公开(公告)号：US20230313160A1

公开(公告)日：2023-10-05

申请号：US18054745

申请日：2022-11-11

Applicant: Duke University

Inventor： Conrad P. Hodgkinson ,  Hualing Sun ,  Richard Pratt ,  Victor J. Dzau

IPC: C12N9/22 ,  C12N15/86 ,  A61P9/12

CPC classification number: C12N9/22 ,  A61P9/12 ,  C12N15/86 ,  C12N2310/20 ,  C12N2750/14143

Abstract: The present disclosure describes compositions and methods for treating hypertension in a subject.

公开(公告)号：US20220175845A1

公开(公告)日：2022-06-09

申请号：US17541917

申请日：2021-12-03

Applicant: Duke University

Inventor： Conrad P. Hodgkinson ,  Victor J. Dzau

IPC: A61K35/33 ,  C12N15/113 ,  C12N5/077

Abstract: The invention provides a method of promoting reprogramming of a cardiac fibroblast into a cardiomyocyte by contacting the cardiac fibroblast with an isolated polynucleotide molecule comprising at least two functional miRNA sequences using a multicistronic expression system for reprogramming of fibroblasts into functional mature cardiomyocytes.

公开(公告)号：US10695378B2

公开(公告)日：2020-06-30

申请号：US15997422

申请日：2018-06-04

Applicant: Duke University

Inventor： Victor J. Dzau ,  Maria Mirotsou ,  Tilanthi Jayawardena

IPC: A61K35/33 ,  A61L27/38 ,  A61L27/54 ,  A61L29/16 ,  A61L31/16 ,  C12N15/113 ,  C12N5/077

Abstract: A method for promoting conversion of cells into cardiomyocytic tissue is carried out by contacting fibrotic tissue (e.g., scar tissue) with a microRNA oligonucleotide or combination of microRNA oligonucleotides. The methods lead to direct reprogramming of fibroblasts to cardiomyocytes or cardiomyoblasts.

公开(公告)号：US20190192533A1

公开(公告)日：2019-06-27

申请号：US16195777

申请日：2018-11-19

Applicant: Duke University

Inventor： Victor J. Dzau ,  Maria Mirotsou

IPC: A61K31/551 ,  A61P9/00 ,  C07D487/04 ,  C07D401/14 ,  A61K45/06 ,  A61K31/437 ,  A61P9/12 ,  A61K35/34 ,  A61P9/10 ,  C12N15/113

CPC classification number: A61K31/551 ,  A61K31/437 ,  A61K35/34 ,  A61K45/06 ,  A61P9/00 ,  A61P9/10 ,  A61P9/12 ,  C07D401/14 ,  C07D487/04 ,  C12N15/1137 ,  C12N2310/141 ,  C12N2320/30 ,  C12Y201/01043 ,  C12Y201/01125 ,  C12Y207/10002 ,  C12Y207/11001

Abstract: A method for promoting the reprogramming of a non-cardiomyocytic cell or tissue into cardiomyocytic cell or tissue comprising is carried out by contacting a non-cardiomyocytic cell or tissue with a modulator of histone methyltransferase activity or expression.

公开(公告)号：US20140296152A1

公开(公告)日：2014-10-02

申请号：US14256174

申请日：2014-04-18

Applicant: THE BRIGHAM AND WOMEN'S HOSPITAL, INC. ,  Duke University

Inventor： Victor J. Dzau ,  Maria Mirotsou

IPC: A61K38/17

CPC classification number: A61K38/1709 ,  A61K9/0019 ,  A61K9/0053 ,  A61K9/0085 ,  A61K38/17 ,  A61K38/18 ,  A61K45/06 ,  C07K14/435 ,  C07K14/475 ,  C12N5/10 ,  C12N15/09 ,  C12N15/63

Abstract: A purified paracrine factor of a mesenchymal stem cell, such as a Secreted frizzled related protein (Sfrp) is useful to reduce cell death an/or tissue injury associated with ischemic conditions.