公开(公告)号：US10775308B2

公开(公告)日：2020-09-15

申请号：US11844551

申请日：2007-08-24

申请人： Daniel G. Stearns ,  Bradley W. Rice

发明人： Daniel G. Stearns ,  Bradley W. Rice

IPC分类号： G01N21/64 ,  A61B5/00 ,  G01N21/47

摘要： Disclosed are apparatus and methods for determining accurate optical property values of turbid media. In one embodiment, the method includes (a) providing a light source, having a first wavelength and a known illumination power, sequentially at a plurality of specific illumination positions on a first surface of the specimen; (b) for each specific position of the light source, obtaining light emission measurements from a second surface of the specimen that is opposite the first surface, wherein the light emission measurements are obtained for a plurality of surface positions of the second surface; and (c) for each specific illumination position of the light source at the first surface of the specimen, determining one or more optical properties for the specimen based on the specific illumination position of the light source, the first wavelength of the light source, the known illumination power of the light source, and the obtained light emission measurements for such each specific illumination position. The optical properties for the plurality of specific illumination positions of the light source are individually determined for each specific illumination position of the light source.

公开(公告)号：US08825140B2

公开(公告)日：2014-09-02

申请号：US13397518

申请日：2012-02-15

申请人： Bradley W. Rice ,  Daniel G. Stearns ,  Tamara L. Troy

发明人： Bradley W. Rice ,  Daniel G. Stearns ,  Tamara L. Troy

IPC分类号： A61B6/00

CPC分类号： G01N21/6456 ,  G01N21/4795 ,  G01N21/6428

摘要： A method of investigating the location and size of a light-emitting source in a subject is disclosed. In practicing the method, one first obtains a light intensity profile by measuring, from a first perspective with a photodetector device, photons which (i) originate from the light-emitting source, (ii) travel through turbid biological tissue of the subject, and (iii) are emitted from a first surface region of interest of the subject. The light-intensity profile is matched against with a parameter-based biophotonic function, to estimate function parameters such as depth and size. The parameters so determined are refined using data other than the first measured light intensity profile, to obtain an approximate depth and size of the source in the subject. Also disclosed is an apparatus for carrying out the method.

摘要翻译： 公开了一种调查受试者中发光源的位置和尺寸的方法。 在实施该方法时，首先通过用光电检测器件从第一个角度测量光源（i）来源于发光源，（ii）穿过受试者的混浊生物组织，以及 （iii）从对象的感兴趣的第一表面区域发射。 光强度曲线与基于参数的生物光子函数匹配，以估计诸如深度和大小的函数参数。 使用除第一测量光强度分布之外的数据来精确地确定如此确定的参数，以获得对象中源的近似深度和大小。 还公开了一种用于执行该方法的装置。

公开(公告)号：US07860549B2

公开(公告)日：2010-12-28

申请号：US12569842

申请日：2009-09-29

申请人： Daniel G. Stearns ,  Bradley W. Rice ,  Michael D. Cable

发明人： Daniel G. Stearns ,  Bradley W. Rice ,  Michael D. Cable

IPC分类号： A61B6/03 ,  A61B6/12

CPC分类号： G01N21/763 ,  A61K49/0013 ,  G01B9/02004 ,  G01B9/0203 ,  G01B9/02041 ,  G01B11/24 ,  G01B11/2518 ,  G01N21/6456 ,  H04N13/204 ,  H04N13/25 ,  H04N13/271

摘要： The present invention provides systems and methods for obtaining a three-dimensional (3D) representation of one or more light sources inside a sample, such as a mammal. Mammalian tissue is a turbid medium, meaning that photons are both absorbed and scattered as they propagate through tissue. In the case where scattering is large compared with absorption, such as red to near-infrared light passing through tissue, the transport of light within the sample is described by diffusion theory. Using imaging data and computer-implemented photon diffusion models, embodiments of the present invention produce a 3D representation of the light sources inside a sample, such as a 3D location, size, and brightness of such light sources.

摘要翻译： 本发明提供用于获得样品（例如哺乳动物）内的一个或多个光源的三维（3D）表示的系统和方法。 哺乳动物组织是一种混浊的培养基，这意味着光子在通过组织传播时被吸收和分散。 在与吸收相比散射大的情况下，例如通过组织的红色至近红外光，通过扩散理论描述样品内的光的传输。 使用成像数据和计算机实现的光子扩散模型，本发明的实施例产生样品内的光源的3D表示，例如这种光源的3D位置，尺寸和亮度。

公开(公告)号：US07616985B2

公开(公告)日：2009-11-10

申请号：US10606976

申请日：2003-06-25

申请人： Daniel G. Stearns ,  Bradley W. Rice ,  Michael D. Cable

发明人： Daniel G. Stearns ,  Bradley W. Rice ,  Michael D. Cable

IPC分类号： A61B6/03 ,  A61B6/12

CPC分类号： G01N21/763 ,  A61K49/0013 ,  G01B9/02004 ,  G01B9/0203 ,  G01B9/02041 ,  G01B11/24 ,  G01B11/2518 ,  G01N21/6456 ,  H04N13/204 ,  H04N13/25 ,  H04N13/271

摘要： The present invention provides systems and methods for obtaining a three-dimensional (3D) representation of one or more light sources inside a sample, such as a mammal. Mammalian tissue is a turbid medium, meaning that photons are both absorbed and scattered as they propagate through tissue. In the case where scattering is large compared with absorption, such as red to near-infrared light passing through tissue, the transport of light within the sample is described by diffusion theory. Using imaging data and computer-implemented photon diffusion models, embodiments of the present invention produce a 3D representation of the light sources inside a sample, such as a 3D location, size, and brightness of such light sources.

公开(公告)号：US07403812B2

公开(公告)日：2008-07-22

申请号：US10151463

申请日：2002-05-17

申请人： Bradley W. Rice ,  Daniel G. Stearns ,  Tamara L. Troy

发明人： Bradley W. Rice ,  Daniel G. Stearns ,  Tamara L. Troy

IPC分类号： A61B6/00

CPC分类号： G01N21/6456 ,  G01N21/4795 ,  G01N21/6428

摘要： A method of investigating the location and size of a light-emitting source in a subject is disclosed. In practicing the method, one first obtains a light intensity profile by measuring, from a first perspective with a photodetector device, photons which (i) originate from the light-emitting source, (ii) travel through turbid biological tissue of the subject, and (iii) are emitted from a first surface region of interest of the subject. The light-intensity profile is matched against with a parameter-based biophotonic function, to estimate function parameters such as depth and size. The parameters so determined are refined using data other than the first measured light intensity profile, to obtain an approximate depth and size of the source in the subject. Also disclosed is an apparatus for carrying out the method.

摘要翻译： 公开了一种调查受试者中发光源的位置和尺寸的方法。 在实施该方法时，首先通过用光电检测器件从第一个角度测量光源（i）来源于发光源，（ii）穿过受试者的混浊生物组织，以及 （iii）从对象的感兴趣的第一表面区域发射。 光强度曲线与基于参数的生物光子函数匹配，以估计诸如深度和大小的函数参数。 使用除第一测量光强度分布之外的数据来精确地确定如此确定的参数，以获得对象中源的近似深度和大小。 还公开了一种用于执行该方法的装置。

公开(公告)号：US08279334B2

公开(公告)日：2012-10-02

申请号：US11871062

申请日：2007-10-11

申请人： David Nilson ,  Michael D. Cable ,  Bradley W. Rice ,  Kevin Kearney

发明人： David Nilson ,  Michael D. Cable ,  Bradley W. Rice ,  Kevin Kearney

IPC分类号： H04N5/225 ,  A61B6/00

CPC分类号： G01B11/2513 ,  A61B5/0059 ,  A61B5/0064 ,  A61B5/107 ,  A61B5/6888 ,  A61B2503/40 ,  G01B11/2518 ,  G01N21/6456 ,  G01N21/763 ,  G06T7/521 ,  H04N13/254

摘要： The present invention integrates a structured light source into an imaging system for reconstructing surface topography of an object being imaged. The structured light source includes a mechanism for transmitting a set of lines onto the object from an angle. The lines are displaced, or phase shifted relative to a stage, when they encounter an object with finite height, such as a mouse. This phase shift provides structured light information for the object. A camera captures the structured light information. Using software that employs a structured light analysis, surface topography data for the object is determined from the phase shift of the lines.

摘要翻译： 本发明将结构化光源集成到成像系统中，用于重建被成像物体的表面形貌。 结构化光源包括用于从一角度将一组线传送到物体上的机构。 当它们遇到具有有限高度的对象（例如鼠标）时，线相对于舞台移位或相移。 该相移提供了对象的结构光信息。 相机拍摄结构光信息。 使用采用结构光分析的软件，根据线的相移确定物体的表面形貌数据。

公开(公告)号：US08044996B2

公开(公告)日：2011-10-25

申请号：US11429420

申请日：2006-05-04

申请人： Bradley W. Rice ,  Heng Xu ,  Chaincy Kuo

发明人： Bradley W. Rice ,  Heng Xu ,  Chaincy Kuo

IPC分类号： H04N13/02 ,  G06K9/00 ,  G01B11/24

CPC分类号： A61B5/1077 ,  A61B5/0059 ,  A61B5/1079 ,  G01B11/25 ,  G01N21/532 ,  G01N21/6428 ,  G01N21/6456 ,  G01N21/763 ,  G01N2021/6439 ,  G06T7/521

摘要： The invention relates to topographic construction that combines photographic and structured light information. The dual modality construction acquires structured light information for an object and photographic images from multiple views about the object. Topographic construction then processes the structured light information and photographic data in the multiple images to generate a surface representation of the object in each modality. The photographic and structured light surface representations are then combined to output a dual modality surface topography.

摘要翻译： 本发明涉及结合照相和结构光信息的地形构造。 双重模式结构从物体的多个视图中获取物体的结构光信息和摄影图像。 然后，地形构造处理多个图像中的结构光信息和摄影数据，以在每个模态中生成对象的表面表示。 然后将照相和结构化的光表面表示组合以输出双模态表面形貌。

公开(公告)号：US07649185B2

公开(公告)日：2010-01-19

申请号：US11682710

申请日：2007-03-06

申请人： Bradley W. Rice ,  David G. Nilson ,  Tamara L. Troy

发明人： Bradley W. Rice ,  David G. Nilson ,  Tamara L. Troy

IPC分类号： G01J1/58 ,  A61B6/00 ,  G12B13/00

CPC分类号： G01N21/278 ,  A61B5/0071 ,  A61B5/0073 ,  A61B5/0084 ,  A61B2560/0233 ,  G01J1/08 ,  G01N21/4795 ,  G01N21/643 ,  G09B23/30

摘要： Described herein is a phantom device that simplifies usage, testing, and development of light imaging systems. The phantom device includes a body and a fluorescent light source internal to the body. The body comprises an optical material designed to at least partially resemble the optical behavior of mammalian tissue. The phantom device has many uses. One use of the phantom device permits testing of tomography software in the imaging system, such as software configured for 3D reconstruction of the fluorescent light source. Another use tests spectral unmixing software in the imaging system. The phantom device also allows a user to compare trans- and epi-fluorescent illumination imaging results.

摘要翻译： 这里描述的是简化光成像系统的使用，测试和开发的幻影装置。 幻影装置包括身体和身体内部的荧光光源。 身体包括设计成至少部分类似于哺乳动物组织的光学行为的光学材料。 幻影装置有很多用途。 幻影设备的一个用途允许对成像系统中的断层摄影软件进行测试，例如配置用于荧光光源的3D重建的软件。 另一种用途是在成像系统中测试光谱解混合软件。 幻影装置还允许用户比较透射和外荧光照明成像结果。

公开(公告)号：US07589786B2

公开(公告)日：2009-09-15

申请号：US11486239

申请日：2006-07-12

申请人： David Nilson ,  Michael D. Cable ,  Bradley W. Rice

发明人： David Nilson ,  Michael D. Cable ,  Bradley W. Rice

IPC分类号： H04N5/225 ,  A61B5/06

CPC分类号： G01N21/6456 ,  A61B5/0059 ,  A61B2503/40 ,  G01N21/763

摘要： Systems and methods are provided for taking images of a sample. The sample is placed in an imaging box comprising a moveable stage that allows images of the sample to be taken from various positions and angles within the imaging box. The images are taken by a camera and sent to a processor. Structured light images obtained from one or more views within the imaging box may be used to build a structured light representations of the sample.

摘要翻译： 提供了用于拍摄样本图像的系统和方法。 将样品放置在包括可移动台的成像盒中，该移动台允许从成像盒内的各种位置和角度拍摄样品的图像。 图像由相机拍摄并发送到处理器。 可以使用从成像盒内的一个或多个视图获得的结构化光图像来构建样品的结构光表示。

公开(公告)号：US07881773B2

公开(公告)日：2011-02-01

申请号：US11485920

申请日：2006-07-12

申请人： Michael D. Cable ,  Bradley W. Rice ,  David Nilson

发明人： Michael D. Cable ,  Bradley W. Rice ,  David Nilson

IPC分类号： A61B5/00

CPC分类号： G01N21/76 ,  A61B5/0035 ,  A61B5/0059 ,  A61B5/0077 ,  A61B6/032 ,  A61B6/037 ,  A61B6/4417 ,  A61B6/5247 ,  A61B8/13 ,  A61B8/4416 ,  G01N21/6456 ,  G01N35/0099 ,  G01T1/1603 ,  G01T1/1648 ,  G01T1/2985

摘要： The invention described herein provides systems and methods for multi-modal imaging with light and a second form of imaging. Light imaging involves the capture of low intensity light from a light-emitting object. A camera obtains a two-dimensional spatial distribution of the light emitted from the surface of the subject. Software operated by a computer in communication with the camera may then convert two-dimensional spatial distribution data from one or more images into a three-dimensional spatial representation. The second imaging mode may include any imaging technique that compliments light imaging. Examples include magnetic resonance imaging (MRI) and computer topography (CT). An object handling system moves the object to be imaged between the light imaging system and the second imaging system, and is configured to interface with each system.

摘要翻译： 本文描述的本发明提供了用于具有光和第二形式的成像的多模式成像的系统和方法。 光成像涉及捕获来自发光物体的低强度光。 相机获得从被摄体的表面发射的光的二维空间分布。 由与摄像机通信的计算机操作的软件然后可以将二维空间分布数据从一个或多个图像转换为三维空间表示。 第二成像模式可以包括补充光成像的任何成像技术。 实例包括磁共振成像（MRI）和计算机地形（CT）。 物体处理系统将要成像的对象移动到光成像系统和第二成像系统之间，并且被配置为与每个系统接口。