公开(公告)号：US20210171516A1

公开(公告)日：2021-06-10

申请号：US17031348

申请日：2020-09-24

Applicant: GENENTECH, INC. ,  XENON PHARMACEUTICALS INC.

Inventor： Philippe BERGERON ,  Kristen BURFORD ,  Sultan CHOWDHURY ,  Christoph Martin DEHNHARDT ,  Thilo FOCKEN ,  Michael Edward GRIMWOOD ,  Abid HASAN ,  Kwong Wah LAI ,  Zhiguo LIU ,  Steven MCKERRALL ,  Teresa Phuongtram NGUYEN ,  Brian Salvatore SAFINA ,  Daniel SUTHERLIN ,  Tao WANG

IPC: C07D417/12 ,  C07D417/14 ,  A61P17/04 ,  C07D401/12 ,  C07D405/14 ,  C07D491/107

Abstract: The invention provides a compound of formula: or a salt thereof, wherein the variables RAA, n, ring A, ring B, R1a, R1b, R2, R3, R4, R5, R6, R7, R8, and R9 have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.

公开(公告)号：US20190300544A1

公开(公告)日：2019-10-03

申请号：US16370756

申请日：2019-03-29

Applicant: GENENTECH, INC.

Inventor： Steven MCKERRALL ,  Brian Salvatore SAFINA ,  Aleksandr KOLESNIKOV ,  Birong ZHANG ,  Wenfeng LIU ,  Kwong Wah LAI

IPC: C07D498/04 ,  C07D471/04 ,  A61P25/24 ,  A61P9/00 ,  A61P11/00

Abstract: The invention provides a compound of formula (I): or a pharmaceutically acceptable salt thereof; wherein, A, B, ring C, R3, R4, R5, R6, and R7 have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.

公开(公告)号：US20180105504A1

公开(公告)日：2018-04-19

申请号：US15799771

申请日：2017-10-31

Applicant: GENENTECH, INC. ,  XENON PHARMACEUTICALS INC.

Inventor： Daniel SUTHERLIN ,  Steven MCKERRALL ,  Michael Scott WILSON ,  Kwong Wah LAI ,  Philippe BERGERON ,  Birong ZHANG

IPC: C07D277/52 ,  C07D239/69 ,  C07D285/08 ,  C07D417/12 ,  C07D213/76 ,  C07D401/12 ,  C07D403/12 ,  C07D261/16

CPC classification number: C07D277/52 ,  A61K31/427 ,  A61P19/02 ,  A61P29/00 ,  C07D213/76 ,  C07D239/69 ,  C07D261/16 ,  C07D285/08 ,  C07D401/12 ,  C07D403/12 ,  C07D417/12

Abstract: The invention provides a compound of formula I: or a pharmaceutically acceptable salt thereof, wherein the variables X, Y1-Y5, R1, R2, R3, R4, and Het have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.

公开(公告)号：US20240336625A1

公开(公告)日：2024-10-10

申请号：US18580607

申请日：2022-07-15

Applicant: Genentech, Inc.

Inventor： Kwong Wah LAI ,  Christian NILEWSKI ,  Richard M. PASTOR ,  Craig STIVALA

IPC: C07D498/04 ,  A61K31/424

CPC classification number: C07D498/04 ,  A61K31/424

Abstract: Described herein are sulfonimidamide compounds, solvates thereof, tautomers thereof, and pharmaceutically acceptable salts of the foregoing. Further described herein are methods of treating a disorder in a subject in need thereof using said compounds, solvates, tautomers, or pharmaceutically acceptable salts thereof, such as NLRP3-mediated disorders.

公开(公告)号：US20240174696A1

公开(公告)日：2024-05-30

申请号：US18526572

申请日：2023-12-01

Applicant: Genentech, Inc.

Inventor： Steven John MCKERRALL ,  Alice Rose WONG ,  James John CRAWFORD ,  Wendy LEE ,  Kwong Wah LAI ,  Guillaume PELLETIER ,  Stéphanie ROY ,  Dana Krystin WINTER ,  Mikiko OKUMURA ,  Ruth Dorel

IPC: C07D519/00 ,  A61P11/00

CPC classification number: C07D519/00 ,  A61P11/00

Abstract: Disclosed are 2,8-diazaspiro[4.5]decane compounds, including (pyrido[3,4-d]pyrimidin-4-yl)-2,8-diazaspiro[4.5]decane compounds, (2,6-naphthyridin-1-yl)-2,8-diazaspiro[4.5]decane compounds, and (1,7-naphthyridin-4-yl)-2,8-diazaspiro[4.5]decane compounds, that are inhibitors of LATS1/2, compositions containing these compounds, and methods for inhibiting LATS1/2 activity.

公开(公告)号：US20200017469A1

公开(公告)日：2020-01-16

申请号：US16495802

申请日：2018-03-22

Applicant: GENENTECH, INC.

Inventor： Daniel SUTHERLIN ,  Steven MCKERRALL ,  Kwong Wah LAI

IPC: C07D401/14

Abstract: The invention provides 4-piperidin-chroman-7-sulfonamide derivatives and salts thereof that are sodium channel modulators, as well as compositions containing such a compound or salt and therapeutic methods for using such a compound, salt, or composition.

公开(公告)号：US20170001990A1

公开(公告)日：2017-01-05

申请号：US15266222

申请日：2016-09-15

Applicant: Genentech, Inc.

Inventor： Jinhua CHEN ,  Charles Z. DING ,  Peter DRAGOVICH ,  Benjamin FAUBER ,  Zhenting GAO ,  Sharada S. LABADIE ,  Kwong Wah LAI ,  Hans Edward PURKEY ,  Kirk ROBARGE ,  Binqing WEI ,  Aihe ZHOU

IPC: C07D409/14 ,  C07D401/04 ,  C07D417/04 ,  C07D491/107 ,  C07D211/86 ,  C07D417/14 ,  C07D491/048 ,  C07D405/14 ,  C07D491/08 ,  C07D498/08 ,  C07D409/04 ,  C07D413/14

CPC classification number: C07D409/14 ,  C07D211/86 ,  C07D401/04 ,  C07D401/14 ,  C07D405/14 ,  C07D409/04 ,  C07D413/14 ,  C07D417/04 ,  C07D417/14 ,  C07D487/08 ,  C07D491/048 ,  C07D491/08 ,  C07D491/107 ,  C07D498/08

Abstract: The invention provides novel compounds having the general formula: and tautomers and pharmaceutically acceptable salts thereof, wherein A1, A2, A3, A4, R1, R4, R5, R6, R7 and R8 are as defined herein, compositions including the compounds and methods of using the compounds.

Abstract translation: 本发明提供具有通式（I）的新化合物及其互变异构体及其药学上可接受的盐，其中A1，A2，A3，A4，R1，R4，R5，R6，R7和R8如本文所定义，包括化合物和 使用化合物的方法。