公开(公告)号：US10377761B2

公开(公告)日：2019-08-13

申请号：US16045371

申请日：2018-07-25

申请人： Gilead Sciences, Inc.

发明人： Michael O'Neil Hanrahan Clarke ,  Edward Doerffler ,  Richard L. Mackman ,  Dustin Siegel

IPC分类号： C07H7/06 ,  C07D487/04 ,  C07D405/14 ,  C07D405/04 ,  C07F9/6561

摘要： Provided herein are formulations, methods and substituted tetrahydrofuranyl-pyrrolo[1,2-f][1,2,4]triazine-4-amine compounds of Formula (I) for treating Pneumovirinae virus infections, including respiratory syncytial virus infections, as well as methods and intermediates for synthesis of tetrahydrofuranyl-pyrrolo[1,2-f][1,2,4]triazine-4-amine compounds.

公开(公告)号：US20190055253A1

公开(公告)日：2019-02-21

申请号：US16045371

申请日：2018-07-25

申请人： Gilead Sciences, Inc.

发明人： Michael O' Neil Hanrahan Clarke ,  Edward Doerffler ,  Richard L. Mackman ,  Dustin Siegel

IPC分类号： C07D487/04 ,  C07F9/6561 ,  C07H7/06 ,  C07D405/04 ,  C07D405/14

CPC分类号： C07D487/04 ,  A61P31/16 ,  C07D405/04 ,  C07D405/14 ,  C07F9/6561 ,  C07H7/06

摘要： Provided herein are formulations, methods and substituted tetrahydrofuranyl-pyrrolo[1,2-f][1,2,4]triazine-4-amine compounds of Formula (I) for treating Pneumovirinae virus infections, including respiratory syncytial virus infections, as well as methods and intermediates for synthesis of tetrahydrofuranyl-pyrrolo[1,2-f][1,2,4]triazine-4-amine compounds.

公开(公告)号：US20170008897A1

公开(公告)日：2017-01-12

申请号：US15182529

申请日：2016-06-14

申请人： Gilead Sciences, Inc.

发明人： Michael O'Neil Hanrahan Clarke ,  Edward Doerffler ,  Richard L. Mackman ,  Dustin Siegel

IPC分类号： C07D487/04 ,  C07F9/6561

CPC分类号： C07D487/04 ,  C07D405/04 ,  C07D405/14 ,  C07F9/6561 ,  C07H7/06

摘要： Provided herein are formulations, methods and substituted tetrahydrofuranyl-pyrrolo[1,2-f][1,2,4]triazine-4-amine compounds of Formula (I) for treating Pneumovirinae virus infections, including respiratory syncytial virus infections, as well as methods and intermediates for synthesis of tetrahydrofuranyl-pyrrolo[1,2-f][1,2,4]triazine-4-amine compounds.

摘要翻译： 本文提供用于治疗肺炎链球菌病毒感染（包括呼吸道合胞病毒感染）的制剂，方法和取代的四氢呋喃基 - 吡咯并[1,2-f] [1,2,4]三嗪-4-胺化合物 作为合成四氢呋喃基 - 吡咯并[1,2-f] [1,2,4]三嗪-4-胺化合物的方法和中间体。

公开(公告)号：US20210284669A1

公开(公告)日：2021-09-16

申请号：US17178156

申请日：2021-02-17

申请人： Gilead Sciences, Inc.

发明人： Byoung-Kwon Chun ,  Edward Doerffler ,  Dustin S. Siegel ,  Andrew C. Stevens ,  Tiago Vieira

IPC分类号： C07F9/6561 ,  A61P31/14 ,  A61P31/16 ,  C07D487/04

摘要： The present disclosure provides a compound of Formula I: which is useful in treating a variety of diseases, such as diseases caused by respiratory syncytial virus (RSV), HRV, hMPV, ebola, Zika, West Nile, Dengue, HCV and/or HBV infections.

公开(公告)号：US20180311263A1

公开(公告)日：2018-11-01

申请号：US15902690

申请日：2018-02-22

申请人： Gilead Sciences, Inc.

发明人： Byoung Kwon Chun ,  Michael O' Neil Hanrahan Clarke ,  Edward Doerffler ,  Hon Chung Hui ,  Robert Jordan ,  Richard L. Mackman ,  Jay P. Parrish ,  Adrian S. Ray ,  Dustin Siegel

IPC分类号： A61K31/685 ,  A61K31/53 ,  A61K31/00 ,  A61K31/6615 ,  A61K31/665 ,  A61K31/683 ,  C07D487/04 ,  C07H15/18 ,  C07H11/00 ,  C07H1/02 ,  C07H1/00 ,  A61K45/06 ,  A61K31/675 ,  C07F9/6561 ,  C07F9/24 ,  C07D519/00

CPC分类号： A61K31/685 ,  A61K31/00 ,  A61K31/53 ,  A61K31/6615 ,  A61K31/665 ,  A61K31/675 ,  A61K31/683 ,  A61K31/7056 ,  A61K31/706 ,  A61K45/06 ,  C07D487/04 ,  C07D519/00 ,  C07F9/2429 ,  C07F9/65616 ,  C07H1/00 ,  C07H1/02 ,  C07H11/00 ,  C07H15/18 ,  A61K2300/00

摘要： Provided are compounds, methods, and pharmaceutical compositions for treating Filoviridae virus infections by administering ribosides, riboside phosphates and prodrugs thereof, of Formula IV: The compounds, compositions, and methods provided are particularly useful for the treatment of Marburg virus, Ebola virus and Cueva virus infections.

公开(公告)号：US10059716B2

公开(公告)日：2018-08-28

申请号：US15610104

申请日：2017-05-31

申请人： Gilead Sciences, Inc.

发明人： Michael O'Neil Hanrahan Clarke ,  Edward Doerffler ,  Richard L. Mackman ,  Dustin Siegel

IPC分类号： C07H7/06 ,  C07D487/04 ,  C07F9/6561 ,  C07D405/04 ,  C07D405/14

摘要： Provided herein are formulations, methods and substituted tetrahydrofuranyl-pyrrolo[1,2-f][1,2,4]triazine-4-amine compounds of Formula (I) for treating Pneumovirinae virus infections, including respiratory syncytial virus infections, as well as methods and intermediates for synthesis of tetrahydrofuranyl-pyrrolo[1,2-f][1,2,4]triazine-4-amine compounds.

公开(公告)号：US09724360B2

公开(公告)日：2017-08-08

申请号：US14926062

申请日：2015-10-29

申请人： Gilead Sciences, Inc.

发明人： Byoung Kwon Chun ,  Michael O' Neil Hanrahan Clarke ,  Edward Doerffler ,  Hon Chung Hui ,  Robert Jordan ,  Richard L. Mackman ,  Jay P. Parrish ,  Adrian S. Ray ,  Dustin Siegel

IPC分类号： C07H15/18 ,  C07H7/06 ,  A61K31/685 ,  C07D487/04 ,  C07D519/00 ,  C07F9/24 ,  C07F9/6561 ,  A61K31/675 ,  A61K45/06 ,  A61K31/00 ,  A61K31/53 ,  C07H1/00 ,  C07H1/02 ,  C07H11/00

CPC分类号： A61K31/685 ,  A61K31/00 ,  A61K31/53 ,  A61K31/6615 ,  A61K31/665 ,  A61K31/675 ,  A61K31/683 ,  A61K45/06 ,  C07D487/04 ,  C07D519/00 ,  C07F9/2429 ,  C07F9/65616 ,  C07H1/00 ,  C07H1/02 ,  C07H11/00 ,  C07H15/18 ,  A61K2300/00

摘要： Provided are compounds, methods, and pharmaceutical compositions for treating Filoviridae virus infections by administering ribosides, riboside phosphates and prodrugs thereof, of Formula IV: The compounds, compositions, and methods provided are particularly useful for the treatment of Marburg virus, Ebola virus and Cueva virus infections.

公开(公告)号：US09701682B2

公开(公告)日：2017-07-11

申请号：US15182529

申请日：2016-06-14

申请人： Gilead Sciences, Inc.

发明人： Michael O'Neil Hanrahan Clarke ,  Edward Doerffler ,  Richard L. Mackman ,  Dustin Siegel

IPC分类号： C07H7/06 ,  C07D405/04 ,  C07D405/14 ,  C07D487/04 ,  C07F9/6561

CPC分类号： C07D487/04 ,  C07D405/04 ,  C07D405/14 ,  C07F9/6561 ,  C07H7/06

摘要： Provided herein are formulations, methods and substituted tetrahydrofuranyl-pyrrolo[1,2-f][1,2,4]triazine-4-amine compounds of Formula (I) for treating Pneumovirinae virus infections, including respiratory syncytial virus infections, as well as methods and intermediates for synthesis of tetrahydrofuranyl-pyrrolo[1,2-f][1,2,4]triazine-4-amine compounds.

公开(公告)号：US08884030B2

公开(公告)日：2014-11-11

申请号：US13958424

申请日：2013-08-02

申请人： Gilead Sciences, Inc.

发明人： Eda Canales ,  Lee S. Chong ,  Michael O'Neil Hanrahan Clarke ,  Edward Doerffler ,  Scott E. Lazerwith ,  Willard Lew ,  Michael Mertzman ,  Philip A. Morganelli ,  William J. Watkins

IPC分类号： C07D409/00 ,  A61K31/497 ,  A61K31/427 ,  C07D493/04 ,  A61K31/4545 ,  A61K45/06 ,  C07D409/14 ,  A61K31/4535 ,  A61K31/454 ,  A61K31/4025 ,  C07D413/12 ,  C07D333/38 ,  A61K31/501 ,  A61K31/381 ,  C07D409/12

CPC分类号： C07D333/38 ,  A61K31/381 ,  A61K31/4025 ,  A61K31/427 ,  A61K31/4535 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/497 ,  A61K31/501 ,  A61K45/06 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12 ,  C07D493/04

摘要： Provided are compounds of Formula I: and pharmaceutically acceptable salts and esters thereof. The compounds, compositions, and methods provided are useful for the treatment of Flaviviridae virus infections, particularly hepatitis C infections.

摘要翻译： 提供式I化合物及其药学上可接受的盐和酯。 所提供的化合物，组合物和方法可用于治疗黄病毒科感染，特别是丙型肝炎感染。

公开(公告)号：US10695357B2

公开(公告)日：2020-06-30

申请号：US16274049

申请日：2019-02-12

申请人： GILEAD SCIENCES, INC.

发明人： Byoung Kwon Chun ,  Michael O'Neil Hanrahan Clarke ,  Edward Doerffler ,  Hon Chung Hui ,  Robert Jordan ,  Richard L. Mackman ,  Jay P. Parrish ,  Adrian S. Ray ,  Dustin Siegel

IPC分类号： A61K31/706 ,  A61K31/7056 ,  A61K31/685 ,  A61K31/53 ,  C07H1/00 ,  C07H1/02 ,  C07H11/00 ,  C07H15/18 ,  A61K31/6615 ,  A61K31/665 ,  A61K31/683 ,  C07D487/04 ,  C07D519/00 ,  C07F9/24 ,  C07F9/6561 ,  A61K31/675 ,  A61K45/06 ,  A61K31/00

摘要： Provided are compounds, methods, and pharmaceutical compositions for treating Filoviridae virus infections by administering ribosides, riboside phosphates and prodrugs thereof, of Formula IV: The compounds, compositions, and methods provided are particularly useful for the treatment of Marburg virus, Ebola virus and Cueva virus infections.