中，并且对于预防和/或治疗与哺乳动物血脂沉积相关的病症，特别是涉及2型糖尿病和高脂血症的疾病特别有效。 本发明还涉及一种用于预防或治疗哺乳动物的2型糖尿病和高脂血症的方法，其包括施用治疗有效量的（ - ） - 氟酸盐的结晶固体和无定形形式的步骤。