公开(公告)号：US12220234B2

公开(公告)日：2025-02-11

申请号：US18182941

申请日：2023-03-13

Applicant: Dexcom, Inc.

Inventor： Peter C Simpson ,  Robert Boock ,  Paul V Neale ,  Sebastian Bohm ,  Matthew D. Wightlin ,  Jack Pryor ,  Jason Mitchell ,  Jeff Jackson ,  Kaushik Patel ,  Antonio C. Llevares

IPC: A61B5/1473 ,  A61B5/145 ,  A61B5/1486 ,  B05C3/02 ,  B05C3/10 ,  B05C3/12 ,  B23K26/362 ,  B05C5/02 ,  B05D1/18 ,  B05D3/06 ,  B23K26/08 ,  C23C2/00

Abstract: Analyte sensors and methods of manufacturing same are provided, including analyte sensors comprising multi-axis flexibility. For example, a multi-electrode sensor system 800 comprising two working electrodes and at least one reference/counter electrode is provided. The sensor system 800 comprises first and second elongated bodies E1, E2, each formed of a conductive core or of a core with a conductive layer deposited thereon, insulating layer 810 that separates the conductive layer 820 from the elongated body, a membrane layer deposited on top of the elongated bodies E1, E2, and working electrodes 802′, 802″ formed by removing portions of the conductive layer 820 and the insulating layer 810, thereby exposing electroactive surface of the elongated bodies E1, E2.

公开(公告)号：US20240000352A1

公开(公告)日：2024-01-04

申请号：US18217338

申请日：2023-06-30

Applicant: Dexcom, Inc.

Inventor： Robert Boock ,  Monica Rixman Swinney ,  Huashi Zhang ,  Michael J. Estes ,  Kristina Lawrence

IPC: A61B5/1486 ,  A61B5/1473 ,  A61B5/145 ,  G01N27/40 ,  A61B5/1468 ,  C12Q1/00

CPC classification number: A61B5/14865 ,  A61B5/1473 ,  A61B5/1486 ,  A61B5/14546 ,  G01N27/40 ,  A61B5/1468 ,  A61B5/14532 ,  C12Q1/006 ,  B33Y70/00

Abstract: Devices and methods are described for providing continuous measurement of an analyte concentration. In some embodiments, the device has a sensing mechanism and a sensing membrane that includes at least one surface-active group-containing polymer and that is located over the sensing mechanism. The sensing membrane may have a bioprotective layer configured to substantially block the effect and/or influence of non-constant noise-causing species.

公开(公告)号：US20230380736A1

公开(公告)日：2023-11-30

申请号：US18205297

申请日：2023-06-02

Applicant: Dexcom, Inc.

Inventor： Naresh C. Bhavaraju ,  Sebastian Böhm ,  Robert Boock ,  Daiting Rong ,  Peter C. Simpson

IPC: A61B5/1495 ,  A61B5/1473 ,  A61B5/1459 ,  A61B5/00 ,  A61B5/145 ,  A61B5/1486

CPC classification number: A61B5/1495 ,  A61B5/1473 ,  A61B5/1459 ,  A61B5/7278 ,  A61B5/14532 ,  A61B5/7246 ,  A61B5/7221 ,  A61B5/14865 ,  A61B2562/04

Abstract: Disclosed herein are devices, systems, and methods for a continuous analyte sensor, such as a continuous glucose sensor. In certain embodiments disclosed herein, various in vivo properties of the sensor's surroundings can be measured. In some embodiments, the measured properties can be used to identify a physiological response or condition in the body. This information can then be used by a patient, doctor, or system to respond appropriately to the identified condition.

公开(公告)号：US20150289819A1

公开(公告)日：2015-10-15

申请号：US14746760

申请日：2015-06-22

Applicant: DexCom, Inc.

Inventor： Apurv Ullas Kamath ,  Aarthi Mahalingam ,  Ying Li ,  Mohammad Ali Shariati ,  James H. Brauker ,  Mark C. Brister ,  Robert Boock

IPC: A61B5/00 ,  A61B5/1495 ,  A61B5/1486 ,  A61B5/145

CPC classification number: A61B5/7203 ,  A61B5/01 ,  A61B5/145 ,  A61B5/14532 ,  A61B5/14539 ,  A61B5/14865 ,  A61B5/1495 ,  A61B5/6848 ,  A61B5/725 ,  A61B5/7257 ,  A61B5/726 ,  A61B5/743 ,  A61B5/7475

Abstract: Systems and methods for detecting noise episodes and processing analyte sensor data responsive thereto. In some embodiments, processing analyte sensor data includes filtering the sensor data to reduce or eliminate the effects of the noise episode on the signal.

Abstract translation: 用于检测噪声发生并响应于此处理分析物传感器数据的系统和方法。 在一些实施例中，处理分析物传感器数据包括过滤传感器数据以减少或消除噪声发作对信号的影响。

公开(公告)号：US11432772B2

公开(公告)日：2022-09-06

申请号：US16000748

申请日：2018-06-05

Applicant: DexCom, Inc.

Inventor： Apurv Ullas Kamath ,  Aarthi Mahalingam ,  Ying Li ,  Mohammad Ali Shariati ,  James H. Brauker ,  Mark C. Brister ,  Robert Boock

IPC: A61B5/00 ,  A61B5/145 ,  A61B5/1486 ,  A61B5/1495 ,  A61B5/01

Abstract: Systems and methods for detecting noise episodes and processing analyte sensor data responsive thereto. In some embodiments, processing analyte sensor data includes filtering the sensor data to reduce or eliminate the effects of the noise episode on the signal.

公开(公告)号：US20220142532A1

公开(公告)日：2022-05-12

申请号：US17583057

申请日：2022-01-24

Applicant: Dexcom Inc.

Inventor： Robert Boock ,  Monica Rixman Swinney ,  Huashi Zhang ,  Michael J. Estes ,  Kristina Lawrence

IPC: A61B5/1486 ,  A61B5/1468 ,  A61B5/1473 ,  A61B5/145 ,  C12Q1/00 ,  G01N27/40

Abstract: Devices and methods are described for providing continuous measurement of an analyte concentration. In some embodiments, the device has a sensing mechanism and a sensing membrane that includes at least one surface-active group-containing polymer and that is located over the sensing mechanism. The sensing membrane may have a bioprotective layer configured to substantially block the effect and/or influence of non-constant noise-causing species.

公开(公告)号：US20190307371A1

公开(公告)日：2019-10-10

申请号：US16452364

申请日：2019-06-25

Applicant: DexCom, Inc.

Inventor： Robert Boock ,  Jeff Jackson ,  Huashi Zhang ,  Jason Mitchell

IPC: A61B5/1473 ,  A61B5/145 ,  A61B5/1486 ,  B05C3/10

Abstract: Described here are embodiments of processes and systems for the continuous manufacturing of implantable continuous analyte sensors. In some embodiments, a method is provided for sequentially advancing an elongated conductive body through a plurality of stations, each configured to treat the elongated conductive body. In some of these embodiments, one or more of the stations is configured to coat the elongated conductive body using a meniscus coating process, whereby a solution formed of a polymer and a solvent is prepared, the solution is continuously circulated to provide a meniscus on a top portion of a vessel holding the solution, and the elongated conductive body is advanced through the meniscus. The method may also comprise the step of removing excess coating material from the elongated conductive body by advancing the elongated conductive body through a die orifice. For example, a provided elongated conductive body 510 is advanced through a pre-coating treatment station 520, through a coating station 530, through a thickness control station 540, through a drying or curing station 550, through a thickness measurement station 560, and through a post-coating treatment station 570.

公开(公告)号：US20180289333A1

公开(公告)日：2018-10-11

申请号：US16000748

申请日：2018-06-05

Applicant: DexCom, Inc.

Inventor： Apurv Ullas Kamath ,  Aarthi Mahalingam ,  Ying Li ,  Mohammad Ali Shariati ,  James H. Brauker ,  Mark C. Brister ,  Robert Boock

IPC: A61B5/00 ,  A61B5/145 ,  A61B5/1486 ,  A61B5/1495 ,  A61B5/01

Abstract: Systems and methods for detecting noise episodes and processing analyte sensor data responsive thereto. In some embodiments, processing analyte sensor data includes filtering the sensor data to reduce or eliminate the effects of the noise episode on the signal.

公开(公告)号：US09763608B2

公开(公告)日：2017-09-19

申请号：US14960011

申请日：2015-12-04

Applicant: DexCom, Inc.

Inventor： Peter C. Simpson ,  Robert Boock ,  Paul V. Neale ,  Sebastian Böhm ,  Matthew Wightlin ,  Jack Pryor ,  Jason Mitchell ,  Jeff Jackson ,  Kaushik Patel ,  Antonio C. Llevares

IPC: A61B5/05 ,  A61B5/1473 ,  A61B5/145 ,  A61B5/1486 ,  B05C3/10

CPC classification number: A61B5/1473 ,  A61B5/14503 ,  A61B5/1451 ,  A61B5/14517 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/14865 ,  A61B2560/0223 ,  A61B2562/0209 ,  A61B2562/043 ,  A61B2562/125 ,  B05C3/10

Abstract: Analyte sensors and methods of manufacturing same are provided, including analyte sensors comprising multi-axis flexibility. For example, a multi-electrode sensor system 800 comprising two working electrodes and at least one reference/counter electrode is provided. The sensor system 800 comprises first and second elongated bodies E1, E2, each formed of a conductive core or of a core with a conductive layer deposited thereon, insulating layer 810 that separates the conductive layer 820 from the elongated body, a membrane layer deposited on top of the elongated bodies E1, E2, and working electrodes 802′, 802″ formed by removing portions of the conductive layer 820 and the insulating layer 810, thereby exposing electroactive surface of the elongated bodies E1, E2.

公开(公告)号：US20160081600A1

公开(公告)日：2016-03-24

申请号：US14960011

申请日：2015-12-04

Applicant: DexCom, Inc

Inventor： Peter C. Simpson ,  Robert Boock ,  Paul V. Neale ,  Sebastian Böhm ,  Matthew Wightlin ,  Jack Pryor ,  Jason Mitchell ,  Jeff Jackson ,  Kaushik Patel ,  Antonio C. Llevares

IPC: A61B5/145

CPC classification number: A61B5/1473 ,  A61B5/14503 ,  A61B5/1451 ,  A61B5/14517 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/14865 ,  A61B2560/0223 ,  A61B2562/0209 ,  A61B2562/043 ,  A61B2562/125 ,  B05C3/10

Abstract: Analyte sensors and methods of manufacturing same are provided, including analyte sensors comprising multi-axis flexibility. For example, a multi-electrode sensor system 800 comprising two working electrodes and at least one reference/counter electrode is provided. The sensor system 800 comprises first and second elongated bodies E1, E2, each formed of a conductive core or of a core with a conductive layer deposited thereon, insulating layer 810 that separates the conductive layer 820 from the elongated body, a membrane layer deposited on top of the elongated bodies E1, E2, and working electrodes 802′, 802″ formed by removing portions of the conductive layer 820 and the insulating layer 810, thereby exposing electroactive surface of the elongated bodies E1, E2.

Abstract translation: 提供分析物传感器及其制造方法，包括包含多轴灵活性的分析物传感器。 例如，提供了包括两个工作电极和至少一个参考/对电极的多电极传感器系统800。 传感器系统800包括第一和第二细长体E1，E2，每个由导电芯或具有沉积在其上的导电层的芯构成，绝缘层810将导电层820与细长主体分隔开;膜层沉积在 通过去除导电层820和绝缘层810的部分而形成的细长体E1，E2和工作电极802'，802“的顶部，从而暴露细长体E1，E2的电活性表面。