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    Optical coherence tomography device and system
    11.
    发明授权
    Optical coherence tomography device and system 有权

    公开(公告)号：US11460292B2

    公开(公告)日：2022-10-04

    申请号：US16478300

    申请日：2018-01-17

    Applicant: Duke University

    Inventor： Adam Wax ,  Michael Crose ,  William Brown

    IPC: G01B9/02091 ,  A61B3/12 ,  A61B5/00 ,  G01J3/02 ,  G01J3/45

    Abstract: An optical coherence tomography (OCT) scan device includes an OCT scan device housing, an interferometer disposed in within the OCT scan device housing and including a light source, a fiber optic coupler including an interferometer output, a reference-arm, and a sample-arm. The OCT scan device further includes a power source configured to provide power to the light source and the remaining components of the OCT scan device, and a controller disposed within the OCT scan device housing and configured to adjust lens focusing parameters in the reference-arm and the sample-arm, and control a scanning function of an optical beam emitting from the sample-arm. The OCT scan device is further configured to transmit and receive control instructions and transmit fundus image data.

    MULTIPLE WINDOW PROCESSING SCHEMES FOR SPECTROSCOPIC OPTICAL COHERENCE TOMOGRAPHY (OCT) AND FOURIER DOMAIN LOW COHERENCE INTERFEROMETRY
    13.
    发明申请
    MULTIPLE WINDOW PROCESSING SCHEMES FOR SPECTROSCOPIC OPTICAL COHERENCE TOMOGRAPHY (OCT) AND FOURIER DOMAIN LOW COHERENCE INTERFEROMETRY 有权
    用于光谱光学相干（OCT）和FOURIER DOMAIN低相干干涉的多窗口处理方案

    公开(公告)号：US20160290867A1

    公开(公告)日：2016-10-06

    申请号：US15050368

    申请日：2016-02-22

    Applicant: Duke University

    Inventor： Adam Wax ,  Robert N. Graf ,  Francisco E. Robles

    IPC: G01J3/453 ,  G01B9/02

    CPC classification number: G01J3/453 ,  G01B9/02044 ,  G01B9/02084 ,  G01B9/02087 ,  G01B9/02091 ,  G01J3/45 ,  G01J2003/4538 ,  G01N21/49

    Abstract: Current apparatuses and methods for analysis of spectroscopic optical coherence tomography (SOCT) signals suffer from an inherent tradeoff between time (depth) and frequency (wavelength) resolution. In one non-limiting embodiment, multiple or dual window (DW) apparatuses and methods for reconstructing time-frequency distributions (TFDs) that applies two windows that independently determine the optical and temporal resolution is provided. For example, optical resolution is provided. For example, optical resolution may relate to scattering information about a sample, and temporal resolution may be related to absorption or depth related information. The effectiveness of the apparatuses and methods is demonstrated in simulations and in processing of measured OCT signals that contain fields which vary in time and frequency. The DW technique may yield TFDs that maintain high spectral and temporal resolution and are free from the artifacts and limitations commonly observed with other processing methods.

    Abstract translation: 分光光学相干断层扫描（SOCT）信号的分析的现有装置和方法遭受时间（深度）和频率（波长）分辨率之间固有的折中。 在一个非限制性实施例中，提供了用于重建施加独立地确定光学和时间分辨率的两个窗口的时间频率分布（TFD）的多重或双窗口（DW）装置和方法。 例如，提供了光学分辨率。 例如，光学分辨率可以涉及关于样本的散射信息，并且时间分辨率可以与吸收或深度相关信息相关。 在模拟和处理包含在时间和频率上变化的场的测量的OCT信号中证明了装置和方法的有效性。 DW技术可以产生维持高光谱和时间分辨率的TFD，并且不存在通常用其它处理方法观察到的伪像和限制。

    Systems and methods for endoscopic angle-resolved low coherence interferometry
    14.
    发明授权
    Systems and methods for endoscopic angle-resolved low coherence interferometry 有权

    公开(公告)号：US10292595B2

    公开(公告)日：2019-05-21

    申请号：US15634456

    申请日：2017-06-27

    Applicant: Duke University

    Inventor： Adam Wax ,  John W. Pyhtila

    IPC: G01B9/02 ,  G01J3/45 ,  A61B5/00 ,  G01N21/31 ,  G01N21/47 ,  A61B1/00

    Abstract: A method of assessing tissue health comprises the steps of obtaining depth-resolved spectra of a selected area of in vivo tissue, and assessing the health of the selected area based on the depth-resolved structural information of the scatterers. Obtaining depth-resolved spectra of the selected area comprises directing a sample beam towards the selected area at an angle, and receiving an angle-resolved scattered sample beam. The angle-resolved scattered sample beam is cross-correlated with the reference beam to produce an angle-resolved cross-correlated signal about the selected area, which is spectrally dispersed to yield an angle-resolved, spectrally-resolved cross-correlation profile having depth-resolved information about the selected area. The angle-resolved, spectrally-resolved cross-correlation profile is processed to obtain depth-resolved information about scatterers in the selected area.

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