公开(公告)号：US20080004096A1

公开(公告)日：2008-01-03

申请号：US11421913

申请日：2006-06-02

申请人： Thore K. H. Graepel ,  Ralf Herbrich ,  David Stern

发明人： Thore K. H. Graepel ,  Ralf Herbrich ,  David Stern

IPC分类号： A63F9/24

CPC分类号： A63F3/022 ,  A63F3/04 ,  G09B19/22

摘要： We describe an apparatus for learning to predict moves in games such as chess, Go and the like, from historical game records. We obtain a probability distribution over legal moves in a given board configuration. This enables us to provide an automated game playing system, a training tool for players and a move selector/sorter for input to a game tree search system. We use a pattern extraction system to select patterns from historical game records. Our learning algorithm learns a distribution over the values of a move given a board position based on local pattern context. In another embodiment we use an Independent Bernoulli model whereby we assume each moved is played independently of other available moves.

摘要翻译： 我们描述一种从历史游戏记录中学习来预测诸如象棋，Go等游戏中的移动的装置。 在给定的电路板配置中，我们获得了合法移动的概率分布。 这使我们能够提供一种自动游戏系统，用于玩家的训练工具和用于输入到游戏树搜索系统的移动选择器/分选器。 我们使用模式提取系统从历史游戏记录中选择模式。 我们的学习算法基于局部模式上下文学习一个给定一个董事会职位的动作值的分布。 在另一个实施例中，我们使用独立的伯努利模型，由此我们假设每个移动都是独立于其他可用移动进行的。

公开(公告)号：US07255710B2

公开(公告)日：2007-08-14

申请号：US10636323

申请日：2003-08-06

申请人： Jason White ,  David Stern ,  Mark Allen ,  David O'Brien

发明人： Jason White ,  David Stern ,  Mark Allen ,  David O'Brien

IPC分类号： A61F2/06

CPC分类号： A61F2/88 ,  A61F2/90

摘要： A stent constructed using elements containing micro-mechanical latching mechanisms is disclosed. The micro-mechanical latching elements allow sliding motion between two surfaces in one direction, and restrict sliding motion in the opposite direction. The micro-mechanical latch surface features are formed using microelectronic mechanical systems (MEMS) manufacturing methods. The male surface of the latching components contains an array of ridges or protrusions, and the receiving surface contains a matching array of recesses. The array of ridges or protrusions and the corresponding recesses have uniformly dissimilar slopes that result in a substantially greater frictional force in one direction than in the opposite direction. The separation distance between the two surfaces is such that the male latch surface is engaged with the receiving surface recesses in the low stress “locked” state, preventing motion in the undesired direction.

摘要翻译： 公开了使用包含微机械闭锁机构的元件构造的支架。 微机械闭锁元件允许在一个方向上的两个表面之间的滑动运动，并且在相反方向上限制滑动运动。 使用微电子机械系统（MEMS）制造方法形成微机械闩锁表面特征。 闩锁部件的阳表面包含脊或突起的阵列，并且接收表面包含匹配的凹槽阵列。 脊或突起的阵列和相应的凹槽具有均匀不相似的斜面，其在一个方向上产生比在相反方向上显着更大的摩擦力。 两个表面之间的分隔距离使得阳锁闩表面在低应力“锁定”状态下与接收表面凹部接合，从而防止在不期望的方向上的运动。

公开(公告)号：US20050281708A1

公开(公告)日：2005-12-22

申请号：US11178087

申请日：2005-07-07

申请人： Mark Trulson ,  James Winkler ,  Maureen Cronin ,  David Stern

发明人： Mark Trulson ,  James Winkler ,  Maureen Cronin ,  David Stern

IPC分类号： C12M1/34 ,  G01J1/20 ,  G01N21/64 ,  G01T1/10

CPC分类号： G01N21/6428 ,  G01N21/6452 ,  G01N21/6456 ,  G01N2021/6417 ,  G01N2021/6423

摘要： In accordance with various embodiments of the invention, an apparatus is provided for hybridizing a nucleic acid microarray immobilized on a surface of a solid substrate. The apparatus comprises at least one assembly for securing the solid substrate during hybridization, the assembly comprising a carrier and a cover having a surface facing the carrier. The carrier and the cover can be dimensioned to receive the solid substrate between the carrier and the surface of the cover so that the surfaces of the cover and the solid substrate define a cavity. In some embodiments, the apparatus can include a fluid control module comprising a manifold, at least one liquid reservoir, at least one waste container, and a vacuum source in fluid communication with the waste container. The manifold can provide fluid communication between the liquid reservoir and the cavity and between the cavity and the waste container, and the vacuum source can provide a pressure difference between the liquid reservoir and the waste container. The apparatus can further include at least one thermal management module for controlling temperature of the nucleic acid microarray immobilized on the surface of the solid substrate, and the thermal management module thermally can contact the assembly; and a pulse valve in fluid communication with the cavity, the pulse valve adapted to agitate fluid within the cavity.

公开(公告)号：US20050269246A1

公开(公告)日：2005-12-08

申请号：US11106289

申请日：2005-04-14

申请人： William Wachter ,  Stephen McCarthy ,  Jeffrey Beck ,  David Stern

发明人： William Wachter ,  Stephen McCarthy ,  Jeffrey Beck ,  David Stern

IPC分类号： C10G11/02 ,  C10G11/04 ,  C10G11/05

CPC分类号： C10G11/04 ,  C10G11/05

摘要： This invention relates to a FCC process using a mesoporous catalytic cracking catalyst. The mesoporous fluidized catalytic cracking catalyst is selective for minimizing the production of coke and light gas. The catalyst comprises at least one amorphous, porous matrix, each matrix having pores ranging in diameter from about 1 Å to about 10 Å and pores ranging in diameter from about 40 Å to about 500 Å, wherein in the pore range from 50 Å to 250 Å, there is a single maximum in differential pore volume distribution over the 50 Å to 250 Å range.

摘要翻译： 本发明涉及使用中孔催化裂化催化剂的FCC方法。 中孔流化催化裂化催化剂是选择性地使焦炭和轻质气体的生产最小化。 催化剂包含至少一种无定形多孔基质，每个基质的孔直径约为约至约10埃，孔径范围为约40至约500，其中孔径范围为50埃至250埃 Å，在50Å至250Å范围内，微分孔体积分布有单一最大值。

公开(公告)号：US20050247887A1

公开(公告)日：2005-11-10

申请号：US11177529

申请日：2005-07-07

申请人： Mark Trulson ,  James Winkler ,  Maureen Cronin ,  David Stern

发明人： Mark Trulson ,  James Winkler ,  Maureen Cronin ,  David Stern

IPC分类号： C12M1/34 ,  G01J1/20 ,  G01N21/64 ,  G01T1/10

CPC分类号： G01N21/6428 ,  G01N21/6452 ,  G01N21/6456 ,  G01N2021/6417 ,  G01N2021/6423

摘要： In accordance with various embodiments of the invention, an apparatus is provided for hybridizing a nucleic acid microarray immobilized on a surface of a solid substrate. The apparatus comprises at least one assembly for securing the solid substrate during hybridization, the assembly comprising a carrier and a cover having a surface facing the carrier. The carrier and the cover can be dimensioned to receive the solid substrate between the carrier and the surface of the cover so that the surfaces of the cover and the solid substrate define a cavity. In some embodiments, the apparatus can include a fluid control module comprising a manifold, at least one liquid reservoir, at least one waste container, and a vacuum source in fluid communication with the waste container. The manifold can provide fluid communication between the liquid reservoir and the cavity and between the cavity and the waste container, and the vacuum source can provide a pressure difference between the liquid reservoir and the waste container. The apparatus can further include at least one thermal management module for controlling temperature of the nucleic acid microarray immobilized on the surface of the solid substrate, and the thermal management module thermally can contact the assembly; and a pulse valve in fluid communication with the cavity, the pulse valve adapted to agitate fluid within the cavity.

摘要翻译： 根据本发明的各种实施方案，提供了一种用于杂交固定在固体基质表面上的核酸微阵列的装置。 该装置包括用于在杂交期间固定固体基底的至少一个组件，该组件包括载体和具有面向载体的表面的盖。 载体和盖的尺寸可以被确定为在载体和盖的表面之间接收固体基质，使得盖和固体基质的表面限定空腔。 在一些实施例中，该装置可以包括流体控制模块，其包括歧管，至少一个液体储存器，至少一个废物容器和与废物容器流体连通的真空源。 歧管可以在液体储存器和空腔之间以及空腔和废物容器之间提供流体连通，并且真空源可以在液体储存器和废物容器之间提供压力差。 该装置还可以包括至少一个用于控制固定在固体基质表面上的核酸微阵列的温度的热管理模块，并且热管理模块可热接触组件; 以及与所述空腔流体连通的脉冲阀，所述脉冲阀适于搅动所述空腔内的流体。

公开(公告)号：US20050070422A1

公开(公告)日：2005-03-31

申请号：US10671080

申请日：2003-09-25

申请人： Tan-Jen Chen ,  John Buchanan ,  Brian Henry ,  Paul Keusenkothen ,  Philip Ruziska ,  David Stern

发明人： Tan-Jen Chen ,  John Buchanan ,  Brian Henry ,  Paul Keusenkothen ,  Philip Ruziska ,  David Stern

IPC分类号： B01J29/00 ,  B01J29/40 ,  B01J29/85 ,  C10G11/05 ,  C10G11/00

CPC分类号： C10G11/05 ,  B01J29/005 ,  B01J29/40 ,  B01J29/85

摘要： A multi component catalyst and catalytic cracking process for selectively producing C3 olefins. The catalyst comprises a first molecular sieve having an intermediate pore size, a second molecular sieve and, optionally a third molecular sieve having a large pore size. At least one of the channels of the second molecular sieve has a pore size index that is less than the pore size index of at least one channel of the first molecular sieve. The process is carried out by contacting a feedstock containing hydrocarbons having at least 5 carbon atoms is contacted, under catalytic cracking conditions, with the multi component catalyst. The catalyst finds application in the cracking of naphtha and heavy hydrocarbon feedstocks.

摘要翻译： 用于选择性生产C3烯烃的多组分催化剂和催化裂化方法。 催化剂包括具有中等孔径的第一分子筛，第二分子筛和任选的具有大孔径的第三分子筛。 第二分子筛的至少一个通道的孔径指数小于第一分子筛的至少一个通道的孔径指数。 该方法通过使含有至少5个碳原子的烃的原料在催化裂化条件下与多组分催化剂接触来进行。 该催化剂可用于石脑油和重质烃原料的裂解。

公开(公告)号：US20050019787A1

公开(公告)日：2005-01-27

申请号：US10768788

申请日：2004-01-30

申请人： Anthony Berno ,  Karel Konvicka ,  David Hinds ,  Nila Patil ,  Naiping Shen ,  David Stern ,  John Sheehan

发明人： Anthony Berno ,  Karel Konvicka ,  David Hinds ,  Nila Patil ,  Naiping Shen ,  David Stern ,  John Sheehan

IPC分类号： C12Q1/68 ,  G01N33/48 ,  G01N33/50 ,  G06F20060101 ,  G06F19/00

CPC分类号： G16B20/00 ,  G16B25/00 ,  G16B40/00

摘要： Computer-implemented methods, data processing apparatus and computer program codes for characterizing an interrogation position, such as a SNP position, in a nucleic acid sequence are provided herein. Computer-implemented methods involving various statistical analyses are provided for characterizing an interrogation position as being associated with a phenotypic trait of interest.

摘要翻译： 本文提供了用于表征核酸序列中的询问位置（例如SNP位置）的计算机实现的方法，数据处理设备和计算机程序代码。 提供涉及各种统计分析的计算机实现的方法，用于将询问位置表征为与感兴趣的表型性状相关联。

公开(公告)号：US06465422B1

公开(公告)日：2002-10-15

申请号：US09062365

申请日：1998-04-17

申请人： Ann Marie Schmidt ,  David Stern

发明人： Ann Marie Schmidt ,  David Stern

IPC分类号： A21K3718

CPC分类号： C07K14/70503 ,  A61K38/00 ,  A61K48/00

摘要： The present invention provides for a method for inhibiting tumor invasion or metastasis in a subject which comprises administering to the subject a therapeutically effective amount of a form of soluble Receptor for Advanced Glycation Endproducts (RAGE). The present invention also provides a method for evaluating the ability of an agent to inhibit tumor invasion in a local cellular environment which comprises: (a) admixing with cell culture media an effective amount of the agent; (b) contacting a tumor cell in cell culture with the media from step (a); (c) determining the amount of spreading of the tumor cell culture, and (d) comparing the amount of spreading of the tumor cell culture determined in step (c) with the amount determined in the absence of the agent, thus evaluating the ability of the agent to inhibit tumor invasion in the local cellular environment. The present invention also provides a pharmaceutical composition which comprises a therapeutically effective amount of the agent evaluated in the aforementioned method and a pharmaceutically acceptable carrier.

摘要翻译： 本发明提供了一种抑制受试者的肿瘤侵袭或转移的方法，其包括向受试者施用治疗有效量的用于高级糖化终产物（RAGE）的可溶性受体的形式。 本发明还提供了一种用于评价药剂在局部细胞环境中抑制肿瘤侵袭的能力的方法，其包括：（a）与细胞培养基混合有效量的药剂; （b）使细胞培养物中的肿瘤细胞与来自步骤（a）的培养基接触; （c）确定肿瘤细胞培养物的铺展量，和（d）将在步骤（c）中测定的肿瘤细胞培养物的扩散量与在不存在试剂的情况下测定的量进行比较，从而评估 在局部细胞环境中抑制肿瘤侵袭的药物。 本发明还提供一种药物组合物，其包含治疗有效量的上述方法评价的药剂和药学上可接受的载体。

公开(公告)号：US06391300B1

公开(公告)日：2002-05-21

申请号：US09192905

申请日：1998-11-16

申请人： Eric Rose ,  David Stern ,  Ann Marie Schmidt ,  Talia Spanier

发明人： Eric Rose ,  David Stern ,  Ann Marie Schmidt ,  Talia Spanier

IPC分类号： A61K3836

CPC分类号： A61M1/3675 ,  A61K38/4846 ,  G01N33/86 ,  G01N2333/9645

摘要： This invention provides a method for inhibiting thrombosis in a patient whose blood is subjected to extracorporeal blood circulation which comprises contacting the extracorporeal circulating blood with a Factor IXa compound in an amount effective to inhibit thrombosis in the blood of a patient and under conditions such that the Factor IXa compound circulates in the patient. The Factor IXa compound may include an active site-blocked Factor IXa compound or Glu-Gly-Arg chloromethyl ketone-inactivated human factor IXa compound. This invention also provides that the effective amount may be from about 0.1 &mgr;g/ml plasma to about 250 &mgr;g/ml plasma or from about 0.5 &mgr;g/ml plasma to about 25 &mgr;g/ml plasma. The patient may be subjected to extracorporeal blood circulation during transplant surgery or cardiopulmonary bypass surgery. This invention further provides for a method for inhibiting thrombosis in a patient whose blood is subjected to extracorporeal blood circulation, which comprises contacting the extracorporeal circulating blood with an agent capable of inhibiting a step of the intrinsic pathway of coagulation in an amount effective to inhibit thrombosis in the blood of a patient and under conditions such that the Factor IXa compound circulates in the patient. The agent may be an active site-blocked Factor XII compound or an active site-blocked Factor XI compound.

摘要翻译： 本发明提供了一种用于抑制血液经受体外血液循环的患者的血栓形成的方法，该方法包括使体外循环血液与因子IXa化合物以有效抑制患者血液中的血栓形成的量接触， 因子IXa化合物在患者体内循环。 因子IXa化合物可包括活性位点封闭的因子IXa化合物或Glu-Gly-Arg氯甲基酮灭活的人因子IXa化合物。 本发明还提供有效量可以为约0.1mug / ml血浆至约250mug / ml血浆或约0.5mug / ml血浆至约25mug / ml血浆。 患者可能在移植手术或心肺分流手术期间受到体外血液循环。 本发明还提供了一种用于抑制血液经受体外血液循环的患者的血栓形成的方法，其包括使体外循环血液与能够抑制凝固途径的步骤的试剂以有效抑制血栓形成的量接触 在患者的血液中和在因子IXa化合物在患者体内循环的条件下。 该试剂可以是活性位点封闭的因子XII化合物或活性位点封闭的因子XI化合物。

公开(公告)号：US6141096A

公开(公告)日：2000-10-31

申请号：US823824

申请日：1997-03-25

申请人： David Stern ,  Peter Fiekowsky

发明人： David Stern ,  Peter Fiekowsky

IPC分类号： G01N21/64

CPC分类号： G01N21/6458 ,  G01N21/6428 ,  B01J2219/00605 ,  B01J2219/00612 ,  B01J2219/00659 ,  B01J2219/00702 ,  G01N2021/174

摘要： Fluorescently marked targets bind to a substrate 230 synthesized with polymer sequences at known locations. The targets are detected by exposing selected regions of the substrate 230 to light from a light source 100 and detecting the photons from the light fluoresced therefrom, and repeating the steps of exposure and detection until the substrate 230 is completely examined. The resulting data can be used to determine binding affinity of the targets to specific polymer sequences.

摘要翻译： 荧光标记的靶结合到在已知位置处与聚合物序列合成的底物230。 通过将衬底230的选定区域暴露于来自光源100的光并从其发荧光的光检测光子并且重复曝光和检测的步骤直到基片230被完全检查来检测靶。 所得数据可用于确定靶向特定聚合物序列的结合亲和力。