公开(公告)号：US20190177432A1

公开(公告)日：2019-06-13

申请号：US16284774

申请日：2019-02-25

Applicant: GENENTECH, INC.

Inventor： Yongmei Chen ,  James Ernst ,  Hok Seon Kim ,  Junichiro Sonoda ,  Christoph Spiess ,  Scott Stawicki ,  Yan Wu

IPC: C07K16/40 ,  C07K14/71 ,  C07K16/28

Abstract: The presently disclosed subject matter provides antibodies that bind KLB and FGFR1, and methods of using the same. In certain embodiments, an antibody of the present disclosure includes a bispecific antibody that binds to an epitope present on FGFR1 and binds to an epitope present on KLB.

公开(公告)号：US20150147333A1

公开(公告)日：2015-05-28

申请号：US14517709

申请日：2014-10-17

Applicant: GENENTECH, INC.

Inventor： Elaine Storm ,  Frederic J. de Sauvage ,  Jeremy M. Murray ,  Cameron L. Noland ,  Yan Wu ,  Christine Tan ,  Jo-Anne Hongo ,  Yongmei Chen

IPC: C07K16/18 ,  A61K39/395 ,  A61K45/06 ,  A61K47/48

CPC classification number: C07K16/18 ,  A61K39/3955 ,  A61K45/06 ,  A61K47/6843 ,  A61K2039/505 ,  C07K16/2818 ,  C07K16/3046 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/75 ,  C07K2317/76 ,  C07K2317/92

Abstract: Provided herein are anti-RSPO antibodies, in particular anti-RSPO2 antibodies and/or anti-RSPO3 antibodies, and methods of using the same.

Abstract translation: 本文提供抗RSPO抗体，特别是抗RSPO2抗体和/或抗RSPO3抗体，以及使用该抗RSP2抗体的方法。

公开(公告)号：US10246518B2

公开(公告)日：2019-04-02

申请号：US15837801

申请日：2017-12-11

Applicant: Genentech, Inc.

Inventor： Yongmei Chen ,  James Ernst ,  Hok Seon Kim ,  Junichiro Sonoda ,  Christoph Spiess ,  Scott Stawicki ,  Yan Wu

IPC: C12N15/13 ,  C07K16/40 ,  C07K14/71 ,  C07K16/28 ,  A61K39/00

Abstract: The presently disclosed subject matter provides antibodies that bind KLB and FGFR1, and methods of using the same. In certain embodiments, an antibody of the present disclosure includes a bispecific antibody that binds to an epitope present on FGFR1 and binds to an epitope present on KLB.

公开(公告)号：US09884919B2

公开(公告)日：2018-02-06

申请号：US15214160

申请日：2016-07-19

Applicant: GENENTECH, INC.

Inventor： Yongmei Chen ,  James Ernst ,  Hok Seon Kim ,  Junichiro Sonoda ,  Christoph Spiess ,  Scott Stawicki ,  Yan Wu

IPC: A61K39/395 ,  C07K16/40 ,  C07K14/71 ,  C07K16/28 ,  A61K39/00

CPC classification number: C07K16/40 ,  A61K2039/505 ,  C07K14/71 ,  C07K16/2863 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/40 ,  C07K2317/41 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/524 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/71 ,  C07K2317/75 ,  C07K2317/92

Abstract: The presently disclosed subject matter provides antibodies that bind KLB and FGFR1, and methods of using the same. In certain embodiments, an antibody of the present disclosure includes a bispecific antibody that binds to an epitope present on FGFR1 and binds to an epitope present on KLB.

公开(公告)号：US09879094B2

公开(公告)日：2018-01-30

申请号：US15234649

申请日：2016-08-11

Applicant: Genentech, Inc.

Inventor： Jasvinder Atwal ,  Yongmei Chen ,  Cecilia Pui Chi Chiu ,  Robert A. Lazarus ,  Weiru Wang ,  Ryan J. Watts ,  Yan Wu ,  Yingnan Zhang

IPC: C07H21/04 ,  C07K16/18 ,  C12P21/08 ,  C07K16/40 ,  A61K39/395 ,  G01N33/573 ,  C12P21/00 ,  A61K47/68 ,  A61K39/00

CPC classification number: C07K16/40 ,  A61K39/3955 ,  A61K47/6871 ,  A61K2039/505 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  C12P21/005 ,  G01N33/573

Abstract: The invention provides antibodies to specific neural proteins and methods of using the same.

公开(公告)号：US09873748B2

公开(公告)日：2018-01-23

申请号：US14582100

申请日：2014-12-23

Applicant: GENENTECH, INC.

Inventor： Yongmei Chen ,  James Ernst ,  Hok Seon Kim ,  Junichiro Sonoda ,  Christoph Spiess ,  Scott Stawicki ,  Yan Wu

IPC: C07K16/28 ,  C07K16/18 ,  C07K16/40 ,  C07K14/71 ,  A61K39/00

CPC classification number: C07K16/40 ,  A61K2039/505 ,  C07K14/71 ,  C07K16/2863 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/40 ,  C07K2317/41 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/524 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/71 ,  C07K2317/75 ,  C07K2317/92

Abstract: The presently disclosed subject matter provides antibodies that bind KLB and FGFR1, and methods of using the same. In certain embodiments, an antibody of the present disclosure includes a bispecific antibody that binds to an epitope present on FGFR1 and binds to an epitope present on KLB.

公开(公告)号：US09512217B2

公开(公告)日：2016-12-06

申请号：US14148414

申请日：2014-01-06

Applicant: Genentech, Inc.

Inventor： Yongmei Chen ,  Yan (Helen) Hu ,  Wenjun Ouyang ,  Scott Stawicki ,  Yan Wu

IPC: A61K39/395 ,  C07K16/24

CPC classification number: C07K16/244 ,  C07K2317/31 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/92

Abstract: The present invention relates generally to antibodies cross-reactive with IL-17A and IL-17F, and bispecific anti-IL-17A/F and their uses.

Abstract translation: 本发明一般涉及与IL-17A和IL-17F交叉反应的抗体，以及双特异性抗IL-17A / F及其用途。