Methods and compositions for detecting BK virus
    12.
    发明授权
    Methods and compositions for detecting BK virus 有权
    检测BK病毒的方法和组合物

    公开(公告)号:US07892795B2

    公开(公告)日:2011-02-22

    申请号:US11246904

    申请日:2005-10-06

    摘要: The invention provides methods and compositions for rapid, sensitive, and highly specific nucleic acid-based (e.g., DNA based) detection of a BK virus in a sample. In general, the methods involve detecting a target nucleic acid having a target sequence of a conserved region of BK viral genomes. The invention also features compositions, including primers, probes, and kits, for use in the methods of the invention.

    摘要翻译: 本发明提供用于样品中BK病毒的快速,灵敏和高度特异性核酸(例如基于DNA)检测的方法和组合物。 通常,所述方法涉及检测具有BK病毒基因组的保守区的靶序列的靶核酸。 本发明还包括用于本发明方法的组合物,包括引物,探针和试剂盒。

    Silicon-germanium heterojunction bipolar transistor
    15.
    发明授权
    Silicon-germanium heterojunction bipolar transistor 有权
    硅 - 锗异质结双极晶体管

    公开(公告)号:US08378457B2

    公开(公告)日:2013-02-19

    申请号:US13239250

    申请日:2011-09-21

    IPC分类号: H01L27/102

    摘要: A SiGe HBT formed on a silicon substrate is disclosed. An active area is isolated by field oxide regions; a collector region is formed in the active area and extends into the bottom of the field oxide regions; pseudo buried layers are formed at the bottom of the field oxide regions, wherein each pseudo buried layer is separated by a lateral distance from the active area and connected to a lateral extension part of the collector region; first deep hole contacts are formed on top of the pseudo buried layers in the field oxide regions to pick up collector electrodes; a plurality of second deep hole contacts with a floating structure, are formed in the field oxide region on top of a lateral extension part of the collector region, wherein N-type implantation regions are formed at the bottom of the second deep hole contacts.

    摘要翻译: 公开了一种形成在硅衬底上的SiGe HBT。 有源区域由场氧化物区域隔离; 在有源区域中形成集电极区域并延伸到场氧化物区域的底部; 伪掩埋层形成在场氧化物区域的底部,其中每个伪掩埋层与有源区域的横向距离分离并连接到集电极区域的横向延伸部分; 第一深孔触点形成在场氧化物区域中的伪掩埋层的顶部上以拾取集电极; 在集电区域的横向延伸部分的顶部上的场氧化物区域中形成多个具有浮动结构的第二深孔触点,其中在第二深孔触点的底部形成有N型注入区域。

    MULTIPLEX DETECTION ASSAY FOR INFLUENZA AND RSV VIRUSES
    18.
    发明申请
    MULTIPLEX DETECTION ASSAY FOR INFLUENZA AND RSV VIRUSES 有权
    用于流感病毒和RSV病毒的多重检测测定

    公开(公告)号:US20090181360A1

    公开(公告)日:2009-07-16

    申请号:US11963699

    申请日:2007-12-21

    IPC分类号: C12Q1/70

    CPC分类号: C12Q1/701

    摘要: The present invention generally relates to a molecular test of Influenza A, Influenza B, Respiratory Syncytial Virus A, and Respiratory Syncytial Virus B in order to identify patients with a viral infection. Accordingly methods and compositions are disclosed to determine the presence or absence of a viral pathogen in a sample containing one or more target nucleic acids from the M gene of Influenza A, Influenza B, Respiratory Syncytial Virus A, and/or Respiratory Syncytial Virus B.

    摘要翻译: 本发明一般涉及A型流感,B型流感,呼吸道合胞病毒A和呼吸道合胞病毒B的分子检测,以鉴定病毒感染患者。 因此,公开了方法和组合物以确定含有来自A型流感,B型流感,呼吸道合胞病毒A和/或呼吸道合胞病毒B的M基因的一种或多种靶核酸的样品中病毒病原体的存在或不存在。

    Parallel polymorphism scoring by amplification and error correction
    19.
    发明申请
    Parallel polymorphism scoring by amplification and error correction 审中-公开
    平行多态性通过放大和纠错得分

    公开(公告)号:US20070009954A1

    公开(公告)日:2007-01-11

    申请号:US11521754

    申请日:2006-09-15

    IPC分类号: C12Q1/68 C12P19/34 C07H21/04

    摘要: This invention provides a method of detecting polymorphisms, e.g., single nucleotide polymorphisms (SNPs), by amplification and error correction. The invention encompasses methods of performing amplification and error correction using an improved generation of nucleic acid polymerases, and methods of multiplexing the assay. The improvement to the polymerases is the joining of a sequence-non-specific nucleic-acid-binding domain to the enzyme in a manner that enhances the ability of the enzyme to bind and catalytically modify the nucleic acid.

    摘要翻译: 本发明提供了通过扩增和错误校正来检测多态性(例如单核苷酸多态性(SNP))的方法。 本发明包括使用改进的核酸聚合酶的产生来进行扩增和纠错的方法,以及多重测定的方法。 对聚合酶的改进是以提高酶结合和催化修饰核酸的能力的方式连接序列非特异性核酸结合结构域与酶。