公开(公告)号：US09284323B2

公开(公告)日：2016-03-15

申请号：US14370466

申请日：2013-01-03

Applicant: Gilead Sciences, Inc.

Inventor： Kerim Babaoglu ,  Gediminas Brizgys ,  Hongyan Guo ,  Paul Hrvatin ,  Eric Lansdon ,  John O. Link ,  Hongtao Liu ,  Ryan McFadden ,  Michael L. Mitchell ,  Yingmei Qi ,  Paul A. Roethle ,  Randall W. Vivian ,  Lianhong Xu ,  Hong Yang

IPC: C07D491/06 ,  A61K45/06 ,  C07C59/64 ,  C07D213/55 ,  C07D231/56 ,  C07D491/04 ,  C07D277/34 ,  A61K31/192 ,  A61K31/426 ,  A61K31/436 ,  A61K31/4402 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/506 ,  A61K31/5377 ,  C07D277/30

CPC classification number: C07D491/06 ,  A61K31/192 ,  A61K31/426 ,  A61K31/436 ,  A61K31/4402 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/506 ,  A61K31/5377 ,  A61K45/06 ,  C07C59/64 ,  C07D213/55 ,  C07D231/56 ,  C07D277/30 ,  C07D277/34 ,  C07D491/04

Abstract: The invention provides compounds and salts thereof as d herein. The invention also provides pharmaceutical compositions comprising a compound disclosed herein, processes for preparing compounds disclosed herein, intermediates useful for preparing compounds disclosed herein and therapeutic methods for treating an HIV infection, treating the proliferation of the HIV virus, treating AIDS or delaying the onset of AIDS or ARC symptoms in a mammal using compounds disclosed herein.

Abstract translation: 本发明提供其化合物及其盐，如本文。 本发明还提供了包含本文公开的化合物的药物组合物，用于制备本文公开的化合物的方法，用于制备本文公开的化合物的中间体和治疗HIV感染的治疗方法，治疗HIV病毒的增殖，治疗AIDS或延迟 使用本文公开的化合物在哺乳动物中的AIDS或ARC症状。

公开(公告)号：US08987250B2

公开(公告)日：2015-03-24

申请号：US13866997

申请日：2013-04-19

Applicant: Gilead Sciences, Inc.

Inventor： Kerim Babaoglu ,  Gediminas Brizgys ,  Jake Cha ,  Xiaowu Chen ,  Hongyan Guo ,  Randall L. Halcomb ,  Xiaochun Han ,  Richard Huang ,  Hongtao Liu ,  Ryan McFadden ,  Michael L. Mitchell ,  Yingmei Qi ,  Paul A. Roethle ,  Lianhong Xu ,  Hong Yang

IPC: A01N43/00 ,  A61K31/00 ,  C07D417/14 ,  C07D417/10 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/506 ,  A61K31/496 ,  A61K31/428 ,  C07D471/04 ,  A61K31/437 ,  A61K31/513 ,  A61K31/497 ,  A61K31/5377 ,  A61K31/454 ,  C07D498/04 ,  A61K31/5383 ,  A61K31/4375 ,  A61K31/4709 ,  A61K31/501 ,  C07D487/04 ,  A61K31/4985 ,  A61K31/553 ,  A61K31/551 ,  A61K45/06 ,  A61K31/4741 ,  C07D277/82 ,  C07D491/06 ,  C07D417/04 ,  C07D277/66

CPC classification number: C07D277/82 ,  A61K31/428 ,  A61K31/436 ,  A61K31/437 ,  A61K31/4375 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/454 ,  A61K31/4709 ,  A61K31/4741 ,  A61K31/496 ,  A61K31/497 ,  A61K31/4985 ,  A61K31/501 ,  A61K31/506 ,  A61K31/513 ,  A61K31/5377 ,  A61K31/538 ,  A61K31/5383 ,  A61K31/551 ,  A61K31/553 ,  A61K45/06 ,  C07D277/66 ,  C07D277/68 ,  C07D417/04 ,  C07D417/10 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D491/06 ,  C07D498/04 ,  A61K2300/00

Abstract: Compounds disclosed herein including compounds of formula I′: and salts thereof are provided. Pharmaceutical compositions comprising compounds disclosed herein, processes for preparing compounds disclosed herein, intermediates useful for preparing compounds disclosed herein and therapeutic methods for treating an HIV infection using compounds disclosed herein are also provided.

Abstract translation: 提供本文公开的化合物，包括式I'化合物及其盐。 还提供了包含本文公开的化合物的药物组合物，用于制备本文公开的化合物的方法，用于制备本文公开的化合物的中间体和使用本文公开的化合物治疗HIV感染的治疗方法。

公开(公告)号：US11753399B2

公开(公告)日：2023-09-12

申请号：US17584643

申请日：2022-01-26

Applicant: Gilead Sciences, Inc.

Inventor： Gediminas Brizgys ,  Eda Canales ,  Chienhung Chou ,  Michael Graupe ,  Jiayao Li ,  Roland D. Saito ,  Scott D. Schroeder ,  Winston C. Tse ,  Qiaoyin Wu ,  Jennifer R. Zhang

IPC: C07D401/14 ,  A61P31/18 ,  C07D405/14 ,  C07D413/14

CPC classification number: C07D401/14 ,  A61P31/18 ,  C07D405/14 ,  C07D413/14

Abstract: The invention provides compounds having Formula (I):




or a pharmaceutically acceptable salt thereof, as well as pharmaceutical compositions comprising the same, processes for their preparation, and methods of treating and preventing HIV infection by their administration.

公开(公告)号：US11702414B2

公开(公告)日：2023-07-18

申请号：US17204463

申请日：2021-03-17

Applicant: Gilead Sciences, Inc.

Inventor： Stephen Ammann ,  Elizabeth M. Bacon ,  Gediminas Brizgys ,  Elbert Chin ,  Chienhung Chou ,  Jeromy J. Cottell ,  Marilyn Ndukwe ,  Marina Shatskikh ,  James G. Taylor ,  Nathan E. Wright ,  Zheng-Yu Yang ,  Sheila M. Zipfel

IPC: C07D471/04 ,  C07D487/04

CPC classification number: C07D471/04 ,  C07D487/04

Abstract: A compound of Formula (I):




pharmaceutically acceptable salts thereof, deuterated analogs thereof, compositions thereof, and methods of treating disease using a compound thereof are disclosed.

公开(公告)号：US20220098187A1

公开(公告)日：2022-03-31

申请号：US17268245

申请日：2019-08-13

Applicant: Gilead Sciences, Inc.

Inventor： Stephen Ammann ,  Elizabeth M. Bacon ,  Gediminas Brizgys ,  Elbert Chin ,  Chienhung Chou ,  Jeromy J. Cottell ,  Marilyn Ndukwe ,  Marina Shatskikh ,  James G. Taylor ,  Nathan E. Wright ,  Zheng-Yu Yang ,  Sheila M. Zipfel

IPC: C07D471/04 ,  C07D519/00

Abstract: A compound of Formula (I): pharmaceutically acceptable salts thereof, deuterated analogs thereof, compositions thereof, and methods of treating disease using a compound thereof are disclosed.

公开(公告)号：US20220009904A1

公开(公告)日：2022-01-13

申请号：US17349288

申请日：2021-06-16

Applicant: Gilead Sciences, Inc.

Inventor： Kevin McCormack Allan ,  Amanda Lynn Vandehey ,  Gediminas Brizgys ,  Sachin Dhar ,  Ian James Doxsee ,  Alex Goldberg ,  Lars V. Heumann ,  Zilin Huang ,  Nathaniel Thomas Kadunce ,  Shahrokh Kazerani ,  Willard Lew ,  Vinh Xuan Ngo ,  Brian Michael O'Keefe ,  Trevor James Rainey ,  Benjamin James Roberts ,  Bing Shi ,  Dietrich P. Steinhuebel ,  Winston C. Tse ,  Anna Michelle Wagner ,  Xianghong Wang ,  Scott Alan Wolckenhauer ,  Chloe Yuyi Wong ,  Jennifer R. Zhang

IPC: C07D401/14 ,  C07D401/12 ,  C07D495/10 ,  C07D339/06 ,  C07C59/50 ,  C07D231/56 ,  C07C45/67 ,  C07D213/61 ,  C07D231/54

Abstract: The present disclosure relates to methods and intermediates useful for preparing a compound of formula I. or a co-crystal, solvate, salt or combination thereof.

公开(公告)号：US10696657B2

公开(公告)日：2020-06-30

申请号：US16277552

申请日：2019-02-15

Applicant: Gilead Sciences, Inc.

Inventor： Amanda L. Vandehey ,  Gediminas Brizgys ,  Vinh X. Ngo ,  Brian M. O'Keefe ,  Trevor J. Rainey ,  Bing Shi ,  Winston C. Tse ,  Anna M. Wagner ,  Xianghong Wang ,  Scott A. Wolckenhauer ,  Chloe Y. Wong

IPC: C07D401/14 ,  C07D401/12 ,  C07D495/10 ,  C07D339/06 ,  C07C59/50 ,  C07D231/56 ,  C07C45/67 ,  C07D213/61 ,  C07D231/54

Abstract: The present disclosure relates to methods and intermediates useful for preparing a compound of formula I: or a co-crystal, solvate, salt or combination thereof.

公开(公告)号：US20200017510A1

公开(公告)日：2020-01-16

申请号：US16508979

申请日：2019-07-11

Applicant: Gilead Sciences, Inc.

Inventor： Stephen Ammann ,  Elizabeth M. Bacon ,  Gediminas Brizgys ,  Elbert Chin ,  Chienhung Chou ,  Jeromy J. Cottell ,  Marilyn Ndukwe ,  James G. Taylor ,  Nathan E. Wright ,  Zheng-Yu Yang ,  Sheila M. Zipfel

IPC: C07D487/04

Abstract: A compound of Formula (I): pharmaceutically acceptable salts thereof, deuterated analogs thereof, compositions thereof, and methods of treating disease using a compound thereof, wherein the variable substituents are disclosed herein.

公开(公告)号：US10336762B2

公开(公告)日：2019-07-02

申请号：US15898095

申请日：2018-02-15

Applicant: Gilead Sciences, Inc.

Inventor： Elizabeth M. Bacon ,  Gediminas Brizgys ,  Elbert Chin ,  Chienhung Chou ,  Jeromy J. Cottell ,  John O. Link ,  James G. Taylor ,  Winston C. Tse ,  Nathan E. Wright ,  Zheng-Yu Yang ,  Jennifer R. Zhang ,  Sheila M. Zipfel

IPC: C07D401/04 ,  C07D413/04 ,  C07D487/04 ,  C07D453/00 ,  C07D519/00 ,  A61P29/00

Abstract: Provided is a compound of Formula (I) wherein the variable groups are defined herein.

公开(公告)号：US20130281434A1

公开(公告)日：2013-10-24

申请号：US13867016

申请日：2013-04-19

Applicant: GILEAD SCIENCES, INC.

Inventor： Kerim Babaoglu ,  Gediminas Brizgys ,  Hongtao Liu ,  Ryan McFadden ,  Michael L. Mitchell ,  Yingmei Qi ,  Paul A. Roethle ,  Lianhong Xu ,  Hong Yang

IPC: C07D491/06 ,  C07D277/82 ,  A61K31/428 ,  C07D417/10 ,  A61K31/5377 ,  C07D417/14 ,  A61K31/444 ,  A61K31/506 ,  A61K31/496 ,  A61K31/4741 ,  A61K31/4439

CPC classification number: C07D277/82 ,  A61K31/428 ,  A61K31/436 ,  A61K31/437 ,  A61K31/4375 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/454 ,  A61K31/4709 ,  A61K31/4741 ,  A61K31/496 ,  A61K31/497 ,  A61K31/4985 ,  A61K31/501 ,  A61K31/506 ,  A61K31/513 ,  A61K31/5377 ,  A61K31/538 ,  A61K31/5383 ,  A61K31/551 ,  A61K31/553 ,  A61K45/06 ,  C07D277/66 ,  C07D277/68 ,  C07D417/04 ,  C07D417/10 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D491/06 ,  C07D498/04 ,  A61K2300/00

Abstract: Compounds of formula I′: or salts thereof are provided. Pharmaceutical compositions comprising a compound of formula I′, processes for preparing compounds of formula I′, intermediates useful for preparing compounds of formula I′ and therapeutic methods for treating the proliferation of the HIV virus, treating AIDS or delaying the onset of AIDS or ARC symptoms in a mammal are also provided.

Abstract translation: 提供式I'化合物或其盐。 包含式I'化合物的药物组合物，制备式I'化合物的方法，可用于制备式I'化合物的中间体和用于治疗HIV病毒增殖的治疗方法，治疗AIDS或延迟AIDS或ARC发作 还提供哺乳动物的症状。