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公开(公告)号：US08809527B2
公开(公告)日：2014-08-19
申请号：US14089633
申请日：2013-11-25
Applicant: Gilead Sciences, Inc.
Inventor： Manoj C. Desai , Randall L. Halcomb , Paul Hrvatin , Hon Chung Hui , Ryan McFadden , Paul A. Roethle , Hong Yang
IPC: C07D475/06 , C07D475/08 , C07D475/12 , C07D487/04
CPC classification number: A61K31/519 , A61K31/527 , A61K31/5377 , A61K31/551 , A61K31/573 , A61K31/683 , A61K31/7056 , A61K31/7072 , A61K31/708 , A61K38/16 , A61K38/21 , A61K38/212 , A61K45/06 , C07D403/12 , C07D475/06 , C07D475/08 , C07D475/10 , C07D475/12 , C07D487/04 , Y02A50/385 , Y02A50/387 , Y02A50/389 , Y02A50/391 , Y02A50/393 , Y02A50/395
Abstract: Provided are modulators of TLRs of Formula II: pharmaceutically acceptable salts thereof, compositions containing such compounds, and therapeutic methods that include the administration of such compounds.
Abstract translation: 提供了式II的TLR的调节剂：其药学上可接受的盐，含有这些化合物的组合物和包括施用这些化合物的治疗方法。
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公开(公告)号：US20130281434A1
公开(公告)日：2013-10-24
申请号：US13867016
申请日：2013-04-19
Applicant: GILEAD SCIENCES, INC.
Inventor： Kerim Babaoglu , Gediminas Brizgys , Hongtao Liu , Ryan McFadden , Michael L. Mitchell , Yingmei Qi , Paul A. Roethle , Lianhong Xu , Hong Yang
IPC: C07D491/06 , C07D277/82 , A61K31/428 , C07D417/10 , A61K31/5377 , C07D417/14 , A61K31/444 , A61K31/506 , A61K31/496 , A61K31/4741 , A61K31/4439
CPC classification number: C07D277/82 , A61K31/428 , A61K31/436 , A61K31/437 , A61K31/4375 , A61K31/4439 , A61K31/444 , A61K31/454 , A61K31/4709 , A61K31/4741 , A61K31/496 , A61K31/497 , A61K31/4985 , A61K31/501 , A61K31/506 , A61K31/513 , A61K31/5377 , A61K31/538 , A61K31/5383 , A61K31/551 , A61K31/553 , A61K45/06 , C07D277/66 , C07D277/68 , C07D417/04 , C07D417/10 , C07D417/14 , C07D471/04 , C07D487/04 , C07D491/06 , C07D498/04 , A61K2300/00
Abstract: Compounds of formula I′: or salts thereof are provided. Pharmaceutical compositions comprising a compound of formula I′, processes for preparing compounds of formula I′, intermediates useful for preparing compounds of formula I′ and therapeutic methods for treating the proliferation of the HIV virus, treating AIDS or delaying the onset of AIDS or ARC symptoms in a mammal are also provided.
Abstract translation: 提供式I'化合物或其盐。 包含式I'化合物的药物组合物，制备式I'化合物的方法，可用于制备式I'化合物的中间体和用于治疗HIV病毒增殖的治疗方法，治疗AIDS或延迟AIDS或ARC发作 还提供哺乳动物的症状。
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公开(公告)号：US09284323B2
公开(公告)日：2016-03-15
申请号：US14370466
申请日：2013-01-03
Applicant: Gilead Sciences, Inc.
Inventor： Kerim Babaoglu , Gediminas Brizgys , Hongyan Guo , Paul Hrvatin , Eric Lansdon , John O. Link , Hongtao Liu , Ryan McFadden , Michael L. Mitchell , Yingmei Qi , Paul A. Roethle , Randall W. Vivian , Lianhong Xu , Hong Yang
IPC: C07D491/06 , A61K45/06 , C07C59/64 , C07D213/55 , C07D231/56 , C07D491/04 , C07D277/34 , A61K31/192 , A61K31/426 , A61K31/436 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/506 , A61K31/5377 , C07D277/30
CPC classification number: C07D491/06 , A61K31/192 , A61K31/426 , A61K31/436 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/506 , A61K31/5377 , A61K45/06 , C07C59/64 , C07D213/55 , C07D231/56 , C07D277/30 , C07D277/34 , C07D491/04
Abstract: The invention provides compounds and salts thereof as d herein. The invention also provides pharmaceutical compositions comprising a compound disclosed herein, processes for preparing compounds disclosed herein, intermediates useful for preparing compounds disclosed herein and therapeutic methods for treating an HIV infection, treating the proliferation of the HIV virus, treating AIDS or delaying the onset of AIDS or ARC symptoms in a mammal using compounds disclosed herein.
Abstract translation: 本发明提供其化合物及其盐，如本文。 本发明还提供了包含本文公开的化合物的药物组合物，用于制备本文公开的化合物的方法，用于制备本文公开的化合物的中间体和治疗HIV感染的治疗方法，治疗HIV病毒的增殖，治疗AIDS或延迟 使用本文公开的化合物在哺乳动物中的AIDS或ARC症状。
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4.发明授权公开(公告)号：US09161934B2
公开(公告)日：2015-10-20
申请号：US14595072
申请日：2015-01-12
Applicant: Gilead Sciences, Inc.
Inventor： Randall L. Halcomb , Paul A. Roethle
IPC: A61K31/522 , A61K31/437 , C07D473/16 , C07D473/18 , C07D473/24 , C07D473/34 , A61K31/5377 , C07D471/04
CPC classification number: A61K31/437 , A61K31/522 , A61K31/5377 , C07D471/04 , C07D473/16 , C07D473/18 , C07D473/24 , C07D473/34
Abstract: The present application includes novel modulators of TLRs, compositions containing such compounds, therapeutic methods that include the administration of such compounds.
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公开(公告)号：US08987250B2
公开(公告)日：2015-03-24
申请号：US13866997
申请日：2013-04-19
Applicant: Gilead Sciences, Inc.
Inventor： Kerim Babaoglu , Gediminas Brizgys , Jake Cha , Xiaowu Chen , Hongyan Guo , Randall L. Halcomb , Xiaochun Han , Richard Huang , Hongtao Liu , Ryan McFadden , Michael L. Mitchell , Yingmei Qi , Paul A. Roethle , Lianhong Xu , Hong Yang
IPC: A01N43/00 , A61K31/00 , C07D417/14 , C07D417/10 , A61K31/4439 , A61K31/444 , A61K31/506 , A61K31/496 , A61K31/428 , C07D471/04 , A61K31/437 , A61K31/513 , A61K31/497 , A61K31/5377 , A61K31/454 , C07D498/04 , A61K31/5383 , A61K31/4375 , A61K31/4709 , A61K31/501 , C07D487/04 , A61K31/4985 , A61K31/553 , A61K31/551 , A61K45/06 , A61K31/4741 , C07D277/82 , C07D491/06 , C07D417/04 , C07D277/66
CPC classification number: C07D277/82 , A61K31/428 , A61K31/436 , A61K31/437 , A61K31/4375 , A61K31/4439 , A61K31/444 , A61K31/454 , A61K31/4709 , A61K31/4741 , A61K31/496 , A61K31/497 , A61K31/4985 , A61K31/501 , A61K31/506 , A61K31/513 , A61K31/5377 , A61K31/538 , A61K31/5383 , A61K31/551 , A61K31/553 , A61K45/06 , C07D277/66 , C07D277/68 , C07D417/04 , C07D417/10 , C07D417/14 , C07D471/04 , C07D487/04 , C07D491/06 , C07D498/04 , A61K2300/00
Abstract: Compounds disclosed herein including compounds of formula I′: and salts thereof are provided. Pharmaceutical compositions comprising compounds disclosed herein, processes for preparing compounds disclosed herein, intermediates useful for preparing compounds disclosed herein and therapeutic methods for treating an HIV infection using compounds disclosed herein are also provided.
Abstract translation: 提供本文公开的化合物，包括式I'化合物及其盐。 还提供了包含本文公开的化合物的药物组合物，用于制备本文公开的化合物的方法，用于制备本文公开的化合物的中间体和使用本文公开的化合物治疗HIV感染的治疗方法。
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Patent Agency Ranking
6.发明申请2- (TERT - BUTOXY) -2- (7 -METHYLQUINOLIN- 6 - YL) ACETIC ACID DERIVATIVES FOR TREATING AIDS 有权2-（叔丁基氧基）-2-（7-甲基喹啉-6-基）乙酸衍生物，用于治疗艾滋病公开(公告)号：US20150045374A1
公开(公告)日：2015-02-12
申请号：US14370464
申请日：2013-01-03
Applicant: Gilead Sciences, Inc.
Inventor： Kerim Babaoglu , Kyla L. Bjornson , Paul Hrvatin , Eric Lansdon , John O. Link , Hongtao Liu , Ryan McFadden , Michael L. Mitchell , Yingmei Qi , Paul A. Roethle , Lianhong Xu
IPC: C07D215/227 , A61K31/4704 , A61K31/506 , C07D519/00 , A61K31/4745 , A61K45/06 , C07D491/06 , A61K31/4741 , A61K31/497
CPC classification number: C07D215/227 , A61K31/4704 , A61K31/4741 , A61K31/4745 , A61K31/497 , A61K31/506 , A61K45/06 , C07D491/06 , C07D519/00
Abstract: The invention provides compounds and salts thereof as d herein. The invention also provides pharmaceutical compositions comprising a compound disclosed herein, processes for preparing compounds disclosed herein, intermediates useful for preparing compounds disclosed herein and therapeutic methods for treating an HIV infection, treating the proliferation of the HIV virus, treating AIDS or delaying the onset of AIDS or ARC symptoms in a mammal using compounds disclosed herein.
Abstract translation: 本发明提供其化合物及其盐，如本文。 本发明还提供了包含本文公开的化合物的药物组合物，用于制备本文公开的化合物的方法，用于制备本文公开的化合物的中间体和治疗HIV感染的治疗方法，治疗HIV病毒的增殖，治疗AIDS或延迟 使用本文公开的化合物在哺乳动物中的AIDS或ARC症状。
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公开(公告)号：US11072615B2
公开(公告)日：2021-07-27
申请号：US16678788
申请日：2019-11-08
Applicant: GILEAD SCIENCES, INC.
Inventor： Brandon Heath Brown , Paul A. Roethle
IPC: A61K31/519 , A61K45/06 , C07D475/06 , C07D487/04
Abstract: The present invention provides crystalline forms, solvates and hydrates of 4-amino-2-butoxy-8-(3-(pyrrolidin-1-ylmethyl)benzyl)-7,8-dihydropteridin-6(5H)-one, and methods of making.
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公开(公告)号：US20190321366A1
公开(公告)日：2019-10-24
申请号：US16201221
申请日：2018-11-27
Applicant: Gilead Sciences, Inc.
Inventor： Manoj C. Desai , Randall L. Halcomb , Paul Hrvatin , Hon Chung Hui , Ryan McFadden , Paul A. Roethle , Hong Yang
IPC: A61K31/519 , A61K38/21 , C07D475/06 , A61K38/16 , A61K31/708 , A61K31/7072 , A61K31/7056 , A61K31/683 , A61K31/573 , A61K31/5377 , A61K45/06 , A61K31/551 , A61K31/527 , C07D475/08 , C07D475/12 , C07D487/04 , C07D475/10 , C07D403/12
Abstract: Provided are modulators of TLRs of Formula II: pharmaceutically acceptable salts thereof, compositions containing such compounds, and therapeutic methods that include the administration of such compounds.
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公开(公告)号：US20180085370A1
公开(公告)日：2018-03-29
申请号：US15659526
申请日：2017-07-25
Applicant: Gilead Sciences, Inc.
Inventor： Manoj C. Desai , Randall L. Halcomb , Paul Hrvatin , Hon Chung Hui , Ryan McFadden , Paul A. Roethle , Hong Yang
IPC: A61K31/519 , A61K38/21 , C07D475/06 , A61K38/16 , A61K31/708 , A61K31/7072 , A61K31/7056 , A61K31/683 , A61K31/573 , A61K31/5377 , A61K45/06 , A61K31/551 , A61K31/527 , C07D403/12 , C07D475/10 , C07D487/04 , C07D475/12 , C07D475/08
CPC classification number: A61K31/519 , A61K31/527 , A61K31/5377 , A61K31/551 , A61K31/573 , A61K31/683 , A61K31/7056 , A61K31/7072 , A61K31/708 , A61K38/16 , A61K38/21 , A61K38/212 , A61K45/06 , C07D403/12 , C07D475/06 , C07D475/08 , C07D475/10 , C07D475/12 , C07D487/04 , Y02A50/385 , Y02A50/387 , Y02A50/389 , Y02A50/391 , Y02A50/393 , Y02A50/395
Abstract: Provided are modulators of TLRs of Formula II: pharmaceutically acceptable salts thereof, compositions containing such compounds, and therapeutic methods that include the administration of such compounds.
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公开(公告)号：US20170313707A1
公开(公告)日：2017-11-02
申请号：US15591711
申请日：2017-05-10
Applicant: Gilead Sciences, Inc.
Inventor： Patricia Andres , Brandon Heath Brown , Krista Marie Diaz , Yoo Joong Kim , Paul A. Roethle , Valeriya Smolenskaya , Fang Wang
IPC: C07D475/06 , A61K31/519 , A61K45/06 , C07D487/04
CPC classification number: C07D475/06 , A61K31/519 , A61K45/06 , C07D487/04 , A61K2300/00
Abstract: The present invention provides crystalline forms, solvates and hydrates of 4-amino-2-butoxy-8-(3-(pyrrolidin-1-ylmethyl)benzyl)-7,8-dihydropteridin-6(5H)-one, and methods of making.
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