公开(公告)号：US20250115620A1

公开(公告)日：2025-04-10

申请号：US18731608

申请日：2024-06-03

Applicant: Gilead Sciences, Inc.

Inventor： Hang Chu ,  Ana Z. Gonzalez Buenrostro ,  Xiaochun Han ,  Anna E. Hurtley ,  Lan Jiang ,  Jiayao Li ,  Gregg M. Schwarzwalder ,  Devleena M. Shivakumar ,  Matthew J. Von Bargen ,  Qiaoyin Wu ,  Hong Yang

IPC: C07D498/20 ,  A61K45/06 ,  A61P31/18 ,  C07D471/22 ,  C07D491/22 ,  C07D497/22 ,  C07D498/22 ,  C07D513/22 ,  C07D515/22

Abstract: The present disclosure relates generally to compounds, of Formula I. Also disclosed are pharmaceutical compositions comprising said compounds and methods of making said compounds. The compounds of the disclosure are useful in treating or preventing human immunodeficiency virus (HIV) infection.

公开(公告)号：US20240300966A1

公开(公告)日：2024-09-12

申请号：US18393778

申请日：2023-12-22

Applicant: Gilead Sciences, Inc.

Inventor： Hang Chu ,  Ana Z. Gonzalez Buenrostro ,  Hongyan Guo ,  Xiaochun Han ,  Anna E. Hurtley ,  Lan Jiang ,  Jiayao Li ,  David W. Lin ,  Michael L. Mitchell ,  Devan Naduthambi ,  Gregg M. Schwarzwalder ,  Suzanne M. Szewczyk ,  Matthew J. Von Bargen ,  Qiaoyin Wu ,  Hong Yang ,  Jennifer R. Zhang

IPC: C07D487/18 ,  A61P31/18 ,  C07D487/22 ,  C07D491/22

CPC classification number: C07D487/18 ,  A61P31/18 ,  C07D487/22 ,  C07D491/22

Abstract: The present disclosure relates generally to certain tricyclic compounds, pharmaceutical compositions comprising said compounds, and methods of making said compounds and pharmaceutical compositions. The compounds of the disclosure are useful in treating or preventing human immunodeficiency virus (HIV) infection.

公开(公告)号：US11897892B2

公开(公告)日：2024-02-13

申请号：US18164317

申请日：2023-02-03

Applicant: Gilead Sciences, Inc.

Inventor： Hang Chu ,  Ana Z. Gonzalez Buenrostro ,  Hongyan Guo ,  Xiaochun Han ,  Anna E. Hurtley ,  Lan Jiang ,  Jiayao Li ,  David W. Lin ,  Michael L. Mitchell ,  Devan Naduthambi ,  Gregg M. Schwarzwalder ,  Suzanne M. Szewczyk ,  Matthew J. Von Bargen ,  Qiaoyin Wu ,  Hong Yang ,  Jennifer R. Zhang

IPC: C07D487/18 ,  A61P31/18 ,  C07D487/22 ,  C07D491/22

CPC classification number: C07D487/18 ,  A61P31/18 ,  C07D487/22 ,  C07D491/22

Abstract: The present disclosure relates generally to certain tricyclic compounds, pharmaceutical compositions comprising said compounds, and methods of making said compounds and pharmaceutical compositions. The compounds of the disclosure are useful in treating or preventing human immunodeficiency virus (HIV) infection.

公开(公告)号：US20230339972A1

公开(公告)日：2023-10-26

申请号：US18334611

申请日：2023-06-14

Applicant: Gilead Sciences, Inc.

Inventor： Hang Chu ,  Ana Z. Gonzalez Buenrostro ,  Xiaochun Han ,  Anna E. Hurtley ,  Lan Jiang ,  Jiayao Li ,  Gregg M. Schwarzwalder ,  Devleena M. Shivakumar ,  Matthew J. Von Bargen ,  Qiaoyin Wu ,  Hong Yang

IPC: C07D498/22 ,  C07D491/22 ,  C07D471/22 ,  C07D513/22 ,  C07D515/22 ,  C07D497/22 ,  A61P31/18

CPC classification number: C07D498/22 ,  C07D491/22 ,  C07D471/22 ,  C07D513/22 ,  C07D515/22 ,  C07D497/22 ,  A61P31/18 ,  C07B2200/05

Abstract: The present disclosure relates generally to compounds, of Formula I:




Also disclosed are pharmaceutical compositions comprising said compounds and methods of making said compounds. The compounds of the disclosure are useful in treating or preventing human immunodeficiency virus (HIV) infection.

公开(公告)号：US20210171543A1

公开(公告)日：2021-06-10

申请号：US17094447

申请日：2020-11-10

Applicant: Gilead Sciences, Inc.

Inventor： Hang Chu ,  Juan A. Guerrero ,  Anna E. Hurtley ,  Lan Jiang ,  Darryl Kato ,  Tetsuya Kobayashi ,  David W. Lin ,  Jonathan William Medley ,  Devan Naduthambi ,  Vickie H. Tsui ,  Chandrasekar Venkataramani ,  William J. Watkins ,  Hong Yang ,  QingMing Zhu

IPC: C07D513/18 ,  C07D519/00 ,  C07D513/20 ,  C07D513/08 ,  C07D513/22 ,  A61K45/06 ,  C07K16/28

Abstract: The present disclosure generally relates to compounds of Formula (I) and pharmaceutical compositions that may be used in methods of treating cancer.

公开(公告)号：US20200331870A1

公开(公告)日：2020-10-22

申请号：US16857021

申请日：2020-04-23

Applicant: Gilead Sciences, Inc.

Inventor： Hang Chu ,  Juan A. Guerrero ,  Anna E. Hurtley ,  Tae H. Hwang ,  Lan Jiang ,  Darryl Kato ,  Tetsuya Kobayashi ,  John E. Knox ,  Scott E. Lazerwith ,  Xiaofen Li ,  David W. Lin ,  Jonathan W. Medley ,  Michael L. Mitchell ,  Devan Naduthambi ,  Zachary Newby ,  Neil H. Squires ,  Vickie H. Tsui ,  Chandrasekar Venkataramani ,  William J. Watkins ,  Hong Yang

IPC: C07D267/20 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D471/04 ,  C07D487/04 ,  C07D498/04

Abstract: The present disclosure generally relates to compounds and pharmaceutical compositions that may be used in methods of treating cancer.

公开(公告)号：US20180118734A1

公开(公告)日：2018-05-03

申请号：US15716431

申请日：2017-09-26

Applicant: Gilead Sciences, Inc.

Inventor： Zhenhong R. Cai ,  Hongyan Guo ,  Mingzhe Ji ,  Haolun Jin ,  Amy Lee ,  Ryan McFadden ,  Michael L. Mitchell ,  Manuel Munoz ,  Hyung-Jung Pyun ,  Lianhong Xu ,  Hong Yang

IPC: C07D417/14 ,  A61K45/06 ,  A61P31/18 ,  A61K31/454 ,  A61K31/428 ,  C07D498/04 ,  A61K31/5383 ,  C07D487/08 ,  A61K31/55 ,  C07D471/04 ,  A61K31/4545 ,  A61K31/496 ,  C07D487/04 ,  A61K31/4985 ,  A61K31/5377 ,  C07D487/10 ,  C07D491/107 ,  C07D417/04 ,  C07D471/08 ,  A61K31/439 ,  A61K31/519 ,  A61K31/551

Abstract: Compounds disclosed herein including compounds of Formula I: and salts thereof are provided. Pharmaceutical compositions comprising compounds disclosed herein, processes for preparing compounds disclosed herein, intermediates useful for preparing compounds disclosed herein and therapeutic methods for treating an HIV infection using compounds disclosed herein are also provided.

公开(公告)号：US08809527B2

公开(公告)日：2014-08-19

申请号：US14089633

申请日：2013-11-25

Applicant: Gilead Sciences, Inc.

Inventor： Manoj C. Desai ,  Randall L. Halcomb ,  Paul Hrvatin ,  Hon Chung Hui ,  Ryan McFadden ,  Paul A. Roethle ,  Hong Yang

IPC: C07D475/06 ,  C07D475/08 ,  C07D475/12 ,  C07D487/04

CPC classification number: A61K31/519 ,  A61K31/527 ,  A61K31/5377 ,  A61K31/551 ,  A61K31/573 ,  A61K31/683 ,  A61K31/7056 ,  A61K31/7072 ,  A61K31/708 ,  A61K38/16 ,  A61K38/21 ,  A61K38/212 ,  A61K45/06 ,  C07D403/12 ,  C07D475/06 ,  C07D475/08 ,  C07D475/10 ,  C07D475/12 ,  C07D487/04 ,  Y02A50/385 ,  Y02A50/387 ,  Y02A50/389 ,  Y02A50/391 ,  Y02A50/393 ,  Y02A50/395

Abstract: Provided are modulators of TLRs of Formula II: pharmaceutically acceptable salts thereof, compositions containing such compounds, and therapeutic methods that include the administration of such compounds.

Abstract translation: 提供了式II的TLR的调节剂：其药学上可接受的盐，含有这些化合物的组合物和包括施用这些化合物的治疗方法。

公开(公告)号：US20130281434A1

公开(公告)日：2013-10-24

申请号：US13867016

申请日：2013-04-19

Applicant: GILEAD SCIENCES, INC.

Inventor： Kerim Babaoglu ,  Gediminas Brizgys ,  Hongtao Liu ,  Ryan McFadden ,  Michael L. Mitchell ,  Yingmei Qi ,  Paul A. Roethle ,  Lianhong Xu ,  Hong Yang

IPC: C07D491/06 ,  C07D277/82 ,  A61K31/428 ,  C07D417/10 ,  A61K31/5377 ,  C07D417/14 ,  A61K31/444 ,  A61K31/506 ,  A61K31/496 ,  A61K31/4741 ,  A61K31/4439

CPC classification number: C07D277/82 ,  A61K31/428 ,  A61K31/436 ,  A61K31/437 ,  A61K31/4375 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/454 ,  A61K31/4709 ,  A61K31/4741 ,  A61K31/496 ,  A61K31/497 ,  A61K31/4985 ,  A61K31/501 ,  A61K31/506 ,  A61K31/513 ,  A61K31/5377 ,  A61K31/538 ,  A61K31/5383 ,  A61K31/551 ,  A61K31/553 ,  A61K45/06 ,  C07D277/66 ,  C07D277/68 ,  C07D417/04 ,  C07D417/10 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D491/06 ,  C07D498/04 ,  A61K2300/00

Abstract: Compounds of formula I′: or salts thereof are provided. Pharmaceutical compositions comprising a compound of formula I′, processes for preparing compounds of formula I′, intermediates useful for preparing compounds of formula I′ and therapeutic methods for treating the proliferation of the HIV virus, treating AIDS or delaying the onset of AIDS or ARC symptoms in a mammal are also provided.

Abstract translation: 提供式I'化合物或其盐。 包含式I'化合物的药物组合物，制备式I'化合物的方法，可用于制备式I'化合物的中间体和用于治疗HIV病毒增殖的治疗方法，治疗AIDS或延迟AIDS或ARC发作 还提供哺乳动物的症状。

公开(公告)号：US20230257389A1

公开(公告)日：2023-08-17

申请号：US18164317

申请日：2023-02-03

Applicant: Gilead Sciences, Inc.

Inventor： Hang Chu ,  Ana Z. Gonzalez Buenrostro ,  Hongyan Guo ,  Xiaochun Han ,  Anna E. Hurtley ,  Lan Jiang ,  Jiayao Li ,  David W. Lin ,  Michael L. Mitchell ,  Devan Naduthambi ,  Gregg M. Schwarzwalder ,  Suzanne M. Szewczyk ,  Matthew J. Von Bargen ,  Qiaoyin Wu ,  Hong Yang ,  Jennifer R. Zhang

IPC: C07D487/18 ,  A61P31/18 ,  C07D487/22 ,  C07D491/22

CPC classification number: C07D487/18 ,  A61P31/18 ,  C07D487/22 ,  C07D491/22

Abstract: The present disclosure relates generally to certain tricyclic compounds, pharmaceutical compositions comprising said compounds, and methods of making said compounds and pharmaceutical compositions. The compounds of the disclosure are useful in treating or preventing human immunodeficiency virus (HIV) infection.