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公开(公告)号：USD469181S1
公开(公告)日：2003-01-21
申请号：US29149767
申请日：2001-10-15
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公开(公告)号：US07629573B2
公开(公告)日：2009-12-08
申请号：US10997324
申请日：2004-11-24
CPC分类号： A61B5/0073 , A61B5/0071 , A61B5/0075 , A61B5/0084 , A61B2560/0233 , G01N21/278 , G01N21/4795 , G01N21/6428 , G01N21/645 , G01N21/6456 , G01N21/763 , G01N2021/6484
摘要： The present invention relates to a phantom device that simplifies usage and testing of a low intensity light imaging system. The phantom device includes a body and a light source internal to the body. The body comprises an optically selective material designed to at least partially resemble the optical behavior of mammalian tissue. Imaging the light source or phantom device may incorporate known properties of the optically selective material. Testing methods described herein assess the performance of a low-level light imaging system (such as the software) by processing light output by the phantom device and comparing the output against known results. The assessment builds a digital representation of the light source or test device and compares one or more components of the digital representation against one or more known properties for the light source or the test device.
摘要翻译： 本发明涉及简化低强度光成像系统的使用和测试的幻影装置。 幻影装置包括身体和身体内部的光源。 身体包括设计成至少部分类似于哺乳动物组织的光学行为的光学选择性材料。 成像光源或幻影装置可以结合光学选择性材料的已知性质。 本文所述的测试方法通过处理幻影装置的光输出并将输出与已知结果进行比较来评估低级光成像系统（例如软件）的性能。 评估建立光源或测试设备的数字表示，并将数字表示的一个或多个组件与光源或测试设备的一个或多个已知属性进行比较。
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公开(公告)号：US06901279B2
公开(公告)日：2005-05-31
申请号：US10912022
申请日：2004-08-04
申请人： Michael D. Cable , Michael Bo Nelson , Bradley W. Rice , Christopher A. Rasco , David N Sprague , David G. Nilson , Rick Dalgetty
发明人： Michael D. Cable , Michael Bo Nelson , Bradley W. Rice , Christopher A. Rasco , David N Sprague , David G. Nilson , Rick Dalgetty
CPC分类号： G02B27/0018 , G01N21/01 , G02B21/16
摘要： An improved imaging apparatus is disclosed that allows a user to perform numerous imaging operations. The imaging apparatus may include one or more improvements to imaging box design to improve illumination control within the imaging box, such as improved door seal arrangements, improved door closing mechanisms, and improved light seals. The present invention may also include one or more improvements to imaging apparatus design to facilitate image capture, such as: an automated filter select device, a moveable stage, automated focus control, f-stop adjustment and stage height, and improved internal illumination for capturing photographic images.
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4.发明授权Optical fiducial timing system for X-ray streak cameras with aluminum coated optical fiber ends 失效带有铝质光纤端头的X射线条纹相机的光学基准定时系统
公开(公告)号：US4730106A
公开(公告)日：1988-03-08
申请号：US937792
申请日：1986-12-04
CPC分类号： H01J29/892
摘要： An optical fiducial timing system is provided for use with interdependent groups of X-ray streak cameras (18). The aluminum coated (80) ends of optical fibers (78) are positioned with the photocathodes (20, 60, 70) of the X-ray streak cameras (18). The other ends of the optical fibers (78) are placed together in a bundled array (90). A fiducial optical signal (96), that is comprised of 2.omega. or 1.omega. laser light, after introduction to the bundled array (90), travels to the aluminum coated (82) optical fiber ends and ejects quantities of electrons (84) that are recorded on the data recording media (52) of the X-ray streak cameras (18). Since both 2.omega. and 1.omega. laser light can travel long distances in optical fiber with only a slight attenuation, the initial arial power density of the fiducial optical signal (96) is well below the damage threshold of the fused silica or other material that comprises the optical fibers (78, 90). Thus the fiducial timing system can be repeatably used over long durations of time.
摘要翻译： 提供光学基准定时系统，用于与相互依赖的X射线条纹照相机组（18）一起使用。 光纤（78）的铝涂层（80）端部与X射线条纹照相机（18）的光电阴极（20,60,70）定位。 光纤（78）的另一端放置在捆扎阵列（90）中。 在引入到束状阵列（90）之后，由2ω或1ω激光组成的基准光信号（96）行进到铝涂层（82）光纤端，并喷射数量的电子（84） 被记录在X射线条纹照相机（18）的数据记录介质（52）上。 由于2Ω和1Ω激光都可以在仅具有轻微衰减的光纤中行进长距离，所以基准光信号（96）的初始心率功率密度远低于熔融二氧化硅或其它材料的损伤阈值 光纤（78,90）。 因此，可以在长时间内重复使用基准定时系统。
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公开(公告)号：US07649185B2
公开(公告)日：2010-01-19
申请号：US11682710
申请日：2007-03-06
申请人： Bradley W. Rice , David G. Nilson , Tamara L. Troy
发明人： Bradley W. Rice , David G. Nilson , Tamara L. Troy
CPC分类号： G01N21/278 , A61B5/0071 , A61B5/0073 , A61B5/0084 , A61B2560/0233 , G01J1/08 , G01N21/4795 , G01N21/643 , G09B23/30
摘要： Described herein is a phantom device that simplifies usage, testing, and development of light imaging systems. The phantom device includes a body and a fluorescent light source internal to the body. The body comprises an optical material designed to at least partially resemble the optical behavior of mammalian tissue. The phantom device has many uses. One use of the phantom device permits testing of tomography software in the imaging system, such as software configured for 3D reconstruction of the fluorescent light source. Another use tests spectral unmixing software in the imaging system. The phantom device also allows a user to compare trans- and epi-fluorescent illumination imaging results.
摘要翻译： 这里描述的是简化光成像系统的使用，测试和开发的幻影装置。 幻影装置包括身体和身体内部的荧光光源。 身体包括设计成至少部分类似于哺乳动物组织的光学行为的光学材料。 幻影装置有很多用途。 幻影设备的一个用途允许对成像系统中的断层摄影软件进行测试，例如配置用于荧光光源的3D重建的软件。 另一种用途是在成像系统中测试光谱解混合软件。 幻影装置还允许用户比较透射和外荧光照明成像结果。
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公开(公告)号：US09314218B2
公开(公告)日：2016-04-19
申请号：US13164640
申请日：2011-06-20
IPC分类号： G01B11/24 , G01N21/17 , G06G7/48 , A61B6/00 , G01N23/04 , A61B6/03 , A61B5/00 , G01N21/76 , A61B6/04
CPC分类号： A61B6/4417 , A61B5/0035 , A61B5/0073 , A61B6/032 , A61B6/035 , A61B6/0457 , A61B6/4405 , A61B6/508 , A61B6/5247 , A61B2503/40 , G01N21/763 , G01N23/046 , G01N2223/419
摘要： An integrated microtomography and optical imaging system includes a rotating table that supports an imaging object, an optical stage, and separate optical and microtomography imaging systems. The table rotates the imaging object about a vertical axis running therethrough to a plurality of different rotational positions during a combined microtomography and optical imaging process. The optical stage can be a trans-illumination, epi-illumination or bioluminescent stage. The optical imaging system includes a camera positioned vertically above the imaging object. The microtomography system includes an x-ray source positioned horizontally with respect to the imaging object. Optical and x-ray images are both obtained while the imaging object remains in place on the rotating table. The stage and table are included within an imaging chamber, and all components are included within a portable cabinet. Multiple imaging objects can be imaged simultaneously, and side mirrors can provide side views of the object to the overhead camera.
摘要翻译： 集成的微影像学和光学成像系统包括支持成像对象的旋转台，光学平台以及单独的光学和微影像成像系统。 在组合的微影像学和光学成像过程期间，桌子将成像对象围绕其穿过的垂直轴旋转到多个不同的旋转位置。 光学舞台可以是反照，外照明或生物发光阶段。 光学成像系统包括垂直地位于成像对象上方的照相机。 微图像系统包括相对于成像对象水平定位的x射线源。 当成像对象保持在旋转台上的适当位置时，都获得光学和X射线图像。 舞台和桌子包括在成像室内，所有组件都包含在便携式机柜中。 可以同时对多个成像对象进行成像，并且侧视镜可以向顶置摄像机提供对象的侧视图。
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公开(公告)号：US20120041302A1
公开(公告)日：2012-02-16
申请号：US12857469
申请日：2010-08-16
申请人： David G. NILSON , Bradley W. RICE , Heng XU , Tamara L. TROY
发明人： David G. NILSON , Bradley W. RICE , Heng XU , Tamara L. TROY
IPC分类号： A61B5/05
CPC分类号： A61B5/055 , A61B5/70 , A61B6/04 , A61B6/0414 , A61B6/0421 , A61B6/0442 , A61B6/0492 , A61B6/508 , A61B6/5247 , A61B2503/40 , A61B2562/17 , A61D1/00 , A61D7/04 , A61G10/026 , A61M16/01 , A61M2250/00
摘要： An imaging subject handling system includes multiple portable imaging subject cartridges that optionally compress and anesthetize living imaging subjects therein during imaging, multiple receiving bases installed within separate imaging systems that interface with the cartridges, and multiple gas delivery systems that deliver an anesthetic gas flow to an installed cartridge. The cartridges include a gas delivery interface that accepts the anesthetic gas flow and provides it to the imaging subject, and one or more walls, a bottom and a top defining a closed interior that retains the anesthetic gas therewithin while the cartridge is in transport between separate imaging systems. The walls, bottom and/or top can be optically transparent and radiolucent to facilitate imaging. The cartridge can include a locking mechanism, a nose cone for the imaging subject, and co-registration features located on outside surfaces to facilitate the merging of images within software from multiple separate imaging systems.
摘要翻译： 成像对象处理系统包括多个便携式成像对象盒，其可选地在成像期间压缩和麻醉其中的生物成像对象，多个接收基座安装在与盒相接触的分开的成像系统内，以及多个气体输送系统，其将麻醉气体流传递到 安装墨盒 药筒包括气体输送界面，其接受麻醉气体流并将其提供给成像对象，以及一个或多个壁，底部和顶部，其限定封闭的内部，其中所述麻醉气体在其间保持在分离 成像系统。 墙壁，底部和/或顶部可以是光学透明的并且是可透射的以便于成像。 盒可以包括锁定机构，用于成像对象的鼻锥，以及位于外表面上的共同配准特征，以便于在多个单独的成像系统内将软件中的图像合并。
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公开(公告)号：US07555334B2
公开(公告)日：2009-06-30
申请号：US10969230
申请日：2004-10-19
CPC分类号： G01N21/6456 , G01J1/42 , G01N21/763 , G01N2021/6439
摘要： Disclosed are methods and apparatus for collecting light emitted from an animal, where a luminescent reporter has been injected into the animal is disclosed. The apparatus includes a chamber for receiving the animal, wherein the chamber is light tight preventing a substantial portion of light emitted from the animal from escaping the chamber when the chamber is closed and the animal is inside the chamber and a light monitoring device for collecting light from different portions of the animal when the animal is inside the closed chamber. The light monitoring device is arranged to collect light over substantially the entire surface area of the body and head of the animal, and the light monitoring device generates a quantified value based on the light collected from the animal. The animal does not have to be under anesthesia.
摘要翻译： 公开了用于收集从动物发射的光的方法和装置，其中发光报告物已经注射到动物中。 所述装置包括用于接收动物的腔室，其中，所述腔室是不透光的，以防止当所述腔室关闭并且所述动物在所述腔室内时从所述动物发射的大部分光逸出所述腔室;以及用于收集光的光监测装置 当动物在封闭室内时，来自动物的不同部分。 光监视装置被布置成在动物的身体和头部的基本上整个表面区域上收集光，并且光监视装置基于从动物收集的光产生量化值。 动物不必在麻醉下。
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公开(公告)号：US06775567B2
公开(公告)日：2004-08-10
申请号：US09795056
申请日：2001-02-21
申请人： Michael D. Cable , Michael Bo Nelson , Bradley W. Rice , Christopher A. Rasco , David N Sprague , David G. Nilson , Rick Dalgetty
发明人： Michael D. Cable , Michael Bo Nelson , Bradley W. Rice , Christopher A. Rasco , David N Sprague , David G. Nilson , Rick Dalgetty
IPC分类号： A61B505
CPC分类号： G02B27/0018 , G01N21/01 , G02B21/16
摘要： An improved imaging apparatus is disclosed that allows a user to perform numerous imaging operations. The imaging apparatus may include one or more improvements to imaging box design to improve illumination control within the imaging box, such as improved door seal arrangements, improved door closing mechanisms, and improved light seals. The present invention may also include one or more improvements to imaging apparatus design to facilitate image capture, such as: an automated filter select device, a moveable stage, automated focus control, f-stop adjustment and stage height, and improved internal illumination for capturing photographic images.
摘要翻译： 公开了一种改进的成像装置，其允许用户执行许多成像操作。 成像装置可以包括对成像盒设计的一个或多个改进以改善成像盒内的照明控制，例如改进的门密封装置，改进的门关闭机构和改进的光密封。 本发明还可以包括对成像装置设计的一个或多个改进以便于图像捕获，例如：自动滤波器选择装置，可移动台，自动对焦控制，f-停止调整和台高度，以及用于捕获的改进的内部照明 摄影图像。
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公开(公告)号：US20120321033A1
公开(公告)日：2012-12-20
申请号：US13164640
申请日：2011-06-20
IPC分类号： G01N23/083
CPC分类号： A61B6/4417 , A61B5/0035 , A61B5/0073 , A61B6/032 , A61B6/035 , A61B6/0457 , A61B6/4405 , A61B6/508 , A61B6/5247 , A61B2503/40 , G01N21/763 , G01N23/046 , G01N2223/419
摘要： An integrated microtomography and optical imaging system includes a rotating table that supports an imaging object, an optical stage, and separate optical and microtomography imaging systems. The table rotates the imaging object about a vertical axis running therethrough to a plurality of different rotational positions during a combined microtomography and optical imaging process. The optical stage can be a trans-illumination, epi-illumination or bioluminescent stage. The optical imaging system includes a camera positioned vertically above the imaging object. The microtomography system includes an x-ray source positioned horizontally with respect to the imaging object. Optical and x-ray images are both obtained while the imaging object remains in place on the rotating table. The stage and table are included within an imaging chamber, and all components are included within a portable cabinet. Multiple imaging objects can be imaged simultaneously, and side mirrors can provide side views of the object to the overhead camera.
摘要翻译： 集成的微影像学和光学成像系统包括支持成像对象的旋转台，光学平台以及单独的光学和微影像成像系统。 在组合的微影像学和光学成像过程期间，桌子将成像对象围绕其穿过的垂直轴旋转到多个不同的旋转位置。 光学舞台可以是反照，外照明或生物发光阶段。 光学成像系统包括垂直地位于成像对象上方的照相机。 微图像系统包括相对于成像对象水平定位的x射线源。 当成像对象保持在旋转台上的适当位置时，都获得光学和X射线图像。 舞台和桌子包括在成像室内，所有组件都包含在便携式机柜中。 可以同时对多个成像对象进行成像，并且侧视镜可以向顶置摄像机提供对象的侧视图。
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