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公开(公告)号：US20140051656A1
公开(公告)日：2014-02-20
申请号：US13956195
申请日：2013-07-31
Applicant: Gilead Sciences, Inc.
Inventor： Hongyan Guo , Darryl Kato , Thorsten A. Kirschberg , Hongtao Liu , John O. Link , Michael L. Mitchell , Jay P. Parrish , Jianyu Sun , James Taylor , Elizabeth M. Bacon , Eda Canales , Aesop Cho , Choung U. Kim , Jeromy J. Cottell , Manoj C. Desai , Randall L. Halcomb , Michael Graupe , Evan S. Krygowski , Scott E. Lazerwith , Qi Liu , Richard L. Mackman , Hyung-Jung Pyun , Joseph H. Saugier , James D. Trenkle , Winston C. Tse , Randall W. Vivian , Scott D. Schroeder , William J. Watkins , Lianhong Xu
IPC: C07D403/14 , A61K45/06 , A61K31/4184
CPC classification number: C07D403/14 , A61K31/4025 , A61K31/4178 , A61K31/4184 , A61K31/427 , A61K31/435 , A61K31/437 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/519 , A61K31/5377 , A61K31/5415 , A61K31/55 , A61K45/06 , A61P31/12 , C07D207/16 , C07D401/14 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D471/08 , C07D471/10 , C07D487/04 , C07D491/113 , C07D495/04 , C07F5/025
Abstract: The invention is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
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公开(公告)号：US20130281434A1
公开(公告)日：2013-10-24
申请号：US13867016
申请日：2013-04-19
Applicant: GILEAD SCIENCES, INC.
Inventor： Kerim Babaoglu , Gediminas Brizgys , Hongtao Liu , Ryan McFadden , Michael L. Mitchell , Yingmei Qi , Paul A. Roethle , Lianhong Xu , Hong Yang
IPC: C07D491/06 , C07D277/82 , A61K31/428 , C07D417/10 , A61K31/5377 , C07D417/14 , A61K31/444 , A61K31/506 , A61K31/496 , A61K31/4741 , A61K31/4439
CPC classification number: C07D277/82 , A61K31/428 , A61K31/436 , A61K31/437 , A61K31/4375 , A61K31/4439 , A61K31/444 , A61K31/454 , A61K31/4709 , A61K31/4741 , A61K31/496 , A61K31/497 , A61K31/4985 , A61K31/501 , A61K31/506 , A61K31/513 , A61K31/5377 , A61K31/538 , A61K31/5383 , A61K31/551 , A61K31/553 , A61K45/06 , C07D277/66 , C07D277/68 , C07D417/04 , C07D417/10 , C07D417/14 , C07D471/04 , C07D487/04 , C07D491/06 , C07D498/04 , A61K2300/00
Abstract: Compounds of formula I′: or salts thereof are provided. Pharmaceutical compositions comprising a compound of formula I′, processes for preparing compounds of formula I′, intermediates useful for preparing compounds of formula I′ and therapeutic methods for treating the proliferation of the HIV virus, treating AIDS or delaying the onset of AIDS or ARC symptoms in a mammal are also provided.
Abstract translation: 提供式I'化合物或其盐。 包含式I'化合物的药物组合物，制备式I'化合物的方法，可用于制备式I'化合物的中间体和用于治疗HIV病毒增殖的治疗方法，治疗AIDS或延迟AIDS或ARC发作 还提供哺乳动物的症状。
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公开(公告)号：US09139541B2
公开(公告)日：2015-09-22
申请号：US14601132
申请日：2015-01-20
Applicant: Gilead Sciences, Inc.
Inventor： Manoj C. Desai , Allen Yu Hong , Hongtao Liu , Randall W. Vivian , Lianhong Xu
IPC: A61K31/426 , A61K45/06 , C07D277/24 , C07D277/28 , A61K31/427 , A61K31/496 , C07D417/14 , A61K31/5377
CPC classification number: A61K31/427 , A61K31/426 , A61K31/4402 , A61K31/4535 , A61K31/47 , A61K31/496 , A61K31/5377 , A61K38/005 , A61K38/05 , A61K45/00 , A61K45/06 , C07C209/78 , C07C227/16 , C07C227/18 , C07C315/04 , C07D277/24 , C07D277/28 , C07D277/30 , C07D417/14 , C07K5/06 , C07K5/06026 , C07K5/06034 , C07K5/06052 , A61K2300/00
Abstract: The present application provides for a compound of Formula I, or a pharmaceutically acceptable salt, solvate, and/or ester thereof, compositions containing such compounds, therapeutic methods that include the administration of such compounds, and therapeutic methods and include the administration of such compounds with at least one additional therapeutic agent.
Abstract translation: 本申请提供式I化合物或其药学上可接受的盐，溶剂合物和/或酯，含有这些化合物的组合物，包括施用这些化合物的治疗方法和治疗方法，包括给予这些化合物 与至少一种另外的治疗剂。
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公开(公告)号：US09096586B2
公开(公告)日：2015-08-04
申请号：US13867016
申请日：2013-04-19
Applicant: Gilead Sciences, Inc.
Inventor： Kerim Babaoglu , Gediminas Brizgys , Hongtao Liu , Ryan McFadden , Michael L. Mitchell , Yingmei Qi , Paul A. Roethle , Lianhong Xu , Hong Yang
IPC: A61K31/425 , A61K31/4965 , A61K31/497 , A61K31/505 , A61K31/44 , A61K31/415 , C07D417/14 , C07D417/10 , A61K31/4439 , A61K31/444 , A61K31/506 , A61K31/496 , A61K31/428 , C07D471/04 , A61K31/437 , A61K31/513 , A61K31/5377 , A61K31/454 , C07D498/04 , A61K31/5383 , A61K31/4375 , A61K31/4709 , A61K31/501 , C07D487/04 , A61K31/4985 , A61K31/553 , A61K31/551 , A61K45/06 , A61K31/4741 , C07D277/82 , C07D491/06 , C07D417/04 , C07D277/66
CPC classification number: C07D277/82 , A61K31/428 , A61K31/436 , A61K31/437 , A61K31/4375 , A61K31/4439 , A61K31/444 , A61K31/454 , A61K31/4709 , A61K31/4741 , A61K31/496 , A61K31/497 , A61K31/4985 , A61K31/501 , A61K31/506 , A61K31/513 , A61K31/5377 , A61K31/538 , A61K31/5383 , A61K31/551 , A61K31/553 , A61K45/06 , C07D277/66 , C07D277/68 , C07D417/04 , C07D417/10 , C07D417/14 , C07D471/04 , C07D487/04 , C07D491/06 , C07D498/04 , A61K2300/00
Abstract: Compounds of formula I′: or salts thereof are provided. Pharmaceutical compositions comprising a compound of formula I′, processes for preparing compounds of formula I′, intermediates useful for preparing compounds of formula I′ and therapeutic methods for treating the proliferation of the HIV virus, treating AIDS or delaying the onset of AIDS or ARC symptoms in a mammal are also provided.
Abstract translation: 提供式I'化合物或其盐。 包含式I'化合物的药物组合物，制备式I'化合物的方法，可用于制备式I'化合物的中间体和用于治疗HIV病毒增殖的治疗方法，治疗AIDS或延迟AIDS或ARC发作 还提供哺乳动物的症状。
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公开(公告)号：US20150111891A1
公开(公告)日：2015-04-23
申请号：US14370466
申请日：2013-01-03
Applicant: Gilead Sciences, Inc.
Inventor： Kerim Babaoglu , Gediminas Brizgys , Hongyan Guo , Paul Hrvatin , Eric Lansdon , John O. Link , Hongtao Liu , Ryan McFadden , Michael L. Mitchell , Yingmei Qi , Paul A. Roethle , Randall W. Vivian , Lianhong Xu , Hong Yang
IPC: C07D491/06 , A61K45/06 , C07C59/64 , A61K31/192 , C07D213/55 , A61K31/5377 , A61K31/4406 , A61K31/4409 , C07D277/30 , A61K31/426 , A61K31/506 , A61K31/436 , A61K31/4402
CPC classification number: C07D491/06 , A61K31/192 , A61K31/426 , A61K31/436 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/506 , A61K31/5377 , A61K45/06 , C07C59/64 , C07D213/55 , C07D231/56 , C07D277/30 , C07D277/34 , C07D491/04
Abstract: The invention provides compounds and salts thereof as d herein. The invention also provides pharmaceutical compositions comprising a compound disclosed herein, processes for preparing compounds disclosed herein, intermediates useful for preparing compounds disclosed herein and therapeutic methods for treating an HIV infection, treating the proliferation of the HIV virus, treating AIDS or delaying the onset of AIDS or ARC symptoms in a mammal using compounds disclosed herein.
Abstract translation: 本发明提供其化合物及其盐，如本文。 本发明还提供了包含本文公开的化合物的药物组合物，用于制备本文公开的化合物的方法，用于制备本文公开的化合物的中间体和治疗HIV感染的治疗方法，治疗HIV病毒的增殖，治疗AIDS或延迟 使用本文公开的化合物在哺乳动物中的AIDS或ARC症状。
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Patent Agency Ranking
公开(公告)号：US20130281433A1
公开(公告)日：2013-10-24
申请号：US13866997
申请日：2013-04-19
Applicant: Gilead Sciences, Inc.
Inventor： Kerim Babaoglu , Gediminas Brizgys , Jake Cha , Xiaowu Chen , Hongyan Guo , Randall L. Halcomb , Xiaochun Han , Richard Huang , Hongtao Liu , Ryan McFadden , Michael L. Mitchell , Yingmei Qi , Paul A. Roethle , Lianhong Xu , Hong Yang
IPC: C07D417/14 , A61K31/4439 , A61K31/444 , A61K31/506 , A61K31/496 , A61K31/428 , C07D471/04 , A61K31/437 , A61K31/513 , A61K31/497 , A61K31/5377 , A61K31/454 , C07D498/04 , A61K31/5383 , A61K31/4375 , A61K31/4709 , A61K31/501 , C07D487/04 , A61K31/4985 , A61K31/553 , A61K31/551 , A61K45/06 , C07D417/10
CPC classification number: C07D277/82 , A61K31/428 , A61K31/436 , A61K31/437 , A61K31/4375 , A61K31/4439 , A61K31/444 , A61K31/454 , A61K31/4709 , A61K31/4741 , A61K31/496 , A61K31/497 , A61K31/4985 , A61K31/501 , A61K31/506 , A61K31/513 , A61K31/5377 , A61K31/538 , A61K31/5383 , A61K31/551 , A61K31/553 , A61K45/06 , C07D277/66 , C07D277/68 , C07D417/04 , C07D417/10 , C07D417/14 , C07D471/04 , C07D487/04 , C07D491/06 , C07D498/04 , A61K2300/00
Abstract: Compounds disclosed herein including compounds of formula I′: and salts thereof are provided. Pharmaceutical compositions comprising compounds disclosed herein, processes for preparing compounds disclosed herein, intermediates useful for preparing compounds disclosed herein and therapeutic methods for treating an HIV infection using compounds disclosed herein are also provided.
Abstract translation: 提供本文公开的化合物，包括式I'化合物及其盐。 还提供了包含本文公开的化合物的药物组合物，用于制备本文公开的化合物的方法，用于制备本文公开的化合物的中间体和使用本文公开的化合物治疗HIV感染的治疗方法。
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公开(公告)号：US20130123311A1
公开(公告)日：2013-05-16
申请号：US13738764
申请日：2013-01-10
Applicant: Gilead Sciences, Inc.
Inventor： Manoj C. Desai , Allen Yu Hong , Hongtao Liu , Randall W. Vivian , Lianhong Xu
IPC: A61K31/427 , A61K45/06 , A61K45/00
CPC classification number: A61K31/427 , A61K31/426 , A61K31/4402 , A61K31/4535 , A61K31/47 , A61K31/496 , A61K31/5377 , A61K38/005 , A61K38/05 , A61K45/00 , A61K45/06 , C07C209/78 , C07C227/16 , C07C227/18 , C07C315/04 , C07D277/24 , C07D277/28 , C07D277/30 , C07D417/14 , C07K5/06 , C07K5/06026 , C07K5/06034 , C07K5/06052 , A61K2300/00
Abstract: The present application provides for a compound of Formula I, or a pharmaceutically acceptable salt, solvate, and/or ester thereof, compositions containing such compounds, therapeutic methods that include the administration of such compounds, and therapeutic methods and include the administration of such compounds with at least one additional therapeutic agent.
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公开(公告)号：US09284323B2
公开(公告)日：2016-03-15
申请号：US14370466
申请日：2013-01-03
Applicant: Gilead Sciences, Inc.
Inventor： Kerim Babaoglu , Gediminas Brizgys , Hongyan Guo , Paul Hrvatin , Eric Lansdon , John O. Link , Hongtao Liu , Ryan McFadden , Michael L. Mitchell , Yingmei Qi , Paul A. Roethle , Randall W. Vivian , Lianhong Xu , Hong Yang
IPC: C07D491/06 , A61K45/06 , C07C59/64 , C07D213/55 , C07D231/56 , C07D491/04 , C07D277/34 , A61K31/192 , A61K31/426 , A61K31/436 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/506 , A61K31/5377 , C07D277/30
CPC classification number: C07D491/06 , A61K31/192 , A61K31/426 , A61K31/436 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/506 , A61K31/5377 , A61K45/06 , C07C59/64 , C07D213/55 , C07D231/56 , C07D277/30 , C07D277/34 , C07D491/04
Abstract: The invention provides compounds and salts thereof as d herein. The invention also provides pharmaceutical compositions comprising a compound disclosed herein, processes for preparing compounds disclosed herein, intermediates useful for preparing compounds disclosed herein and therapeutic methods for treating an HIV infection, treating the proliferation of the HIV virus, treating AIDS or delaying the onset of AIDS or ARC symptoms in a mammal using compounds disclosed herein.
Abstract translation: 本发明提供其化合物及其盐，如本文。 本发明还提供了包含本文公开的化合物的药物组合物，用于制备本文公开的化合物的方法，用于制备本文公开的化合物的中间体和治疗HIV感染的治疗方法，治疗HIV病毒的增殖，治疗AIDS或延迟 使用本文公开的化合物在哺乳动物中的AIDS或ARC症状。
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公开(公告)号：US08987250B2
公开(公告)日：2015-03-24
申请号：US13866997
申请日：2013-04-19
Applicant: Gilead Sciences, Inc.
Inventor： Kerim Babaoglu , Gediminas Brizgys , Jake Cha , Xiaowu Chen , Hongyan Guo , Randall L. Halcomb , Xiaochun Han , Richard Huang , Hongtao Liu , Ryan McFadden , Michael L. Mitchell , Yingmei Qi , Paul A. Roethle , Lianhong Xu , Hong Yang
IPC: A01N43/00 , A61K31/00 , C07D417/14 , C07D417/10 , A61K31/4439 , A61K31/444 , A61K31/506 , A61K31/496 , A61K31/428 , C07D471/04 , A61K31/437 , A61K31/513 , A61K31/497 , A61K31/5377 , A61K31/454 , C07D498/04 , A61K31/5383 , A61K31/4375 , A61K31/4709 , A61K31/501 , C07D487/04 , A61K31/4985 , A61K31/553 , A61K31/551 , A61K45/06 , A61K31/4741 , C07D277/82 , C07D491/06 , C07D417/04 , C07D277/66
CPC classification number: C07D277/82 , A61K31/428 , A61K31/436 , A61K31/437 , A61K31/4375 , A61K31/4439 , A61K31/444 , A61K31/454 , A61K31/4709 , A61K31/4741 , A61K31/496 , A61K31/497 , A61K31/4985 , A61K31/501 , A61K31/506 , A61K31/513 , A61K31/5377 , A61K31/538 , A61K31/5383 , A61K31/551 , A61K31/553 , A61K45/06 , C07D277/66 , C07D277/68 , C07D417/04 , C07D417/10 , C07D417/14 , C07D471/04 , C07D487/04 , C07D491/06 , C07D498/04 , A61K2300/00
Abstract: Compounds disclosed herein including compounds of formula I′: and salts thereof are provided. Pharmaceutical compositions comprising compounds disclosed herein, processes for preparing compounds disclosed herein, intermediates useful for preparing compounds disclosed herein and therapeutic methods for treating an HIV infection using compounds disclosed herein are also provided.
Abstract translation: 提供本文公开的化合物，包括式I'化合物及其盐。 还提供了包含本文公开的化合物的药物组合物，用于制备本文公开的化合物的方法，用于制备本文公开的化合物的中间体和使用本文公开的化合物治疗HIV感染的治疗方法。
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10.发明申请2- (TERT - BUTOXY) -2- (7 -METHYLQUINOLIN- 6 - YL) ACETIC ACID DERIVATIVES FOR TREATING AIDS 有权2-（叔丁基氧基）-2-（7-甲基喹啉-6-基）乙酸衍生物，用于治疗艾滋病公开(公告)号：US20150045374A1
公开(公告)日：2015-02-12
申请号：US14370464
申请日：2013-01-03
Applicant: Gilead Sciences, Inc.
Inventor： Kerim Babaoglu , Kyla L. Bjornson , Paul Hrvatin , Eric Lansdon , John O. Link , Hongtao Liu , Ryan McFadden , Michael L. Mitchell , Yingmei Qi , Paul A. Roethle , Lianhong Xu
IPC: C07D215/227 , A61K31/4704 , A61K31/506 , C07D519/00 , A61K31/4745 , A61K45/06 , C07D491/06 , A61K31/4741 , A61K31/497
CPC classification number: C07D215/227 , A61K31/4704 , A61K31/4741 , A61K31/4745 , A61K31/497 , A61K31/506 , A61K45/06 , C07D491/06 , C07D519/00
Abstract: The invention provides compounds and salts thereof as d herein. The invention also provides pharmaceutical compositions comprising a compound disclosed herein, processes for preparing compounds disclosed herein, intermediates useful for preparing compounds disclosed herein and therapeutic methods for treating an HIV infection, treating the proliferation of the HIV virus, treating AIDS or delaying the onset of AIDS or ARC symptoms in a mammal using compounds disclosed herein.
Abstract translation: 本发明提供其化合物及其盐，如本文。 本发明还提供了包含本文公开的化合物的药物组合物，用于制备本文公开的化合物的方法，用于制备本文公开的化合物的中间体和治疗HIV感染的治疗方法，治疗HIV病毒的增殖，治疗AIDS或延迟 使用本文公开的化合物在哺乳动物中的AIDS或ARC症状。
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