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    PRMT1 FOR TARGET GENES OF CANCER THERAPY AND DIAGNOSIS
    2.
    发明申请
    PRMT1 FOR TARGET GENES OF CANCER THERAPY AND DIAGNOSIS 有权
    PRMT1用于目标癌基因治疗和诊断

    公开(公告)号：US20110160293A1

    公开(公告)日：2011-06-30

    申请号：US13060672

    申请日：2009-08-25

    Applicant: Yusuke Nakamura ,  Ryuji Hamamoto ,  Akira Togashi

    Inventor： Yusuke Nakamura ,  Ryuji Hamamoto ,  Akira Togashi

    IPC: A61K31/7052 ,  C12Q1/68 ,  G01N33/53 ,  C12Q1/02 ,  C12Q1/48 ,  C07H21/00 ,  C12N15/63 ,  A61P35/00

    CPC classification number: C12N15/1137 ,  C12N2310/14 ,  C12Q1/6886 ,  C12Q2600/136 ,  C12Q2600/154 ,  C12Q2600/158 ,  C12Y201/01125 ,  G01N33/57407 ,  G01N33/57484 ,  G01N2500/10

    Abstract: Objective methods for diagnosing a predisposition to developing cancer, particularly bladder cancer, gastric cancer, colorectal cancer, breast cancer, esophageal cancer, lung cancer, lymphoma, pancreatic cancer and testicular cancer, are described herein. In one embodiment, the diagnostic method involves determining an expression level of PRMT1 gene. The present invention further provides methods of screening for therapeutic agents useful in the treatment of PRMT1 associated disease, such as a cancer, e.g. bladder cancer, gastric cancer, colorectal cancer, breast cancer, esophageal cancer, lung cancer, lymphoma, pancreatic cancer and testicular cancer. The present invention further provides methods of inhibiting the cell growth and treating or alleviating symptoms of PRMT1 associated diseases. The present invention also features products, including double-stranded molecules and vectors encoding thereof as well as to compositions comprising them.

    Abstract translation: 本文描述了用于诊断发展中的癌症，特别是膀胱癌，胃癌，结肠直肠癌，乳腺癌，食管癌，肺癌，淋巴瘤，胰腺癌和睾丸癌的易感性的客观方法。 在一个实施方案中，诊断方法包括确定PRMT1基因的表达水平。 本发明还提供筛选用于治疗PRMT1相关疾病例如癌症的治疗剂的方法，例如癌症。 膀胱癌，胃癌，结肠直肠癌，乳腺癌，食管癌，肺癌，淋巴瘤，胰腺癌和睾丸癌。 本发明还提供了抑制细胞生长和治疗或减轻PRMT1相关疾病症状的方法。 本发明还涉及包括双链分子和编码它们的载体以及包含它们的组合物的产品。

    PRMT1 for target genes of cancer therapy and diagnosis
    9.
    发明授权
    PRMT1 for target genes of cancer therapy and diagnosis 有权
    PRMT1用于癌症治疗和诊断的靶基因

    公开(公告)号：US08512944B2

    公开(公告)日：2013-08-20

    申请号：US13060672

    申请日：2009-08-25

    Applicant: Yusuke Nakamura ,  Ryuji Hamamoto ,  Akira Togashi

    Inventor： Yusuke Nakamura ,  Ryuji Hamamoto ,  Akira Togashi

    IPC: C12Q1/00

    CPC classification number: C12N15/1137 ,  C12N2310/14 ,  C12Q1/6886 ,  C12Q2600/136 ,  C12Q2600/154 ,  C12Q2600/158 ,  C12Y201/01125 ,  G01N33/57407 ,  G01N33/57484 ,  G01N2500/10

    Abstract: Objective methods for diagnosing a predisposition to developing cancer, particularly bladder cancer, gastric cancer, colorectal cancer, breast cancer, esophageal cancer, lung cancer, lymphoma, pancreatic cancer and testicular cancer, are described herein. In one embodiment, the diagnostic method involves determining an expression level of PRMT1 gene. The present invention further provides methods of screening for therapeutic agents useful in the treatment of PRMT1 associated disease, such as a cancer, e.g. bladder cancer, gastric cancer, colorectal cancer, breast cancer, esophageal cancer, lung cancer, lymphoma, pancreatic cancer and testicular cancer. The present invention further provides methods of inhibiting the cell growth and treating or alleviating symptoms of PRMT1 associated diseases. The present invention also features products, including double-stranded molecules and vectors encoding thereof as well as to compositions comprising them.

    Abstract translation: 本文描述了用于诊断发展中的癌症，特别是膀胱癌，胃癌，结肠直肠癌，乳腺癌，食管癌，肺癌，淋巴瘤，胰腺癌和睾丸癌的易感性的客观方法。 在一个实施方案中，诊断方法包括确定PRMT1基因的表达水平。 本发明还提供筛选用于治疗PRMT1相关疾病例如癌症的治疗剂的方法，例如癌症。 膀胱癌，胃癌，结肠直肠癌，乳腺癌，食管癌，肺癌，淋巴瘤，胰腺癌和睾丸癌。 本发明还提供了抑制细胞生长和治疗或减轻PRMT1相关疾病症状的方法。 本发明还涉及包括双链分子和编码它们的载体以及包含它们的组合物的产品。

    27419, a novel human arginine-N-methyl transferase and uses thereof
    10.
    发明申请
    27419, a novel human arginine-N-methyl transferase and uses thereof 审中-公开
    27419，一种新的人精氨酸-N-甲基转移酶及其用途

    公开(公告)号：US20020090627A1

    公开(公告)日：2002-07-11

    申请号：US09970638

    申请日：2001-10-03

    Inventor： Rachel Meyers

    IPC: C12Q001/68 ,  C07H021/04 ,  C12N009/10 ,  C12P021/02 ,  C12N005/06 ,  C07K014/435

    CPC classification number: C12N9/1007 ,  C12Q1/6883 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Y201/01125

    Abstract: The invention provides isolated nucleic acids molecules, designated 27419 nucleic acid molecules, which encode novel methyltransferase family members, preferably arginine methyltransferase family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 27419 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 27419 gene has been introduced or disrupted. The invention still further provides isolated 27419 proteins, fusion proteins, antigenic peptides and anti-27419 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

    Abstract translation: 本发明提供分离的核酸分子，命名为27419核酸分子，其编码新的甲基转移酶家族成员，优选精氨酸甲基转移酶家族成员。 本发明还提供了反义核酸分子，含有27419个核酸分子的重组表达载体，其中引入了表达载体的宿主细胞和其中已经引入或破坏了27419基因的非人转基因动物。 本发明还进一步提供了分离的27419蛋白，融合蛋白，抗原肽和抗27419抗体。 还提供了利用本发明组合物的诊断方法。

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