公开(公告)号：US10065958B2

公开(公告)日：2018-09-04

申请号：US14613719

申请日：2015-02-04

Applicant: Gilead Sciences, Inc.

Inventor： Richard L. Mackman ,  Jay P. Parrish ,  Adrian S. Ray ,  Dorothy Agnes Theodore

IPC: C07D487/04 ,  C07F9/6561 ,  C07H19/04 ,  A61K9/00 ,  A61K31/706 ,  A61K45/06 ,  C07H7/06

CPC classification number: C07D487/04 ,  A61K9/0078 ,  A61K31/706 ,  A61K45/06 ,  C07F9/6561 ,  C07H7/06 ,  C07H19/04

Abstract: Provided are methods for treating Paramyxoviridae virus infections by administering ribosides, riboside phosphates and prodrugs thereof, of Formula I: wherein the 1′ position of the nucleoside sugar is substituted. The compounds, compositions, and methods provided are particularly useful for the treatment of Human parainfluenza and Human respiratory syncytial virus infections.

公开(公告)号：US20160122374A1

公开(公告)日：2016-05-05

申请号：US14926062

申请日：2015-10-29

Applicant: Gilead Sciences, Inc.

Inventor： Byoung Kwon Chun ,  Michael O' Neil Hanrahan Clarke ,  Edward Doerffler ,  Hon Chung Hui ,  Robert Jordan ,  Richard L. Mackman ,  Jay P. Parrish ,  Adrian S. Ray ,  Dustin Siegel

IPC: C07F9/6561 ,  A61K31/675 ,  A61K45/06 ,  A61K31/685

CPC classification number: A61K31/685 ,  A61K31/00 ,  A61K31/53 ,  A61K31/6615 ,  A61K31/665 ,  A61K31/675 ,  A61K31/683 ,  A61K45/06 ,  C07D487/04 ,  C07D519/00 ,  C07F9/2429 ,  C07F9/65616 ,  C07H1/00 ,  C07H1/02 ,  C07H11/00 ,  C07H15/18 ,  A61K2300/00

Abstract: Provided are compounds, methods, and pharmaceutical compositions for treating Filoviridae virus infections by administering ribosides, riboside phosphates and prodrugs thereof, of Formula IV: The compounds, compositions, and methods provided are particularly useful for the treatment of Marburg virus, Ebola virus and Cueva virus infections.

Abstract translation: 本发明提供了通过给予式IV的核糖苷，核苷磷酸酯及其前体药物治疗丝状病毒感染的化合物，方法和药物组合物：所提供的化合物，组合物和方法特别可用于治疗马尔堡病毒，埃博拉病毒和Cueva 病毒感染。

公开(公告)号：US20150111839A1

公开(公告)日：2015-04-23

申请号：US14579348

申请日：2014-12-22

Applicant: Gilead Sciences, Inc.

Inventor： Richard L. Mackman ,  Jay P. Parrish ,  Adrian S. Ray ,  Dorothy A. Theodore

IPC: C07H7/06 ,  A61K45/06 ,  A61K9/00 ,  A61K31/706

CPC classification number: C07D487/04 ,  A61K9/0078 ,  A61K31/706 ,  A61K45/06 ,  C07F9/6561 ,  C07H7/06 ,  C07H19/04

Abstract: Provided are methods for treating Paramyxoviridae virus infections by administering ribosides, riboside phosphates and prodrugs thereof, of Formula I: wherein the 1′ position of the nucleoside sugar is substituted. The compounds, compositions, and methods provided are particularly useful for the treatment of Human parainfluenza and Human respiratory syncytial virus infections.

Abstract translation: 本发明提供了通过给予式I的核糖苷，其核苷糖苷及其前体药物来治疗副粘病毒科病毒感染的方法：其中核苷糖的1'位置被取代。 提供的化合物，组合物和方法特别可用于治疗人类副流感和人类呼吸道合胞病毒感染。

公开(公告)号：US20230125751A1

公开(公告)日：2023-04-27

申请号：US17854818

申请日：2022-06-30

Applicant: Gilead Sciences, Inc.

Inventor： Richard L. Mackman ,  Jay P. Parrish ,  Adrian S. Ray ,  Dorothy Agnes Theodore

IPC: C07D487/04 ,  C07H19/04 ,  A61K9/00 ,  A61K31/706 ,  A61K45/06 ,  C07H7/06 ,  C07F9/6561

Abstract: Provided are methods for treating Paramyxoviridae virus infections by administering ribosides, riboside phosphates and prodrugs thereof, of Formula I: wherein the 1′ position of the nucleoside sugar is substituted. The compounds, compositions, and methods provided are particularly useful for the treatment of Human parainfluenza and Human respiratory syncytial virus infections.

公开(公告)号：US10695357B2

公开(公告)日：2020-06-30

申请号：US16274049

申请日：2019-02-12

Applicant: GILEAD SCIENCES, INC.

Inventor： Byoung Kwon Chun ,  Michael O'Neil Hanrahan Clarke ,  Edward Doerffler ,  Hon Chung Hui ,  Robert Jordan ,  Richard L. Mackman ,  Jay P. Parrish ,  Adrian S. Ray ,  Dustin Siegel

IPC: A61K31/706 ,  A61K31/7056 ,  A61K31/685 ,  A61K31/53 ,  C07H1/00 ,  C07H1/02 ,  C07H11/00 ,  C07H15/18 ,  A61K31/6615 ,  A61K31/665 ,  A61K31/683 ,  C07D487/04 ,  C07D519/00 ,  C07F9/24 ,  C07F9/6561 ,  A61K31/675 ,  A61K45/06 ,  A61K31/00

Abstract: Provided are compounds, methods, and pharmaceutical compositions for treating Filoviridae virus infections by administering ribosides, riboside phosphates and prodrugs thereof, of Formula IV: The compounds, compositions, and methods provided are particularly useful for the treatment of Marburg virus, Ebola virus and Cueva virus infections.

公开(公告)号：US10251898B2

公开(公告)日：2019-04-09

申请号：US15902690

申请日：2018-02-22

Applicant: Gilead Sciences, Inc.

Inventor： Byoung Kwon Chun ,  Michael O'Neil Hanrahan Clarke ,  Edward Doerffler ,  Hon Chung Hui ,  Robert Jordan ,  Richard L. Mackman ,  Jay P. Parrish ,  Adrian S. Ray ,  Dustin Siegel

IPC: A61K31/706 ,  A61K31/7056 ,  A61K31/685 ,  C07D487/04 ,  C07D519/00 ,  C07F9/24 ,  C07F9/6561 ,  A61K31/675 ,  A61K45/06 ,  A61K31/00 ,  A61K31/53 ,  C07H1/00 ,  C07H1/02 ,  C07H11/00 ,  C07H15/18 ,  A61K31/6615 ,  A61K31/665 ,  A61K31/683

Abstract: Provided are compounds, methods, and pharmaceutical compositions for treating Filoviridae virus infections by administering ribosides, riboside phosphates and prodrugs thereof, of Formula IV: The compounds, compositions, and methods provided are particularly useful for the treatment of Marburg virus, Ebola virus and Cueva virus infections.

公开(公告)号：US09949994B2

公开(公告)日：2018-04-24

申请号：US15246240

申请日：2016-08-24

Applicant: Gilead Sciences, Inc.

Inventor： Byoung Kwon Chun ,  Michael O'Neil Hanrahan Clarke ,  Edward Doerffler ,  Hon Chung Hui ,  Robert Jordan ,  Richard L. Mackman ,  Jay P. Parrish ,  Adrian S. Ray ,  Dustin Siegel

IPC: C07H15/18 ,  C07H7/06 ,  A61K31/685 ,  C07D487/04 ,  C07D519/00 ,  C07F9/24 ,  C07F9/6561 ,  A61K31/675 ,  A61K45/06 ,  A61K31/00 ,  A61K31/53 ,  C07H1/00 ,  C07H1/02 ,  C07H11/00

CPC classification number: A61K31/685 ,  A61K31/00 ,  A61K31/53 ,  A61K31/6615 ,  A61K31/665 ,  A61K31/675 ,  A61K31/683 ,  A61K45/06 ,  C07D487/04 ,  C07D519/00 ,  C07F9/2429 ,  C07F9/65616 ,  C07H1/00 ,  C07H1/02 ,  C07H11/00 ,  C07H15/18 ,  A61K2300/00

Abstract: Provided are compounds, methods, and pharmaceutical compositions for treating Filoviridae virus infections by administering ribosides, riboside phosphates and prodrugs thereof, of Formula IV: The compounds, compositions, and methods provided are particularly useful for the treatment of Marburg virus, Ebola virus and Cueva virus infections.

公开(公告)号：US20170042961A1

公开(公告)日：2017-02-16

申请号：US15244926

申请日：2016-08-23

Applicant: Gilead Sciences, Inc.

Inventor： William E. Delaney, IV ,  John O. Link ,  Hongmei Mo ,  David W. Oldach ,  Adrian S. Ray ,  William J. Watkins ,  Cheng Yong Yang ,  Weidong Zhong

IPC: A61K38/05 ,  A61K31/675 ,  A61K31/7068 ,  A61K31/381 ,  A61K31/4184 ,  A61K31/501 ,  A61K31/706

CPC classification number: A61K38/05 ,  A61K31/381 ,  A61K31/40 ,  A61K31/401 ,  A61K31/4025 ,  A61K31/407 ,  A61K31/4178 ,  A61K31/4184 ,  A61K31/4188 ,  A61K31/4353 ,  A61K31/4436 ,  A61K31/501 ,  A61K31/5377 ,  A61K31/662 ,  A61K31/675 ,  A61K31/7056 ,  A61K31/706 ,  A61K31/7068 ,  A61K38/212 ,  A61K45/06 ,  A61K2300/00

Abstract: This invention relates to combinations of therapeutic molecules useful for treating hepatitis C virus infection. The present invention relates to methods, uses, dosing regimens, and compositions.

Abstract translation: 本发明涉及可用于治疗丙型肝炎病毒感染的治疗分子的组合。 本发明涉及方法，用途，给药方案和组合物。

公开(公告)号：US20160361330A1

公开(公告)日：2016-12-15

申请号：US15246240

申请日：2016-08-24

Applicant: Gilead Sciences, Inc.

Inventor： Byoung Kwon Chun ,  Michael O'Neil Hanrahan Clarke ,  Edward Doerffler ,  Hon Chung Hui ,  Robert Jordan ,  Richard L. Mackman ,  Jay P. Parrish ,  Adrian S. Ray ,  Dustin Siegel

IPC: A61K31/685 ,  A61K31/675 ,  A61K45/06 ,  C07F9/6561 ,  A61K31/53 ,  C07D487/04

CPC classification number: A61K31/685 ,  A61K31/00 ,  A61K31/53 ,  A61K31/6615 ,  A61K31/665 ,  A61K31/675 ,  A61K31/683 ,  A61K45/06 ,  C07D487/04 ,  C07D519/00 ,  C07F9/2429 ,  C07F9/65616 ,  C07H1/00 ,  C07H1/02 ,  C07H11/00 ,  C07H15/18 ,  A61K2300/00

Abstract: Provided are compounds, methods, and pharmaceutical compositions for treating Filoviridae virus infections by administering ribosides, riboside phosphates and prodrugs thereof, of Formula IV: The compounds, compositions, and methods provided are particularly useful for the treatment of Marburg virus, Ebola virus and Cueva virus infections.

Abstract translation: 所提供的化合物，组合物和方法特别可用于治疗马尔堡病毒，埃博拉病毒和奇瓦病毒感染。

公开(公告)号：US09452154B2

公开(公告)日：2016-09-27

申请号：US14513900

申请日：2014-10-14

Applicant: Gilead Sciences, Inc.

Inventor： William E. Delaney, IV ,  John O. Link ,  Hongmei Mo ,  David W. Oldach ,  Adrian S. Ray ,  William J. Watkins ,  Cheng Yong Yang ,  Weidong Zhong

IPC: A61K31/675 ,  A61K31/4184 ,  A61K31/381 ,  A61K31/40 ,  A61K31/401 ,  A61K31/4025 ,  A61K31/407 ,  A61K31/4178 ,  A61K31/4188 ,  A61K31/4353 ,  A61K31/4436 ,  A61K31/662 ,  A61K31/7056 ,  A61K45/06 ,  A61K31/501 ,  A61K31/5377 ,  A61K38/21 ,  A61K31/706

CPC classification number: A61K38/05 ,  A61K31/381 ,  A61K31/40 ,  A61K31/401 ,  A61K31/4025 ,  A61K31/407 ,  A61K31/4178 ,  A61K31/4184 ,  A61K31/4188 ,  A61K31/4353 ,  A61K31/4436 ,  A61K31/501 ,  A61K31/5377 ,  A61K31/662 ,  A61K31/675 ,  A61K31/7056 ,  A61K31/706 ,  A61K31/7068 ,  A61K38/212 ,  A61K45/06 ,  A61K2300/00

Abstract: This invention relates to combinations of therapeutic molecules useful for treating hepatitis C virus infection. The present invention relates to methods, uses, dosing regimens, and compositions.