公开(公告)号：US20070154918A1

公开(公告)日：2007-07-05

申请号：US11608978

申请日：2006-12-11

申请人： David LaFleur ,  Steven Ruben ,  Craig Rosen ,  Paul Moore ,  Yanggu Shi ,  Hla Kyaw ,  Ying-Fei Wei

发明人： David LaFleur ,  Steven Ruben ,  Craig Rosen ,  Paul Moore ,  Yanggu Shi ,  Hla Kyaw ,  Ying-Fei Wei

IPC分类号： C12Q1/68 ,  G01N33/53 ,  C07H21/04 ,  C12P21/06 ,  C07K14/705

CPC分类号： C12Q1/6883 ,  A61K35/13 ,  A61K38/00 ,  C07K14/47 ,  G01N33/6893 ,  Y02A50/465

摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.

摘要翻译： 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的病症的诊断和治疗方法。

公开(公告)号：US20060281095A1

公开(公告)日：2006-12-14

申请号：US11002754

申请日：2004-12-03

申请人： David LaFleur ,  Steven Ruben ,  Craig Rosen ,  Paul Moore ,  Yanggu Shi ,  Hla Kyaw ,  Ying-Fei Wei

发明人： David LaFleur ,  Steven Ruben ,  Craig Rosen ,  Paul Moore ,  Yanggu Shi ,  Hla Kyaw ,  Ying-Fei Wei

IPC分类号： C12Q1/68 ,  C07H21/04 ,  C12P21/06 ,  C07K14/47

CPC分类号： C12Q1/6883 ,  A61K35/13 ,  A61K38/00 ,  C07K14/47 ,  G01N33/6893 ,  Y02A50/465

摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.

公开(公告)号：US20050037467A1

公开(公告)日：2005-02-17

申请号：US10936773

申请日：2004-09-09

申请人： Steven Ruben ,  Ping Feng ,  David LaFleur ,  Paul Moore ,  Yanggu Shi ,  Hla Kyaw ,  Yi Li ,  ZhiZhen Zeng ,  Kenneth Carter ,  Gregory Endress ,  Ying-Fei Wei ,  Ping Fan ,  Craig Rosen

发明人： Steven Ruben ,  Ping Feng ,  David LaFleur ,  Paul Moore ,  Yanggu Shi ,  Hla Kyaw ,  Yi Li ,  ZhiZhen Zeng ,  Kenneth Carter ,  Gregory Endress ,  Ying-Fei Wei ,  Ping Fan ,  Craig Rosen

IPC分类号： A61K38/00 ,  C07K14/47 ,  C12N5/02 ,  C07H21/04

CPC分类号： C07K14/47 ,  A61K38/00

摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.

摘要翻译： 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。

公开(公告)号：US20060223077A1

公开(公告)日：2006-10-05

申请号：US11229770

申请日：2005-09-20

申请人： Jian Ni ,  Reinhard Ebner ,  David LaFleur ,  Paul Moore ,  Henrik Olsen ,  Craig Rosen ,  Steven Ruben ,  Daniel Soppet ,  Paul Young ,  Yanggu Shi ,  Kimberly Florence ,  Ying-Fei Wei ,  Charles Florence ,  Jing-Shan Hu ,  Yi Li ,  Hla Kyaw ,  Carrie Fischer ,  Ann Ferrie ,  Ping Fan ,  Ping Feng ,  Gregory Endress ,  Patrick Dillon ,  Kenneth Carter ,  Laurie Brewer ,  Guo-Liang Yu ,  Zhizhen Zeng ,  John Greene

发明人： Jian Ni ,  Reinhard Ebner ,  David LaFleur ,  Paul Moore ,  Henrik Olsen ,  Craig Rosen ,  Steven Ruben ,  Daniel Soppet ,  Paul Young ,  Yanggu Shi ,  Kimberly Florence ,  Ying-Fei Wei ,  Charles Florence ,  Jing-Shan Hu ,  Yi Li ,  Hla Kyaw ,  Carrie Fischer ,  Ann Ferrie ,  Ping Fan ,  Ping Feng ,  Gregory Endress ,  Patrick Dillon ,  Kenneth Carter ,  Laurie Brewer ,  Guo-Liang Yu ,  Zhizhen Zeng ,  John Greene

IPC分类号： C12Q1/68 ,  C07H21/04 ,  C12P21/06 ,  C12N9/00 ,  C07K14/47

CPC分类号： C07K14/47 ,  A61K48/00

摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.

公开(公告)号：US20050153335A1

公开(公告)日：2005-07-14

申请号：US11002756

申请日：2004-12-03

申请人： David LaFleur ,  Steven Ruben ,  Craig Rosen ,  Paul Moore ,  Yanggu Shi ,  Hla Kyaw ,  Ying-Fei Wei

发明人： David LaFleur ,  Steven Ruben ,  Craig Rosen ,  Paul Moore ,  Yanggu Shi ,  Hla Kyaw ,  Ying-Fei Wei

IPC分类号： G01N33/50 ,  A61K31/711 ,  A61K38/00 ,  A61K48/00 ,  A61P7/02 ,  A61P9/00 ,  A61P9/10 ,  C07K14/47 ,  C07K16/18 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/09 ,  C12N15/12 ,  C12P21/02 ,  C12Q1/68 ,  G01N33/15 ,  C07H21/04 ,  C12N9/00

CPC分类号： C12Q1/6883 ,  A61K35/13 ,  A61K38/00 ,  C07K14/47 ,  G01N33/6893 ,  Y02A50/465

摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.

摘要翻译： 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的病症的诊断和治疗方法。

公开(公告)号：US20050079537A1

公开(公告)日：2005-04-14

申请号：US11002755

申请日：2004-12-03

申请人： David LaFleur ,  Steven Ruben ,  Craig Rosen ,  Paul Moore ,  Yanggu Shi ,  Hla Kyaw ,  Ying-Fei Wei

发明人： David LaFleur ,  Steven Ruben ,  Craig Rosen ,  Paul Moore ,  Yanggu Shi ,  Hla Kyaw ,  Ying-Fei Wei

IPC分类号： G01N33/50 ,  A61K31/711 ,  A61K38/00 ,  A61K48/00 ,  A61P7/02 ,  A61P9/00 ,  A61P9/10 ,  C07K14/47 ,  C07K16/18 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/09 ,  C12N15/12 ,  C12P21/02 ,  C12Q1/68 ,  G01N33/15 ,  C07H21/04 ,  C12N9/00

CPC分类号： C12Q1/6883 ,  A61K35/13 ,  A61K38/00 ,  C07K14/47 ,  G01N33/6893 ,  Y02A50/465

摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.

公开(公告)号：US20050009085A1

公开(公告)日：2005-01-13

申请号：US10918446

申请日：2004-08-16

申请人： David LaFleur ,  Steven Ruben ,  Craig Rosen ,  Paul Moore ,  Yanggu Shi ,  Hla Kyaw ,  Ying-Fei Wei

发明人： David LaFleur ,  Steven Ruben ,  Craig Rosen ,  Paul Moore ,  Yanggu Shi ,  Hla Kyaw ,  Ying-Fei Wei

IPC分类号： G01N33/50 ,  A61K31/711 ,  A61K38/00 ,  A61K48/00 ,  A61P7/02 ,  A61P9/00 ,  A61P9/10 ,  C07K14/47 ,  C07K16/18 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/09 ,  C12N15/12 ,  C12P21/02 ,  C12Q1/68 ,  G01N33/15 ,  C07H21/04

CPC分类号： C12Q1/6883 ,  A61K35/13 ,  A61K38/00 ,  C07K14/47 ,  G01N33/6893 ,  Y02A50/465

摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.

摘要翻译： 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的病症的诊断和治疗方法。

公开(公告)号：US06416984B1

公开(公告)日：2002-07-09

申请号：US08468024

申请日：1995-06-06

申请人： William A. Haseltine ,  Steven M. Ruben ,  Ying-Fei Wei ,  Mark D. Adams ,  Robert D. Fleischmann ,  Claire M. Fraser ,  Rebecca A. Fuldner ,  Ewen F. Kirkness ,  Craig A. Rosen

发明人： William A. Haseltine ,  Steven M. Ruben ,  Ying-Fei Wei ,  Mark D. Adams ,  Robert D. Fleischmann ,  Claire M. Fraser ,  Rebecca A. Fuldner ,  Ewen F. Kirkness ,  Craig A. Rosen

IPC分类号： C12N900

CPC分类号： C07K14/47 ,  Y10T436/143333

摘要： The invention discloses three human DNA repair proteins and DNA (RNA) encoding such proteins and a procedure for producing such proteins by recombinant techniques. One of the human DNA repair proteins, hMLH1, has been mapped to chromosome 3 while hMLH2 has been mapped to chromosome 2 and hMLH3 has been mapped to chromosome 7. The polynucleotide sequences of the DNA repair proteins may be used for therapeutic and diagnostic treatments of a hereditary susceptibility to cancer.

摘要翻译： 本发明公开了三种人类DNA修复蛋白和编码这种蛋白质的DNA（RNA），以及通过重组技术生产此类蛋白质的方法。 人类DNA修复蛋白hMLH1已被映射到染色体3，而hMLH2已被映射到染色体2，并且hMLH3已经被定位到染色体7上.DNA修复蛋白的多核苷酸序列可用于治疗和诊断治疗 遗传易感性癌症。

公开(公告)号：US06372456B1

公开(公告)日：2002-04-16

申请号：US09177304

申请日：1998-10-23

申请人： Ying-Fei Wei ,  Steven M. Ruben ,  Craig A. Rosen

发明人： Ying-Fei Wei ,  Steven M. Ruben ,  Craig A. Rosen

IPC分类号： C12N1519

CPC分类号： C07K16/24 ,  A61K38/00 ,  C07K14/522

摘要： The present invention relates to a novel CK(&agr;-6 protein which is a member of the alpha chemokine family. In particular, isolated nucleic acid molecules are provided encoding the human CK&agr;-6 protein. CK&agr;-6 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of CK&agr;-6 activity. Also provided are diagnostic methods for detecting CNS and immune system-related disorders and therapeutic methods for treating CNS and immune system-related disorders.

摘要翻译： 本发明涉及一种新的CK（α-6蛋白，其是α趋化因子家族的成员，特别是编码人CKalpha-6蛋白的分离的核酸分子，也提供了CKalpha-6多肽 本发明还涉及用于鉴定CKalpha-6活性的激动剂和拮抗剂的筛选方法，还提供了用于检测CNS和免疫系统相关疾病的诊断方法以及用于治疗CNS和 免疫系统相关疾病。

公开(公告)号：US20080317756A1

公开(公告)日：2008-12-25

申请号：US12010210

申请日：2008-01-22

申请人： Ying-Fei Wei ,  Yi Li ,  Jian Ni ,  Craig A. Rosen ,  Steven M. Ruben

发明人： Ying-Fei Wei ,  Yi Li ,  Jian Ni ,  Craig A. Rosen ,  Steven M. Ruben

IPC分类号： A61K39/395 ,  G01N33/566 ,  C12Q1/68 ,  A61K31/7105 ,  G01N33/53 ,  A61K38/17

CPC分类号： C07K14/521 ,  A61K38/00 ,  C07K14/522 ,  C07K2319/00 ,  C12N2799/026 ,  Y02A50/423 ,  Y10T436/143333

摘要： The present invention relates to a novel CKα-5 protein which is a member of the alpha chemokine family. In particular, isolated nucleic acid molecules are provided encoding the human CKα-5 protein. CKα-5 polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. Antibodies and fragments thereof that specifically bind to CKα-5 polypeptides are also disclosed, as are compositions and methods for making such antibodies. The invention further relates to screening methods for identifying agonists and antagonists of CKα-5 activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.