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55 条记录 (耗时 0.086 秒)

    N-substituted cycloalkyl and polycycloalkyl .alpha.-substituted TRP derivatives
    11.
    发明授权
    N-substituted cycloalkyl and polycycloalkyl .alpha.-substituted TRP derivatives 失效
    N-取代的环烷基和多环烷基α-取代的TRP衍生物

    公开(公告)号：US5264419A

    公开(公告)日：1993-11-23

    申请号：US726652

    申请日：1991-07-12

    申请人： David C. Horwell ,  Martyn C. Pritchard ,  Edward Roberts

    发明人： David C. Horwell ,  Martyn C. Pritchard ,  Edward Roberts

    IPC分类号： A61K38/00 ,  C07D209/20 ,  C07K5/02 ,  C07K5/078 ,  A61K37/02 ,  C07K5/06 ,  C07K5/08

    CPC分类号： C07K5/06156 ,  C07D209/20 ,  C07K5/0202 ,  A61K38/00

    摘要： Novel peptoids of .alpha.-substituted Trp derivatives useful as agents in the treatment of obesity, hypersecretion of gastric acid in the gut, gastrin-dependent tumors, or as antipsychotics are disclosed. Further the compounds are antianxiety agents and antiulcer agents. They are agents useful for preventing the response to withdrawal from chronic treatment or use of nicotine, diazepam, alcohol, cocaine, caffeine, or opioids. The compounds are also useful in the treatment and/or prevention of panic attacks. Also disclosed are pharmaceutical compositions and methods of treatment using the peptoids as well as processes for preparing them and novel intermediates useful in their preparation. An additional feature of the invention is the use of the subject compounds to prepare diagnostic compositions.

    摘要翻译： 公开了用作治疗肥胖症，胃肠胃酸分泌过多，胃泌素依赖性肿瘤或抗精神病药物的α-取代的Trp衍生物的新型拟肽。 此外，化合物是抗焦虑剂和抗溃疡剂。 它们是可用于预防慢性治疗或使用尼古丁，地西泮，酒精，可卡因，咖啡因或阿片样物质的缓解反应的药剂。 这些化合物也可用于治疗和/或预防恐慌发作。 还公开了药物组合物和使用拟肽的治疗方法以及制备它们的方法和可用于其制备的新型中间体。 本发明的另一个特征是本发明化合物用于制备诊断组合物的用途。

    N-substituted cycloalkyl and polycycloalkyl polyhydro-.beta.-carboline-phenylalanine- and phenethylamine derivatives
    12.
    发明授权
    N-substituted cycloalkyl and polycycloalkyl polyhydro-.beta.-carboline-phenylalanine- and phenethylamine derivatives 失效
    N-取代的环己基和多环烷基多羟基 - （βA）-CARBOLINE-苯乙烯胺和苯乙烯衍生物

    公开(公告)号：US5244905A

    公开(公告)日：1993-09-14

    申请号：US726651

    申请日：1991-07-12

    申请人： David C. Horwell ,  Edward Roberts ,  Uwe Trostmann

    发明人： David C. Horwell ,  Edward Roberts ,  Uwe Trostmann

    IPC分类号： C07D471/04

    CPC分类号： C07D471/04

    摘要： Novel substituted polyhydro-.beta.-carboline derivatives useful as agents in the treatment of obesity, hypersecretion of gastric acid in the gut, gastrin-dependent tumors, or as antipsychotic agents are disclosed. Further the compounds are antianxiety agents and antiulcer agents. Further, the compounds are useful for treating and/or preventing panic attacks. They are agents useful for preventing the response to withdrawal from chronic treatment with or use of nicotine, caffeine, diazepam, alcohol, cocaine or opioids. Also disclosed are pharmaceutical compositions and methods of treatment using the compounds as well as processes for preparing them and novel intermediates useful in their preparation. An additional feature of the invention is the use of the subject compounds in diagnostic compositions.

    摘要翻译： 新型取代的多羟基-β-咔啉衍生物可用作治疗肥胖症，胃肠胃分泌过多，胃泌素依赖性肿瘤或抗精神病药物。 此外，化合物是抗焦虑剂和抗溃疡剂。 此外，这些化合物可用于治疗和/或预防恐慌发作。 它们是可用于防止慢性治疗或使用尼古丁，咖啡因，地西泮，酒精，可卡因或阿片样物质的戒断反应的药剂。 还公开了使用该化合物的药物组合物和治疗方法以及其制备方法和可用于其制备的新型中间体。 本发明的另一个特征是本发明化合物在诊断组合物中的用途。

    N-substituted cycloalkyl and polycycloalkyl alpha-substituted Trp derivatives
    13.
    发明授权
    N-substituted cycloalkyl and polycycloalkyl alpha-substituted Trp derivatives 失效
    N-取代的环烷基和多环烷基α-取代的Trp衍生物

    公开(公告)号：US5574013A

    公开(公告)日：1996-11-12

    申请号：US68005

    申请日：1993-05-27

    申请人： David C. Horwell ,  Maryin C. Pritchard ,  Edward Roberts

    发明人： David C. Horwell ,  Maryin C. Pritchard ,  Edward Roberts

    IPC分类号： A61K38/00 ,  C07D209/20 ,  C07K5/02 ,  C07K5/078 ,  A61K38/05 ,  C07K5/00

    CPC分类号： C07K5/06156 ,  C07D209/20 ,  C07K5/0202 ,  A61K38/00

    摘要： Novel peptoids of .alpha.-substituted Trp derivatives useful as agents in the treatment of obesity, hypersecretion of gastric acid in the gut, gastrin-dependent tumors, or as antipsychotics are disclosed. Further the compounds are antianxiety agents and antiulcer agents. They are agents useful for preventing the response to withdrawal from chronic treatment or use of nicotine, diazepam, alcohol, cocaine, caffeine, or opioids. The compounds are also useful in the treatment and/or prevention of panic attacks. Also disclosed are pharmaceutical compositions and methods of treatment using the peptoids as well as processes for preparing them and novel intermediates useful in their preparation. An additional feature of the invention is the use of the subject compounds to prepare diagnostic compositions.

    摘要翻译： 公开了用作治疗肥胖症，胃肠胃酸分泌过多，胃泌素依赖性肿瘤或抗精神病药物的α-取代的Trp衍生物的新型拟肽。 此外，化合物是抗焦虑剂和抗溃疡剂。 它们是可用于预防慢性治疗或使用尼古丁，地西泮，酒精，可卡因，咖啡因或阿片样物质的缓解反应的药剂。 这些化合物也可用于治疗和/或预防恐慌发作。 还公开了药物组合物和使用拟肽的治疗方法以及制备它们的方法和可用于其制备的新型中间体。 本发明的另一个特征是本发明化合物用于制备诊断组合物的用途。